AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesNamed Groups
AcetaldehydeEthanolCyanamideAldehyde DehydrogenaseAldehyde OxidoreductasesAlcohol DehydrogenaseCentral Nervous System DepressantsDisulfiramAldehydesAlcoholsAlcohol DeterrentsPyruvate DecarboxylaseToxicity Tests, AcuteFlushingFermentationAlcohol DrinkingNADCytochrome P-450 CYP2E1AcetoinLiver Diseases, AlcoholicButanonesAlcoholismAlcohol OxidoreductasesAlcoholicsLiver
Aldehyde dehydrogenaseMetabolite of ethanolConcentrationsLevels of acetaldehydeAcetic acidToxicMetabolitesToxicityConsumptionDehydrogenation of ethanolMutagenicLiverDehydrogenaseConversion of ethanolMetabolism of ethanolBlood ethanolOxidation of ethanolEnzymeHarmful effectsAcetoneSignificantlyAlcoholismCompoundPsychoactiveHangoverAcuteSerumEthanol'sProducesExposureSequentialAqueousAlcohol-inducedBreakdownHumansRatsEmissionsReactionMetabolic productSolubleAdverse effectsHepatotoxicityNumerousConsumeSituProductionDigestiveOral cavityChronicFindingsNADHNADPHCytochromeReactivityIntoxicationIntermediateConsequence
Aldehyde dehydrogenase9
Metabolite of ethanol3
  • In the current study, we aimed to analyse changes of the ventricular IK1 in the presence of acetaldehyde, the primary metabolite of ethanol. (muni.cz)
  • Recent biochemical and epidemiological findings strongly suggest that acetaldehyde, the first metabolite of ethanol, plays an important role in alcohol-related carcinogenesis in the UADT consisting oral cavity, pharynx, larynx and esophagus 5-8 . (hippokratia.gr)
  • Acetaldehyde (CH 3 CHO, CAS # 75-07-0) is a metabolite of ethanol which comprises in the human body after the consumption of alcoholic beverages 9-11 . (hippokratia.gr)
Concentrations15
  • The VOCs or the concentrations that were generated during the animal exposures had no measurable effect on the pulmonary responses. (cdc.gov)
  • Cardiac inward rectifier potassium current IK1 is inhibited by acetaldehyde at clinically relevant concentrations: a role in arrhythmogenesis related to alcohol consumption? (muni.cz)
  • We have recently published a study describing a significant effect of ethanol at clinically relevant concentrations on the ventricular IK1. (muni.cz)
  • Extremely high concentrations of ethanol and its metabolites significantly increase the risk of gastrointestinal diseases and cancers," he told Medical News Today . (medicalnewstoday.com)
  • High acute concentrations of acetaldehyde in vivo (acetaldehydemia) can lead to undesirable effects such as cardiovascular complications, drowsiness, nausea, headache, asthma and facial flushing, while chronic acetaldehydemia can lead to cirrhosis and esophageal cancer. (justia.com)
  • Blood alcohol and acetaldehyde concentrations were determined in rats administered a single dose of alcohol and treated with DA-5513 or commercially available hangover relief beverages (Yeomyungê and Ukonê). (biomedcentral.com)
  • Blood alcohol and acetaldehyde concentrations were lower in the groups treated with DA-5513 or Yeomyungê, as compared with control rats. (biomedcentral.com)
  • However, scientists have found acetaldehyde concentrations in the lungs of smokers are far greater than for non-smokers. (articlesurfing.org)
  • The highest acetaldehyde concentrations were generally found in fortified wines (118 ± 120 mg/l, range 12-800 mg/l). (who.int)
  • 100 µM) concentrations of acetaldehyde. (who.int)
  • Three recent studies have reported acetaldehyde air concentrations in facilities that produce and use flavorings. (who.int)
  • In a facility that manufactures flavorings, modified dairy products and bacterial additives, NIOSH (2007) reported mean, full-shift time-weighted average (TWA) acetaldehyde air concentrations of 0.14 ppm in the powder production room, 0.07 ppm in the liquid production room, and 0.07 ppm in the pre-production corridor. (who.int)
  • TWA acetaldehyde air concentrations were 0.44 ppm in the spray-drying room, 0.343 ppm in the powder production room, 0.273 ppm in the liquid production room, and 0.029 ppm in the pre-production corridor. (who.int)
  • In a small popcorn popping plant, NIOSH (2009b) reported that acetaldehyde concentrations in air were less than the detectable (0.09 ppm) or quantifiable (0.15 ppm) concentrations. (who.int)
  • The chemical exposure levels were lower than or similar to baseline background concentrations, with the exception of methylene chloride and acetaldehyde. (cdc.gov)
Levels of acetaldehyde2
  • Thus, Huh-7 may be more vulnerable to ethanol toxicity because of the higher levels of acetaldehyde. (springer.com)
  • In an investigation to evaluate environmental tobacco smoke exposure among casino dealers in three U.S. casinos, NIOSH (2009a) found that the levels of acetaldehyde in full-shift personal breathing zone ranged from 4.8 to 17.0 g/m3. (who.int)
Acetic acid5
  • On oxidation it forms acetic acid and ethanol on reduction. (sigmaaldrich.com)
  • Ethanol infusion increased the ratio of total hepatocellular NADH/NAD+, and the ratio of free NADH/NAD+ in cytosol and mitochondria as a consequence of sequential oxidations of ethanol producing acetaldehyde and acetic acid in the respective compartments. (aspetjournals.org)
  • The acetaldehyde is broken down into acetic acid and then to carbon dioxide and water. (guenael-parolier.fr)
  • Acetaldehyde is then broken down into acetic acid. (healthwomen.click)
  • Acetaldehyde is primarily used as an intermediate in the manufacturing of acetic acid, flavorings, aniline dyes, plastics and synthetic rubber, in some fuel compounds and in the manufacture of numerous other products (Muttray et al. (who.int)
Toxic10
  • In the air, ethanol itself will break down into highly toxic constituents (acetaldehyde and peroxyacetylnitrates [PAN] ), and Pennsylvania has yet to assess the effects of public exposure. (blogspot.com)
  • AdhE loss of function could mitigate ethanol stress by reducing intracellular levels of ethanol and its highly toxic precursor, acetaldehyde. (researchgate.net)
  • Ethanol, a main component of alcoholic drinks, is a psychoactive substance with toxic and dependence-producing properties," said Maccioni. (medicalnewstoday.com)
  • The toxic effects of the treatment were associated with the injection volume and may be related to ethanol-induced pulmonary vasoconstriction and transient right ventricular dysfunction. (jmedscindmc.com)
  • There is increasing evidence that a majorpart of the tumour-promoting action of alcohol might be mediatedvia its first, toxic and carcinogenic metabolite acetaldehyde. (hippokratia.gr)
  • In both cases, there is a reduction of k 2 in Equation 1, resulting in a failure to clear acetaldehyde from the blood as rapidly as it is formed, allowing its concentration to reach toxic levels. (justia.com)
  • Metabolism of ethanol occurs in the liver and produces acetaldehyde, which is toxic. (healthwomen.click)
  • Epidemics of heart failure in persons who had consumed beer contaminated with arsenic in the 1900s and cobalt in the 1960s also obscured the observation that alcohol could exhibit a direct toxic effect. (medscape.com)
  • In the 1950s, evidence began to emerge that supported the idea of a direct toxic myocardial effect of alcohol, and research during the last 25 years has been particularly productive in characterizing the disease entity of alcoholic cardiomyopathy (AC). (medscape.com)
  • However, although these mechanisms may play a role in selected patients, most evidence in the literature indicates that the effects of alcohol on the myocardium are independent of these factors and that the effect is a direct toxic result of ethanol or its metabolites. (medscape.com)
Metabolites5
  • The gastrointestinal tract is in contact with the highest amount of ethanol and its metabolites during alcohol consumption. (medicalnewstoday.com)
  • While researchers state the complete physical process of how alcohol-associated bowel disease happens is not entirely understood, they believe it involves the metabolism of ethanol and the metabolites acetaldehyde and acetate it creates. (medicalnewstoday.com)
  • Ethyl glucuronide and ethyl sulfate are minor metabolites of ethanol that can be used to help identify recent ethanol exposure, even after ethanol is no longer measurable. (guenael-parolier.fr)
  • Concerns have mostly centered around windows of detection and the sources of the ethanol metabolites when monitoring abstinence (i.e. non-beverage versus beverage). (guenael-parolier.fr)
  • The cellular and molecular gastroenterology and hepatology addresses this automatically demonstrates acute toxicity of ethanol is caused by ethanol, rather than acetaldehyde, via novel non-oxidative metabolites of fatty acid ethyl esters. (scholarsresearchlibrary.com)
Toxicity4
  • In addition to the toxicity of ethanol, the main psychoactive component of alcoholic beverages, other physiological symptoms may arise from the activity of acetaldehyde, a metabolite of alcohol. (definitions.net)
  • Although it is unclear what additional pathophysiological roles FAEEs play in acute and chronic ethanol toxicity in other organs, these findings warrant additional study in this area. (scholarsresearchlibrary.com)
  • Another unfortunate result of acute acetaldehyde toxicity, well known to heavy drinkers, is the hangover. (justia.com)
  • Despite the numerous studies found in the literature concerning the effect of alcoholism on the health of the oral cavity, it is still important to produce new studies for a better understanding of the toxicity of alcoholism in the palatal mucosa. (bvsalud.org)
Consumption17
  • Short-term effects of alcohol consumption include intoxication and dehydration. (wikipedia.org)
  • Even light and moderate alcohol consumption have negative effects on health, such as by increasing a person's risk of developing several cancers. (wikipedia.org)
  • The short-term effects of alcohol consumption range from a decrease in anxiety and motor skills at lower doses to unconsciousness, anterograde amnesia, and central nervous system depression at higher doses. (wikipedia.org)
  • A 2016 systematic review and meta-analysis found that moderate ethanol consumption brought no mortality benefit compared with lifetime abstention from ethanol consumption. (wikipedia.org)
  • Unlike acetaldehyde, acetate is innocuous and may even be responsible for some of the positive health benefits of alcohol consumption. (huffpost.com)
  • Alcohol intoxication, also known as alcohol poisoning, commonly described as drunkenness or inebriation, is the negative behavior and physical effects caused by a recent consumption of alcohol. (definitions.net)
  • The effects of beverage alcohol (ethanol) on the body are determined largely by the rate at which it and its main breakdown product, acetaldehyde, are metabolized after consumption. (nih.gov)
  • It was originally proposed that ellagitannins and other phenols with distinct functionalities be studied for their effects on oxygen consumption and acetaldehyde production. (avf.org)
  • Acetaldehyde has been implicated as a major factor in oral carcinogenesis associated with alcohol consumption. (hippokratia.gr)
  • The compositions of the invention are expected to ameliorate some of the negative side effects associated with the consumption of alcohol, such as hangover and facial flushing. (justia.com)
  • The present invention is generally related to compositions and methods that diminish the negative side effects associated with the consumption of ethanol. (justia.com)
  • Another means by which ethanol consumption may result in acetaldehydemia is by excessively rapid metabolism of ethanol (i.e., by increasing k 1 in Equation 1). (justia.com)
  • Moreover, after long-term ethanol consumption kidney reduce decreasing glutathione/oxidized glutathione ratio, what indicate oxidative stress [24]. (precisionfda.org)
  • Chronic ethanol consumption leads to induction of cytochrome P450 2E1 associated with an increased production of reactive oxygen species, which are an important factor in ethanol-related carcinogenesis. (precisionfda.org)
  • Addolorato G, Capristo E, Greco AV, Stefanini GF, Gasbarrini G. Influence of chronic alcohol abuse on body weight and energy metabolism: is excess ethanol consumption a risk factor for obesity or malnutrition? (biomedcentral.com)
  • Some studies have suggested that a genetic vulnerability exists to the myocardial effects of alcohol consumption. (medscape.com)
  • During alcohol consumption, acetaldehyde is formed in the digestive system by microbes in normal gut and flora. (who.int)
Dehydrogenation of ethanol2
  • Each state of the catalyst exhibits distinct selectivity for the dehydrogenation of ethanol reaction with the single-atom alloy phase exhibiting high selectivity to acetaldehyde and hydrogen versus a range of products from Pd clusters. (nature.com)
  • It can be seen from Equation 1 that when the rate of the ALDH-catalyzed reaction (k 2 ) is not high enough to keep pace with the rate of the ALD-catalyzed dehydrogenation of ethanol (k 2 ), acetaldehyde will accumulate. (justia.com)
Mutagenic1
  • Numerous experiments have shown that acetaldehyde has direct mutagenic and carcinogenic effect because of interferes with DNA synthesis and repair and forms of stable adducts [22]. (precisionfda.org)
Liver15
  • Long-term effects of alcohol include changes in the metabolism of the liver and brain, several types of cancer and alcohol use disorder. (wikipedia.org)
  • Physical effects include irregular heartbeat , an impaired immune response, liver cirrhosis , increased cancer risk , and severe withdrawal symptoms if stopped suddenly. (wikipedia.org)
  • Ethanol (5 mM) had only a modest effect on the oxidation of acetaminophen in rat liver microsomes, 7 to 14% inhibition over a range of acetaminophen concentration of 0.1 to 3 mM, whereas a 30 to 40% decline of covalent binding of acetaminophen-derived material was observed in vivo (peak acetaminophen concentration approximately 3 mM). (aspetjournals.org)
  • How much and how often you imbibe can increase these effects, leading to health problems such as liver disease , pancreatitis , mental health issues , and certain cancers like gastric cancer and colorectal cancer . (medicalnewstoday.com)
  • Ethanol in alcohol is broken down by the liver into a carcinogenic compound called acetaldehyde . (medicalnewstoday.com)
  • the remainder is metabolized, mainly by the liver, where alcohol dehydrogenase converts ethanol to acetaldehyde. (msdmanuals.com)
  • Significantly, these investigations found that high blood ethanol levels, rather than acetaldehyde levels, were related with acute liver injury as measured by increased serum transaminases and hepatic Endoplasmic Reticulum (ER) stress. (scholarsresearchlibrary.com)
  • Furthermore, FAEEs were discovered to raise ER stress measurements in ethanol-challenged primary hepatocytes, suggesting the direct action of adiposederived factors on the liver. (scholarsresearchlibrary.com)
  • Furthermore, their study is the first to show that FAEEs directly contribute to liver injury via increased ER stress in hepatocytes, which supports prior work on the development of alcohol-associated pancreatitis using binge ethanol with and without FAEEs. (scholarsresearchlibrary.com)
  • The present study investigated the in vivo effects of DA-5513 (Morning careê Kang Hwang) on biological parameters relevant to hangover relief and alcoholic fatty liver. (biomedcentral.com)
  • The effects of DA-5513 on alcoholic fatty liver were also determined in rats fed alcohol-containing Lieber-DeCarli diets for 4 weeks. (biomedcentral.com)
  • These findings suggest that DA-5513 could have a beneficial effect on alcohol-induced hangovers and has the potential to ameliorate alcoholic fatty liver. (biomedcentral.com)
  • Acetaldehyde is a compound produced in the liver in small amounts as a by-product in the metabolism of alcohol. (articlesurfing.org)
  • In cirrhosis, excess production of SHBG in liver and increased prolactin levels were detected while exploring the cause of gynecomastia and high level of liver estrogen receptors was added to the direct suppressing effect of estrogen on Leydig cell functions [ 7 ]. (gastrores.org)
  • Other factors associated with the appearance of oral cancer include the action of alcohol in facilitating the passage of carcinogens via the cell membrane of the oral mucosa and the effect of alcohol on the heightened metabolic activity of the liver which could thereby activate carcinogenic substances 15-16 . (bvsalud.org)
Dehydrogenase5
Conversion of ethanol2
  • The pathway of wine oxidation, as currently understood, encompasses the cascade of reactions incited by the oxidation of phenols in the presence of oxygen, eventually coming to the conversion of ethanol into acetaldehyde. (avf.org)
  • The enzymatic conversion of ethanol produced by the physiological oral microflora may lead to accumulation of increased levels of the carcinogenic intermediate acetaldehyde 2,12,13 . (hippokratia.gr)
Metabolism of ethanol1
  • This mechanism is saturable at essentially typical drink levels, resulting in the overexpression of cytochrome P-450 2E 1 (CYP 2 E 1 ), whose oxidative metabolism of ethanol also generates acetaldehyde and reactive oxygen species such as superoxide. (scholarsresearchlibrary.com)
Blood ethanol3
  • thus, high blood ethanol levels were related with hepatic fatty acid production as well as enhanced lipolysis and adipocyte mortality in epididymis fat. (scholarsresearchlibrary.com)
  • Blood ethanol levels are also useful in the diagnosis of alcoholism because individuals who habitually use this drug become tolerant. (medscape.com)
  • This diagnosis is suggested when a person can function in a relatively normal capacity (without evidence of intoxication) with a blood ethanol level greater than 150 mg/dL. (medscape.com)
Oxidation of ethanol3
  • However, acetaminophen alone also increased free NADH/NAD+ in cytosol, and there was no indication that N-acetyl-p-benzoquinoneimine consumed NADH generated by the oxidation of ethanol. (aspetjournals.org)
  • Clearly, based on the CV curve for the oxidation of ethanol, with increasing temperature, the overall oxidation current increased, and the onset potential and peak potential both negatively shifted, indicating that thermal activation allows the oxidation reaction to proceed easier. (pku.edu.cn)
  • Effect of Temperature on the Electrocatalytic Oxidation of Ethanol[J]. Acta Phys. (pku.edu.cn)
Enzyme3
  • To deter- mine the effect of the G609D mutation on Cphy3925 enzyme activity, we purified WT and ET versions of the enzyme (Fig. 3A) and tested their in vitro catalysis of the two-step, bidirectional reactions converting acetyl-CoA to ethanol using either NADH or NADPH cofactors. (researchgate.net)
  • The effects of vacuum packaging on browning, phenolic content, the enzyme activity of phenylalanine ammonia lyase (PAL), polyphenol oxidase (PPO), and peroxidase (POD), and PPO , PAL , POD , and ERF genes expression in fresh-cut lotus root were studied. (ashs.org)
  • Individuals with certain mitochondrial deoxyribonucleic acid (DNA) mutations and angiotensin-converting enzyme (ACE) genotypes (DD genotype) may be particularly susceptible to the damaging effects of alcohol. (medscape.com)
Harmful effects5
  • According to the World Health Organization's 2018 Global Status Report on Alcohol and Health, there are more than 3 million people who die from the harmful effects of alcohol each year, which amounts to more than 5% of the burden of disease worldwide. (wikipedia.org)
  • Because acetaldehyde has harmful effects on the body, people carrying these alleles are less likely to drink and have a lower risk of alcohol dependence. (nih.gov)
  • Drinking alcohol , even in moderate amounts, can have harmful effects on health. (medicalnewstoday.com)
  • The current study was highly thorough, and the study should be commended for their extensive and original work proving the harmful effects of ethanol in a binge drinking scenario. (scholarsresearchlibrary.com)
  • Education, prevention, and access to addiction treatment and support are essential in addressing this public health concern and mitigating the harmful effects of MDMA abuse. (oakforestrecovery.com)
Acetone3
  • Multiple VOCs (e.g., methyl methacrylate, acetaldehyde, ethanol, acetone, benzene , xylene) were identified when spot welding using either the adhesive or the anti-spatter spray that were not present when welding alone. (cdc.gov)
  • Formaldehyde, acetaldehyde, and butyraldehyde were the most significant carbonyls from the n-butanol blend, while formaldehyde, acetone, and 2-methylpropanal were the most significant from the i-butanol blend. (greencarcongress.com)
  • A well-documented by-product of hypoglycemia (low blood sugar) is a state called ketoacidosis, which causes the production of acetone -- and acetone, like acetaldehyde, will be reported by the Brethalyzer as alcohol. (articlesurfing.org)
Significantly3
  • Ethanol blended with gasoline is more volatile (evaporates more easily) than gasoline with other additives, and ethanol blends combined with other gasoline in the vehicle gas tank can be more volatile still, putting significantly more pollution into the air. (blogspot.com)
  • According to the results of this study, the significantly higher levels of salivary acetaldehyde production in oral cancer patients and individuals with poor dental health status may suggest a possible link between increased salivary acetaldehyde production and oral cancer. (hippokratia.gr)
  • Beer (9 ± 7 mg/l, range 0-63 mg/l) had significantly lower acetaldehyde contents than wine (34 ± 34 mg/l, range 0-211 mg/l), or spirits (66 ± 101 mg/l, range 0-1159 mg/l). (who.int)
Alcoholism2
  • Persons with alcoholism may consume smaller amounts of essential nutrients and vitamins and/or exhibit impaired gastrointestinal absorption of these nutrients secondary to the direct effects of alcohol. (medscape.com)
  • Likewise, an ALDH2 variant with reduced activity results in acetaldehyde buildup and also has a protective effect against alcoholism. (nih.gov)
Compound2
  • The compound in alcoholic drinks which causes drunkenness is called ethanol. (healthwomen.click)
  • Occupational exposure to acetaldehyde may occur by inhalation and skin exposure at workplaces where this compound is produced or used. (who.int)
Psychoactive2
  • Ethanol is the principal psychoactive constituent in alcoholic beverages, which are usually consumed with the specific intent of experiencing some of ethanol's effects on the central nervous system. (justia.com)
  • MDMA, also known as ecstasy or Molly, is a synthetic psychoactive drug that gained popularity for its euphoric and empathogenic effects. (oakforestrecovery.com)
Hangover4
  • An herbal infusion with hemp seeds, for example, was discovered to boost the activity of ADH while inhibiting ALDH, therefore slowing down the breakdown of acetaldehyde and dragging out the hangover effects. (huffpost.com)
  • These effects may not arise until hours after ingestion and may contribute to the condition colloquially known as a hangover. (definitions.net)
  • Here are a few effects of CBD that make it the Ultimate Hangover Cure. (hovawartclub.hu)
  • Wiese J, McPherson S, Odden MC, Shlipak MG. Effect of Opuntia ficus indica on symptoms of the alcohol hangover. (biomedcentral.com)
Acute1
  • Importantly, high-fat diet feeding combined with acute ethanol binge had the most pronounced effect of elevating serum transaminases and acetaldehyde levels compared with binge or high-fat diet challenge alone, thus confirming the aforementioned comorbidity of obesity in humans that take in binge drinking compared the effects of intragastric and intraperitoneal injection of ethanol in wild-type mice to the effects of intraperitoneal administration of acetaldehyde in wild-type mice. (scholarsresearchlibrary.com)
Serum2
  • To convert serum ethanol level to BAC, move the decimal point 3 places to the left. (medscape.com)
  • Example, a 100 mg/dL serum ethanol level is equivalent to a 0.10 (g/dL) BAC, or 0.10% (weight/volume). (medscape.com)
Ethanol's1
  • Some of the adverse effects of alcohol are thought to be caused, not by the ethanol itself, but by ethanol's first metabolite, acetaldehyde. (huffpost.com)
Produces2
  • C. phytofermentans thus likely produces ethanol by the concerted action of multiple ADHs, and these other ADHs, especially Cphy1029, are responsi- ble for ethanol produced by the ET strain. (researchgate.net)
  • The exact manner in which alcohol produces this effect is not known, but the effect is consistent, is observed throughout the heart, and may be exaggerated under stressful conditions. (medscape.com)
Exposure2
  • SUBJECTS AND METHODS: The present study assessed operating room workers' exposure to chemical compounds and aerosolized particulates generated during T&A. We also investigated the effect of 3 different smoke-controlling methods: smoke-evacuator pencil cautery (SE), cautery with suction held by an assistant (SA), and cautery without suction (NS). (cdc.gov)
  • CONCLUSIONS: Although the exposure levels to chemicals were considerably lower than the OELs, continuous exposures to these chemicals could cause adverse health effects to surgical personnel. (cdc.gov)
Sequential1
  • Here, analysis of the products formed by sequential condensation reactions of acetaldehyde and 2‐butenal suggests that 2‐ and 4‐MB products form via aromatization of 2,4,6‐octatrienal and of highly reactive acyclic intermediate(s) formed via self‐addition of 2‐butenal, respectively. (scite.ai)
Aqueous1
  • In this work, dopamine n-butenylamide (DBA) modified GLM nanodroplets were prepared via directional ultrasound of bulk liquid metal in ethanol aqueous solution as well as DBA self-assembly, followed by grafting with urea-based gelators via radical polymerization to obtain GLM-based supramolecular gelators (Gelator@GLM). (bvsalud.org)
Alcohol-induced1
  • It is well established that acetaldehyde is the culprit in hangovers and in alcohol-induced facial flushing, and it is the principal suspect in alcohol-associated cancers as well vide infra. (justia.com)
Breakdown2
  • On the other hand, some drinks, including Sprite (known in China as Xue bi) and a type of soda water, were found to have the opposite effect: increasing the activity of ALDH and thus speeding up the breakdown of acetaldehyde. (huffpost.com)
  • For example, certain ADH1B and ADH1C variants that are commonly found in East Asian populations lead to more rapid ethanol breakdown and acetaldehyde accumulation in the body. (nih.gov)
Humans2
  • The aim of this review is to define and characterise common fermented foods (kefir, kombucha, sauerkraut, tempeh, natto, miso, kimchi, sourdough bread), their mechanisms of action (including impact on the microbiota), and the evidence for effects on gastrointestinal health and disease in humans. (mdpi.com)
  • Acetaldehyde is possibly carcinogenic to humans (Group 2B) because there is inadequate evidence in humans for the carcinogenicity of acetaldehyde, and there is sufficient evidence in experimental animals for the carcinogenicity of acetaldehyde. (who.int)
Rats1
  • The effect of 5 mM ethanol, maintained by a constant infusion, on the hepatotoxicity and disposition of acetaminophen was examined in 3-methylcholanthrene-induced rats. (aspetjournals.org)
Emissions3
  • Ethanol blends also increase VOC emissions from gasoline, one of major necessary components that combine to create polluting ground level ozone smog. (blogspot.com)
  • This study points to the need for more extensive emissions measurements for these new fuels as well as research to gain a better understanding of the biological effects of the NMOG components that they produce, the team concludes. (greencarcongress.com)
  • Sources of acetaldehyde are industrial burning processes, traffic emissions or emissions emerging from the combustion of wood. (who.int)
Reaction2
Metabolic product2
  • These effects decrease over the course of a few hours, as the ethanol is gradually metabolized by the body into acetyl CoA, a common metabolic product and energy source. (justia.com)
  • Amongst the explanations for this pathogenesis is the cytotoxic and mitogenic effect of acetaldehyde, a metabolic product of alcohol which can result in atrophy of the oral epithelium, thereby increasing the vulnerability of the mucosa to physical-chemical attacks 14 . (bvsalud.org)
Soluble1
  • Effect of root application of soluble silicon on white rust disease in Alternanthera Sessilis ('Mukunuwenna') Leaves. (gov.lk)
Adverse effects1
  • Regular use can lead to a range of adverse effects, including cardiovascular problems such as high blood pressure and irregular heartbeat. (oakforestrecovery.com)
Hepatotoxicity1
Numerous1
  • Alcohol use has also been shown to have numerous effects on the cardiovascular system other than heart failure. (medscape.com)
Consume3
  • The yield of 2‐butenal decreases with increasing conversion of acetaldehyde (for conversions greater than 15 %), because secondary condensation reactions, which form C 6 and C 8 enal products, consume 2‐butenal. (scite.ai)
  • The team of scientists had hypothesized that what you consume after drinking booze could alter the effect of alcohol on your body. (huffpost.com)
  • While it is evident that wines consume oxygen over time and acetaldehyde becomes increasingly apparent with age, the rate of oxidation can vary unpredictably among different wines, and it was hypothesized that different phenolic structural features, particularly those of oak ellagitannins, are the reason for such variability in oxidation. (avf.org)
Situ2
  • First-principles based Monte Carlo calculations explain the origin of this active site ensemble size tuning effect, and this work serves as a demonstration of what should be a general phenomenon that enables in situ control over catalyst selectivity. (nature.com)
  • The temperature-controlled electrode was applied to investigate the electrooxidation of ethanol using both in situ FTIRS and cyclic voltammetry using a commercial Pt/C catalyst at different temperatures. (pku.edu.cn)
Production12
  • Subsidized ethanol production from U.S. corn is not a renewable energy source. (blogspot.com)
  • Fuel ethanol production would remove available livestock feed resources. (blogspot.com)
  • Ethanol production is inefficient with 29% more fossil fueled energy needed to produce a gallon of ethanol, than is available in that gallon of ethanol for energy use. (blogspot.com)
  • Expression of pQexpE increased cellulolysis by ϳ 30% in both the WT and ET strains (Fig. 5A) and boosted ethanol production by 70% relative to the ET strain ( P Ͻ 0.01), thereby restoring ethanol yields to WT levels (Fig. 5B). (researchgate.net)
  • In this study, saliva samples from oral cancer patients and healthy individuals were incubated in vitro with ethanol in order to investigate factors which can influence salivary acetaldehyde production. (hippokratia.gr)
  • After in vitro incubation of the samples with ethanol, the levels of salivary acetaldehyde production was measured by head space gas chromatography. (hippokratia.gr)
  • Poor dental health status, infrequent oral hygiene habits and dental visits, smoking and presence of a dental prosthesis were significant parameters for increased levels of salivary acetaldehyde production from alcohol. (hippokratia.gr)
  • The evaluation of salivary acetaldehyde production after in vitro incubation with ethanol may be useful for early detection of oral cancer. (hippokratia.gr)
  • Improved oral hygiene can effectively decrease the level of salivary acetaldehyde production in oral cavity. (hippokratia.gr)
  • Many fruits, such as apples, may have their own metabolic pathways for acetaldehyde production. (who.int)
  • A task-based acetaldehyde air concentration of 0.19 ppm was measured during pouring and mixing of ingredients for a fruit flavor in the liquid production room. (who.int)
  • The highest task-based acetaldehyde air concentration (4.02 ppm) was measured during packaging of a powdered dairy-flavored product in the powder production room. (who.int)
Digestive1
Oral cavity1
  • Most of them contain significant levels of alcohol (Listerine, for example is 27% alcohol) and create a mouth alcohol effect: they remain in the oral cavity for 20 minutes or so -- just long enough to be breathed into the Breathalyzer, with the same results mentioned in number 4. (articlesurfing.org)
Chronic1
  • Furthermore, chronic MDMA users may develop tolerance, requiring higher doses to achieve the desired effects, which can exacerbate these psychological issues. (oakforestrecovery.com)
Findings1
  • Together, these findings illustrate that the atomic-scale structure of the active sites in bimetallic catalysts has a critical effect on their chemical reactivity and selectivity. (nature.com)
NADH3
  • Ethanol infusion also increased the ratio of total hepatocellular NADPH/NADP+, apparently through transhydrogenation of NADP+ by NADH in mitochondria. (aspetjournals.org)
  • A previous study reported an ethanol-tolerant C. thermocellum strain with AdhE mutations (P704L and H735R) that shifted the cofactor specificity from NADH to NADPH, which was proposed to confer ethanol resistance by altering the internal redox balance (9). (researchgate.net)
  • Together, these enzymes couple decarboxylation of pyruvate to ethanol with the oxidation of NADH and thus represent an alternative to the AdhE ethanol formation pathway. (researchgate.net)
NADPH1
  • The mutated Cphy3925 lost NAD(H)-dependent activities, but, unlike the mutated AdhE in C. thermocellum , the G609D mutation did not result in NADPH-dependent ADH activity (Fig. 3B to E). Instead, our results support the notion that the ET strain arrested AdhE-mediated interconversion of acetyl-CoA, acetaldehyde, and ethanol, which helps explain why the C. phytofermentans ET strain had lower ethanol yield. (researchgate.net)
Cytochrome1
  • Thus, a mechanism other than direct inhibition of cytochrome(s) P-450 by ethanol is invoked to account for the protective effect of ethanol. (aspetjournals.org)
Reactivity1
Intoxication1
  • Urine ethanol samples are known to be imprecise in estimating BAC and the degree of intoxication. (medscape.com)
Intermediate2
  • Acetaldehyde is an industrially important solvent used as an intermediate for the synthesis of a wide range of compounds. (sigmaaldrich.com)
  • The interaction of Criegee intermediate (CH 2 OO) with acetaldehyde has been measured. (sigmaaldrich.com)
Consequence1
  • These results showed specific changes in kidney antioxidant system and glutathione status as a consequence of long-term ethanol administration. (precisionfda.org)