• arterial
  • Conclusions Patients with COPD have increased skin elastin degradation compared with controls, which is related to emphysema severity and arterial stiffness. (bmj.com)
  • Is systemic elastin degradation the mechanism of increased arterial stiffness and skin wrinkling in chronic obstructive pulmonary disease? (bmj.com)
  • Men with chronic obstructive pulmonary disease (COPD) have increased skin elastin degradation compared with controls matched for age and smoking history, and this was associated with arterial stiffness and emphysema severity. (bmj.com)
  • Extracellular matrix components such as elastin and collagen are fundamental structural elements of the arterial wall and may be involved in vascular function, arterial aging, and atherosclerosis. (ahajournals.org)
  • skin
  • Objectives To investigate whether patients with COPD have evidence of systemic elastin degradation in the skin. (bmj.com)
  • Methods The authors measured cutaneous elastin degradation using immunohistochemistry (percentage area of elastin fibres) in sun-exposed (exposed) and non-sun-exposed (non-exposed) skin biopsies in 16 men with COPD and 15 controls matched for age and cigarette smoke exposure. (bmj.com)