Elegans genes fungal. Medical search. Frequent questions

My PhD studies utilised molecular and survival analyses to describe immunological gene 'trade-offs' during infection with the bacteria Salmonella Typhimurium and fungal pathogen Cryptococcus neoformans in the model host Caenorhabditis elegans. (derby.ac.uk)
Scientists at the University of Birmingham funded by the Biotechnology and Biological Sciences Research Council (BBSRC) have discovered that a gene called DAF-16 is strongly involved in determining the rate of ageing and average lifespan of the laboratory worm Caenorhabditis elegans (C. elegans) and its close evolutionary cousins. (birmingham.ac.uk)
Dr May and colleagues compared longevity, stress resistance and immunity in four related species: Caenorhabditis elegans, Caenorhabditis briggsae, Caenorhabditis remanei and Caenorhabditis brenneri. (birmingham.ac.uk)
To investigate lifespan, the researchers compared the longevity of four species of nematode worm (Caenorhabditis elegans, Caenorhabditis briggsae, Caenorhabditis remanei and Caenorhabditis brenneri) and also the expression of DAF-16. (birmingham.ac.uk)
They found, for example, that Caenorhabditis remanei lives longer than Caenorhabditis elegans and DAF-16 expression is also 12 fold higher. (birmingham.ac.uk)
The final experiment tested how well NPD6433 treatment worked in a live laboratory model organism-the worm Caenorhabditis elegans -which was infected with a pathogenic yeast that can cause systemic infection in humans after invading through the intestines. (scitechdaily.com)
Because of the associated growth of interest in other CRs, the database has grown over the years to include a broad range of chemosensory genes and proteins, that includes in addition to ORs the taste papilla receptors (TPRs), vomeronasal organ receptors (VNRs), insect olfactory receptors (IORs), Caenorhabditis elegans chemosensory receptors (CeCRs), fungal pheromone receptors (FPRs) [these are informal abbreviations for tracking in ORDB, pending development of consensus nomenclature by the field]. (ttu.edu)
Several Caenorhabditis elegans hypothetical proteins. (embl.de)
In Caenorhabditis elegans , deficiency of DCAP-1/DCP1, the essential co-factor of the major cytoplasmic mRNA decapping enzyme, impacts normal development, stress survival and ageing. (uoa.gr)
The study was designed to find out how L.rhamnosus Lcr35® resisted C. albicans in two different experimental models: the in vitro Caco-2 cell model and the in vivo Caenorhabditis elegans model . (biose.com)
Caenorhabditis elegans , Drosophila melanogaster , Homo sapiens , Arabidopsis thaliana , Saccharomyces cerevisiae , Schizosaccharomyces pombe and Encephalitozoon cuniculi . (biomedcentral.com)
The use of the soil nematode Caenorhabditis elegans as a model host to study the pathogenesis of Fusarium spp. (houstonmethodist.org)
These invertebrate systems such as Caenorhabditis elegans , Drosophila melanogaster, Dictyostelium discoideum and Galleria mellonella offer a number of advantages over mammalian vertebrate models, predominantly because they allow the study of strains without the ethical considerations associated with mammalian studies [ 11 - 13 ]. (biomedcentral.com)
This model of how nuclear positioning works is primarily based on experiments in Caenorhabditis elegans worms with mutations in the genes for either the UNC-84 or ANC-1 protein ( Starr and Fridolfsson, 2010 ). (elifesciences.org)
Caenorhabditis elegans is an important model organism with many useful features, including rapid development and aging, easy cultivation, and genetic tractability. (molcells.org)
The roundworm Caenorhabditis elegans is an outstanding model organism for studying molecular genetics, developmental biology, neuroscience, and cell biology. (molcells.org)
reported that the cytochrome b5 is required for biosynthesis of polyunsaturated fatty acids in Caenorhabditis elegans (Zhang et al. (springeropen.com)
These nematodes are only distantly related to Caenorhabditis elegans and have evolved to occupy an unusual niche, tunneling through epithelial cells of the large intestine. (nature.com)

For almost 1000 different genes, the researchers looked at how much NPD6433 suppressed growth in yeast when the yeast was missing one copy of the gene. (scitechdaily.com)
Importantly, this was true in worms infected with yeast that were resistant to a standard anti-fungal medication. (scitechdaily.com)
Yeast constitutive and repressible acid phosphatases (genes PHO3 and PHO5). (embl.de)
Moreover, in addition to having a pro-longevity activity in the C. elegans model, Lcr35® protects the animal from the fungal infection, even if the yeast is still detectable in its intestine. (biose.com)
Dr. Hu has 16 years of research experience in human pluripotent stem cells (PSCs) with diverse graduate and postdoctoral training ranging from fungal biochemistry, marine molecular biology, C elegans genetics, budding yeast biochemistry/genetics, mouse toxicology, and stem cell biology. (unthsc.edu)

As T. elegans belongs to the white rot fungi group, they are important in breaking down lignin from trees and they do so extracellularly, non-specifically, and non-hydrolytically. (wikipedia.org)
Given this data, we would hypothesize that: (i) the evolution of the fungal PPIases is driven, at least in part, by the size of the proteome, (ii) evolutionary pressures differ both between the different PPIase families and the different fungi, and (iii) whilst the cyclophilins and parvulins have evolved to perform conserved functions, the FKBPs have evolved to perform more variable roles. (biomedcentral.com)
In contrast to other fungi that cause zygomycosis, which have a worldwide distribution and are rarely found in immunocompetent hosts, A. elegans has been reported mainly in areas with warm climates as an emerging pathogen that causes mostly cutaneous infections after injury to the skin ( 1 ). (cdc.gov)
is underestimated because these fungi do not usually sporulate on standard fungal culture media used in clinical laboratories. (cdc.gov)
Generate new information about fungal diseases and disease-causing fungi. (cdc.gov)
Genome sequence comparisons across species using bioinformatics revealed three members of the RCAN gene family, RCAN1 , RCAN2 , and RCAN3 , present in most jawed vertebrates, with one member observed in most invertebrates and fungi. (molcells.org)

In conclusion, we describe a new model system for the study of Fusarium pathogenesis and evolutionarily preserved host responses to this important fungal pathogen. (houstonmethodist.org)
The versatility of fungal pathogenicity mechanisms and their development of resistance to antifungal drugs indicate the importance of understanding the nature of host-pathogen interactions. (biomedcentral.com)
Here, we briefly discuss the methods, requirements, advantages, and disadvantages of different survival assays using C. elegans , such as lifespan assays crucial for aging research, various abiotic stress resistance assays, and pathogen resistance assays important for studying immunity. (molcells.org)

ORDB began as a database of vertebrate OR genes and proteins and continues to support sequencing and analysis of these receptors by providing a comprehensive archive with search tools for this expanding family. (ttu.edu)
Nearly all these proteins are subunits of known or predicted multiprotein complexes, in agreement with the balance hypothesis of evolution of gene copy number. (biomedcentral.com)
The gene set of the last common ancestor of the crown group consists of 3,413 KOGs and largely includes proteins involved in genome replication and expression, and central metabolism. (biomedcentral.com)
This domain occurred 26 times on human genes ( 52 proteins). (umbc.edu)
The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)
The major characteristics of Nrf2 are to some extent mimicked by Nrf2-dependent genes and their proteins including heme oxygenase-1 (HO-1), which besides removing toxic heme, produces biliverdin, iron ions and carbon monoxide. (springer.com)

Advance the use of genomics and metagenomics for detecting fungal pathogens and antifungal drug resistance. (cdc.gov)

We observed that Fusarium conidia consumed by C. elegans can cause a lethal infection and result in more than 90% killing of the host within 120 hours, and the nematode had a significantly longer survival when challenged with Fusarium proliferatum compared to other species. (houstonmethodist.org)
The Toll receptor had been discovered in 1985 as a regulator of embryo polarity, but Dr. Hoffmann's group linked it to fungal infection in flies in 1996 and then to Gram-positive bacterial infections. (newswise.com)
Are functional pathways up-regulated during bacterial infection also up- regulated during fungal infection? (g6g-softwaredirectory.com)
Gene expression data from mice with low-dose whipworm infection provide a detailed description of a regulated T H 1-like immune response to the infected cecum that is not limited to the immediate site of infection. (nature.com)

It has recently been suggested to be a complex of three different species: T. elegans, T. aesculi, and T. repanda. (wikipedia.org)
To do that, we looked at a gene that we already knew to be involved in the ageing process, called DAF-16, to see how it may determine the different rates of ageing in different species. (birmingham.ac.uk)
Research into the stress resistance and immunity of the four species involved exposing them to high temperature, heavy metals and a range of bacterial and fungal diseases. (birmingham.ac.uk)
The fungus Apophysomyces elegans (order Mucorales) is a thermotolerant species that causes severe infections among humans. (cdc.gov)
A polyphasic study of clinical and environmental strains of A. elegans, including analysis of several genes, showed that the genus contained 4 well-characterized species ( 3 ). (cdc.gov)
Researchers have discovered a new way to combat fungal infections by blocking their ability to make fatty acids, potentially affecting a broad range of fungal species. (scitechdaily.com)
The screening identified several compounds that reduced fungal growth by at least 50% in each of the four species, and after eliminating ones that were already known, the researchers were left with three new possibilities. (scitechdaily.com)
Our research indicates that targeting fatty acid synthesis is a promising alternative therapeutic strategy for fungal infections and one which might not require tailor-made solutions for individual species. (scitechdaily.com)
Comparative analysis of genomes from distant species provides new insights into gene functions, genome evolution and phylogeny. (biomedcentral.com)
Orthologs are defined as homologous genes that evolved via vertical descent from a single ancestral gene in the last common ancestor of the compared species. (biomedcentral.com)
Orthology and paralogy are intimately linked because, if a duplication (or a series of duplications) occurs after the speciation event that separated the compared species, orthology becomes a relationship between sets of paralogs, rather than individual genes (in which case, such genes are called co-orthologs). (biomedcentral.com)
Furthermore, a comprehensive analysis was performed to characterize conserved motifs and gene structures, which could provide an intuitive comprehension to learn the relationship between structure and functions of the fatty acid desaturases genes in different Aspergillus species. (springeropen.com)
This study provided a better understanding of the evolution and functions of the fatty acid desaturases gene family in the four Aspergillus species, and would be useful for seeking methods to improve the production of unsaturated fatty acids and enhance efforts for the genetic improvement of strains to adapt to the complex surrounding environment. (springeropen.com)

Interestingly, mycelium production appears to be a major contributor in nematode killing in this model system, and C. elegans mutant strains with the immune response genes, tir-1 (encoding a protein containing a TIR domain that functions upstream of PMK-1) and pmk-1 (the homolog of the mammalian p38 MAPK) lived significantly shorter when challenged with Fusarium compared to the wild type strain. (houstonmethodist.org)

A detailed understanding of the molecular and cellular mechanisms underlying pigment cell specification in sea urchin embryos will first require isolation of the genes responsible for this developmental process. (silverchair.com)
Track the emergence and spread of fungal diseases by conducting molecular surveillance and genomic epidemiology. (cdc.gov)
For example, the name of a gene and its chromosomal location, molecular function, or its identity as over-expressed in a particular type of cancer. (g6g-softwaredirectory.com)

Gene insertion has the potential to revolutionize research with strains. (biosynsis.com)

Like bacterial resistance to antibiotics, fungal resistance to medications is also growing worldwide, and the death toll will likely rise in the near future unless something is done now. (scitechdaily.com)
Poupet notes, however, that it will be important to test these results in other models-human cells, non-human mammals, or even humans-since bacterial metabolism would likely change at human body temperature (37 °C) compared to the preferred temperature of C. elegans (20 °C), which was used for the experiments. (biose.com)
Autoluminescent plants engineered to express a bacterial bioluminescence gene cluster in plastids have not been widely adopted because of low light output. (nature.com)
For most C. elegans survival assays, both solid and liquid media systems with bacterial foods are employed. (molcells.org)

Gene coexpression analysis refers to the en masse discovery of coexpressed genes from a large variety of transcriptomic experiments. (mdpi.com)
Experiments in C. elegans reveal new insights into how the ANC-1 protein helps to anchor the nucleus and other organelles in place. (elifesciences.org)
Many in vivo experiments using C. elegans can be done in a relatively short time. (molcells.org)

PPIase numbers within these fungal repertoires appears associated with genome size and orthology between repertoires was found to be low. (biomedcentral.com)
Also, the repertoire of Cryptococcus neoformans may represent a better model fungal system within which to study the functions of the PPIases as its genome size and genetic tractability are equal to those of Saccharomyces cerevisiae , whilst its repertoires exhibits greater orthology to that of humans. (biomedcentral.com)
Parsimonious scenarios of eukaryotic genome evolution and gene sets for ancestral eukaryotic forms were reconstructed. (biomedcentral.com)
C. elegans is also amenable to sophisticated, yet convenient, genetic techniques, such as feeding RNAi, transgenesis via microinjection, mutagenesis screening, and CRISPR/Cas9 genome editing. (molcells.org)
C. elegans is a popular experimental model that combines transparency, reproducible anatomy, traceable cell lineage, sequenced genome and facile genetics, allowing to dissect animal development, physiology, and behaviour across scales of genes, cells and tissues. (embl.org)
Meanwhile, lectures by internationally established researchers will present a variety of C. elegans research topics, spanning studies of the genome and epigenome, through cell cycle and death, to tissue specification, connectivity and function. (embl.org)
The c.elegans from genome editing to imaging is one of the best C.elegans practical courses and I would strongly recommend C.elegans researchers in their early careers to attend this course. (embl.org)
Given a set of genes, GeneMerge can tell you, for example, whether these genes are statistically over-represented in a particular functional or biochemical class, clustered in a region of the genome, or are associated with a particular RNAi or deletion phenotype. (g6g-softwaredirectory.com)
These text files link each gene in a genome with a particular datum of information. (g6g-softwaredirectory.com)
The population set is comprised of those genes from which the study set was drawn, often a genome. (g6g-softwaredirectory.com)
Gene insertion, also known as targeted integration, is a type of gene editing that involves adding a new gene to a specific location in the genome. (biosynsis.com)
This results in the insertion of the new gene into the genome. (biosynsis.com)

The protein that is encoded by this gene is of a class called 'forkhead transcription factors', which act to control the expression of other genes. (birmingham.ac.uk)
ORDB contains public and private sections which provide tools for investigators to analyse the functions of these very large gene families of G protein-coupled receptors. (ttu.edu)
With 35,000 genes and hundreds of thousands of protein states to identify, correlate, and understand, it no longer suffices to rely on studies of one gene, gene product, or process at a time. (genomicglossaries.com)
His lab also demonstrated that KLF4 quickly reprograms the pluripotency surface marker gene, PODXL, which encodes the carrier protein of TRA-1-60 and TRA-1-81. (unthsc.edu)

Defining characteristics of T. elegans include skeletal hyphae, thin-walled basidiospores, and a poroid hymenophore. (wikipedia.org)

But other fungal infections are more serious, and the Candida , Cryptococcus , and Aspergillus types of fungus are responsible for millions of deaths every year. (scitechdaily.com)

These areas of the world often lack the laboratory infrastructure needed to diagnose fungal diseases, and limited availability of antifungal medications means that some patients may not have access to lifesaving treatments. (cdc.gov)
CDC is working with partners to improve access to fungal diagnostics and antifungal medications around the globe. (cdc.gov)
Poupet's project indeed uncovered clues about the mechanisms by which Lcr35® worked: by repressing genes of the p38 MAPK signalling pathway and genes involved in the antifungal response. (biose.com)

The architecture GBD/FH3-FH1-FH2-DAD appears common to almost all Dictyostelium , fungal and metazoan formins, for which we propose the denomination of conventional formins, and implies a common regulatory mechanism. (biomedcentral.com)

Researchers have developed invertebrate model hosts in order to facilitate the study of evolutionarily preserved elements of fungal virulence and host immunity [ 10 ]. (biomedcentral.com)
Because many genetic factors discovered using C. elegans are evolutionarily conserved, survival assays can provide insights into mechanisms underlying physiological processes in mammals, including humans. (molcells.org)

Among these three, the one least toxic to human cells also reduced the growth of Aspergillus fumigatus , an extremely common fungal mold that is deadly to immuno-compromised individuals. (scitechdaily.com)
Aspergillus awamori phytases A and B ( EC 3.1.3.8 ) (gene phyA and phyB). (embl.de)
In the present study, a total of 13, 12, 8 and 8 candidate fatty acid desaturases genes were identified in the Aspergillus oryzae , Aspergillus flavus , Aspergillus fumigatus and Aspergillus nidulans genomes through database searches, which were classified into five different subfamilies based on phylogenetic analysis. (springeropen.com)

We wanted to find out how normal ageing is being governed by genes and what effect these genes have on other traits, such as immunity. (birmingham.ac.uk)
Dr May continued: "DAF-16 is part of a group of genes that drive the biological processes involved in ageing, immunity and responses to physical or environmental stresses. (birmingham.ac.uk)
C. elegans survival assays have played key roles in identifying novel genetic factors that regulate many aspects of animal physiology, such as aging and lifespan, stress response, and immunity against pathogens. (molcells.org)
C. elegans survival assays have been key tools for studying physiological processes, including aging, stress resistance, and immunity. (molcells.org)

This enables us to identify candidate genes underlying glucosinolate diversity, trichome density, and study the genetics of biochemical variation for glucosinolate and saponins. (pacb.com)

It is active in most cells and is very similar to human genes called FOXO1, FOXO3, FOXO4 and FOXO6. (birmingham.ac.uk)

All these findings suggest that the IR of cellulase genes regulates their own gene expression by coupling with the NMD pathway, which might involve the TOR pathway. (researchsquare.com)
This 7-day course will present experimental practices in C. elegans research, while introducing historic and up-to-date findings in various research topics. (embl.org)

CD Biosynsis offers ex vivo gene insertion services, which involve the modification of cells outside the body before they are transplanted back into the patient. (biosynsis.com)
CD Biosynsis is also developing in vivo gene insertion technologies, which involve the direct modification of cells within the body. (biosynsis.com)

for example, C. elegans stress resistance and lifespan assays usually take several days and weeks, respectively. (molcells.org)

We describe the use of CRISPR-Cas9 RNP in combination with single-cell RNA sequencing to functionally characterize the impact of gene invalidation in ALI cultures. (bvsalud.org)

Rather than correcting individual mutations, gene insertion can theoretically correct virtually all mutations in a gene. (biosynsis.com)

Genes whose expression levels rise and fall similarly in a large set of samples, may be considered coexpressed. (mdpi.com)
Leveraging the number and diversity of individuals in the HLCA, we identify gene modules that are associated with demographic covariates such as age, sex and body mass index, as well as gene modules changing expression along the proximal-to-distal axis of the bronchial tree. (bvsalud.org)
Gene expression analysis was carried out on a subset of 66 clones with real time quantitative PCR and 40 clones were positive. (silverchair.com)
Real-time PCR was used to study the expression pattern of formin genes. (biomedcentral.com)
Expression of forC, D, I and J increased during transition to multi-cellular stages, while the rest of genes displayed less marked developmental variations. (biomedcentral.com)
We found that major cellulase genes ( cel7a , cel7b , and cel3a ) exhibited concomitant decrease in IR rates and increase in their gene expression in T . reesei under cellulase-producing condition (cellulose and lactose) that was accompanied with a more active NMD pathway, as compared to non cellulase-producing condition (glucose). (researchsquare.com)
Eukaryotic 5'-3' mRNA decay plays important roles during development and in response to stress, regulating gene expression post-transcriptionally. (uoa.gr)
She is currently a Senior Investigator leading the Chromosome Structure and Epigenetics Mechanism Unit within the Laboratory of Receptor Biology and Gene Expression at the Center for Cancer Research of the NCI/NIH in Bethesda. (elifesciences.org)
These range from receptors for microbial aggressors, to intracellular signaling cascades, which control the expression of immune response genes, and the genes encoding potent antimicrobial peptides," Dr. Hoffmann explained. (newswise.com)
In addition, the expression pattern of 13 fatty acid desaturases genes of A. oryzae was tested in different growth stages and under salt stress treatment. (springeropen.com)
characterized 19 genes encoding fatty acid desaturases and analyzed their expression profiles in Gossypium raimondii under low temperature (Liu et al. (springeropen.com)

CDC's lead group for preventing illness and death from fungal diseases in the United States and throughout the world. (cdc.gov)
The goal of CDC's Mycotic Diseases Branch (MDB) is to prevent illness and death from fungal diseases . (cdc.gov)
We are one of few public health groups in the world devoted to the prevention and control of fungal diseases. (cdc.gov)
We also investigate outbreaks and develop interventions to prevent fungal diseases. (cdc.gov)
Provide training and education about fungal diseases. (cdc.gov)
Calculate the number of people who get sick from fungal diseases. (cdc.gov)
Track trends and patterns in how fungal diseases affect people. (cdc.gov)
Promote education and awareness about fungal diseases. (cdc.gov)
Develop and evaluate ways to prevent fungal diseases. (cdc.gov)
Help prepare healthcare facilities and laboratories in other countries to better detect and treat fungal diseases. (cdc.gov)
Many people at risk for and suffering from fungal diseases live in limited-resource settings. (cdc.gov)
Sign up for the Fungal Diseases Newsletter for updates from CDC's Mycotic Diseases Branch. (cdc.gov)
The SARS-CoV-2 pandemic has shown we are yet to see such networks developed for fungal diseases. (rachelgrunwald.com)
COG-UK), and while their formation are not trivial, we are yet to see such networks developed for fungal diseases. (rachelgrunwald.com)

Scientists from the RIKEN Center for Sustainable Research Science (CSRS) and the University of Toronto have uncovered a new way to attack fungal infections. (scitechdaily.com)
We work with partners to understand who gets fungal infections and why they get them by using epidemiology and microbiology research. (cdc.gov)

The research in Birmingham is now moving on to look at the way in which DAF-16 coordinates a complex network of genes in order to balance the differing needs of an individual's immune system over time. (birmingham.ac.uk)

C. elegans is a popular model for studying aging because of short lifespan and genetic tractability. (molcells.org)
Agar-based solid culture systems are the most common C. elegans lifespan assay approach. (molcells.org)

The abscess was surgically resected and the causative organism was identified as N. puris by culture and then 16S PCR of the rRNA gene. (microbiologyresearch.org)

We resolve chromosomal sequences and infer sex chromosome-specific parasite genes and new potential drug targets. (nature.com)
Site-specific chromosomal gene insertion: Flp recombinase versus Cas9 nuclease. (biosynsis.com)

In a study, researchers found that compounds isolated from T. elegans were able to inhibit microbial growth. (wikipedia.org)
We will target both, participants with no prior experience in working with C. elegans who want to use this model organism to advance their research, as well as experienced C. elegans researchers who want to expand their tool set. (embl.org)

The course lectures and practical modules develop in three axes of genes, cells, tissues. (embl.org)

Sequencing the genomes of multiple, taxonomically diverse eukaryotes enables in-depth comparative-genomic analysis which is expected to help in reconstructing ancestral eukaryotic genomes and major events in eukaryotic evolution and in making functional predictions for currently uncharacterized conserved genes. (biomedcentral.com)
GeneMerge offers a web-based & standalone version written in PERL (a high-level general-purpose, interpreted, dynamic programming language) that returns a range of functional and genomic data for a given set of study genes and provides statistical rank scores for over- representation of particular functions or categories in the data set. (g6g-softwaredirectory.com)

Schizosaccharomyces pombe acid phosphatase (gene pho1). (embl.de)

The ability of genes or alleles to affect the representation of the host organism in a biome is an operational definition for the "function" of the gene (in that context). (genomicglossaries.com)

Examination of the sets of KOGs lost in individual lineages reveals co-elimination of functionally connected genes. (biomedcentral.com)

T. elegans prefers an intermediate temperature range of around 25-35 °C and can grow in both the soil and on synthetic media. (wikipedia.org)

Furthermore, we used the C. elegans model to assess the efficacy and toxicity of various compounds against Fusarium. (houstonmethodist.org)
According to the model, if the nuclei in hyp-7 cells are exclusively anchored via the SUN-KASH bridge, then loss of the genes for UNC-84 or ANC-1 should have an identical effect and result in the same amount of nuclear clustering. (elifesciences.org)

Meanwhile, in mutant worms lacking the gene for ANC-1 (right), the ER and mitochondria are fragmented, and the nuclei are unanchored and clustered together. (elifesciences.org)

GeneMerge returns descriptive information regarding genes under investigation and statistically-based 'rank scores' regarding over- representation of descriptors in a given set of genes. (g6g-softwaredirectory.com)

encoded by Nfe2l2 gene) is a transcription factor responsible for the regulation of cellular redox balance and protective antioxidant and phase II detoxification responses in mammals [ 1 , 2 ]. (springer.com)
Cas9-Targeted Mutagenesis buy acyclovir without a prescription of the ERF Transcription Factor Gene OsERF922. (rachelgrunwald.com)
Do co- regulated genes show non-random enrichment for a certain family of transcription factor binding sites? (g6g-softwaredirectory.com)

This result meant that NPD6433 likely works by inhibiting fatty acid synthase and thus prevents fatty acids from being made inside fungal cells. (scitechdaily.com)
The results revealed that the fatty acid desaturases genes in A. oryzae were highly expressed in adaptive phase growth and up-regulated under salt stress treatment. (springeropen.com)
The fatty acid desaturases domain was the essential domain of the fatty acid desaturases gene family. (springeropen.com)
Most studies of fatty acid desaturases gene family focused on plants and animals. (springeropen.com)
cloned and characterized fatty acid desaturases gene family from Salvia hispanica and Perilla frutescens (Xue et al. (springeropen.com)

Other KOGs show a variety of phyletic patterns, which points to major contributions of lineage-specific gene loss and the 'invention' of genes new to eukaryotic evolution. (biomedcentral.com)

Chemical compounds from the Kenyan polypore Trametes elegans (Spreng:Fr. (wikipedia.org)

These conserved KOGs are often essential for survival and might approximate the minimal set of essential eukaryotic genes. (biomedcentral.com)
We demonstrated that amphotericin B, voriconazole, mancozeb, and phenyl mercury acetate significantly prolonged the survival of Fusarium-infected C. elegans, although mancozeb was toxic at higher concentrations. (houstonmethodist.org)
Survival assays using C. elegans are powerful methods for studying physiological processes. (molcells.org)
In this review, we describe diverse types of C. elegans survival assays and discuss the aims, uses, and advantages of specific assays. (molcells.org)

A subset of high quality and rare information, retrieved and organized by systematic literature- searching tools from existing databases, and related to a subset of genes functioning together in '-omic' sciences. (genomicglossaries.com)

One noticeable advantage of C. elegans for such assays is that synchronized isogenic populations are simple to prepare because the worm usually exists as a self-fertilizing hermaphrodite that produces hundreds of isogenic progeny. (molcells.org)

CD Biosynsis has several advantages over other companies in the field of gene insertion. (biosynsis.com)

The various zoological phyla have played with a toolbox of genes encoding receptors, adaptors, kinases, transactivators, and antimicrobial peptides according to their own agendas, essentially their own environments and pathogens," he said. (newswise.com)

Of 16 isolates tested in this study, only 2 from soil in India were A. elegans . (cdc.gov)
These 3D experimental models allow to follow the regeneration steps of fully differentiated mucociliary epithelium and to study gene function by performing gene invalidation. (bvsalud.org)
The team (which includes some of the authors involved in the 2018 study) found, as expected, that removing the gene for ANC-1 led to nuclear clustering in hyp-7 cells, indicating that nuclear anchorage had been lost ( Figure 1 ). (elifesciences.org)
The study set is comprised of genes that are currently under investigation. (g6g-softwaredirectory.com)
It contains functional or categorical data associated with each gene in the study set and rank scores for over-represented functions/categories, as well as other pertinent data. (g6g-softwaredirectory.com)
Rank scores for functional or categorical overrepresentation within the study set of genes is obtained using the hypergeometric distribution. (g6g-softwaredirectory.com)

T. elegans shares a commensalistic relationship with various host plants where it provides potection to the plant against assault from other pathogens. (wikipedia.org)

On the basis of whole-transcriptome analyses, we identify many genes that are expressed in a sex- or life stage-specific manner and characterize the transcriptional landscape of a morphological region with unique biological adaptations, namely, bacillary band and stichosome, found only in whipworms and related parasites. (nature.com)

T. elegans has potential natural antimicrobial properties. (wikipedia.org)

Trametes elegans, also known as Lenzites elegans and Daedalea elegans, is a common polypore and wood-decay fungus with a pantropical distribution found on hardwood hosts in regions including Australia, New Zealand, and Japan. (wikipedia.org)
2) List of genes for which No standard gene name can be found. (g6g-softwaredirectory.com)

The KOG analysis reveals a conserved core of largely essential eukaryotic genes as well as major diversification and innovation associated with evolution of eukaryotic genomes. (biomedcentral.com)

To efficiently extract functional and evolutionary information from multiple genomes, rational classification of genes based on homologous relationships is indispensable. (biomedcentral.com)

Currently, there are only three major classes of anti-fungal medications, and all of them work by destroying the barrier that surrounds fungal cells. (scitechdaily.com)

In the presence of the NMD pathway inhibitor that successfully repressed the NMD pathway, the mRNA levels of cellulase genes were sharply down-regulated, but the rates of IR in these genes were significantly up-regulated. (researchsquare.com)
In addition, the NMD pathway inhibitor caused the downregulated mRNA levels of two important genes of the target of rapamycin (TOR) pathway, trfkbp12 and trTOR1 . (researchsquare.com)
The absence of gene trfkbp12 made the cellulase production in T . reesei more sensitive to the NMD pathway inhibitor. (researchsquare.com)

New secondary mesenchyme specific genes, expressed exclusively in pigment cells, were isolated from sea urchin embryos using a differential screening of a macroarray cDNA library. (silverchair.com)

Conservation of KOGs through the phyletic range of eukaryotes strongly correlates with their functions and with the effect of gene knockout on the organism's viability. (biomedcentral.com)

Anatomy8

Organisms8

Diseases1

Chemicals and Drugs13

Analytical, Diagnostic and Therapeutic Techniques and Equipment5

Psychiatry and Psychology1

Phenomena and Processes30

Information Science3

Caenorhabditis18

Yeast5

Fungi6

Pathogen3

Proteins6

Genomics1

Infection4

Species13

Mammalian1

Molecular3

Strains1

Bacterial4

Experiments3

Genome12

Protein4

Hyphae1

Cryptococcus1

Antifungal3

Dictyostelium1

Evolutionarily2

Aspergillus3

Immunity4

Genetics1

Human genes1

Findings2

Vivo2

Resistance1

CRISPR1

Mutations1

Expression11

Diseases14

Infections2

Immune1

Lifespan2

RRNA1

Chromosomal2

Researchers2

Tissues1

Genomic2

Schizosaccharomyces1

Alleles1

Functionally1

Temperature1

Model2

Mutant1

Statistically1

Transcription factor3

Fatty5

Patterns1

Compounds1

Survival4

Databases1

Worm1

Advantages1

Receptors1

Study6

Host1

Analyses1

Antimicrobial1

Found2

Analysis1

Evolutionary1

Medications1

Pathway3

Secondary1

Strongly1