• extracellular matrix
  • MMP-12 degrades lung extracellular matrix components and generates the production of elastin fragments that are chemotactic to monocytes and which drive disease progression. (bmj.com)
  • The composition of the arterial extracellular matrix and the adaptative synthesis of elastin and collagen in hypertension may also influence the degree of reversibility of arterial remodeling in response to antihypertensive treatment and the development of hypertensive arteriopathy. (ahajournals.org)
  • degradation
  • Background Development of emphysema and vascular stiffness in chronic obstructive pulmonary disease (COPD) may be due to a common mechanism of susceptibility to pulmonary and systemic elastin degradation. (bmj.com)
  • Objectives To investigate whether patients with COPD have evidence of systemic elastin degradation in the skin. (bmj.com)
  • In the entire cohort of ex-smokers, cutaneous elastin degradation was associated with emphysema severity, FEV 1 and pulse wave velocity. (bmj.com)
  • Conclusions Patients with COPD have increased skin elastin degradation compared with controls, which is related to emphysema severity and arterial stiffness. (bmj.com)
  • Systemic elastin degradation due to increased proteolytic activity may represent a novel shared mechanism for the pulmonary, vascular and cutaneous features of COPD. (bmj.com)
  • Is systemic elastin degradation the mechanism of increased arterial stiffness and skin wrinkling in chronic obstructive pulmonary disease? (bmj.com)
  • Men with chronic obstructive pulmonary disease (COPD) have increased skin elastin degradation compared with controls matched for age and smoking history, and this was associated with arterial stiffness and emphysema severity. (bmj.com)
  • Systemic elastin degradation due to increased proteolytic activity may represent a novel shared mechanism for the pulmonary, vascular and cutaneous features of chronic obstructive pulmonary disease. (bmj.com)
  • Degradation of elastin, starch and casein is positive. (wikipedia.org)
  • elastase
  • Detection of desmosine in urine, plasma or sputum samples can be a marker for elastin breakdown due to high elastase activity related to certain diseases. (wikipedia.org)
  • glycine
  • These hydrophobic domains, consisting overwhelmingly of alanine, proline, glycine, and valine, tend towards instability and disorderliness, ensuring that the elastin does not lock into any specific confirmation. (wikipedia.org)
  • arterial
  • The elastin-null mice (ELN −/− ) die of obstructive arterial disease, 2 whereas the ELN +/− mice have reduced absolute quantities of elastin and are hypertensive, phenotypes similar to those observed in patients with supravalvular aortic stenosis and Williams syndrome. (ahajournals.org)
  • Investigating the genetic basis and pathophysiological consequences of the modulation of elastin levels, rather than the impact of absolute elastin deficit, is central to our understanding of mechanisms involved in arterial pathologies. (ahajournals.org)
  • Comparison between fresh and digested tissues shows that, at 35% strain, a minimum of 48% of the arterial load is carried by elastin, and a minimum of 43% of the change in stiffness of arterial tissue is due to the change in elastin stiffness. (wikipedia.org)
  • synthesis
  • 7 The aortic elastin deficit in the BN rat is, at least in part, caused by decreased tropoelastin synthesis during the period of rapid growth. (ahajournals.org)
  • Extrapolating from an in-vitro elastin model under physiological conditions, the researchers found that the ratios of IDP to DESP corresponded extremely closely with values based on both a calculation of a theoretical Chichibabin pyridine synthesis of 3 mol allysine and 1 mol ammonia, and reported ratios of 2,3,5- to 3,4,5-trisubstituted pyridine ratios of a Chichibabin pyridine synthesis involving phenylacetaldehyde. (wikipedia.org)
  • They concluded with relative certainty that the pyridine cross-links found in elastin were, in fact, due to an in-vivo Chichibabin pyridine synthesis of ammonia and allysine. (wikipedia.org)
  • genetic
  • 5 Identification of genetic loci underlying the elastin content is the first step toward understanding which facet of elastin biology leads to a deficit of this parameter in the BN rat. (ahajournals.org)
  • highly
  • One of the major reasons that elastin can withstand high levels of stress in the body without experiencing any physical deformation is that the underlying tropoelastin contains domains that are highly hydrophobic. (wikipedia.org)
  • area
  • I did find in the first few weeks of using BRAD Biophotonic Ultra Elastin Lift that I developed a few whiteheads around the nose and mouth area. (truthinaging.com)