• Background: Especially in childhood, sublingual immunotherapy (SLIT) could offer advantages over subcutaneous therapy. (uni-luebeck.de)
  • [ 1 ] Several studies and meta-analyses support the efficacy of both subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT) for allergic rhinitis and asthma . (medscape.com)
  • In animals with subcutaneous tumors, combined radio-immunotherapy with anti-C1-INH and irradiation at 8 Gy × 2 significantly prolonged survival compared to control animals, whereas irradiation or anti-C1-INH treatment as single therapies did not lead to significantly increased survival compared to control animals. (lu.se)
  • Conclusions: Anti-C1-INH treatment could improve the efficacy of irradiation delivered at sub-therapeutic doses and delay tumor growth in the subcutaneous tumor microenvironment. (lu.se)
  • Immunotherapy represents a real revolution in cancer therapies and has been shown to be superior to standard chemotherapy in advanced melanoma, lung, renal and bladder cancer. (seerave.org)
  • Results simultaneously reported in the same edition of the journal by an American team (Dr. Jennifer Wargo, MD Anderson, Texas) support these findings showing that the composition of microbiota in melanoma patients predicts the response to anti-PD-1 immunotherapy. (seerave.org)
  • October 12, 2022 - For some people with melanoma, pembrolizumab (Keytruda) before surgery may be better than getting the immunotherapy only after surgery, a new study shows. (nih.gov)
  • This work reveals similarities shared between glioblastoma and melanoma, immunosuppressive factors that are unique to the glioblastoma microenvironment, and potential co-targets for enhancing the efficacy of neoadjuvant immune checkpoint blockade," said Dr. Yue Lu, co-lead author of the paper describing the research. (isbscience.org)
  • Reports of spontaneous regression and tumour infiltration with T-lymphocytes makes melanoma candidate for immunotherapies. (mdpi.com)
  • With recent success stories in melanoma, breast cancer, gastric cancer, renal cell carcinoma, prostate cancer, Hodgkin's lymphoma, squamous cell lung cancer, and other malignancies, immunotherapy has emerged as perhaps the most paradigm-changing treatment strategy to occur on the oncologic front in the last 35 years. (jnccn.org)
  • Our findings also suggest TET activity as a biomarker for predicting the efficacy of and patient response to anti-PD-1/PD-L1 therapy, and stimulation of TET activity as an adjuvant immunotherapy of solid tumors. (jci.org)
  • Furthermore, the composition of the intestinal microbiota is a new predictive factor for success," summarized Dr. Bertrand Routy, hematologist and member of the team of Professor Laurence Zitvogel, director of the "Immunology of tumors and immunotherapy" laboratory (Inserm/Paris-Sud University/Gustave Roussy). (seerave.org)
  • Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors. (seerave.org)
  • We believe that the integrated biological, clinical and methodological insights derived from comparing two classes of tumors widely seen as at the opposite ends of the spectrum with respect to immunotherapy treatments should be of interest to broad scientific and clinical audiences," said ISB President Dr. Jim Heath , corresponding author of the paper. (isbscience.org)
  • Immunotherapy can take advantage of the immunogenic response that chemotherapy elicits in tumors. (amegroups.org)
  • Potentially, a short course may sensitize refractory tumors to anti-PD-1, increasing the fraction of patients who respond to immunotherapies. (aacrjournals.org)
  • Overall, the study suggests that "the efficacy of combination of anti-PD-1 treatment and chemotherapy was significantly improved for vaccinated nasopharyngeal cancer patients," the authors write. (medscape.com)
  • Although the potential association between COVID-19 vaccination and increased efficacy of anti-PD-1 therapy in recurrent metastatic nasopharyngeal cancer is "interesting," the finding "needs to be validated in a larger cohort study," Li and colleagues conclude. (medscape.com)
  • The purpose of this study is to determine whether a 12-week, home-based, virtually supervised exercise intervention is feasible and improves various health outcomes among individuals with advanced lung cancer receiving immunotherapy. (dana-farber.org)
  • A study published in the journal Science by a research team from Gustave Roussy, INSERM, INRA, AP-HP, IHU Médiaterranée Infections* and Paris-Sud University shows that prescribed antibiotics impair the efficacy of immunotherapy in cancer patients. (seerave.org)
  • In a cohort of 249 patients treated with anti-PD-1/PD-L1 based immunotherapy for advanced lung, kidney or bladder cancer, 28% received antibiotics for minor infections (dental, urinary or lung infections) but their general health status was not different from patients not receiving antibiotics. (seerave.org)
  • The precise composition of the gut microbiota was established by metagenomics both before and during immunotherapy in 153 patients with advanced lung or kidney cancer. (seerave.org)
  • The objective of this unique study is to develop microbiome-based biomarkers that predict the response to immunotherapy in patients with lung cancer. (seerave.org)
  • The researchers also investigated factors that might explain an efficacy-effectiveness gap in stage IV non-small cell lung cancer. (d4-pharma.com)
  • It came up with the conclusion that immunotherapy ( Cytokine-Induced Killer Cells , CIK ) play an important role in controlling the cancer cells, the rate of tumor recurrence was reduced. (immunotherapychina.com)
  • CHICAGO -- An immunotherapy drug improved survival in patients with advanced nonsquamous non-small cell lung cancer (NSCLC), a researcher said here. (medpagetoday.com)
  • An immunotherapy drug (nivolumab, known as Opdivo) improved survival in patients with advanced nonsquamous non-small cell lung cancer (NSCLC) compared with docetaxel. (medpagetoday.com)
  • In a separate study presented here, researchers found that the immunotherapy drug also appears to be beneficial in patients with liver cancer. (medpagetoday.com)
  • If the results from an early stage trial hold up, it will be the first time immunotherapy has been shown to have anti-tumor activity in patients with advanced hepatocellular carcinoma, according to Anthony El-Khoueiry, MD , of the University of Southern California Norris Comprehensive Cancer Center in Los Angeles. (medpagetoday.com)
  • Japanese researchers found a link between the gut microbiome and a positive response to the immunotherapy drug Opdivo in patients with gastric cancer, which could point to novel biomarkers of drug response. (gastriccancer.org)
  • Brain cancer represents one of the most challenging settings for achieving immunotherapy success. (isbscience.org)
  • The fruitful collaboration between scientists and clinicians provides a tremendous opportunity for improving patient care and achieving an understanding of cancer immunotherapy at the deepest levels. (isbscience.org)
  • The association between specific genetic mutations and immunotherapy benefits has been widely known, while such studies in pan-cancer are still limited. (biomedcentral.com)
  • Finally, the cancer patients from 9 studies treated with immune checkpoint inhibitors were included to investigate the efficacy of immunotherapy. (biomedcentral.com)
  • Our findings demonstrated that SPEN mutation might strongly predict immunotherapy efficacy in pan-cancer. (biomedcentral.com)
  • Thus, we aimed to investigate the association between SPEN mutation and the prognosis and immunotherapy in human cancer. (biomedcentral.com)
  • Oegstgeest, March 1, 2022 - ISA today announces the publication of extension data from a key study using lead product ISA101b in the Journal of ImmunoTherapy of Cancer . (optimumcomms.com)
  • Adding combination immunotherapy consisting of cancer vaccine, anti-PD-1 and anti-CSF1R antibodies to gemcitabine. (amegroups.org)
  • The combination immunotherapy of the GVAX cancer vaccine, anti-PD-1 antibody and anti-CSF-1R antibody has been shown to improve survival in a murine model of metastatic pancreatic adenocarcinoma. (amegroups.org)
  • Phase I/II open label nonrandomized safety and efficacy study of the viral vectored ChAdOx1-MVA 5T4 immunotherapy in combination with PD-1 checkpoint blockade in intermediate-risk localized or locally advanced prostate cancer and advanced metastatic prostate cancer. (ox.ac.uk)
  • Here we describe the development of FUS-activated therapeutic bacteria in which a brief thermal stimulus activates sustained release of anti-cancer immunotherapy. (nature.com)
  • The recent FDA approvals of the programmed cell death protein 1 (PD-1)-targeted checkpoint inhibitors pembrolizumab and nivolumab mark the latest successes in the rapidly expanding field of cancer immunotherapies. (frontiersin.org)
  • Nowadays, immunotherapy has become an important alternative to fight cancer. (mdpi.com)
  • Summary: A recent multicenter study published in The Lancet highlights the promising efficacy of immunotherapy in advanced lung cancer patients. (lcfamerica.org)
  • They noted that the interaction was the opposite for the two immunotherapeutic strategies across the varied types of cancer studied, with women deriving more benefit from combination treatment of chemotherapy and an anti-PD1/PD-L1 agent and men benefiting more from immunotherapy administered as monotherapy. (esmo.org)
  • Several examples of cancer immunotherapies in action are briefly presented. (jnccn.org)
  • CAR T cell immunotherapy for human cancer. (msdmanuals.com)
  • This article reviews the recent literature regarding the efficacy and safety of allergen immunotherapy in the treatment of house dust mite-allergic asthma, with a focus on paediatric populations. (amsj.org)
  • There have been many investigations into the role of allergen immunotherapy in preventing the development of allergic asthma, and potentially its treatment following formal diagnosis, as evidenced by studies demonstrating significant improvements in medication use, asthma symptoms, and respiratory function. (amsj.org)
  • Allergen immunotherapy (AIT) has been around for over 100 years, and plenty of advances have occurred since the first report of successful grass pollen immunotherapy in 1911. (medscape.com)
  • In my practice," he told MedPage Today, "I would most likely give the immunotherapy first and save the chemotherapy for later. (medpagetoday.com)
  • One way to elicit an immunogenic response to immune checkpoint inhibition may be chemotherapy, as many preclinical and clinical studies have demonstrated improved anti-tumor responses and survival with combination chemotherapy/immunotherapy regimens ( 1 - 4 ). (amegroups.org)
  • The authors concluded that their analysis confirmed a large and significant interaction between the sex of the patients and the efficacy of anti-PD1 or anti-PD-L1 agents given in monotherapy or combined with chemotherapy. (esmo.org)
  • UroToday.com) Dr. Chris Labaki reports on the efficacy first-line (1L) immunotherapy (IO)-based regimens in patients with sarcomatoid and/or rhabdoid (S/R) metastatic non-clear cell renal cell carcinoma (nccRCC). (urotoday.com)
  • Immunotherapy with checkpoint inhibition And combination therapies have demonstrated substantial efficacy among patients with metastatic sarcomatoid/rhabdoid (S/R) clear cell RCC (ccRCC) Compared to the older VEGF targeted therapies. (urotoday.com)
  • For immunotherapy in metastatic NSCLC, some efforts have been made to assess the possible efficacy-effectiveness gap. (d4-pharma.com)
  • We investigated the efficacy and safety of pembrolizumab in patients with metastatic ACC. (biomedcentral.com)
  • Mice with liver-metastatic pancreatic adenocarcinoma were followed for 120 days to determine if adding immunotherapy, which comprised of varying combinations of GVAX, anti-PD-1 antibody and anti-CSF-1R antibody, to gemcitabine improved survival. (amegroups.org)
  • Define and identify the side effect profile and presenting symptoms of toxicities from immunotherapies. (astro.org)
  • The analysis comprised data from 9291 patients with advanced solid tumours that showed a larger benefit in males receiving immunotherapy as monotherapy. (esmo.org)
  • Conversely, stimulating TET activity by systematic injection of its cofactor ascorbate/vitamin C increased chemokines and tumor-infiltrating lymphocytes, leading to enhanced antitumor immunity and anti-PD-L1 efficacy and extended lifespan of tumor-bearing mice. (jci.org)
  • Moreover, oral administration of this bacterium to mice with an unfavorable microbiota restored the anti- tumor activity of the immunotherapy. (seerave.org)
  • To demonstrate a direct cause and effect relationship between the composition of gut microbiota and the efficacy of immunotherapy, favorable microbiota (taken from patients who had a good response to PD-1 immunotherapy) and unfavorable microbiota (from patients with therapeutic failure) were transferred to mice deprived of gut microbiota. (seerave.org)
  • The mice receiving the favorable microbiota did better when treated with immunotherapy than those who received the unfavorable microbiota. (seerave.org)
  • Tumor-infiltrating CD8+ T-cells and myeloid cells, harvested after the mice were treated for 2 weeks, were analyzed with flow cytometry to characterize the effect the chemo-immunotherapy regimen had on the tumor microenvironment (TME). (amegroups.org)
  • One way in which biologists and medics use immunotherapy is by injecting antigen-incubated Dendritic Cells (DCs) into mice to stimulate an immune response. (mdpi.com)
  • Recently, micro-invasive treatments showed well application prospective in treating primary hepatocellular carcinoma (HCC), while tumor immunotherapy is a hot topic in tumor treatment. (immunotherapychina.com)
  • University of Birmingham researchers have received a £1.8M grant by the NIHR EME Programme investigating BCG vaccine efficacy in reducing COPD exacerbations. (birmingham.ac.uk)
  • This educational session provides a comprehensive review of the safety, toxicity, and efficacy of currently available commercial immunotherapies combined with radiation therapy. (astro.org)
  • We will then review the published safety and toxicity data of these immunotherapies in combination with radiation therapy. (astro.org)
  • Identify the currently available safety and toxicity profile of radiation combined with immunotherapies. (astro.org)
  • This study is to exclusively target patients receiving anti-PD-1/PD-L-1 where other treatments may impact the study outcomes of intervention feasibility and efficacies. (dana-farber.org)
  • A recent study published in Scientific Reports aimed to assess how outcomes of immunotherapy in real-world (effectiveness) parallel to outcomes in clinical trial (efficacy) data. (d4-pharma.com)
  • Therefore, the researchers aimed to assess how clinical outcomes of specific immunotherapy drugs for patients with stage IV NSCLC in real-world data compared to the data produced from clinical trials. (d4-pharma.com)
  • Ipilimumab is an immune checkpoint inhibitor, a type of immunotherapy that can down-regulate inhibitory signals affecting T-cell activation to unleash more dramatic anti-tumoral responses and offer the possibility of deep and durable remissions in up to 20% of patients. (jnccn.org)
  • More research is required to investigate immunotherapy in populations who are polysensitised or who have severe or uncontrolled asthma - preliminary evidence suggests immunotherapy may have a role in the treatment of these patients. (amsj.org)
  • This review suggests that immunotherapy effectively improves asthma symptoms and severity in paediatric populations. (amsj.org)
  • Allergen-specific immunotherapy has been demonstrated to be more cost effective and improves the patient's quality of life more efficiently than standard allergy medications. (medscape.com)
  • 4 An up-to-date list of WHO international biological reference preparations is available at http://www.who.int/bloodproducts/catalogue/en/ (accessed 11 May 2017). (who.int)
  • In addition, IO based regimens or combinations had also demonstrated efficacy in advanced non clear cell renal cell carcinoma (nccRCC). (urotoday.com)
  • therefore the authors of this abstract to assess the efficacy of these IO regimens among patients with S/R nccRCC. (urotoday.com)
  • However, there was no difference in survival between the three chemo-immunotherapy treatment regimens. (amegroups.org)
  • The chemo-immunotherapy regimens also increased the number of tumor-infiltrating PD1+CD137+CD8+ T-cells and interferon-gamma-expressing PD1+CD137+CD8+ T-cells, but these increases were not statistically significant. (amegroups.org)
  • Gemcitabine with GVAX and anti-PD1 with or without anti-CSF-1R also improved the infiltration of effector CD8+ T-cells, and the presence of anti-CSF-1R in the chemo-immunotherapy regimens decreased the infiltration of myeloid cells. (amegroups.org)
  • The overlapping mechanisms of the components in the chemo-immunotherapy regimens may explain the lack of survival difference between the various regimens, and this remains to be explored. (amegroups.org)
  • Chimeric antigen receptor (CAR) T-cell therapy is an example of how immunotherapy is revolutionizing the treatment of hematologic malignancies with unprecedented response rates in patients with relapsed/refractory lymphoma, multiple myeloma, and acute lymphoblastic leukemia. (ajmc.com)
  • 2,3 Cellular therapy centers, manufacturers, payers, and policy makers will need to work together to address barriers to care as new CAR T-cell products with improved efficacy and tolerability are approved for use in more diverse malignancies. (ajmc.com)
  • instead of targeting tumor cells, the goal of immunotherapy is to augment and expand the immune system's intrinsic antitumor response. (frontiersin.org)
  • Passive cellular immunotherapy references A number of immunologic interventions, both passive and active, can be directed against tumor cells. (msdmanuals.com)
  • These risk factors may cause loss of efficacy and quality of the protein drug, potentially leading to patient safety concerns. (lu.se)
  • [ 14 ] Efficacy and safety in North America was established in a large study (n=1500) of adults and children aged 5-65 years. (medscape.com)
  • It coordinates activities leading to the adoption of recommendations for assuring the quality, safety and efficacy of such substances and the establishment of international reference materials. (who.int)
  • 1 See resolution WHA67.21 (2014) on access to biotherapeutic products, including similar biotherapeutic products, and ensuring their quality, safety and efficacy. (who.int)
  • To improve the treatment efficacy, researchers are looking for vulnerabilities in surgically removed glioblastoma tissues, but this has been difficult due to the vast differences within the tumor and between patients. (isbscience.org)
  • The primary endpoint of the analysis was to assess the difference in treatment efficacy between males and females, measured in terms of difference of the overall survival (OS) and expressed as log hazard ratio (HR). The pooled OS HR and 95% confidence interval (CI) was calculated in males and females using random-effects model and the heterogeneity between the two estimates was evaluated using an interaction test. (esmo.org)
  • This study identified an efficacy-effectiveness gap in overall survival for 1L pembrolizumab. (d4-pharma.com)
  • Thus, this study went beyond previous research by identifying possible reasons for observed gaps in efficacy and effectiveness. (d4-pharma.com)
  • This study was to investigate the efficacy of cytokine-induced killer cells (CIK) combined micro-invasive treatments (transcatheter arterial chemoembolization and radiofrequency ablation) on the recurrence of HCC. (immunotherapychina.com)
  • Changing the microbiota in the mouse re-established the effectiveness of immunotherapy by activating certain immune cells. (seerave.org)
  • Consequently, there could be a gap in the efficacy demonstrated in RCTs and the effectiveness of therapies in clinical practice. (d4-pharma.com)
  • Furthermore, patient characteristics have not been compared with trial cohorts in the search for factors to explain any efficacy-effectiveness gap. (d4-pharma.com)
  • They also investigated factors that might explain any observed efficacy-effectiveness gap. (d4-pharma.com)
  • This framework can be used to uncover pathophysiological and molecular features that determine the effectiveness of immunotherapies," added Dr. Alphonsus Ng, co-lead author of the paper. (isbscience.org)
  • Presently, RCTs are still the standard to prove the efficacy of new oncology therapies. (d4-pharma.com)
  • Innovations in immunotherapy have led to the development of multiple immune-targeted therapies to manage malignancy. (ajmc.com)
  • Single-agent pembrolizumab has modest efficacy as a salvage therapy in ACC regardless of the tumor's hormonal function, microsatellite instability status, or programmed cell death ligand-1 status. (biomedcentral.com)
  • The authors explored patients' gut microbiota composition by metagenomic analysis and demonstrated that the bacterium Akkermansia muciniphila was associated with a better clinical response to anti-PD-1 antibody immunotherapy. (seerave.org)
  • A favorable microbiota composition, rich in Akkermansia muciniphila, was found in patients with the best clinical response to immunotherapy and in those whose disease had not progressed for at least 3 months. (seerave.org)
  • Objective response rates also favored immunotherapy, with rates of 19% versus 12%, Paz-Ares said. (medpagetoday.com)
  • Immunotherapy of oncological diseases of the gastrointestinal tract allows achieving high rates of objective response and disease control (13,1% and 56,1%, respectively) in gastric and esophageal cancers, CRC and HCC. (oncovestnik.ru)
  • Is Response to Allergy Immunotherapy Predictable? (medscape.com)
  • December 28, 2022 - A clinical trial led by NCI has resulted in FDA approval of the immunotherapy drug atezolizumab (Tecentriq) to treat advanced alveolar soft part sarcoma. (nih.gov)
  • Cancers induced by human papillomaviruses (HPV) should be responsive to immunotherapy by virtue of expressing the immunogenic oncoproteins E6/E7. (nih.gov)
  • Efficacy was not shown in the clinical trial participants aged 18 years or older. (medscape.com)