Globally, lymphedema following infection with the filarial parasite Wuchereria bancrofti is more common in women than in men ( 6 , 16 , 17 ). (cdc.gov)
Loa loa is a member of the filarial nematode (roundworm) family, which also includes worms that cause river blindness ( Onchocerca volvulus ) and elephantiasis ( Wuchereria bancrofti ). (broadinstitute.org)
1. Lymphatic filariasis in Africa is caused by a filarial worm, Wuchereria bancrofti, that is transmitted mainly by female Anopheles and Culex mosquitoes. (who.int)
This disease is caused by the filarial worm Wuchereria ( W.bancrofti and W. malayi ). (excellup.com)
The filarial nematode Brugia malayi represents a leading cause of disability in the developing world, causing lymphatic filariasis in nearly 40 million people. (nyu.edu)
It is basically a syndrome caused by nematode parasite called the filarial worm. (healthaio.com)
Filarial nematode infections are a major health concern in several countries. (bvsalud.org)
Wolbachia are essential for multiple components of filarial nematode biology including larval growth and the production of offspring and, ultimately, survival of many filarial nematodes, including the causative parasites of onchocerciasis and lymphatic filariasis, making this symbiont a very attractive chemotherapeutic target for the treatment of both diseases. (biomedcentral.com)
The development of lymphatic filariasis is attributed to filarial parasites, which belong to the nematode family. (healthida.com)
Overview of Filarial Nematode Infections Filarioidea are a superfamily of threadlike, parasitic worms, with numerous families, genus, and species. (msdmanuals.com)
Filarial nematode phenotypic screening cascade to identify compounds with anti-parasitic activity for drug discovery optimization. (microbiology-bonn.de)
Wolbachia ( w Bm) is an obligate endosymbiotic bacterium of Brugia malayi , a parasitic filarial nematode of humans and one of the causative agents of lymphatic filariasis. (biomedcentral.com)
Parasites11
The disease is spread by mosquitoes infected with filarial worm parasites and can lead to severe, irreversible disfigurement (elephantiasis) and chronic pain. (cdc.gov)
Also known as elephantiasis, this NTD is caused by infection by filarial parasites transmitted through the bite of infected female mosquitoes. (kit.nl)
Lymphatic filariasis is caused by infections from parasites called filarial worms and leads to abnormal enlargements of body parts, which causes great pain. (borgenproject.org)
Infection occurs when filarial parasites are transmitted to humans through mosquitoes. (askdrmakkar.com)
Elephantiasis is produced due to the disease Filariasis which is caused by parasites, which spread through mosquito bites to humans. (askdrshah.com)
Elephantiasis is caused by filarial parasites and it happens over a long period of time due to the recurrence of infection. (askdrshah.com)
This parasitic infection is caused by filarial parasites and transmitted through mosquito vectors. (healthida.com)
Lymphatic filariasis is caused by filarial parasites and is transmitted through mosquito vectors and human hosts. (healthida.com)
The presence of filarial parasites in the lymphatic system triggers inflammatory responses, causing damage and obstruction to the lymphatic vessels, leading to the characteristic symptoms of lymphatic filariasis such as lymphedema, hydrocele, and elephantiasis. (healthida.com)
Filarial parasites can cause debilitating diseases such as lymphatic filariasis (elephantiasis) and onchocerciasis (river blindness), but they also modulate the immune system of their hosts to prevent the development of pathology and to enable their long-term survival within the host. (microbiology-bonn.de)
There is a pressing need for new drugs against filarial parasites, such as B. malayi . (biomedcentral.com)
Infection11
Lymphedema of the limb is a physically deforming and socially stigmatizing consequence of filarial infection that affects ≈15 million persons worldwide ( 6 ). (cdc.gov)
Elephantiasis] is typically caused by infection with parasitic worms, transmitted through certain mosquito species. (kff.org)
Filarial infection can also cause tropical pulmonary eosinophilia syndrome. (cdc.gov)
In tropical and subtropical areas where elephantiasis is common, the infection is continuing to increase due to the rapid and unplanned growth of cities, which creates numerous breeding sites for the mosquitoes that transmit the disease. (hpathy.com)
Elephantiasis is a parasitic infection which results in swelling of the legs and arms. (healthaio.com)
Patients with chronic disabilities like elephantiasis, lymphoedema or hydrocele are advised to maintain rigorous hygiene and take necessary precautions to prevent secondary infection and aggravation of the disease condition. (who.int)
Elephantiasis is a parasitic infection that results to extreme swelling of the limbs. (worced.com)
AAWZ1066S showed far superior efficacy (depletion of Wolbachia and sterilisation of microfilaria production) than the 'Gold-standard' anti- Wolbachia drug, doxycycline, at 7-day treatment regimens in two independent filarial infection animal models. (biomedcentral.com)
The treatment of Elephantiasis is essentially targeted at treating the active infection of Filaria. (askdrshah.com)
So the lymphatic swelling would not reduce significantly even after successful treatment of Filarial infection. (askdrshah.com)
Filarial nematodes are in general pretty nasty creatures," says Broad researcher Chris Desjardins. (broadinstitute.org)
In addition to its growing clinical importance due to serious reactions after ivermectin treatment, Loa loa is an interesting subject of study because it is unique among filarial nematodes. (broadinstitute.org)
Diethylcarbamazine has synergistic effects in combination with emodepside on Brugia, inhibiting motility: emodepside is an anthelmintic that has effects on filarial nematodes and is under trial for the treatment of river blindness. (bvsalud.org)
Hydrocele4
In endemic areas, filarial hydrocele is a major cause of disability and disfigurement, as well as a source of direct and indirect economic loss, social stigma, family discord, and sexual burden. (medscape.com)
2. The main complications of lymphatic fi lariasis are elephantiasis, lymphoedema and hydrocele. (who.int)
The main manifestations of LF are elephantiasis, lymphoedema and hydrocele (see photos, Annex 2). (who.int)
When lymphatic filariasis develops into chronic conditions it leads to lymphoedema (tissue swelling) or elephantiasis (skin/tissue thickening) of limbs and hydrocele (scrotal swelling). (askdrmakkar.com)
Elephantiasis Massive swelling of the legs also known as lymphatic FILARIASIS, It is caused by obstructed lymph vessels, which prevents drainage of lymph from the surrounding tissue. (hpathy.com)
Nearly 1.4 billion people in 73 countries worldwide are threatened by lymphatic filariasis, commonly known as elephantiasis. (who.int)
Onchocerciasis (river blindness) and lymphatic filariasis (elephantiasis) are neglected tropical diseases (NTDs) that cause severe disability and affect more than 106 million people, according to the latest reports from WHO. (biomedcentral.com)
Global programmes for control and elimination, such as APOC and OEPA for onchocerciasis and GPELF for lymphatic filariasis have been developed and made significant progress, but existing approaches principally target only the early larval stage of filarial worms known as microfilaria. (biomedcentral.com)
For the last 12 years, the Ministry of Health and Population has been launching a mass drug administration programme against lymphatic filariasis or elephantiasis in Banke district. (kathmandupost.com)
Filariasis is the disease which is caused by a group of filarial worms. (ijpjournal.com)
2) Filarial immunomodulation and its beneficial impact on life-style diseases such as diet-induced insulin resistance in both the L. sigmodontis animal model as well as a human study with filariasis patients in Cameroon. (microbiology-bonn.de)
This medication can also be helpful in people dealing with lymphatic filariasis - a disease caused by filarial worms, which affects the lymphatic system. (kuetherbrainandspine.com)
Mosquitoes1
The mosquito-borne parasitic disease is caused by filarial worms transmitted by different kinds of mosquitoes including Culex, Anopheles, and Aedes. (kathmandupost.com)
River blindness1
In worms like those that cause river blindness and elephantiasis, Wolbachia provides an undetermined, yet essential, role. (broadinstitute.org)
Lymphedema4
Although the factors responsible for the initiation and progression of filarial lymphedema to its most severe form, elephantiasis, have been debated, recurrent episodes of bacterial acute dermatolymphangioadenitis (ADLA) play a major role ( 7 - 9 ). (cdc.gov)
Lammie PJ, Cuenco KT, Punkosdy GA. The pathogenesis of filarial lymphedema: is it the worm or is it the host? (medscape.com)
People with lymphedema and elephantiasis are not likely to benefit from DEC treatment because most people with lymphedema are not actively infected with the filarial parasite. (cdc.gov)
Heavy infections can lead to elephantiasis, which has serious effects on individuals' lives. (bvsalud.org)
Disease11
This method of contracting the disease is known as podoconiosis, or non-filarial elephantiasis…" (Senthilingam, 4/10). (kff.org)
A new insight into the pathogenesis of filarial disease. (medscape.com)
Podoconiosis, also known as non-filarial elephantiasis, was recently designated a neglected tropical disease by the World Health Organization (WHO). (nih.gov)
The painful and profoundly disfiguring visible manifestations of the disease, lymphoedema, elephantiasis and scrotal swelling occur later in life and can lead to permanent disability. (askdrmakkar.com)
This disease is caused by the filarial worm. (healthaio.com)
Filarial hydroceles are more difficult to excise surgically than idiopathic hydroceles, because of scarring and fibrosis. (medscape.com)
Motile adult worms may be seen in symptomatic and subclinical filarial hydroceles. (medscape.com)
Lymphoedema1
Acute episodes of local inflammation involving skin, lymph nodes and lymphatic vessels often accompany chronic lymphoedema or elephantiasis. (askdrmakkar.com)
Adult filarial2
Reasons for this discrepancy are unclear but may be related to differences in the "preferred" anatomic location of the adult filarial worm between men and women ( 18 ) and biologic factors, particularly pregnancy, that further stress the lymphatic system in women. (cdc.gov)
The characteristic movements of adult filarial worms are called the filarial dance sign (FDS) and are a reliable diagnostic finding. (medscape.com)
Podoconiosis2
Podoconiosis is endemic non-filarial elephantiasis which affects people who walk barefoot on irritant clay soils for many years. (rdsjournal.org)
He explains that while Loa loa does less damage than a few of its filarial cousins, sometimes causing pain or swelling under the skin, it is still "horrifying" since the worm often goes unnoticed until it enters the eye. (broadinstitute.org)
It is when the mosquito sucks blood containing eggs of filarial worm. (worced.com)
Chronic1
Elephantiasis nostras verrucosa is the end-stage manifestation of chronic, non-filarial, lymphatic insufficiency. (scienceopen.com)
Humans1
Their definitive hosts are vertebrates, but only a few filarial species infect humans. (msdmanuals.com)
Genital1
Various surgical procedures have been developed to remove the edematous tissue in patients with genital elephantiasis. (medscape.com)
Infections3
It also increases the risk of frequent bacterial infections that harden and thicken the skin (elephantiasis). (askdrmakkar.com)
Eosinophils in filarial infections: Inducers of protection or pathology? (microbiology-bonn.de)
Discovery of Substituted Di(pyridin-2-yl)-1,2,4-thiadiazol-5-amines as Novel Macrofilaricidal Compounds for the Treatment of Human Filarial Infections. (microbiology-bonn.de)
Manifestation1
Ir-reversible 'elephantiasis' is the major clinical manifestation for LF. (ijpjournal.com)
Tissue2
Elephantiasis is caused by obstructed lymph vessels, which prevents drainage of lymph from the surrounding tissue. (hpathy.com)
Elephantiasis is the enlargement and hardening of limbs or body parts due to tissue swelling. (askdrmakkar.com)
Legs1
Once Elephantiasis takes place, that is, in the cases with large swelling of limps, legs, hands, genitals, etc. homeopathic medicines do not or cannot cure the swollen body parts. (askdrshah.com)
Africa1
More than 120 million people have been affected by elephantiasis: one third in India, another third in Africa, and most of the rest in Southeast Asia, the Pacific, and the Americas. (hpathy.com)
Swollen1
Elephantiasis can look ugly and disfiguring due to large swollen body parts, including a large scrotum. (askdrshah.com)