Our results reveal how tumour-derived EVPs dysregulate hepatic function and their targetable potential, alongside TNF inhibition, for preventing fatty liver formation and enhancing the efficacy of chemotherapy. (nature.com)
In combination with the chemotherapy agents, TCEE treatment further enhanced the tumor suppression efficiency of cisplatin and doxorubicin. (hindawi.com)
Chemotherapy agents such as doxorubicin, cisplatin, and 5-fluorouracil are the primary choices for treating liver cancer cases but the response rate and overall survival remained poor [ 3 , 4 ]. (hindawi.com)
Furthermore, the combined drug effects of TCEE with conventional chemotherapy agents, cisplatin and doxorubicin, were also analyzed to clarify whether TCEE enhances or antagonizes the cytotoxicity of the selected chemotherapy agents in hepatocellular carcinoma cells. (hindawi.com)
As a result, chemotherapy efficacy diminishes, immune response impairs, and malignant phenotypes are preferentially selected. (brown.edu)
My results showed promise in improving the efficacy of doxorubicin (a chemotherapy drug), inhibition of cancer cell proliferation, and hampering cancer cell migration. (brown.edu)
Biocon Biologics Ltd), BT-ON013 - following adjuvant chemotherapy with doxorubicin and cyclophosphamide, in combination with paclitaxel or docetaxel - in combination with adjuvant chemotherapy consisting of docetaxel and carboplatin. (who.int)
Chemotherapy with streptozocin (STZ) in combination with 5-FU or doxorubicin (Dox) represents a standard of care for patients with metastatic pancreatic neuroendocrine neoplasms (pNEN). (cancerindex.org)
Methods Patients with platinum-sensitive recurrent ovarian cancer received intravenous (IV) paclitaxel at 60 mg/m 2 followed by IV carboplatin at an area under the curve of 6 and IV pegylated liposomal doxorubicin at 30 mg/m 2 on day 1 in a 28-day cycle (DC-LOP) or IV gemcitabine at 1000 mg/m 2 on days 1 and 8 in a 21-day cycle (GC-LOP). (bmj.com)
The objective was to define the mechanism of the growth inhibition of active hexose correlated compound (AHCC) alone and evaluate its activity in combination with pegylated liposomal doxorubicin (PLD). (researchgate.net)
Industrial Relevance: This study presents an example of the successful integration of a well- known herbal supplement, AHCC, with traditional western medicine cytotoxic agent, pegylated liposomal doxorubicin, for the treatment of recurrent ovarian cancer. (researchgate.net)
alone and evaluate its activity in combinatio n with pegylated liposomal doxorubicin (PLD). (researchgate.net)
apalutamide will decrease the level or effect of doxorubicin liposomal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
doxorubicin liposomal will decrease the level or effect of dabigatran by P-glycoprotein (MDR1) efflux transporter. (medscape.com)
Secondly, nanoparticles were loaded with DOX and their in vitro and ex vivo/in vivo delivery was assessed, in comparison with liposomal Doxorubicin (Caelyx). (dovepress.com)
Integrin α 2 ß 1 Targeting DGEA-Modified Liposomal Doxorubicin Enhances Antitumor Efficacy against Breast Cancer. (bvsalud.org)
Cyclophosphamide2
First Efficacy Results of a Randomized, Open- Label, Phase III Study of Adjuvant Doxorubicin Plus Cyclophosphamide, Followed by Docetaxel with or without. (slideplayer.com)
2 First Efficacy Results of a Randomized, Open-Label, Phase III Study of Adjuvant Doxorubicin Plus Cyclophosphamide, Followed by Docetaxel with or without Capecitabine, in High-Risk Early Breast Cancer O'Shaughnessy J et al. (slideplayer.com)
Antitumor4
In this study, we aim to explore the feasibility of a novel tumor target therapeutic strategy: Targeting PEPT1 to improve the antitumor efficacy of Doxorubicin in human HCC therapy. (oncotarget.com)
Doxorubicin-tripeptide conjugate was then observed to clarify the target delivery by PEPT1 and the antitumor effect on human hepatocarcinoma in vivo and in vitro . (oncotarget.com)
The aims of this study are to clarify the antitumor effects of TCEE on human hepatocellular carcinoma cells and also evaluate the combination drug effects with conventional chemotherapy agents, cisplatin and doxorubicin. (hindawi.com)
In this study, we constructed a nano-drug delivery system (NPF@DOX) targeting FAP to increase the therapeutic efficiency of synergistic chemo-photothermal therapy against OSCC.Methods: We utilized PEGylated nano-graphene oxide (NGO) to link doxorubicin (DOX) and fluorescently-labeled, FAP-targeted peptide chains via hydrogen bonding and π-π bonding to enhance the targeting capability of NPF@DOX. (doaj.org)
The purpose of the current study was to fabricate biocompatible multifunctional drug-loaded nanoscale moieties for co-therapy (chemo-photothermal therapy) with maximum efficacy and minimum side effects. (beilstein-journals.org)
Anticancer3
In this study we developed a new polymer from epoxidized soybean oil that can efficently load and release water-soluble anticancer drug doxorubicin hydrochloride (DOX) and enhances its efficacy against multidrug resistant breast cancer cells. (usda.gov)
This work is intended to develop and evaluate a new polymer-lipid hybrid nanoparticle system that can efficiently load and release water-soluble anticancer drug doxorubicin hydrochloride (Dox) and enhance Dox toxicity against multidrug-resistant (MDR) cancer cells. (usda.gov)
Two of the limitations associated with cancer treatment are the low efficacy and the high dose-related side effects of anticancer drugs. (beilstein-journals.org)
Toxicity3
Our results reveal that targeting PEPT1 may contribute to the efficient delivery of Doxorubicin to hepatocarcinoma cells and the reduction of drug toxicity. (oncotarget.com)
Despite of being highly effective, the use of Doxorubicin has many limitations due to the significant toxicity and side effects occurred during and after HCC treatment. (oncotarget.com)
However, the efficacy of traditional treatments is hindered by systemic toxicity, limited therapeutic effects, and drug resistance. (doaj.org)
Tumor2
This study aimed to evaluate the anti-tumor efficacy of olaratumab and doxorubicin in patients. (koreamed.org)
The purpose of this work was to document the efficacy and side effects of vincristine sulphate treatment on TVTc. (vin.com)
Vitro2
Herein, we report in vitro anticancerous effects of doxorubicin (DOX) loaded on gold nanorods coated with the polyelectrolyte poly(sodium-4-styrenesulfonate) (PSS-GNRs) with and without NIR laser (808 nm, power density = 1.5 W/cm 2 for 2 min) irradiation. (beilstein-journals.org)
SiNPs-TZ (1:8 Hc-TZ) nanoparticles loaded with Doxorubicin (DOX-SiNPs-TZ) showed a similar DOX delivery capability than Caelyx (at 6 h p.i.), in in vitro and ex vivo assays. (dovepress.com)
Tolerability3
And this fact does not reflect high tolerability or robust efficacy. (forbes.com)
Doxorubicin is known as the "Red Devil", nomenclature that reflects its red color in the intravenous infusion bag and its poor tolerability, with anemia, low white blood cell counts that predispose to infection, heart failure, nausea, vomiting and diarrhea among its expected toxicities. (forbes.com)
2,3 Cellular therapy centers, manufacturers, payers, and policy makers will need to work together to address barriers to care as new CAR T-cell products with improved efficacy and tolerability are approved for use in more diverse malignancies. (ajmc.com)
Drugs3
The proposed combination of all three drugs may improve efficacy and response. (drugpatentwatch.com)
Electrochemical sensors can also help to monitor the concentrations of drugs such as doxorubicin used in cancer therapy in biofluids. (stanford.edu)
Nanotechnology has improved drug delivery by targeting specific organs to optimize the efficacy and safety profiles of individual drugs. (msdmanuals.com)
Conjugation1
Furthermore, the improvement of the toxic and side effect of Doxorubicin after conjugation was also evaluated by some biochemical tests. (oncotarget.com)
Chemotherapeutic1
Doxorubicin is a traditional chemotherapeutic agent for a wide variety of cancers. (oncotarget.com)
Treatment6
As a testament to the overall lack of progress in the treatment of this cancer type, it is sobering to recognize that the most effective drug for the treatment of patients with advanced sarcoma, doxorubicin, was approved in 1975! (forbes.com)
Treatment options for advanced sarcoma patients following disease progression on doxorubicin (called refractory disease) are even less palatable. (forbes.com)
Additional data from real-world settings further support the efficacy, safety and impact of ADCETRIS treatment in its approved indications for multiple types of lymphoma. (businesswire.com)
Finally, the treatment efficacy of DOX-SiNPs-TZ (1:8 Hc-TZ) was evaluated in vivo by PET and supported by MS-based proteomics profiling of tumors. (dovepress.com)
These findings demonstrated a promising detection specificity and treatment efficacy for our system (SiNPs-TZ, 1:8 Hc-TZ), encouraging its potential use as a new theranostic agent for HER2-positive BC lesions. (dovepress.com)
Hydroxyurea has proven clinical efficacy for SCA - treatment significantly reduces disease manifestations and prolongs survival. (cdc.gov)
Drug2
Currently, there are many studies being conducted in the search for anthracyclines with better anti-tumour efficacy or with reduced side effects using different nanotechnology-based drug delivery systems. (wikipedia.org)
This is useful to maximize therapeutic dose and efficacy while minimizing adverse response from high drug concentration. (stanford.edu)
Breast cancer1
The new polymer-lipid hybrid nanoparticle system is effective for delivery of Dox and enhances its efficacy against MDR breast cancer cells. (usda.gov)
Proven1
However, to improve resection and survival rates, doxorubicin, an agent with proven efficacy will be added to the C5V therapy (C5VD). (childrens.com)
Clinical trial1
The abstracts, including five oral presentations, highlight updated and interim efficacy and safety clinical trial results for ADCETRIS in both early- and advanced stage settings of classical Hodgkin lymphoma (cHL), and in patients with other CD30-expressing lymphomas and other rare cancers. (businesswire.com)
Concentrations3
Discontinuation of zafirlukast could decrease dihydrocodeine plasma concentrations, decrease opioid efficacy, and potentially lead to a withdrawal syndrome in those with physical dependence to dihydrocodeine. (pdr.net)
If zafirlukast is discontinued, hydrocodone plasma concentrations will decrease resulting in reduced efficacy of the opioid and potential withdrawal syndrome in a patient who has developed physical dependence to hydrocodone. (pdr.net)
For some substances there is also a risk assessment made on the basis of concentrations measured in the environment in Sweden and efficacy studies with high quality. (janusinfo.se)
Safety1
This is a phase 1b open-label study evaluating the preliminary safety and maximum tolerated dose of a new formulation of INNO-206 administered at doses of 230 mg/m2, 350 mg/m2 and 450 mg/m2 (165, 260, 325 mg/m2 doxorubicin equivalents, respectively) through intravenous infusion on Day 1 every 21 days for up to 6 cycles. (drugpatentwatch.com)
High2
DAMGO and 6beta-glycine substituted 14-O-methyloxymorphone but not morphine show peripheral, preemptive antinociception after systemic administration in a mouse visceral pain model and high intrinsic efficacy in the isolated rat vas deferens. (springer.com)
High exposure to VPA can lead to carnitine depletion causing a misbalance between the intra-mitochondrial beta-oxidation and the microsomal co-oxidation, a pathway that produces toxic metabolites such as 4-en-VPA which inhibits ammonia elimination. (unav.edu)
Patients2
Patients were randomized (1:1) to either pembrolizumab 200 mg intravenously every 3 weeks with lenvatinib 20 mg orally once daily or investigator's choice of doxorubicin or paclitaxel. (fda.gov)
With all that risk, you might expect considerable upside in terms of efficacy, but the response rate in patients with newly diagnosed sarcoma is approximately 17% and responses are transient when they occur. (forbes.com)
Improve1
Reduced pore size was found to improve signals where the smallest pore size of 9.3 nm gave a signal gain of 194% compared to 32% for planar electrode at saturating concentration of doxorubicin. (stanford.edu)
Decrease2
apalutamide will decrease the level or effect of doxorubicin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
enzalutamide will decrease the level or effect of doxorubicin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
Cancer1
IMPLICATIONS FOR PUBLIC HEALTH RESEARCH AND PRACTICE: Tailoring outreach and education strategies to address differences in perceived ability to lower chances of getting cancer (emotion) and confidence in the ability to complete FCH (self-efficacy) could help encourage less engaged individuals to learn about their FCH and gather cancer information. (cdc.gov)
Effects1
doxorubicin decreases effects of adenovirus types 4 and 7 live, oral by pharmacodynamic antagonism. (medscape.com)
Response1
Additional efficacy outcome measures included objective response rate (ORR) and duration of response (DOR), also BICR-assessed. (fda.gov)
Activity1
In addition to providing evidence of the efficacy of AHCC, the mechanism of improved activity was also investigated. (researchgate.net)
Found1
This method was found to generate a higher signal to noise ratio for easier quantification of doxorubicin levels. (stanford.edu)
Data1
We used cross-sectional data from the Health Information National Trends Survey (HINTS 5, Cycle 2) and variables (e.g., emotion and self-efficacy) associated with the Theory of Motivated Information Management to assess the process of FCH gathering and information seeking. (cdc.gov)