- Adrenodoxin-NADP+ reductase (EC 1.18.1.6, adrenodoxin reductase, nicotinamide adenine dinucleotide phosphate-adrenodoxin reductase, ADR, NADPH:adrenal ferredoxin oxidoreductase) is an enzyme with systematic name adrendoxin:NADP+ oxidoreductase. (wikipedia.org)
- This enzyme catalyses the following chemical reaction 2 reduced adrenodoxin + NADP+ ⇌ {\displaystyle \rightleftharpoons } 2 oxidized adrenodoxin + NADPH + H+ Adrenodoxin-NADP+ reductase is a flavoprotein (FAD). (wikipedia.org)
- Stoichiometry of mitochondrial cytochromes P-450, adrenodoxin and adrenodoxin reductase in adrenal cortex and corpus luteum. (wikipedia.org)
- cDNA sequence of adrenodoxin reductase. (wikipedia.org)
- In the Class I apparatus, two electrons from NAD(P)H are transferred to the FAD-containing ferredoxin reductase (FdR) and then to P450 via the iron-sulfur cluster-containing ferredoxin (Fdx). (nature.com)
- Bovine adrenodoxin (Adx) and adrenodoxin reductase (AdR) are involved in steroid hormone biosynthesis in the adrenal gland mitochondria. (nature.com)
- Monooxygenase reactions demand electron donation from NADPH by way of adrenodoxin reductase and adrenodoxin [26,27]. (piminhibitor.com)
- The mitochondrial P450 system electron transport chain including adrenodoxin reductase and adrenodoxin has been shown to leak electrons leading to the formation of superoxide radical. (hyperlinked.wiki)
- The electron transport system which catalyzes this reaction consists of adrenodoxin reductase, NADP, adrenodoxin, and cytochrome P-450. (lookformedical.com)
- The enzyme, which transfers electrons from NADPH to adrenodoxin molecules, is the first component in the mitochondrial cytochrome P450 electron transfer systems, and is involved in the biosynthesis of all steroid hormones. (expasy.org)
- The 30-kDa membrane-bound c-type cytochrome protein of mitochondria that functions as an electron donor to CYTOCHROME C GROUP in the mitochondrial and bacterial RESPIRATORY CHAIN. (lookformedical.com)
- A bacterial protein from Pseudomonas, Bordetella, or Alcaligenes which operates as an electron transfer unit associated with the cytochrome chain. (lookformedical.com)
- During the bovine estrous cycle, plasma levels of progesterone increase in parallel to the levels of P450scc and its electron donor adrenodoxin, indicating that progesterone secretion is a result of enhanced expression of P450scc in the corpus luteum. (hyperlinked.wiki)
- A chemical reaction in which an electron is transferred from one molecule to another. (lookformedical.com)
- Formally, this redox change involves a single-electron, reversible equilibrium between the Fe(II) and Fe(III) states of the central iron atom (From Enzyme Nomenclature, 1992, p539). (lookformedical.com)
- These proteins participate in all major pathways of electron transport: photosynthesis, respiration, hydroxylation and bacterial hydrogen and nitrogen fixation. (bvsalud.org)
- Most P450s require redox partners for the electron transfer during catalysis. (nature.com)
- In this study, we compare three pairs of frequently-used surrogate redox partner Sel Fdx1499/ Sel FdR0978, Adx/AdR and Pdx/PdR and in terms of their electron transfer properties. (nature.com)
- Electron Transport Complex II" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ouhsc.edu)
- This graph shows the total number of publications written about "Electron Transport Complex II" by people in this website by year, and whether "Electron Transport Complex II" was a major or minor topic of these publications. (ouhsc.edu)
- Below are the most recent publications written about "Electron Transport Complex II" by people in Profiles. (ouhsc.edu)
- an oxygenase-like protein with a Rieske electron carrier domain, from the silkworm Bombyx mori and the fruitfly Drosophila melanogaster. (biologists.com)
- Here, electron leakage benefits within the generation of superoxide and also other ROS [26,28]. (piminhibitor.com)
- Functional interactions of adrenodoxin with several human mitochondrial cytochrome P450 enzymes. (nih.gov)
- Figure 1 shows the electron transfer system involving cytochrome P- 450 as conceived by Omura, et al. (nih.gov)
- In this way, cytochrome bs might serve as a second electron donor to cytochrome P- 450 and thus satisfy the requirement of two electrons for the overall reaction. (nih.gov)
- 1. Functional interactions in cytochrome P450BM3: flavin semiquinone intermediates, role of NADP(H), and mechanism of electron transfer by the flavoprotein domain. (nih.gov)
- Fatty acid substrate binding alters electron-transfer properties of the flavoprotein domain. (nih.gov)
- Phylogenetic analysis indicated that a tryptophan residue corresponding to Trp359 is conserved across FprA-type enzymes and in adrenodoxin reductases. (manchester.ac.uk)
- Proposed electron transfer system employed in the microsomal metabolism of drugs. (nih.gov)
- Scheme showing how NADH and cytochrome bs might contribute to the electron transfer system employed in the microsomal metabolism of drugs SOURCE: Estabrook, R. (11). (nih.gov)
- 19. Obligatory intermolecular electron-transfer from FAD to FMN in dimeric P450BM-3. (nih.gov)