AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesInformation ScienceNamed GroupsHealth CareGeographicals
Treatment FailureHeart FailureTreatment OutcomeDrug CombinationsAntimalarialsSulfadoxineDrug Therapy, CombinationPyrimethamineDrug ResistanceAnti-Bacterial AgentsRetrospective StudiesMalaria, FalciparumRecurrenceChloroquineTime FactorsProspective StudiesFollow-Up StudiesArtemisininsDrug Administration ScheduleAmodiaquineFluorenesDouble-Blind MethodSurvival AnalysisPlasmodium falciparumProguanilKidney Failure, ChronicAtovaquoneFailure to ThriveAntiprotozoal AgentsDihydropteroate SynthasePrognosisHIV InfectionsAntineoplastic Combined Chemotherapy ProtocolsAnti-HIV AgentsDrug Resistance, ViralMicrobial Sensitivity TestsCefiximeLiver Failure, AcuteCombined Modality TherapyAntitubercular AgentsDisease-Free SurvivalSurvival RateAmoxicillinParasitic Sensitivity TestsAdministration, OralCohort StudiesDose-Response Relationship, DrugAntineoplastic AgentsRisk FactorsMetronidazoleDrug MonitoringAzithromycinPenicillin G ProcaineEthanolaminesKaplan-Meier EstimateViral LoadDrug Resistance, BacterialClinical Trials as TopicRandomized Controlled Trials as TopicLiver FailureGonorrheaMelarsoprolAnti-Infective AgentsParasitemiaDoxorubicinPredictive Value of TestsFluoxymesteroneSeverity of Illness IndexAcute DiseaseSalvage TherapyDisease ProgressionAntiretroviral Therapy, Highly ActiveMultiple Organ FailureGenotypeVincristineMutationUgandaHodgkin DiseaseDrug Resistance, NeoplasmDisease Models, AnimalPatient ComplianceTrypanosoma brucei gambienseChronic DiseaseCyclophosphamideCD4 Lymphocyte CountTetrahydrofolate DehydrogenaseAntimonyPrednisoneEquipment FailureStaphylococcal InfectionsCeftriaxoneMefloquineVancomycinMycoplasma genitaliumInfusions, IntravenousPolymerase Chain ReactionSesquiterpenesNeoplasm Recurrence, LocalHIV-1Remission Induction
Long-Term EfficacySystematic Review and Meta-AnalysisTolerabilitySafetyTherapeuticEndpointsAimed to evaluateTerms of efficacyInfectionsOutcomes includedHeart failureSystemicEvaluateVaccineSSRIRemissionAntimicrobialPharmacologicalVaginalVisceral leishmaniasisRegimensFindingsEffectivenessInvestigatorsPatients were randomizedOutpatientAmphotericinLeft ventricularAssessCorticosteroidsPhaseMalariaImplantation failure1990ConclusionsProgressionCognitivePlaceboConsistentPsychological treatmentsResultsACTsResistanceTrialsVersusAcuteOptimizeVirologicIntention to tr1000 mgMechanismsTherapyDiscontinuationDataGuidelinesDurationCompare
Long-Term Efficacy1
  • The present study compared the long-term efficacy of antithyroid drugs (ATD), radioactive iodine (RAI), and surgery in GD/TPP. (hindawi.com)
Systematic Review and Meta-Analysis3
  • We undertook a systematic review and meta-analysis infection process contrasts with that of chlamydia infec- to determine the efficacy of doxycycline (100 mg 2×/d for 21 tions caused by C. trachomatis serovars A-K, which are days) for rectal LGV in MSM. (cdc.gov)
  • Wibawa I, Mariadi I, Shalim C, Sindhughosa D. Efficacy of probiotics in the treatment of minimal hepatic encephalopathy: a systematic review and meta-analysis. (termedia.pl)
  • We present a systematic review and meta-analysis of all existing cytisine studies, consider the drug's safety and present a verdict regarding its efficacy and recommendations concerning its licensing. (bmj.com)
Tolerability4
  • Objectives To determine the efficacy and tolerability of β blockers in a broad age range of women and men with heart failure with reduced ejection fraction (HFrEF) by pooling individual patient data from placebo controlled randomised trials. (bmj.com)
  • Subjects who completed the acute trial were offered to enroll in a 12-month, open-label treatment phase with l -methylfolate and continued SSRI treatment, with scheduled visits for efficacy, safety, and tolerability every 12 weeks. (psychiatrist.com)
  • And this fact does not reflect high tolerability or robust efficacy. (forbes.com)
  • Doxorubicin is known as the "Red Devil", nomenclature that reflects its red color in the intravenous infusion bag and its poor tolerability, with anemia, low white blood cell counts that predispose to infection, heart failure, nausea, vomiting and diarrhea among its expected toxicities. (forbes.com)
Safety22
  • Safety and efficacy of ibopamine in congestive heart failure during two years of follow-up treatment. (unl.pt)
  • This study was designed to assess the efficacy and safety of berberine for chronic congestive heart failure (CHF). (nih.gov)
  • 4 The authors of "Efficacy and Safety of Rivaroxaban in Patients with Heart Failure and Non-Valvular Atrial Fibrillation: Insights from ROCKET-AF" postulated that the predictability of rivaroxaban made it a useful alternative to warfarin in patients with AF and HF. (acc.org)
  • Since 62.5% of patients in the ROCKET AF trial had a history of HF or a low ejection fraction (EF), this large subgroup (n=9033) allowed for exploration of the efficacy and safety of rivaroxaban in AF patients with HF. (acc.org)
  • Efficacy and safety of liposomal amphotericin B (Am-Bisome) for visceral leishmaniasis in endemic developing countries. (ajtmh.org)
  • Antimalarials should not be given concomitantly, unless there is no other treatment option, due to limited safety data. (nih.gov)
  • PARIS and TARRYTOWN, N.Y., Oct. 22, 2023 (GLOBE NEWSWIRE) -- Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN) and Sanofi today announced that positive results from a Phase 3 trial evaluating the investigational use of Dupixent ® (dupilumab) showed consistent efficacy and safety for up to one year (52 weeks) in children aged 1 to 11 years with eosinophilic esophagitis (EoE). (biospace.com)
  • Data from this Phase 3 trial support the potential of dupilumab to treat EoE in children, with sustained efficacy and safety, which is particularly critical for these children. (biospace.com)
  • This potential use of Dupixent in children with EoE aged 1 to 11 years is currently under clinical development, and its safety and efficacy have not been fully evaluated by any regulatory authority in this setting. (biospace.com)
  • Objectives To compare the efficacy and safety of SB4 (an etanercept biosimilar) with reference product etanercept (ETN) in patients with moderate to severe rheumatoid arthritis (RA) despite methotrexate (MTX) therapy. (bmj.com)
  • Other efficacy endpoints as well as safety, immunogenicity and pharmacokinetic parameters were also measured. (bmj.com)
  • Etanercept is well established and has been widely used in clinical practice for about 15 years, with a well-characterised pharmacological, efficacy and safety profile. (bmj.com)
  • The efficacy and safety of ponatinib in CML and Ph+ ALL patients resistant or intolerant to dasatinib or nilotinib, or with the T315I mutation, were evaluated in the PACE trial. (businesswire.com)
  • This study evaluated the safety and efficacy of switching HIV-infected patients with stable viral suppression on nonnucleoside reverse transcriptase inhibitor/nucleoside reverse transcriptase inhibitor (NNRTI/NRTI) therapy to lopinavir/ritonavir (LPV/r) monotherapy. (researchgate.net)
  • Larger, randomized trials are warranted to evaluate the safety, efficacy, and patient population who might benefit from LPV/r monotherapy. (researchgate.net)
  • CORK, Ireland (June 6, 2013) -- Janssen R&D Ireland (Janssen) today announced primary efficacy and safety results from four Japanese Phase 3 clinical studies demonstrating that the use of the investigational NS3/4A protease inhibitor simeprevir (TMC435) led to sustained virologic response 12 weeks after the end of treatment (SVR12) in patients with genotype 1 hepatitis C, when administered once daily with pegylated interferon and ribavirin. (jnj.com)
  • Presented at the European Society of Cardiology (ESC) Congress 2023 , results of the study, which was stopped for efficacy by the data and safety monitoring board 1 year after randomization was completed, suggest undergoing catheter ablation was associated with a 76% reduction in risk of the trial's primary composite endpoint relative to medical therapy alone. (consultantlive.com)
  • A single-center, open-label, investigator-initiated, superiority, randomized clinical trial, CASTLE-HTx was launched with the intent of exploring the safety and efficacy of catheter ablation in patients with end-stage heart failure and symptomatic atrial fibrillation who were referred to a single center in the Netherlands for evaluation for heart transplantation or implantation of a left ventricular assist device. (consultantlive.com)
  • In a context of limited information on ACTs, the safety and efficacy of three ACTs, namely artemether-lumefantrine (AL), mefloquine-artesunate (MQAS) and dihydroartemisinin-piperaquine (DHAPQ) were assessed in malaria-infected pregnant women. (bmj.com)
  • Background: Vascular-targeted photodynamic therapy, a novel tissue-preserving treatment for low-risk prostate cancer, has shown favourable safety and efficacy results in single-arm phase 1 and 2 studies. (lu.se)
  • Perfect for occupational and environmental health and safety (OEHS) professionals, Musculoskeletal Disorders: The Fatigue Failure Mechanism will also earn a place in the libraries of ergonomists, physical therapists, biomechanists, industrial hygienists, occupational physicians, orthopedists, and musculoskeletal disorder researchers. (cdc.gov)
  • A patient's choice of contraceptive method involves factors such as efficacy, safety, noncontraceptive benefits, cost, and personal considerations. (medscape.com)
Therapeutic11
  • Heart failure (HF) is an additional risk factor for thromboembolic events in patients with AF 3 and those with HF, as compared to those without HF, on vitamin K antagonists spend even less time on average in the therapeutic range and thus may have increased risk of bleeding and/or thromboembolism. (acc.org)
  • The 95% CI of the adjusted treatment difference was −9.41% to 4.98%, which is completely contained within the predefined equivalence margin of −15% to 15%, indicating therapeutic equivalence between SB4 and ETN. (bmj.com)
  • Antitumor necrosis factor antibodies and calcineurin inhibitors have shown good therapeutic efficacy for steroid-refractory ulcerative colitis (UC). (hindawi.com)
  • This study aimed to compare therapeutic efficacies between IFX- and Tac-based strategies for steroid-refractory UC. (hindawi.com)
  • The findings of our study showed that IFX and Tac have similar short-term therapeutic efficacy for steroid-refractory UC. (hindawi.com)
  • On the other hand, anti-TNF antibodies, such as infliximab (IFX) or adalimumab, and calcineurin inhibitors, such as cyclosporin A (CsA) or tacrolimus (Tac), have shown good salvage therapeutic efficacies for inducing remission in steroid-refractory UC. (hindawi.com)
  • To understand the difference in efficacy between treatment with anti-TNF antibodies and calcineurin inhibitors, some studies have compared the therapeutic outcomes with IFX-based treatment versus CsA-based treatment [ 17 - 20 ]. (hindawi.com)
  • Moreover, there are no published data with which to compare therapeutic efficacies between IFX-based treatment and Tac-based treatment. (hindawi.com)
  • The understanding of the complex pathophysiologic processes of alcoholic hepatitis is the key to elucidating new therapeutic treatments. (wjgnet.com)
  • The aims of this article are to review the current knowledge regarding therapeutic mechanisms of mesenchymal stem cells in acute liver failure, to discuss recent advancements in preclinical and clinical studies in the treatment of mesenchymal stem cells, and to summarize the methodological improvement of mesenchymal stem cell transplantation in treating liver failure. (springer.com)
  • Although there is a great deal of preclinical and clinical research about MSCs in the treatment of ALF, the exact mechanism underlying the therapeutic role of MSCs remains unclear [ 6 ]. (springer.com)
Endpoints2
  • Other efficacy endpoints and pharmacokinetic endpoints were comparable. (bmj.com)
  • The co-primary endpoints were treatment failure (histological progression of cancer from low to moderate or high risk or death during 24 months' follow-up) and absence of definite cancer (absence of any histology result definitely positive for cancer at month 24). (lu.se)
Aimed to evaluate1
  • Thus this study aimed to evaluate and compare the efficacy and treatment outcomes of ATD, RAI, and surgery as primary treatment for GD/TPP by following the natural course of patients. (hindawi.com)
Terms of efficacy2
  • Conclusions SB4 was shown to be equivalent with ETN in terms of efficacy at week 24. (bmj.com)
  • With all that risk, you might expect considerable upside in terms of efficacy, but the response rate in patients with newly diagnosed sarcoma is approximately 17% and responses are transient when they occur. (forbes.com)
Infections10
  • Germany have shown that rectal LGV accounts for 8%-16% ly evidence for the efficacy of tetracyclines for reducing of rectal chlamydia infections in MSM ( 3 , 4 ). (cdc.gov)
  • Resistance that develops in one organism or location can also spread rapidly and unpredictably, through for instance exchange of genetic material between different bacteria, and can affect antibiotic treatment of a wide range of infections and diseases. (who.int)
  • Coartem Tablets are a combination of artemether and lumefantrine, both antimalarials, indicated for treatment of acute, uncomplicated malaria infections due to Plasmodium falciparum (P. falciparum) in patients 2 months of age and older with a bodyweight of 5 kg and above. (nih.gov)
  • Unfortunately, 14 patients did not clear their infections, meaning that they did not get cured for malaria using this three day dihydroartemisinin-piperaquine treatment. (cdc.gov)
  • XYDALBA™ was approved by the EMA in February 2015 as a treatment for Acute Bacterial Skin and Skin Structure Infections (ABSSSIs) in adults and by the U.S. Food and Drug Administration (FDA) in May 2014 for the treatment of adult patients with ABSSSI caused by susceptible Gram-positive bacteria, including MRSA. (prnewswire.com)
  • The development and optimization of combination therapies hold promise in combating complex infections and reducing treatment failures. (medgadget.com)
  • Acute liver failure (ALF) is a life-threatening clinical syndrome characterized by rapid hepatocellular necrosis due to various acute injuries induced by hepatotoxic drugs, immune-mediated attack, or viral infections. (springer.com)
  • This undermines the effectiveness of the available treatment options and thus contributes to the persistence of microbial infections. (who.int)
  • This was a cross sectional hospital- vancomycin as the drug of choice in the treatment of based study involving 300 patients of all ages with 6 infections caused by MRSA. (who.int)
  • Effectiveness of antiviral treatment in human influenza A(H5N1) infections: analysis of a Global Patient Registry. (cdc.gov)
Outcomes included1
  • Secondary efficacy outcomes included death from all-causes, myocardial infarction, and the composite (and individual components) of stroke, systemic embolism, or vascular death. (acc.org)
Heart failure38
  • the major secondary outcome was admission to hospital for heart failure. (bmj.com)
  • Heart Failure Drug a New Treatment Option for Alcoholism? (medscape.com)
  • Spironolactone, a potassium-sparing diuretic typically used to treat heart failure and hypertension, shows promise in treating alcohol use disorder (AUD), new research suggests. (medscape.com)
  • LOS ANGELES - When it comes to the optimal treatment of patients with heart failure with preserved ejection fraction and diabetes, cardiologists like Mark T. Kearney, MB ChB, MD , remain stumped. (the-hospitalist.org)
  • Over the years, the diagnosis of heart failure with preserved ejection fraction has been notoriously difficult [to treat], controversial, and ultimately involves aggressive catheterization of the heart to assess diastolic dysfunction, complex echocardiography, and invasive tests," Dr. Kearney said at the World Congress on Insulin Resistance, Diabetes, and Cardiovascular Disease. (the-hospitalist.org)
  • These patients have an ejection fraction of over 50% and classic signs and symptoms of heart failure. (the-hospitalist.org)
  • The message here is, if you have a patient with ejection fraction heart failure and diabetes, get them on the optimal dose of a beta-blocker, even at the expense of an ACE inhibitor. (the-hospitalist.org)
  • In 2016, the European Society of Cardiology introduced guidelines for physicians to make a diagnosis of heart failure with preserved ejection fraction. (the-hospitalist.org)
  • Signs and symptoms of heart failure, elevated BNP [brain natriuretic peptide], and echocardiography allow us to make a diagnosis of heart failure with preserved ejection fraction," Dr. Kearney, who is also dean of the Leeds University School of Medicine. (the-hospitalist.org)
  • In a large, unpublished cohort study conducted at Leeds, Dr. Kearney and colleagues evaluated how many patients met criteria for heart failure with reduced ejection fraction or heart failure with preserved ejection fraction after undergoing a BNP measurement. (the-hospitalist.org)
  • After assessment, 23% had no heart failure, 44% had heart failure with preserved ejection fraction, and 33% had heart failure with reduced ejection fraction. (the-hospitalist.org)
  • AMSTERDAM, the Netherlands-Disappointing many who hoped this large, randomized, double-blind trial would show a clear win, HEART-FID is the latest trial of iron supplementation in heart failure to miss its primary endpoint. (tctmd.com)
  • The US Food and Drug Administration is already persuaded by the data to date: earlier this summer the regulator granted a new indication to IV iron in heart failure. (tctmd.com)
  • Guidelines in both the US and Europe already recommend screening for iron deficiency, while the EU recommendations go one step further to specify that intravenous FCM can be considered to prevent future heart failure admissions in symptomatic patients recently hospitalized. (tctmd.com)
  • As Ponikowski pointed out in his presentation, iron deficiency is one of the most common comorbidities in chronic heart failure, plaguing roughly 50% of patients, a number that reaches 70-80% among patients with acutely decompensated heart failure. (tctmd.com)
  • Data from the DIAMOND trial suggest use of patiromer (Veltassa) could help patients maintain optimized heart failure therapy , even if they have a history of hyperkalemia. (hcplive.com)
  • Presented at the American College of Cardiology's 71st Annual Scientific Sessions , results of the phase 3b trial suggest use of patiromer was associated with a significant reduction in blood potassium levels among patients taking RAASi medications for heart failure. (hcplive.com)
  • On the basis of these results, unless accessibility or affordability of medications is an issue, there's no good reason not to use potassium binders to optimize heart failure medical therapy," said Javed Butler, MD, MPH, MBA, president of Baylor, Scott & White Research Institute in Texas and distinguished professor of medicine at the University of Mississippi, in a statement from the ACC. (hcplive.com)
  • Although RAASi therapy carries a class 1 level of recommendation for us in patients with heart failure, patients with a history of or current hyperkalemia often have RAASi therapy discontinued or down titrated. (hcplive.com)
  • These results are further evidence for the use of potassium binders to optimize heart failure medical therapy", added Butler, in a statement from Vifor Pharma , the study's sponsor. (hcplive.com)
  • To assess second year Doctor of Pharmacy students' academic performance in and perceptions of a heart failure (HF) virtual patient simulation used in a required pharmacotherapy course. (ajpe.org)
  • A heart failure virtual patient simulation was created to augment heart failure pharmacotherapy course material at the University at Buffalo School of Pharmacy and Pharmaceutical Sciences in the fall of 2019. (ajpe.org)
  • The primary objective was to compare student performance on heart failure pharmacotherapy examination questions in a cohort of students who completed a virtual patient simulation in 2019 compared to a control cohort who completed a paper-based case activity in 2018. (ajpe.org)
  • Overall, the proportion of correctly answered heart failure pharmacotherapy examination questions was 83.3% in the virtual simulation group compared to 79.2% in the paper-based case group. (ajpe.org)
  • Use of a heart failure virtual patient simulation was associated with improved examination performance and was well received by students. (ajpe.org)
  • One disease area that may lend itself well to simulation in a learning environment is heart failure, which is a commonly encountered disease state projected to affect nearly eight million people in the United States by 2030. (ajpe.org)
  • The CASTLE-HTx trial provides insight into the effects of catheter ablation in patients with AFib and end-stage heart failure, with potentially practice-changing implications. (consultantlive.com)
  • Results of the CASTLE-HTx trial indicate undergoing catheter ablation was linked to a significantly lower risk of death, urgent transplantation, or left ventricular assist device (LVAD) implantation compared with medical therapy in patients with end-stage heart failure and atrial fibrillation. (consultantlive.com)
  • Comparing atrial fibrillation ablation with medical therapy in patients with end-stage heart failure, ablation was associated with lower rates of death, urgent heart transplantation or LVAD implantation, along with a reduction in atrial fibrillation burden and improved LVEF," said Christian Sohns, MD, of the Heart and Diabetes Center North Rhine-Westphalia. (consultantlive.com)
  • We found that catheter ablation of atrial fibrillation plus medical therapy in patients with end-stage heart failure who were referred for transplantation evaluation was associated with a lower likelihood of a composite of death from any cause, implantation of a left ventricular assist device, or urgent heart transplantation than medical therapy alone," investigators wrote. (consultantlive.com)
  • Catheter Ablation in End-Stage Heart Failure with Atrial Fibrillation [published online ahead of print, 2023 Aug 27]. (consultantlive.com)
  • Atrial fibrillation ablation improves outcomes in patients with end-stage heart failure. (consultantlive.com)
  • https://www.escardio.org/The-ESC/Press-Office/Press-releases/Atrial-fibrillation-ablation-improves-outcomes-in-patients-with-end-stage-heart-failure. (consultantlive.com)
  • Sudden death in patients with myocardial infarction and left ventricular dysfunction, heart failure, or both. (medscape.org)
  • The EPHESUS trial: eplerenone in patients with heart failure due to systolic dysfunction complicating acute myocardial infarction. (medscape.org)
  • Eplerenone Post-AMI Heart Failure Efficacy and Survival Study. (medscape.org)
  • Mode of death in heart failure: findings from the ATLAS trial. (medscape.org)
  • ACCF/HRS/AHA/ASE/HFSA/SCAI/SCCT/SCMR 2013 Appropriate Use Criteria for Implantable Cardioverter-Defibrillators and Cardiac Resynchronization Therapy: A Report of the American College of Cardiology Foundation Appropriate Use Criteria Task Force, Heart Rhythm Society, American Heart Association, American Society of Echocardiography, Heart Failure Society of America, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Computed Tomography, and Society for Cardiovascular Magnetic Resonance. (medscape.org)
Systemic3
  • The primary efficacy outcome was all stroke or systemic embolism. (acc.org)
  • Owing to the excellent efficacy of systemic administration of corticosteroids, most patients achieve remission even if they required second-line treatment. (hindawi.com)
  • they invade the dermis and deeper tissues, and may require prolonged systemic treatment. (vin.com)
Evaluate2
  • These new approaches can also be applied to evaluate the efficacy of job rotation scenarios and to quantify exoskeleton efficacy. (cdc.gov)
  • The aim was to evaluate the efficacy and effectiveness of tooth -supported fixed prostheses in partially edentulous patients with stage IV periodontitis . (bvsalud.org)
Vaccine3
  • Vaccine efficacy against laboratory-confirmed symptomatic COVID-19 was estimated to be 78% in adults 18-59 years of age. (who.int)
  • Lack of data prevented estimating the efficacy of the vaccine in individuals 60 years of age and older and with comorbidities. (who.int)
  • We here at CDC are preparing for the possibility of widespread community transmission of COVID 19 here in the U. S. So, since there's no vaccine or treatment, non- pharmaceutical interventions are going to be the most important response strategy against COVID 19. (cdc.gov)
SSRI1
  • 2 , 3 , 4 In the Sequenced Treatment Alternatives to Relieve Depression (STAR * D) trial, 5 among those who remitted with selective serotonin reuptake inhibitor (SSRI) monotherapy, 40.1% had a relapse or recurrence over the subsequent 12 months. (psychiatrist.com)
Remission2
  • 1 Failure to achieve and sustain remission can be associated with high risk of relapse or recurrence, continued psychosocial impairments, an increase in the use of medical services, potential worsening of comorbid medical illness, ongoing risk of suicide, and greater difficulty in achieving remission over time. (psychiatrist.com)
  • Other drugs such as thiopurines are used for maintaining remission when the remission was achieved with calcineurin inhibitors because of the absence of long-term treatment data. (hindawi.com)
Antimicrobial10
  • The indirect impact of antimicrobial resistance, however, extends beyond increased health risks and encompasses economic losses due to reduced productivity caused by sickness (of both human beings and animals) and higher costs of treatment. (who.int)
  • Staphylococci have a relatively predictable pattern of antimicrobial sensitivity and empirical treatment is often successful. (vin.com)
  • This increasing prevalence creates a growing demand for effective antimicrobial treatments. (medgadget.com)
  • This necessitates the development of novel antimicrobial agents to combat resistant strains and overcome treatment challenges. (medgadget.com)
  • Developing novel antimicrobial agents can help fill these gaps and provide better treatment outcomes. (medgadget.com)
  • Technological advancements contribute to the expansion of the antimicrobial therapeutics market by facilitating the discovery of novel compounds and enhancing treatment options. (medgadget.com)
  • The discovery and development of innovative antimicrobial agents that can overcome resistance mechanisms and effectively target pathogens can create new treatment options and address unmet medical needs. (medgadget.com)
  • Combination therapies involving multiple antimicrobial agents or combining antimicrobials with non-antibiotic agents offer opportunities for improved treatment outcomes. (medgadget.com)
  • Applying precision medicine principles to antimicrobial therapeutics can help optimize treatment regimens, improve patient outcomes, and reduce the unnecessary use of broad-spectrum antibiotics. (medgadget.com)
  • Personalized approaches can enhance the effectiveness of antimicrobial treatments and minimize the development of resistance. (medgadget.com)
Pharmacological1
  • Pharmacological treatment, with fludrocortisone first‑line (see the NICE evidence summary: unlicensed off-label medicine on fludrocortisone for orthostatic hypotension ). (nice.org.uk)
Vaginal1
  • Earlier preparations of metronidazole for topical vaginal therapy demonstrated low efficacy against trichomoniasis. (cdc.gov)
Visceral leishmaniasis2
  • Do the diminishing efficacy and increasing toxicity of sodium stibogluconate in the treatment of visceral leishmaniasis in Bihar, India, justify its continued use as a first-line drug? (ajtmh.org)
  • Treatment of visceral leishmaniasis in Kenya by aminosidine alone or combined with sodium stibogluconate. (ajtmh.org)
Regimens1
  • 3. What treatment regimens are used to prevent the adverse consequences of PKU? (nih.gov)
Findings1
  • Background papers were written and tables of evidence constructed summarizing the type of study (e.g., randomized controlled trial, case series), the study population and setting, the treatments or other interventions, outcome measures assessed, reported findings, and weaknesses and biases in study design and analysis. (cdc.gov)
Effectiveness1
  • What is known about the effectiveness of these treatment and management strategies overall and with respect to variables such as time of initiation of dietary management, level of phenylalanine at various ages, methods for enhancing dietary compliance, duration of dietary management, and dietary regimen for women of childbearing age and other adults? (nih.gov)
Investigators3
  • With this in mind, investigators sought to assess whether treatment with patiromer, which is a novel potassium binder from Vifor Pharma, was associated with a lowering of serum potassium levels. (hcplive.com)
  • Defibrillators in Non-Ischemic Cardiomyopathy Treatment Evaluation (DEFINITE) Investigators. (medscape.org)
  • Treatment was open-label, but investigators assessing primary efficacy outcomes were masked to treatment allocation. (lu.se)
Patients were randomized2
  • In the treatment phase, patients were randomized to continued patiromer or placebo therapy. (hcplive.com)
  • In CONCERTO-1, treatment-naïve patients were randomized to receive simeprevir or placebo for 12 weeks plus pegylated interferon and ribavirin for 24 or 48 weeks. (jnj.com)
Outpatient3
  • Efficacy of outpatient implantation failure. (or.jp)
  • Please make an appointment at our outpatient clinic if you are having trouble conceiving due to implantation failure or if you would like to have an implantation test before undergoing IVF. (or.jp)
  • Implantation Failure Outpatient Testing Flow. (or.jp)
Amphotericin2
  • Liposomal amphotericin B (AmBisome) in the treatment of complicated kala-azar under field conditions. (ajtmh.org)
  • For example, Candida auris , a pathogen of great clinical significance, causes candidiasis (especially in immunocompromised people) and has become resistant to treatments with several antifungals, including amphotericin B and fluconazole. (asm.org)
Left ventricular1
  • Symptoms, a 6-minute walk test, left ventricular (LV) ejection fraction (EF), frequency and complexity of VPCs, and quality of life were assessed after 8 weeks of treatment and during a mean 24-month follow-up. (nih.gov)
Assess1
  • A systematic review was undertaken to assess the efficacy of cytisine in smoking cessation. (bmj.com)
Corticosteroids1
  • 5-Aminosalicylates or topical treatments are usually the first-line treatment, and corticosteroids are the second-line treatment. (hindawi.com)
Phase3
  • The late-breaking data to be presented at ACG feature results from children enrolled in the extended active treatment period (Part B) of a Phase 3 trial, following 16 weeks of Dupixent treatment or placebo in Part A of the trial. (biospace.com)
  • and for the treatment of adult patients with T315I-positive CML (chronic phase, accelerated phase, or blast phase) or T315I positive Ph+ ALL. (businesswire.com)
  • We compared this treatment with the standard of care, active surveillance, in men with low-risk prostate cancer in a phase 3 trial. (lu.se)
Malaria4
  • Health Organization, about drug resistant malaria treatment in Vietnam. (cdc.gov)
  • For the treatment of falciparum malaria, WHO is recommending the use of a type of drug called artemisinin-based combination therapy, or ACTs. (cdc.gov)
  • In Vietnam, the recommended treatment for falciparum malaria has long been the ACT dihydroartemisinin-piperaquine. (cdc.gov)
  • Charlotte Rasmussen] The treatment for falciparum malaria in this area of Vietnam has now been changed to another ACT--artesunate-mefloquine. (cdc.gov)
Implantation failure7
  • If a low level of beta-hCG is found in the blood when determining pregnancy after IVF, it should not be considered as a failure of IVF, but rather as a miscarriage before implantation or a very early miscarriage, in which there was implantation failure (disorder). (or.jp)
  • The definition of implantation failure is the inability to establish a pregnancy even after multiple transfers of morphologically and functionally good embryos (good grade embryos). (or.jp)
  • However, it is important to perform the main tests for implantation failure in order to prevent the next IVF attempt from failing. (or.jp)
  • For implantation failure outpatients, we will start with the necessary tests to investigate causes of failure. (or.jp)
  • Repeated implantation failure (RIF) is the repeated failure of the embryo to implant onto the side of the uterus wall following IVF treatment. (wikipedia.org)
  • Repeated implantation failure should not be confused with recurrent IVF failure. (wikipedia.org)
  • Repeated implantation failure specifically refers to those failures due to unsuccessful implanting to the uterus wall. (wikipedia.org)
19901
  • For the purpose of review, a medline search was conducted looking for articles about efficacy of treatments in treatment resistant schizophrenia since 1990. (priory.com)
Conclusions1
  • Conclusions Cytisine is an effective treatment for smoking cessation with efficacy comparable to that of other currently licensed treatments. (bmj.com)
Progression4
Cognitive2
  • Fujii et al (1997) reported that patients with treatment resistant schizophrenia show significant global cognitive improvement, as measured by Wechsler Adult Intelligence Scale-Revised (WAIS-R) Full Scale, after a minimum of one year of treatment with clozapine. (priory.com)
  • Efficacy of cognitive-behavioural therapy and other. (cambridge.org)
Placebo1
  • Of the 439 patients in each arm, 360 randomized to patiromer and 367 randomized to placebo therapy completed the study treatment. (hcplive.com)
Consistent1
  • The proportion of patients with treatment resistant schizophrenia has been consistent over time since the introduction of conventional antipsychotics (Conley and Buchanan, 1997). (priory.com)
Psychological treatments1
  • Researchers are studying whether psychological treatments can prevent relapse after patients go off antidepressant medication, reports the Wall Street Journal, noting that 'SSRIs have long been. (madinamerica.com)
Results5
  • After the examination, we will explain the treatment plan based on the results. (or.jp)
  • Treatment of the patient and sex partner results in relief of symptoms, microbiologic cure, and reduction of transmission. (cdc.gov)
  • Overall, the results showed that piperaquine resistance is now present in Vietnam, and there was a sharp increase in the proportion of treatment failures. (cdc.gov)
  • These results solidify ponatinib as an important and valuable treatment option for refractory patients with CML where no other TKI therapy is appropriate, including those who have the T315I mutation," stated Jorge Cortes, M.D., professor and deputy chair, Department of Leukemia, The University of Texas MD Anderson Cancer Center, and a leading investigator in the PACE trial. (businesswire.com)
  • Will Near Term Clinical Trial Results Transform Treatment Options For Sarcoma Patients? (forbes.com)
ACTs2
  • As a consequence, there has been treatment failures following treatments with ACTs. (cdc.gov)
  • For the latter, WHO recommends the use of Artemisinin-based Combinations Treatments (ACTs) in the second and third trimester of pregnancy. (bmj.com)
Resistance8
  • The treatment resistance of patients with schizophrenia is a frequent and important clinical problem. (priory.com)
  • The introduction of clozapine necessitated a clear definition of treatment resistance. (priory.com)
  • Prior to the approval of Iclusig, there were patients with CML for whom no targeted treatment was available, either because they had developed resistance mutations or intolerance to other approved treatments. (businesswire.com)
  • Two patients were withdrawn with virologic failure but demonstrated no evidence of virologic resistance. (researchgate.net)
  • A. fumigatus has shown a rise in azole resistance since the 1990s, resulting in treatment failures and prompting its inclusion on the CDC's 'watch list. (asm.org)
  • We must use antibiotics responsibly to preserve their efficacy and minimise the development and spread of resistance. (vin.com)
  • Some infectious diseases lack effective treatment options or face limitations in existing therapies, either due to resistance, toxicity, or other factors. (medgadget.com)
  • Synergistic combinations can enhance efficacy, broaden the spectrum of activity, and reduce the development of resistance. (medgadget.com)
Trials4
  • However, medication dosages and treatment duration that define adequate drug trials have undergone revisions. (priory.com)
  • Though various authors have used varied definitions of treatment resistant schizophrenia, the most common definition of treatment resistant schizophrenia denotes patients who despite at least two adequate trials of classical neuroleptic drugs have persistent moderate to severe, positive, or disorganization, or negative symptoms together with poor social and work function over a prolonged period of time (Meltzer 1997). (priory.com)
  • Will Clinical Trials Transform Treatment Options For Sarcoma Patients? (forbes.com)
  • However, the comparative efficacy of this treatment among periodontitis and non- periodontitis patients is unclear due to the absence of clinical trials. (bvsalud.org)
Versus1
  • To do so it compared the outcomes of people randomly allocated to case management versus people randomly allocated to 'treatment as usual' (the definition of which differed between studies). (findings.org.uk)
Acute4
  • 6 , 7 Use of adjunctive treatment is an acceptable and potentially effective strategy in the acute management of MDD for an inadequate response to monotherapy. (psychiatrist.com)
  • Acute liver failure is a life-threatening clinical syndrome characterized by rapid development of hepatocellular necrosis leading to high mortality and resource costs. (springer.com)
  • The only curative treatment for acute liver failure is liver transplantation, but there are many restrictions on the application of liver transplantation. (springer.com)
  • In recent years, a growing number of studies have shown that stem cells can effectively treat acute liver failure. (springer.com)
Optimize1
  • Early and effective treatment of ABSSSI is critical to optimize patient recovery and for certain patients may also help to avoid potentially lengthy and costly hospital stays. (prnewswire.com)
Virologic1
  • Coadministration with drugs that induce or inhibit these enzymes can alter NNRTI drug concentrations, resulting in virologic failure or adverse effects. (medscape.com)
Intention to tr1
  • Intention-to-treat (ITT) analysis was used for all efficacy outcomes. (acc.org)
1000 mg2
  • Clinical history (previous treatment) No good level of functioning over past 5 years Received 3 periods of treatment in preceding 5 years with antipsychotics of at least 2 different chemical classes for at least 6 weeks, with an equivalent of at least 1000 mg chlorpromazine daily without significant relief. (priory.com)
  • XYDALBA™ is the first and only IV antibiotic approved for the treatment of ABSSSI with a two-dose regimen of 1000 mg followed one week later by 500 mg, each administered over 30 minutes, and a single dose regimen of 1500 mg also administered over 30 minutes. (prnewswire.com)
Mechanisms1
  • Previous studies have proven that rodent and human MSCs can differentiate into HLCs in vitro and in vivo , which is one of the mechanisms of MSCs in the treatment of liver failure. (springer.com)
Therapy7
  • The four studies examined the use of simeprevir in patients who were treatment naïve, as well as patients who were non-responders to prior therapy or relapsed following treatment with pegylated interferon with or without ribavirin. (jnj.com)
  • In CONCERTO-3, patients who relapsed after previous interferon-based therapy received simeprevir plus pegylated interferon and ribavirin for 12 weeks, followed by response-guided treatment of pegylated interferon and ribavirin alone for 12 or 36 weeks. (jnj.com)
  • Men with low-risk, localised prostate cancer (Gleason pattern 3) who had received no previous treatment were randomly assigned (1:1) to vascular-targeted photodynamic therapy (4 mg/kg padeliporfin intravenously over 10 min and optical fibres inserted into the prostate to cover the desired treatment. (lu.se)
  • Men with low-risk, localised prostate cancer (Gleason pattern 3) who had received no previous treatment were randomly assigned (1:1) to vascular-targeted photodynamic therapy (4 mg/kg padeliporfin intravenously over 10 min and optical fibres inserted into the prostate to cover the desired treatment zone and subsequent activation by laser light 753 nm with a fixed power of 150 mW/cm for 22 min 15 s) or active surveillance. (lu.se)
  • Interpretation: Padeliporfin vascular-targeted photodynamic therapy is a safe, effective treatment for low-risk, localised prostate cancer. (lu.se)
  • This treatment might allow more men to consider a tissue-preserving approach and defer or avoid radical therapy. (lu.se)
  • Tooth -supported fixed prostheses seemed to be a valid treatment approach to restore masticatory function in patients with stage IV periodontitis once periodontal therapy has been accomplished. (bvsalud.org)
Discontinuation1
  • all cases were mild or moderate and did not lead to study treatment discontinuation), injection site reaction (n=5/37, n=5/18), cough (n=3/37, n=4/18) and headache (n=3/37, n=4/18). (biospace.com)
Data3
  • Beginning in the spring of 1992, CDC personnel systematically reviewed literature on each of the major STDs, focusing on data and reports that have become available since the 1989 STD Treatment Guidelines were published. (cdc.gov)
  • CDC personnel presented the key questions on STD treatment suggested from their literature reviews and presented the data available to answer those questions. (cdc.gov)
  • The support we provide can include financial support, training in how to do efficacy monitoring, providing quality assured drug, and reviewing the data. (cdc.gov)
Guidelines2
  • These guidelines for the treatment of patients with sexually transmitted diseases (STDs) were developed by staff members of CDC after consultation with a group of invited experts who met in Atlanta on January 19-21, 1993. (cdc.gov)
  • Despite the availability of the recent guidelines [ 9 ], the primary treatment of overt hyperthyroidism due to GD remains controversial and varies significantly in different parts of the world [ 6 ]. (hindawi.com)
Duration3
  • Alfred Health, Melbourne, Victoria, Australia one rationale for this 3-week duration of treatment ( 12 ). (cdc.gov)
  • Meltzer and Okayli (1995) have reported decrease in suicidality of treatment resistant schizophrenic patients with clozapine treatment of 6 months to 7 years duration. (priory.com)
  • Some authors have studied the relationship between the duration and efficacy of clozapine treatment. (priory.com)
Compare1
  • How does an intervention designed to enhance coordination and continuity of services, known as 'case management', compare to treatment as usual? (findings.org.uk)