• Two major quantitative trait loci (QTLs) for number of internal elastic lamina lesions were identified on rat chromosomes 5 and 10, with the maximum "log of the odds ratio" (LOD) scores at D5Rat119 (LOD 5.0) and at D10Mit2 (LOD 4.5), respectively, together contributing 33.5% to the genetic variance. (mcw.edu)
  • Histopathological lesions involve all layers of the arterial wall and are associated with multinucleated giant cells, fragmented internal elastic lamina and polymorphic cellular infiltrates, including T lymphocytes and macrophages. (nih.gov)
  • Ulceration of the AORTA by an ATHEROSCLEROTIC PLAQUE by penetrating through and disrupting the internal elastic lamina of the TUNICA INTIMA. (bvsalud.org)
  • AAD events are initiated by a circumferential or transverse tear of the intima, followed by rapid leakage of blood into the artery wall, which undergoes thrombosis and rupture of the aorta ( 1 , 2 ). (frontiersin.org)
  • The aorta is the largest artery in the body. (cedars-sinai.org)
  • The heart is connected directly to the aorta, which is the largest artery in the body. (ukbiobank.ac.uk)
  • Why the wall of artery is much thicker and more elastic than the wall of veins? (onteenstoday.com)
  • Which is more elastic artery or a vein? (onteenstoday.com)
  • However, the main artery to the body leaving the left ventricle is the aorta, whereas the main vein bringing blood back to the heart from the body enters the right atrium which is also known as the vena cava. (markedbyteachers.com)
  • Furthermore, the aortic pulse wave travels at much faster speed in the stiff artery, and the reflected wave from the peripheral sites further amplifies the systolic BP in the central aorta. (mhmedical.com)
  • The largest artery is the aorta, which extends from the left ventricle down the left side of the body. (physio-pedia.com)
  • The right recurrent laryngeal nerve wraps round the right subclavian artery, while the left recurrent laryngeal nerve wraps around the arch of the aorta and the ligamentum arteriosum. (ehd.org)
  • Coarctation of the aorta (Chap. 264) typically occurs near the insertion of the ligamentum arteriosum, adjacent to the left subclavian artery. (mhmedical.com)
  • The researchers analyzed senile aortas, which exhibited characteristics of vascular aging, including increased wall thickness, fibrous cap formation, arterial calcification and elastic lamina fragmentation. (cas.cn)
  • However, elastic fibers, lymphocytes, and tracheal glands are not seen in the submucosa or lamina propria. (medscape.com)
  • A trait of vascular fragility, characterized by the formation of abrupt defects within the elastic laminae of the abdominal aorta, has been identified in Brown Norway (BN) rats. (mcw.edu)
  • hearts and abdominal aortas were collected and histopathology evaluated. (biomedcentral.com)
  • Of abdominal aorta is completely torn apart at the first meeting. (haucti.rest)
  • These heart rate dynamics explain the unique hemodynamic design in rorqual whales consisting of a large-diameter, highly compliant, elastic aortic arch that allows the aorta to accommodate blood ejected by the heart and maintain blood flow during the long and variable pauses between heartbeats. (cascadiaresearch.org)
  • the rest being primarily muscle cells called vascular smooth muscle cells that line the aorta. (medlineplus.gov)
  • Together, elastic fibers and vascular smooth muscle cells provide flexibility and resilience to the aorta. (medlineplus.gov)
  • This hypothesis is supported by the association between retinal vascular remodelling and impaired carotid flow and aortic elastic properties. (atlantis-press.com)
  • A shortage of tropoelastin reduces the amount of mature elastin protein that is processed and available for forming elastic fibers. (medlineplus.gov)
  • As a result, elastic fibers that make up the aorta are thinner than normal. (medlineplus.gov)
  • However, those close to the heart have the thickest walls, containing a high percentage of elastic fibers in all three of their tunics. (onteenstoday.com)
  • It is comprised of smooth muscle cells and elastic fibers called elastin. (onteenstoday.com)
  • Hematoxylin and eosin staining was used to measure the thickness and diameter ratio of the aortic media of mice in each group, Masson staining was used to observe the content of collagen fibers in the aorta of mice in each group, elastic fibers in the aorta of mice in each group were stained, and transforming growth factor-beta and phosphoinositide 3-kinase/protein kinase B pathway protein expression. (ijpsonline.com)
  • The aorta is the conduit through which blood ejected from the left ventricle is delivered to the systemic arterial bed. (mhmedical.com)
  • Any measurable or observable characteristic related to the proportions of proteins, minerals, nutrients, gases, or other substances in the part of the descending aorta superior to the aortic hiatus of the diaphragm. (mcw.edu)
  • In humans, the aorta is about one inch in diameter and extends upward from the left ventricle, before arching downward through the chest. (microscopyu.com)
  • The heart pumps oxygenated blood out of the left ventricle and into the aorta to begin systemic circulation. (physio-pedia.com)
  • Histologically, compromised aortic integrity is the result of ECM remodeling within the aorta, including collagen degradation, elastic fiber fragmentation, and medial layer degeneration ( 4 , 5 ). (frontiersin.org)
  • Other changes begin to happen, such as an imbalance of elastin and collagen in the middle of the vessels, making them less elastic and supple. (onteenstoday.com)
  • Collagen gives walls of the aorta their elastic strength. (ifspb.com)
  • When the collagen protein breaks down, a weak area can develop in the aorta. (ifspb.com)
  • When collagen breaks down, the walls of the aorta become weak, and the inner layer can develop minute tears. (ifspb.com)
  • The aorta is also more prone to rupture than is any other vessel, especially with the development of aneurysmal dilation, since its wall tension, as governed by Laplace's law (i.e., proportional to the product of pressure and radius), will be increased. (mhmedical.com)
  • A proximal aneurysm of the aorta is seen (5 x 4 cm), with focal rupture and hemopericardium (not shown). (medscape.com)
  • When the aorta becomes damaged or loses its ability to contract and relax as blood is pumped through it, an aneurysm can develop. (cedars-sinai.org)
  • An aneurysm is a weakened spot in the walls of the aorta. (cedars-sinai.org)
  • When an aneurysm develops in the area of the aorta that descends from the chest into the abdomen it is known as a thoracoabdominal aortic aneurysm. (cedars-sinai.org)
  • Tortuosity of the aorta can lead to a number of complications, such as aneurysm formation, dissection, and thrombosis. (haucti.rest)
  • Diastolic blood pressure, distensibility of the ascending aorta, and stiffness index of ascending and descending aorta did not differ significantly between the two groups. (bmj.com)
  • Conclusions Children born preterm already have higher systolic blood pressure and decreased distensibility of the descending aorta in comparison to children born at term at preschool age. (bmj.com)
  • The elastic, fiber rich media layer of these vessels expands during systole and recoils during diastole. (freezingblue.com)
  • The aorta is distended during systole to allow a portion of the stroke volume and elastic energy to be stored, and it recoils during diastole so that blood continues to flow to the periphery. (mhmedical.com)
  • The participants also underwent three MRI scans: one measured blood flow to the brain, another measured brain activity during the Stroop task, and the third measured the stiffness of the aorta. (medicalnewstoday.com)
  • The aorta is the largest blood vessel in the body - it carries oxygen-rich blood away from the heart to the rest of the body. (medicalnewstoday.com)
  • This defect is a narrowing (stenosis) of the large blood vessel that carries blood from the heart to the rest of the body (the aorta). (medlineplus.gov)
  • A thickened aorta is less flexible and resilient to the stress of constant blood flow and pumping of the heart. (medlineplus.gov)
  • Aortic narrowing causes the heart to work harder to pump blood through the aorta, resulting in the signs and symptoms of SVAS. (medlineplus.gov)
  • These layers allow the aorta to absorb the force of the blood as it is pumped from the heart to the rest of the body. (cedars-sinai.org)
  • Identification of factors that contribute to stiffening of the aorta will offer insight into potential lifestyle modifications or treatments that can prevent or reverse aortic stiffening and limit the premature morbidity and deaths attributable to aortic stiffening and high blood pressure. (ukbiobank.ac.uk)
  • Since they must receive the blood directly from the heart which pumps the blood at a pressure sufficient to enable circulation, they need thick and elastic walls to both sustain the pressure (and so keep the blood flowing) and to withstand the pressure (and not get affected by the pressure). (onteenstoday.com)
  • Which blood vessel is more elastic? (onteenstoday.com)
  • Do all blood vessels have thin elastic walls? (onteenstoday.com)
  • Why do blood vessels need to be elastic? (onteenstoday.com)
  • What causes blood vessels to become less elastic? (onteenstoday.com)
  • This code is used to describe a condition in which the aorta, the largest blood vessel in the body, is abnormally twisted or coiled. (haucti.rest)
  • A twisting of the aorta or enlargement of the heart's blood vessels is called a tortuous aortic arch. (haucti.rest)
  • The tortuous aorta is a twisting or deformation of an aorta, causing it to narrow or constrict, restricting blood flow. (haucti.rest)
  • In addition to pain and fatigue, the narrowing of the aorta causes blood flow to be obstructed. (haucti.rest)
  • AADs can be classified according to origin of the intimal tear and/or involvement of the ascending aorta. (frontiersin.org)
  • The disease is characterized by up-regulation of growth factors (TGF-β 1 , PDGF-A and B). Apoptosis was detected in the intimal layer of affected aortas. (biomedcentral.com)
  • Usually, the wall of the aorta or its branches thickens irregularly, with intimal wrinkling. (msdmanuals.com)
  • Stanford type A dissections involve the ascending aorta and are treated via emergency surgical repair, whereas type B dissections only involve the descending aorta and usually require endovascular repair and/or medical therapy. (frontiersin.org)
  • Congenital anomalies of the aorta usually involve the aortic arch and its branches. (mhmedical.com)
  • Thoracic aortic aneurysms (TAAs) can involve the aortic root, ascending aorta, arch, descending aorta, or a combination of these locations. (medscape.com)
  • Most surgically resected TAAs involve the ascending aorta. (medscape.com)
  • To compensate, the smooth muscle cells that line the aorta increase in number, making the aorta thicker and narrower than usual. (medlineplus.gov)
  • Aneurysms can happen at any point along the aorta. (cedars-sinai.org)
  • Most commonly, the pathogenesis of the aneurysms is due to noninflammatory, medial degeneration of the elastic aortic wall. (medscape.com)
  • Over time, the wall of the aorta can become damaged. (medlineplus.gov)
  • Elastic properties of the ascending and descending aorta were calculated using computerised wall contour analysis out of transthoracic M-mode echocardiographic tracings. (bmj.com)
  • At the molecular level, diseased aortas present SMC apoptosis and activation of inflammation ( 5 , 6 ). (frontiersin.org)
  • For building materials on base of gypsum with special applications in medicine, and panels with sonic absorbent and thermal isolator properties are demand to determine the elastic characteristics to enhance the manufacturing process and usefully. (asme.org)
  • Most congenital anomalies of the aorta do not cause symptoms and are detected during catheter-based procedures. (mhmedical.com)
  • The diagnosis of suspected congenital anomalies of the aorta typically is confirmed by computed tomographic (CT) or magnetic resonance (MR) angiography. (mhmedical.com)
  • Low- and high-stress elastic moduli were calculated from the equibiaxial stress strain curve to determine the local mechanical properties. (canada.ca)
  • Owing to its continuous exposure to high pulsatile pressure and shear stress, the aorta is particularly prone to injury and disease resulting from mechanical trauma. (mhmedical.com)
  • The condition is described as supravalvular because the section of the aorta that is narrowed is located just above the valve that connects the aorta with the heart (the aortic valve). (medlineplus.gov)
  • Our research project will define factors that contribute to stiffening of the aorta and will examine consequences of aortic stiffening on brain, kidney and heart structure and function. (ukbiobank.ac.uk)