Efficacy patients mesylates. Medical search. Frequent questions

The goal of this clinical trial is to evaluate the safety, tolerability and pharmacokinetics (PK) profiles* of MDI-1228_mesylate Ophthalmic Solution in patients with allergic conjunctivitis and healthy adult participants. (abnewswire.com)
Intermittent target inhibition with dasatinib 100 mg once daily preserves efficacy and improves tolerability in imatinib-resistant and -intolerant chronic-phase chronic myeloid leukemia. (medscape.org)
The Fortovase formulation no longer meets the demands of convenience and tolerability expected by patients today… we have determined that it is time to focus our resources on the availability of Invirase, which offers significant improvements in convenience and [gastrointestinal] tolerance," said Frederick Schmid, vice president of virology/HIV at Roche. (pharmatimes.com)
Phase I study is a dose-escalation study comprising two dose levels of imatinib mesylate (200 and 400 mg/day, respectively) with fixed dose of pembrolizumab (200 mg every 3 weeks) to evaluate safety and tolerability and determine recommended phase II dose. (elsevierpure.com)
Efficacy, safety and tolerability seem comparable to that reported in developed countries. (uwi.edu)
STOP 301: A phase 3, open-label study of safety, tolerability, and exploratory efficacy of INP104, precision olfactory delivery (POD ®) of dihydroergotamine mesylate, over 24/52 weeks in acute treatment of migraine attacks in adult patients. (reliasmedia.com)
We are currently pursuing options to advance PUR3100 into a Phase 2 clinical trial to investigate PUR3100 efficacy, safety, tolerability in treating acute migraine subjects. (abc4.com)

Impel NeuroPharma, Inc., a commercial-stage biopharmaceutical company developing transformative therapies for people suffering from diseases with high unmet medical needs, with an initial focus on the central nervous system, announced that the U.S. Food and Drug Administration (FDA) approved TRUDHESA (dihydroergotamine mesylate) nasal spray (0.725 mg per spray) for the acute treatment of migraine with or without aura in adults. (mobilehealthtimes.com)
Using Impel's proprietary Precision Olfactory Delivery (POD) technology, TRUDHESA gently delivers dihydroergotamine mesylate (DHE) quickly to the bloodstream through the vascular-rich upper nasal space. (mobilehealthtimes.com)
8. Safety and Pharmacokinetics of Dihydroergotamine Mesylate Administered via a Novel (Tempo™) Inhaler. (shrewdconsulting.com)
10. Intrapulmonary and Intravenous Administrations of Dihydroergotamine Mesylate (DHE) Have Similar Cardiovascular Effects in the Conscious Dog. (shrewdconsulting.com)
22. STOP 101: A Phase 1, Randomized, Open-Label, Comparative Bioavailability Study of INP104, Dihydroergotamine Mesylate (DHE) Administered Intranasally by a I123 Precision Olfactory Delivery (POD®) Device, in Healthy Adult Subjects. (shrewdconsulting.com)
Dihydroergotamine mesylate (DHE) has been available as a nasal spray (Migranal) since 1997. (reliasmedia.com)

Doxazosin mesylate is a quinazoline compound that is a selective inhibitor of the alpha 1 subtype of alpha adrenergic receptors. (nih.gov)
The high efficacy of tyrosine kinase inhibitor, imatinib mesylate (IM), is well-documented in patients with hypereosinophilic syndromes (HES) and detectable rearrangements of platelet-derived growth factor receptor α or β (PDGFRA/B) [1]. (efim.org)
Phase III, randomized, open-label study of daily imatinib mesylate 400 mg versus 800 mg in patients with newly diagnosed, previously untreated chronic myeloid leukemia in chronic phase using molecular end points: tyrosine kinase inhibitor optimization and selectivity study. (medscape.org)
Imatinib mesylate is an example of an inhibitor of a tyrosine kinase involved in the pathogenesis of chronic myelogenous leukemia that has shown some efficacy, albeit limited, in the treatment of Philadelphia chromosome-positive ALL. (medscape.com)
Imatinib mesylate, a small-molecule inhibitor of the KIT tyrosine kinase, provides a rapid but not durable clinical response in KIT-mutant melanoma. (elsevierpure.com)
However, patients on imatinib can acquire secondary KIT mutations that render the protein insensitive to the inhibitor. (utmb.edu)
Imatinib mesylate is a tyrosine kinase inhibitor. (thegiconnection.com)
Imatinib mesylate (IM) is a small molecule inhibitor of protein tyrosine kinases. (prinsesmaximacentrum.nl)
To explore the security and efficacy from the selective 5-serotonin and norepinephrine reuptake inhibitor duloxetine hydrochloride and alpha-adrenergic receptor blocker (alpha-blocker) doxazosin mesylate-controlled tablets in the treating discomfort disorder in chronic prostatitis/chronic pelvic discomfort symptoms (CP/CPPS). (bio-biz-navi.com)
Patients with the FIP1L1/PDGFRA -associated fusion gene are more often males and may be responsive to low-dose imatinib (a tyrosine kinase inhibitor). (msdmanuals.com)
One of the best-characterized forms of HES is the one associated with FIP1L1-PDGFRA gene rearrangement, which was recently demonstrated as responsive to treatment with the small molecule kinase inhibitor drug, imatinib mesylate. (wjgnet.com)
A Multi-center, Randomized, Double-blind, Placebo-controlled Phase III Trial of the FLT3 Inhibitor Gilteritinib Administered as Maintenance Therapy Following Allogeneic Transplant for Patients With FLT3/ITD AML (BMT CTN 1506) Rochester, Minn., Scottsdale/Phoenix, Ariz. (mayo.edu)
Farnesyltransferase inhibitor tipifarnib is well leurocristine tolerated, induces stabilization of disease, and inhibits farnesylation and oncogenic tumor survival pathways in patients with advanced multiple myeloma. (hsp90-inhibitors.com)
To estimate the total value of survival gains associated with first- and second-line TKI therapy in chronic myeloid leukemia (CML) and the fraction of tyrosine kinase inhibitor (TKI)- related survival-gain value retained by patients and drug companies. (ajmc.com)
Odd Twist in Phase 3 Alzheimer's Trial for Novel Tau Inhibitor Although the novel tau aggregation inhibitor hydromethylthionine mesylate did not reach its coprimary endpoints, investigators insist there's more to the story - especially with the control agent used. (medscape.com)
Because alternatives to the use of rifampin for antituberculosis treatment are now available, the previously recommended practice of stopping protease inhibitor therapy to allow the use of rifampin for TB treatment is no longer recommended for patients with HIV-related TB. (cdc.gov)

Patients will usually have scheduled meetings with their healthcare provider while they are being treated with imatinib mesylate. (thegiconnection.com)

Although clinical trial data have quantified patient survival gains associated with tyrosine kinase inhibitors in chronic myeloid leukemia, the overall value of these benefits is unknown. (ajmc.com)

Parlodel (bromocriptine mesylate) is a dopamine receptor agonist used to treat certain conditions caused by a hormone imbalance in which there is too much prolactin in the blood (hyperprolactinemia), and to treat these disorders when they are caused by brain tumors that can produce prolactin. (rxlist.com)
Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. (nature.com)
Surgery is the primary treatment for patients with localized or potentially resectable gastrointestinal stromal tumors. (medscape.com)
NCCN Task Force report: update on the management of patients with gastrointestinal stromal tumors. (medscape.com)
Imatinib mesylate is FDA approved for the treatment of all phases of Philadelphia chromosome-positive chronic myelogenous leukemia and it is also approved for the treatment of c-Kit positive gastrointestinal stromal tumors (GIST). (thegiconnection.com)
The goals of this study were to determine the maximum tolerated dose (MTD) of IL-2 combined with IM at a constant dose of 400 mg, the pharmacokinetics of IM and IL-2, as well as toxicity and clinical efficacy of this immunotherapeutic regimen in patients affected by advanced tumors. (prinsesmaximacentrum.nl)
Imatinib mesylate (Gleevec, Novartis), which was approved for three phases (chronic, accelerated, and blast crisis) of chronic myelogenous leukemia (CML) in May 2001 and gastrointestinal stromal tumors (GIST) in February 2002, serves as an example of drug development focused on expedited patient access. (medscape.com)
With the development of tumor molecular heterogeneity theory(12), there are still some patients with GIST who are sensitive to radiotherapy, especially for the patients with advanced stage(13-16).In addition, with the development of imaging technology and modern tissue and organ radiation technology, it has become a reality to concentrate high-dose radiation locally in abdominal cavity tumors(12), which challenges RT's insensitivity to GISTs. (researchsquare.com)

To determine the frequency and severity of adverse effects of Gleevec in this cohort of patients as assessed by CTC. (knowcancer.com)
Tasigna demonstrated that significantly fewer patients progressed to more advanced stages of the disease than the standard of care Gleevec (imatinib mesylate) tablets* at 12 months. (salesandmarketingnetwork.com)
Tasigna also showed a statistically significant improvement over Gleevec in every other measure of efficacy in the trial, including major molecular response (MMR) and complete cytogenetic response (CCyR) at 12 months(1). (salesandmarketingnetwork.com)
All filings are based on data showing superior efficacy for Tasigna in the first head-to-head comparison of the drug against the standard of care Gleevec in newly diagnosed Ph+ CML patients. (salesandmarketingnetwork.com)
If approved for the first-line indication, Tasigna will be the first drug for newly diagnosed patients to become available since the approval of Gleevec in 2002. (salesandmarketingnetwork.com)
Recently presented data showed that Tasigna surpassed Gleevec in every measure of treatment efficacy designated in the study including prevention of disease progression at 12 months," said David Epstein, CEO of the Novartis Pharmaceuticals Division. (salesandmarketingnetwork.com)
This randomized, open-label, multicenter trial compared the efficacy and safety of Tasigna versus Gleevec in adult patients with newly diagnosed Ph+ CML in chronic phase(1). (salesandmarketingnetwork.com)
In the ENESTnd clinical trial significantly fewer patients at 12 months progressed to accelerated or blastic phase on Tasigna 300 mg twice daily than on Gleevec 400 mg once daily (2 patients vs. 11 patients)(1), demonstrating a significant improvement in disease control. (salesandmarketingnetwork.com)
Fewer patients discontinued due to adverse events from the Tasigna 300 mg twice daily arm of the study compared to the Gleevec 400 mg once daily arm. (salesandmarketingnetwork.com)
Tasigna has been approved in more than 80 countries for the treatment of chronic phase and accelerated phase Ph+ CML in adult patients resistant or intolerant to at least one prior therapy, including Gleevec. (salesandmarketingnetwork.com)

The chemical name of doxazosin mesylate is 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(1,4-benzodioxan-2-ylcarbonyl) piperazine methanesulfonate. (nih.gov)
Doxazosin mesylate is freely soluble in dimethylsulfoxide, soluble in dimethylformamide, slightly soluble in methanol, ethanol, and water (0.8% at 25°C), and very slightly soluble in acetone and methylene chloride. (nih.gov)
Each doxazosin mesylate tablet, for oral administration, contains 1 mg, 2 mg, 4 mg, or 8 mg of doxazosin as the free base. (nih.gov)
In the human prostate, doxazosin mesylate antagonizes phenylephrine (alpha 1 agonist)-induced contractions, in vitro , and binds with high affinity to the alpha 1c adrenoceptor. (nih.gov)
Doxazosin mesylate acts within 1 to 2 weeks to decrease the severity of BPH symptoms and improve urinary flow rate. (nih.gov)
Since alpha 1 adrenoceptors are of low density in the urinary bladder (apart from the bladder neck), doxazosin mesylate should maintain bladder contractility. (nih.gov)
The efficacy of doxazosin mesylate was evaluated extensively in over 900 patients with BPH in double-blind, placebo-controlled trials. (nih.gov)
Doxazosin mesylate treatment was superior to placebo in improving patient symptoms and urinary flow rate. (nih.gov)
Uroflowmetric evaluations were performed at times of peak (2 to 6 hours post-dose) and/or trough (24 hours post-dose) plasma concentrations of doxazosin mesylate. (nih.gov)
In all three studies, doxazosin mesylate resulted in statistically significant relief of obstructive and irritative symptoms compared to placebo. (nih.gov)
Statistically significant improvements of 2.3 to 3.3 mL/sec in maximum flow rate were seen with doxazosin mesylate in STUDIES 1 and 2 , compared to 0.1 to 0.7 mL/sec with placebo. (nih.gov)
36 patients received a dose of 8 mg doxazosin mesylate. (nih.gov)
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The FDA first granted approval for advanced GIST patients in 2002. (wikipedia.org)
The efficacy of the inhibitors imatinib mesylate and sunitinib malate in GIST patients has been linked to their inhibition of these mutant KIT proteins. (utmb.edu)
Phase II trial of neoadjuvant/adjuvant imatinib mesylate (IM) for advanced primary and metastatic/recurrent operable gastrointestinal stromal tumor (GIST): early results of RTOG 0132/ACRIN 6665. (medscape.com)
Imatinib mesylate also appears to have growth inhibitory effects in some diseases such as GIST that is c-Kit positive. (thegiconnection.com)
In this report, we describe a case of TLS in a patient with gastrointestinal stromal tumour (GIST) that occurred 15 days after commencement of imatinib. (touchoncology.com)
5 Against this background, we report a case of delayed TLS in a patient with advanced GIST treated with imatinib. (touchoncology.com)
In recent years, reports on the efficacy and safety of RT in GIST have been emerging (17-21),the RT research of 15 cases of GIST published by John J Cuaron (22) in 2013 and the RT single arm clinical trial of 25 cases of GIST published by Heikki Joensuu (23) in 2015 provide the effective basis for the application of RT in GIST. (researchsquare.com)

A retrospective study was done to assess the efficacy and toxicity of IM in treating chronic myeloid leukaemia (CML) in Trinidad and Tobago. (uwi.edu)
Cancer chemotherapy has long relied on generalized and nonspecific treatments that often involve substantial patient toxicity. (ajmc.com)

In the trial, TRUDHESA was generally well tolerated and exploratory efficacy findings showed it provided rapid, sustained, and consistent symptom relief. (mobilehealthtimes.com)
In the STOP 301 study, patient-reported exploratory efficacy findings reported that more than a third of patients (38%) had pain freedom, two-thirds (66%) had pain relief, and more than half (52%) had freedom from their most bothersome migraine symptom at two hours after their first dose of TRUDHESA. (mobilehealthtimes.com)

Herein, we designed clinical trial of co-administrating imatinib mesylate and pembrolizumab (anti-PD-1 antibody) to evaluate its safety and efficacy.Methods and analysis:This is an open-label, single-arm, phase I/II clinical trial involving Japanese patients with metastatic KIT-mutant melanoma that are refractory to standard therapy including anti-PD-1 therapy. (elsevierpure.com)
Safety and efficacy have not been established. (mayoclinic.org)
Safety and efficacy of antiviral combination therapy in symptomatic patients of Covid-19 infection - a randomised controlled trial (SEV-COVID Trial): A structured summary of a study protocol for a randomized controlled trial. (cdc.gov)

The efficacy of INP104 is based on the relative bioavailability compared to DHE nasal spray (Migranal) in healthy subjects. (reliasmedia.com)

It is also used to maintain remission in chronic phase CML patients. (wikipedia.org)
EAST HANOVER, N.J., Feb. 19 -- (Healthcare Sales & Marketing Network) -- Novartis announced today that Tasigna (nilotinib) 200 mg capsules has been granted priority review by the US Food and Drug Administration (FDA) for the treatment of adult patients with newly diagnosed Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML) in chronic phase. (salesandmarketingnetwork.com)
Now this priority review designation brings us one step closer to offering patients who are newly diagnosed with Ph+ CML in the chronic phase a promising new treatment option. (salesandmarketingnetwork.com)
The regulatory submissions are based on data from the ENESTnd (Evaluating Nilotinib Efficacy and Safety in Clinical Trials of Newly Diagnosed Ph+ CML Patients) Phase III clinical trial. (salesandmarketingnetwork.com)
On August 2023, Shanghai Medinno Pharmaceutical Technology Co., Ltd. announced a study of Phase 1 Clinical Trials for MDI-1228_mesylate Ophthalmic Solution. (abnewswire.com)
International randomized study of interferon vs STI571 (IRIS) 8-year follow up: sustained survival and low risk for progression or events in patients with newly diagnosed chronic myeloid leukemia in chronic phase treated with imatinib [abstract]. (medscape.org)
Nilotinib as front-line treatment for patients with chronic myeloid leukemia in early chronic phase. (medscape.org)
ENESTnd update: continued superiority of nilotinib versus imatinib in patients with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP) [abstract]. (medscape.org)
Results of dasatinib therapy in patients with early chronic-phase chronic myeloid leukemia. (medscape.org)
Efficacy and safety of dasatinib compared with imatinib in patients with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP): minimum 24-month follow-up from the DASISION trial [abstract]. (medscape.org)
Pleural effusion in patients with chronic-phase chronic myeloid leukemia (CML-CP) who received first-line dasatinib in the DASISION trial: patient characteristics, management, and outcomes [abstract]. (medscape.org)
The primary endpoint of the phase II study is the objective response rate after 4 cycles (3 weeks/cycle) of pembrolizumab and imatinib mesylate at the dose determined in phase I, based on RECIST version 1.1. (elsevierpure.com)
Boehringer Ingelheim presented positive results of its Phase 3 RE-VERSE AD study for idarucizumab as a reversal agent for the anticoagulant effect of Pradaxa (dabigatran) in patients needing emergency surgery or for life-threatening or uncontrolled bleeding events. (empr.com)
Boehringer Ingelheim announced results from an interim analysis of the Phase 3 RE-VERSE AS patient study with idarucizumab for urgent reversal of the anticoagulant effect of Pradaxa (dabigatran etexilate mesylate). (empr.com)
IDHIFA failed to demonstrate improved OS in adult patients with late stage AML and an IDH2 mutation versus conventional care regimens in a Phase 3 confirmatory study evaluating efficacy and safety. (canada.ca)
21. The Leadership Study: A Phase 2 Study to Evaluate the Efficacy and Safety of the Novel, Oral SHIP1 Activator, AQX-1125, in Subjects with Moderate to Severe Interstitial Cystitis/Bladder Pain Syndrome. (shrewdconsulting.com)
A041501, A Phase III Trial to Evaluate the Efficacy of the Addition of Inotuzumab Ozogamicin (a Conjugated Anti-CD22 Monoclonal Antibody) to Frontline Therapy in Young Adults (Ages 18-39 Years) With Newly Diagnosed Precursor B-Cell ALL Rochester, Minn. (mayo.edu)
This partially randomized phase III trial studies the side effects of inotuzumab ozogamicin and how well it works when given with frontline chemotherapy in treating patients with newly diagnosed B acute lymphoblastic leukemia. (mayo.edu)
A Phase 2 Single Arm, Multicenter Trial to Evaluate the Efficacy of the BiTE Antibody Blinatumomab in Adult Subjects With Relapsed/Refractory Philadelphia Positive B-precursor Acute Lymphoblastic Leukemia (Alcantara Study) Rochester, Minn. This study seeks adult subjects with R/R Ph+ B-precursor ALL. (mayo.edu)
A third Phase 3 trial, Study C (N=31), was an open-label, sequential efficacy and safety study in patients aged 2 to 17 years with type 1 diabetes. (gvokeglucagon.com)
Blood Manuscript describes a phase II trial of tipifarnib for the treatment of patients with multiple myeloma. (hsp90-inhibitors.com)
Antipsychotic Shows Benefit for Alzheimer's Agitation Researchers reported that a phase 3 study showed statistically significant improvement in patients with agitation related to Alzheimer's who took the atypical antipsychotic brexpiprazole. (medscape.com)
Double-Blind, Randomized, Placebo-Controlled Phase III Clinical Trial to Evaluate the Efficacy and Safety of treating Healthcare Professionals with the Adsorbed COVID-19 (Inactivated) Vaccine Manufactured by Sinovac - PROFISCOV: A structured summary of a study protocol for a randomised controlled trial. (cdc.gov)

A population study of imatinib in chronic myeloid leukaemia demonstrates lower efficacy than in clinical trials. (medscape.org)
To determine the presenting features and evolution of patients diagnosed with chronic myeloid leukaemia between 1983 and 1999 at the University Hospital of the West Indies. (uwi.edu)

By comparison, TLS in patients with solid organ tumours treated with cytotoxic chemotherapy occurs within 3 days (95% CI 2.9-4.4). (touchoncology.com)

Sunitinib has shown efficacy against certain imatinib-resistant mutants, although a subset that resides in the activation loop, including D816H/V, remains resistant. (utmb.edu)

This population of children represents the largest group of patients with cancer refractory to current therapies. (medscape.com)
Totally, a target size of 22 patients will be expected.Discussion:If this study shows efficacy and acceptable safety profile, it will contribute to the development of novel treatment option for patients with KIT-mutant melanoma that are refractory to standard therapy.Trial registration:NCT04546074. (elsevierpure.com)

Our Parlodel (bromocriptine mesylate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
Parlodel® (bromocriptine mesylate) is an ergot derivative with potent dopamine receptor agonist activity. (rxlist.com)
Each Parlodel® (bromocriptine mesylate) SnapTabs® tablet for oral administration contains 2½ mg and each capsule contains 5 mg bromocriptine (as the mesylate). (rxlist.com)
Bromocriptine mesylate is chemically designated as Ergotaman-3',6',18-trione, 2-bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)-, (5'α)-monomethanesulfonate (salt). (rxlist.com)
Parlodel (bromocriptine mesylate) is indicated for the treatment of dysfunctions associated with hyperprolactinemia including amenorrhea with or without galactorrhea, infertility or hypogonadism . (rxlist.com)

T he FDA has approved a new intranasal formulation of d ihydroergotamine mesylate (INP104) for the acute treatment of migraine headaches. (reliasmedia.com)
INP104 shares the same contraindications and warning as other DHE formulations (e.g., peripheral ischemia following coadministration with strong CYP3A4 inhibitors, patients with cardiovascular risk factors). (reliasmedia.com)

Comparison of a low molecular weight heparin and unfractionated heparin for the prevention of deep vein thrombosis in patients undergoing abdominal surgery. (keywen.com)
A clinical trial of vena caval filters in the prevention of pulmonary embolism in patients with proximal deep vein thrombosis. (keywen.com)
Boehringer Ingelheim announced results from the RE-COVER II study evaluating dabigatran compared to warfarin in patients diagnosed with acute deep vein thrombosis (DVT) and/or pulmonary embolism (PE). (empr.com)
Boehringer Ingelheim) in patients with deep vein thrombosis (DVT) and pulmonary embolism (PE). (empr.com)

No patients in the study had a prolongation of the QT interval >500 milliseconds(1). (salesandmarketingnetwork.com)
METHODS: This was a 1-yr retrospective cohort study involving all COVID-19 patients admitted to intensive care units in six hospitals affiliated with Yale New Haven Health System from February 13, 2020, to March 4, 2021. (bvsalud.org)
RESULTS: This study analyzed 2,070 patients after excluding 23 patients who died within 24 h after intensive care unit admission and 3 patients who remained hospitalized on the last day of data censoring. (bvsalud.org)
This trial also aims to study the preliminary efficacy of MDI-1228_mesylate Ophthalmic Solution in patients with allergic conjunctivitis. (abnewswire.com)
A prospective randomized trial of prevention measures in patients at high risk for contrast nephropathy: results of the P.R.I.N.C.E. Study. (keywen.com)
13. A Randomized, Double Blind, Placebo-Controlled Study of MAP0004 in Adult Patients with Migraine. (shrewdconsulting.com)
The patient involved in this study gave written informed consent authorizing use and disclosure of his protected health information. (wjgnet.com)
The purpose of this study is to evaluate the rate of complete MRD response by flow cytometry after 4 weekly doses of daratumumab-hyaluronidase (Day 29) among patients with MRD positive T-ALL in hematologic morphologic complete remission or complete remission with incomplete hematologic recovery. (mayo.edu)
The primary objective of this study is to demonstrate the efficacy of Iomab-B, in conjunction with a Reduced Intensity Conditioning (RIC) regimen and protocol-specified allogeneic hematopoietic stem cell transplant (HCT), versus Conventional Care. (mayo.edu)
Gvoke HypoPen was evaluated in adult patients aged 18-74 years with type 1 diabetes in 2 multicenter, randomized, controlled, blinded, 2-way crossover non-inferiority studies: Study A (N=80) and Study B (N=81). (gvokeglucagon.com)
This retrospective study identified CML patient data from the Surveillance, Epidemiology and End Results registry, dasatinib clinical trials, and insurance claims data sets. (ajmc.com)
Reconvalescent plasma/camostat mesylate in early SARS-CoV-2 Q-PCR positive high-risk individuals (RES-Q-HR): a structured summary of a study protocol for a randomized controlled trial. (cdc.gov)
Proactive Prophylaxis With Azithromycin and HydroxyChloroquine in Hospitalised Patients With COVID-19 (ProPAC-COVID): A structured summary of a study protocol for a randomised controlled trial. (cdc.gov)

Specifically adult patients with unresectable, recurrent and/or metastatic dermatofibrosarcoma protuberans (DFSP). (wikipedia.org)
Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. (nature.com)
Primary treatment for patients with metastatic GISTs is imatinib. (medscape.com)

Imatinib mesylate is administered orally, in the form of a capsule, and the dose depends on several factors, including the condition being treated, the size of the patient, the particular regimen being used, and the overall health of the patient. (thegiconnection.com)
Ideally, the management of TB among HIV-infected patients taking antiretroviral drugs requires a) directly observed therapy, b) availability of experienced and coordinated TB/HIV care givers, and in most situations, c) use of a TB treatment regimen that includes rifabutin instead of rifampin. (cdc.gov)

5 It is noteworthy that in high-risk patients with haematological malignancies, targeted therapy including TKIs, monoclonal antibodies, chimeric antigen receptors and proteasome inhibitors are often associated with TLS. (touchoncology.com)

Sudden deaths have been reported in patients receiving nilotinib. (salesandmarketingnetwork.com)
Superior efficacy of nilotinib compared with imatinib in newly-diagnosed patients with chronic myeloid leukemia in chronic (CML-CP): ENESTnd minimum 24-month follow-up [abstract]. (medscape.org)

The conventional dose of remifentanil combined with dexmedetomidine anesthesia has a good anesthetic effect in clinical applications, but at the same time, drug-related side effects are strong, and even excessive sedation of patients occurs, which is not conducive to patient safety [ 4 ]. (hindawi.com)
And, importantly, it is a self-administered, single dose that can be taken anytime during a migraine attack, so patients don't need to worry about missing the opportunity to benefit from using TRUDHESA within a certain timeframe. (mobilehealthtimes.com)
From these two studies, The American College of Chest Physicians has recommended LMWH or low-dose warfarin for the prevention in patients with CVCs. (keywen.com)
However, elderly patients are more likely to have age-related heart or kidney problems, which may require caution and an adjustment in the dose for patients receiving this medicine. (mayoclinic.org)

Parlodel treatment is indicated in patients with prolactin-secreting adenomas , which may be the basic underlying endocrinopathy contributing to the above clinical presentations. (rxlist.com)
For treatment-naïve patients, take atazanavir simultaneously with the H2RA or at least 10 h afterwards. (medscape.com)
See dosage adjustment recommendations if coadministered in treatment-experienced patients. (medscape.com)
Some patients may need to continue taking Imatinib for an extended period of time to maintain remission, and some patients may eventually require additional treatment options. (wikipedia.org)
The FDA granted approval for the treatment of dermatofibrosarcoma protuberans (DFSP) patients in 2006. (wikipedia.org)
Six-year follow-up of patients receiving imatinib for the first-line treatment of chronic myeloid leukemia. (medscape.org)
Many of my patients need more from their migraine treatment, and TRUDHESA offers a non-oral, fast-acting, reliable option that overcomes many current medication challenges," said Stephanie J. Nahas-Geiger, MD, MSEd, Associate Professor in the Department of Neurology, and Program Director of the Headache Medicine Fellowship Program, Thomas Jefferson University. (mobilehealthtimes.com)
I think patients will be very receptive to this treatment, because it pairs the long-proven benefits of DHE with a patient-friendly delivery system. (mobilehealthtimes.com)
Hence, hydroxychloroquine with nafamostat mesylate might be a treatment option for severe COVID-19. (elsevierpure.com)
[ 1 ] If patients are resistant to imatinib therapy, treatment with sunitinib may be introduced. (medscape.com)
What are the common (occur in 30% or more of patients) side effects of treatment with imatinib mesylate? (thegiconnection.com)
What are the less common (occur in 10% to 29% of patients) side effects of treatment with imatinib mesylate? (thegiconnection.com)
Are there any special precautions patients should be aware of before starting treatment? (thegiconnection.com)
Patients should inform their physician of any other medication they are taking (whether prescription or over-the-counter, including vitamins, herbs, etc.) as they may interfere with treatment. (thegiconnection.com)
5 Two Surgical Trial in Lobar Intracerebral Haemorrhage I and II) trials randomised 1541 patients with ICH to early surgery or conservative treatment showed a nonsignificant benefit of surgery if patients with ICH had a Glascow Coma Scale (GCS) score of 9-12 and the volumes of ICH were large. (bmj.com)
This treatment was administered at three week intervals to 17 patients. (prinsesmaximacentrum.nl)
18. Exon skipping and dystrophin restoration in Duchenne Muscular Dystrophy patients after systemic phosphorodiamidate morpholino oligomer treatment. (shrewdconsulting.com)
Another limitation is that some patients with eosinophilia and organ damage that characterize hypereosinophilic syndrome require treatment earlier than the 6 months necessary to confirm the traditional diagnostic criteria. (msdmanuals.com)
FDA has implemented several programs intended to reduce the review time of a new pharmaceutical and accelerate patient access to medications for the treatment of serious or life-threatening diseases. (medscape.com)
Over 38 million patients suffer from migraine in the United States and there is currently no orally inhaled DHE treatment option for patients. (abc4.com)
Early diagnosis and effective treatment of TB among HIV-infected patients are critical for curing TB, minimizing the negative effects of TB on the course of HIV, and interrupting the transmission of Mycobacterium tuberculosis to other persons in the community. (cdc.gov)
All HIV-infected patients undergoing treatment for TB should be evaluated for antiretroviral therapy, because most patients with HIV-related TB are candidates for concurrent administration of antituberculosis and antiretroviral drug therapies. (cdc.gov)
Physicians and patients also should be aware that paradoxical reactions might occur during the course of TB treatment when antiretroviral therapy restores immune function. (cdc.gov)
Over the past 60 years, due to the advancement of hemo- the Work Group and tasked it with planning, developing, dialysis (HD) technology and the introduction of medical reviewing, and disseminating appropriate HD treatment insurance, dialysis treatment has become widespread, en- guidelines in accordance with international standards. (bvsalud.org)

Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial. (medscape.com)

In three placebo-controlled studies of 14 to 16 weeks duration obstructive symptoms (hesitation, intermittency, dribbling, weak urinary stream, incomplete emptying of the bladder) and irritative symptoms (nocturia, daytime frequency, urgency, burning) of BPH were evaluated at each visit by patient-assessed symptom questionnaires. (nih.gov)
5. Potential Effects of Fluticasone Propionate on Bone Mineral Density in Patients With Asthma: A 2-Year Randomized, Double-Blind, Placebo-Controlled Trial. (shrewdconsulting.com)

Imatinib mesylate inhibits the growth signaling processes, suppressing replication and ultimately causing death of Philadelphia-chromosome positive chronic myeloid leukemia cells. (thegiconnection.com)

Although recent improvement in survival is encouraging, there continues to be a subset of patients with childhood ALL who relapse, and about 20% of patients die of the disease. (medscape.com)
TKI costs were used to estimate the fraction of survival gain value retained by patients and drug companies. (ajmc.com)
These estimates indicate that the introduction of TKI drugs to treat CML has generated significant social value as a result of survival gains, the vast majority of which has accrued to patients. (ajmc.com)

Imatinib mesylate for unmutated hypereosinophilic syndromes: Does it work? (efim.org)
One limitation of the traditional definition is that it does not include those patients with some of the same abnormalities (eg, chromosomal defects) that are known causes of hypereosinophilic syndrome but who do not fulfill the traditional hypereosinophilic syndrome definition for degree or duration of eosinophilia. (msdmanuals.com)

We are grateful for all the patients and investigators who participated in our clinical trials and who were instrumental in bringing this needed advancement to the migraine community. (mobilehealthtimes.com)
Exploratory objectives included efficacy assessments of migraine measures and a patient acceptability questionnaire. (mobilehealthtimes.com)
Unlike some oral acute treatments that need to be taken within one hour of attack onset to be most effective, STOP 301 reported TRUDHESA offered consistent efficacy even when taken late into a migraine attack. (mobilehealthtimes.com)

In a statement, the company said that the decision to withdraw Fortovase had not come as a result of safety or efficacy issues, but notes that its newer HIV offering, Invirase (saquinavir mesylate), has become the preferred formulation of saquinavir. (pharmatimes.com)

Pulmatrix's product candidates are based on its proprietary engineered dry powder delivery platform, iSPERSE™, which seeks to improve therapeutic delivery to the lungs by maximizing local concentrations and reducing systemic side effects to improve patient outcomes. (abc4.com)

Surgery may be indicated in patients who have locally advanced or previously unresectable disease after a positive response to preoperative imatinib, in addition to limited disease progression on systemic therapy. (medscape.com)
CTAD 2023 No Influence of APOE Status on Donanemab Efficacy New data from TRAILBLAZER-ALZ 2 show robust amyloid clearance with donanemab in APOE4 carriers and noncarriers, mitigating the risk of disease progression and dependency. (medscape.com)

The approval of TRUDHESA marks the culmination of more than a decade of research and advanced engineering to pair the proven efficacy of DHE with our innovative POD technology. (mobilehealthtimes.com)
Boehringer Ingelheim announced that it has submitted a Biologics License Application (BLA) to the FDA, requesting accelerated approval for the use of idarucizumab to reverse the anticoagulant effect of Pradaxa (dabigatran etexilate mesylate). (empr.com)

100% (30/30) of pediatric patients achieved a target glucose increase of ≥25 mg/dL. (gvokeglucagon.com)

Turalio (pexidartinib) is FDA approved for use in patients with symptomatic tenosynovial giant cell tumor (FDA.gov). (jax.org)

Here, we report the case of a Japanese patient with COVID-19 with severe respiratory failure who improved following the administration of hydroxychloroquine and continuous hemodiafiltlation with nafamostat mesylate. (elsevierpure.com)

Imatinib for newly diagnosed patients with chronic myeloid leukemia: incidence of sustained responses in an intention-to-treat analysis. (medscape.org)

According to a small trial, imatinib is an effective drug in some patients with aggressive fibromatosis. (wikipedia.org)
The Food and Drug Administration (FDA) has granted Priority Review to the Biologics License Application (BLA) for idarucizumab (Boehringer Ingelheim) to reverse the anticoagulant effect of Pradaxa (dabigatran etexilate mesylate) in patients needing emergency intervention or experiencing an uncontrolled or life-threatening bleeding event. (empr.com)
Boehringer Ingelheim announced that the FDA has accepted for filing the supplemental New Drug Application (sNDA) for Pradaxa (dabigatran etexilate mesylate) for the prophylaxis of deep venous thrombosis (DVT) and pulmonary embolism (PE) in patients who have had primary elective total hip replacement surgery. (empr.com)
It is important for patients to remember that physicians have the ability to prescribe medication for conditions other than those for which the drug has been approved by the FDA. (thegiconnection.com)
Patients who have received a prescription of this drug for a condition other than which it is approved may wish to discuss this issue with their physician. (thegiconnection.com)
Patients may wish to discuss with their physician the other less common side effects of this drug, some of which may be serious. (thegiconnection.com)
If possible, avoid large crowds or people who are sick or not feeling well, as this drug may leave some patients susceptible to infection. (thegiconnection.com)
It is important that patients inform their physician of any pre-existing conditions (chicken pox, heart disease, kidney disease, liver disease, lung disease, etc.) as they may worsen with this drug. (thegiconnection.com)
[ 1 ] One factor influencing the duration of drug development is the Food and Drug Administration's (FDA's) review of an agent's efficacy and safety data. (medscape.com)
Approximately 90% of this value is retained by patients and society, while approximately 10% is recouped by drug companies. (ajmc.com)
We conclude by emphasizing the need to inform patients and physicians about herb-drug interactions and how to advise patients on appropriate use of herbal supplements to minimize the risk for interactions. (cancernetwork.com)

It is the largest global randomized comparison of two oral therapies ever conducted in newly diagnosed Ph+ CML patients. (salesandmarketingnetwork.com)
Promising Allergic Conjunctivitis Pipeline Therapies in the various stages of development include MDI-1228_mesylate Ophthalmic Solution, MATA trees or MATA grass, and others. (abnewswire.com)
It appeared that both haemostatic and surgical therapies showed trend of benefit in either mortality or functional outcome in subgroups of patients with ICH but not in all outcome measures. (bmj.com)

Chemicals and Drugs4

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes1

Anthropology, Education, Sociology and Social Phenomena3

Technology, Industry, Agriculture1

Information Science1

Health Care3

Geographicals1

Tolerability7

Dihydroergotamine mesylate6

Inhibitor16

Treated with Imatinib Mesylate1

Tyrosine1

Tumors8

Gleevec10

Doxazosin mesylate20

GIST7

Toxicity2

Exploratory efficacy2

Safety and Efficacy3

Nasal spray1

Phase23

Chronic myeloid l2

Chemotherapy1

Imatinib-resistant1

Refractory2

Bromocriptine5

INP1042

Deep vein throm4

Study13

Metastatic3

Regimen2

Inhibitors1

Nilotinib2

Dose4

Treatment24

Gastrointestinal stroma1

Placebo-controlled2

Inhibits1

Survival3

Hypereosinophilic2

Migraine3

Formulation1

Concentrations1

Progression2

Approval2

Pediatric1

Symptomatic1

Hydroxychloroquine1

Newly diagnosed patients1

Drug11

Therapies3