• Following oral administration of aqueous solutions containing 100 to 400 mg of pentoxifylline, the pharmacokinetics of the parent compound and Metabolite l are dose-related and not proportional (non-linear), with half-life and area under the blood-level time curve (AUC) increasing with dose. (drugs.com)
  • The pharmacokinetics of cervical epidural-administered triamcinolone is consistent with our previous study of lumbar ESI, demonstrating that the elimination half-life is longer than that which has been reported following intravenous triamcinolone. (hindawi.com)
  • Metabolism and elimination Pharmacokinetics refers to the processes of drug absorption, distribution, metabolism, and elimination. (msdmanuals.com)
  • The elimination kinetics of Metabolite V are not dose-dependent. (drugs.com)
  • The elimination of urinary TTCA followed pseudo first order kinetics. (cdc.gov)
  • 7 Limitations in that study design indicated the need for a better controlled study to provide greater confidence in the human TCAA elimination kinetics. (bmj.com)
  • The terminal elimination half-life of cervical epidural-administered triamcinolone in a noncompartmental analysis was 219 hours. (hindawi.com)
  • The terminal elimination half-life of lumbar epidural-administered triamcinolone in a noncompartmental analysis was 523 hours, and the peak triamcinolone concentration of 4.1 ng/mL was detected within 24 hours after administration. (hindawi.com)
  • GLPG1972 was rapidly absorbed (median time to maximum concentration, 4 hours), and eliminated with a mean apparent terminal elimination half-life of ≈10 hours. (lu.se)
  • In patients with hepatic dysfunction, the elimination half-life is longer and the waiting time would be 2 days before breastfeeding again. (e-lactancia.org)
  • The apparent plasma half-life of pentoxifylline varies from 0.4 to 0.8 hours and the apparent plasma half-lives of its metabolites vary from 1 to 1.6 hours. (drugs.com)
  • However, terfenadine carboxylate apparent elimination half-life (t1/2) was not altered. (nih.gov)
  • Since the magnitude of PBDE exposure is lower in Australia than in North America we observed an apparent 1st order elimination curve over time from which we have estimated the serum elimination half-lives for BDE28, BDE47, BDE99, BDE100, and BDE153 to be 0.942, 1.19, 1.03, 2.16, and 4.12 years, respectively. (cdc.gov)
  • 18 F-Labeled compounds such as 18 F-FDG and 18 F-fluorodopa ( 18 F-FDOPA) have the urinary bladder wall as the critical organ associated with the dynamics of urinary excretion of the shorter half-life isotope ( 10 , 11 ). (snmjournals.org)
  • To measure accurately urinary elimination half life of trichloroacetic acid (TCAA). (bmj.com)
  • We previously performed a longitudinal pilot study to measure the urinary elimination half life of TCAA. (bmj.com)
  • This study was designed to measure the half life of urinary elimination for TCAA. (bmj.com)
  • Cmax and the area under the concentration versus time curve, AUC0-∞, increased proportionally to the dose. (rti.org)
  • AUC stands for "area under the curve" and reflects the concentration of a drug and the length of time it's present in blood plasma, Johnson continued. (thepigsite.com)
  • Terfenadine carboxylate area under the plasma drug concentration-time curve (AUC), Cmax, and time to reach Cmax (tmax) were increased by both strengths of juice. (nih.gov)
  • Area under the plasma concentration-time curve (56.8-67.6 μg · h/mL) and time to maximum concentration (4 hours) were similar between studies. (lu.se)
  • This has been demonstrated both by time-kill curves and by MBC/MIC ratios (minimum bactericidal concentration/minimum inhibitory concentration) using broth dilution methodology. (globalrph.com)
  • TCAA elimination half life curves were generated from a two week washout period using TCAA-free bottled water. (bmj.com)
  • Regions of interest were placed over composite images of each organ for which activity was visualized to generate time-activity curves. (snmjournals.org)
  • Conclusions and Clinical Relevance -Use of the OP to administer fentanyl to cats resulted in a shorter initial lag phase to a therapeutic serum concentration, higher bioavailability, and faster elimination after removal, compared with use of a TP. (avma.org)
  • The Tmax value, which is the amount of time a drug is present in serum at the maximum concentration, was only 15 minutes, she said. (thepigsite.com)
  • Serum elimination half-lives adjusted for ongoing exposure of tri-to hexabrominated diphenyl ethers: Determined in persons moving from North America to Australia. (cdc.gov)
  • The objective of the study was to determine the human serum elimination half-life of polybrominated diphenyl ethers (PBDEs) adjusted for ongoing exposure in subjects moving from a higher exposure region (North America) to a lower exposure region (Australia). (cdc.gov)
  • The human serum elimination half-life adjusted for ongoing exposure can allow us to assess the effectiveness and reduction in exposure in the general population following phase out of commercial penta- and octaBDE in 2004 in the United States. (cdc.gov)
  • After consumption, wheat-bran ferulic acid and oat-bran avenanthramides showed similar time to reach peak plasma concentration and elimination half-life, but oat avenanthramides had a higher maximal plasma concentration compared with ferulic acid. (preparedfoods.com)
  • however, this was not the case for time of peak plasma concentration. (nih.gov)
  • Eszopiclone is rapidly absorbed, with a time to peak concentration (t max ) of approximately 1 hour and a terminal-phase elimination half-life (t 1/2 ) of approximately 6 hours. (healthyplace.com)
  • A prolonged time to peak effect and a long elimination half-life are characteristics of this delivery mechanism. (medscape.com)
  • A longitudinal pilot exposure/intervention study measured the elimination half life of TCAA in urine. (bmj.com)
  • Compared with non-elderly adults, subjects 65 years and older had an increase of 41% in total exposure (AUC) and a slightly prolonged elimination of eszopiclone (t 1/2 approximately 9 hours). (healthyplace.com)
  • and elimination half-life of the specific phenolic metabolites have been widely used to measure and compare bioavailability. (preparedfoods.com)
  • The bioavailability of ferulic acid, avenanthramides and alk(en)ylresorcinols in commonly consumed whole-grain cereals has recently been assessed in human studies. (preparedfoods.com)
  • Taken together, oat avenanthramides have both high bioavailability and in vitro antioxidant activity in comparison to ferulic acid and alk(en)ylresorcinols. (preparedfoods.com)
  • At the time the studies were conducted, the investigators concluded that "The high distribution to lung and slow elimination following a single dose of [Draxxin] are desirable pharmacokinetic attributes for an antimicrobial drug indicated for the treatment of respiratory disease in swine. (thepigsite.com)
  • In contrast, elsewhere in Europe meat lead concentrations increased over time, an unexplained and previously undescribed finding. (researchgate.net)
  • For IA responsive compounds the respective half lives at carbon - disulfide concentrations of 50, 150, and 500ppm were 12.6, 6.1, and 4.4 hours. (cdc.gov)
  • Lung concentrations were 61.4 times the plasma AUC ( Figure 1, Table 1 ). (thepigsite.com)
  • The major metabolites are Metabolite l (1-[5-hydroxyhexyl]-3,7-dimethylxanthine) and Metabolite V (1-[3-carboxypropyl]-3,7-dimethylxanthine), and plasma levels of these metabolites are 5 and 8 times greater, respectively, than pentoxifylline. (drugs.com)
  • After administration of the 400 mg extended-release TRENTAL tablet, plasma levels of the parent compound and its metabolites reach their maximum within 2 to 4 hours and remain constant over an extended period of time. (drugs.com)
  • The saturated solubility and mean dissolution time, in the case of F8 and F12, were significantly higher than the coarse drug powder. (dovepress.com)
  • Fentanyl concentration changed significantly faster in initial and elimination phases when the OP was used. (avma.org)
  • However, the distributions of elimination half-life (44.2 h), elimination rate constant (0.0219/h), clearance (26.6 ml/min), and volume of distribution (83 L) all were significantly skewed and deviated significantly fron normal. (nih.gov)
  • Multiple dosing significantly reduced ARGS levels vs baseline at all time points for all doses vs placebo. (lu.se)
  • BPAF was cleared rapidly with a plasma elimination half-life of ≤3.35 h. (rti.org)
  • The maximal plasma concentration of rye bran alkyl- and alkenylresorcinols was much higher compared with either ferulic acid or avenanthramides, and their rates of elimination were slower. (preparedfoods.com)
  • Following administration of 200 mg (100 mg/mL) Tigan I.M. injection, the time to reach maximum plasma concentration (T) was about half an hour, about 15 minutes longer for Tigan 300 mg oral capsule than an I.M. injection. (linkedlifedata.com)
  • Because each stage of the malarial life cycle exhibits distinct biochemical and other characteristics (i.e., it expresses different proteins or locates in different sites within the body), a drug may kill one stage but have little effect on another. (nationalacademies.org)
  • Free BPAF was cleared rapidly in mice with an elimination half-life of ≤4.22 h. (rti.org)
  • The elimination half-life was shorter following cervical ESI than that which has been reported following lumbar ESI. (hindawi.com)
  • Doses were calculated from residence times using the MIRDOSE3 program. (snmjournals.org)
  • When it is possible to do so, milk detections of each patient to determine the total elimination of the drug would be the best indicator to resume breastfeeding between two cycles of chemotherapy. (e-lactancia.org)
  • The mechanism likely involved reduced presystemic drug elimination by inhibition of more than one metabolic pathway. (nih.gov)
  • Cyclobenzaprine 5 mg taken three times a day is the most commonly prescribed dosage of the drug. (projectknow.com)
  • The half time of elimination ranged from 4.9 to 5.5 hours for the 8 to 16 hour collection. (cdc.gov)
  • In the similar period TE elimination had a range of half lives from 7.9 to 9.1 hours. (cdc.gov)
  • The half life for TE lengthened after the 16 hour mark to 13.1 hours. (cdc.gov)
  • The half-life remained unchanged, approximately 6 hours. (healthyplace.com)
  • The elimination half-life, of a few hours in adults, can be 10 times longer in preterm infants and during the neonatal period, reaching adult values by 3-5 months of age. (e-lactancia.org)
  • This elimination half-life after lumbar epidural administration is much longer than the elimination half-life of intravenous administration and is likely explained by the suspension and redistribution of the depot preparation within the epidural fat and the epidural anatomy [ 7 - 9 ]. (hindawi.com)
  • Anaphylaxis/hypersensitivity reactions (including life-threatening): Discontinue daptomycin for injection and treat signs/symptoms. (nih.gov)
  • Physicians should advise patients to administer preservative-free artificial tears at least 4 times a day beginning on the first day of infusion and continuing until completion of treatment as this may reduce corneal symptoms (see section 4.4). (medicines.org.uk)
  • Just 10-20% of all sufferers experience a complete elimination of symptoms with time. (zmescience.com)
  • For half of all sufferers, symptoms decrease in intensity as the years pass, but for the other half, things stay more or less the same. (zmescience.com)
  • At any time after the infection is established, the vast majority of plasmodia will be in some stage of asexual maturation leading to another round of multiplication within the patient's bloodstream. (nationalacademies.org)
  • The use of these 5-HT 3 receptor antagonists have been shown to improve patients' satisfaction, decrease recovery and discharge times and reduced an unanticipated hospital admission especially when they are used prophylactically 25 26 .This prospective, randomized, double blind placebo controlled study was undertaken to compare the efficacy of granisetron and ondansetron in prevention PONV in patients undergoing gynecological laparoscopic surgeries. (ispub.com)
  • Only one visitor remained in Australia for a period of time similar to the elimination half-life and had a sufficiently high initial concentration of PBDEs to derive a half-life. (cdc.gov)
  • All results were below the provisional health advisory level that EPA was using at that time. (ny.gov)
  • The recurrent mood disorders should be conceptualized not as trivial, mental, or illusory phenomena that can easily be modified by patients' acts of will, but as serious and potentially life-threatening medical illnesses that have clearly defined mood, cognitive, motor, somatic, and neurobiological concomitants. (beatcfsandfms.org)
  • Euglycemic diabetic ketoacidosis (EDKA) is a potentially life-threatening condition and a reported side effect of antidiabetic sodium-glucose-cotransporter-2-inhibitors (SGLT2-I). The analysis of the herein presented case and its management formed the incentive to prepare this multidisciplinary work and includes an overview about perioperative SGLT2-I-induced ketoacidosis. (frontiersin.org)
  • Diabetic ketoacidosis (DKA) is a potentially life-threatening condition and sometimes hard to identify when other seemingly related parameters, such as hyperglycemia, are missing. (frontiersin.org)
  • In the first half-year 2000 the Group's gross premiums showed a total rise of 15% compared with the same period last year, reaching Euro 15.2bn. (munichre.com)
  • Sleep latency, total sleep time, duration of wakefulness, and sleep quality have been shown to improve with CBT. (medscape.com)
  • That's not true - you can use antihistamines for a long period of time without them diminishing in intensity at all. (zmescience.com)
  • In the second half-year Munich Re will complete the acquisition of Mercur Assistance, whose increasingly sought-after services will further augment the range offered by the Munich Re Group. (munichre.com)
  • The pentoxifylline AUC was increased and elimination rate decreased in an older population (60-68 years, n=6) compared to younger individuals (22-30 years, n=6) (see PRECAUTIONS, Geriatric Use ). (drugs.com)
  • Individual elimination half lives ranged from 2.1 to 6.3 days, for single compartment exponential decay, the model which fit the data. (bmj.com)
  • The elimination half-life of Draxxin in the lungs - the time it takes for the concentration of Draxxin to decline by 50% - was about 6 days. (thepigsite.com)
  • It was concluded that the difference between the two assumptions (linear model versus a steady state situation to estimate cadmium carry-over in cattle) is negligible in the animal's first five years of life, but will become relevant at higher ages. (ac.be)
  • In other words, in each life-cycle stage the parasite manifests unique biological properties that can offer a target for the action of one or more antimalarial drugs. (nationalacademies.org)
  • 2 ] It is estimated that one-third to one-half of people with cancer experience sleep disturbances. (cancer.gov)
  • Many people avoid taking antihistamines because they don't want to feel sleepy or lethargic all the time. (zmescience.com)
  • We help thousands of people change their lives with our treatment programs. (projectknow.com)
  • People with HIV can enjoy long, healthy lives by taking ARV treatment. (who.int)
  • Last time I tried it-against doctor's order-the only reason I didn't end up in the psych ward was because it was homecoming week during my son's senior year. (elephantjournal.com)
  • However, if the pills never worked, it's time to consult a doctor and find an alternative treatment. (zmescience.com)
  • However, while this was the case some time ago, most modern-age pills don't cause drowsiness. (zmescience.com)
  • ask if client wants pills one at a time or all at once. (freezingblue.com)
  • I ended up losing 110 pounds over the course of a year from this illness, dancing the whole time. (elephantjournal.com)
  • Thus, the treating physician should be aware of the nuances in the management of patients with acute and recurrent mood disorders so that treatment can be optimized from the outset and the impact of the illness on patients, their lives, and their families can be minimized. (beatcfsandfms.org)
  • The illness should be treated with the same respect as is given to the early diagnosis and treatment of a malignancy, with the same skills brought to bear in choosing targeted and, at times, multimodal therapeutics. (beatcfsandfms.org)
  • This study was undertaken to determine the activity of 18 F-FPCIT that could be injected into patients for clinical studies without exceeding accepted dosimetry guidelines while, at the same time, permitting the acquisition of high-quality images. (snmjournals.org)
  • Every time you read, share, comment or heart you help an article improve its Rating-which helps Readers see important issues & writers win $$$ from Elephant. (elephantjournal.com)
  • Previous experience and management of pain, even from very early stages in life, alter the responses and behavior toward further "painful" experiences and events. (nysora.com)
  • Of the phenolics in whole grains, alk(en)ylresorcinols are found in high levels in wheat and rye, and ferulic acid makes up 90% of the phenolic compounds found in wheat. (preparedfoods.com)
  • Les nouveau-nés présentant une suspicion de septicémie néonatale traités dans un hôpital de la ville d'Al Ramadi (Iraq) en 2005 ont fait l'objet d'un dosage de la PCR sérique et d'hémocultures (méthode de référence) lors de l'admission puis 48 heures, 4 jours et enfin 6 jours après le début du traitement. (who.int)
  • Whether the effect on overall quality of life is superior to that of the more limited palliations used before 1971 is still unclear. (medscape.com)
  • The sleep cycle is repeated four to six times during a 7- to 8-hour sleep period. (cancer.gov)