• The net effect is a reduction in pulmonary vascular resistance and improvement in cardiac output and reduced need for inotropes. (monash.edu)
  • This paradoxical response (vasodilation in some vascular beds) distinguishes it from other vasoconstrictor agents. (monash.edu)
  • The direct vasoconstrictor potential of PNU-142633 was evaluated in vascular beds. (uky.edu)
  • Effects of vasopressin on pulmonary and systemic vascular mechanics. (eddyjoemd.com)
  • We designed this study to investigate the effect of the administration of oral doses of aqueous extract from Solanum nigrum fruit on plasma glucose, lipid profiles, and the sensitivity of the vascular mesenteric bed to Phenylephrine in diabetic and non-diabetic rats. (medscimonit.com)
  • Administration of Solanum nigrum caused Ca/Mg ratio, plasma glucose, high-density lipoprotein (HDL), low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), total cholesterol, and triglyceride concentrations to return to normal levels, and was shown to decrease alteration in vascular reactivity to vasoconstrictor agents. (medscimonit.com)
  • In mesenteric vascular beds (MVBs) isolated from vehicle-treated SHRs and preconstricted with norepinephrine (NE) ex vivo, vasodilator responses to insulin were significantly impaired, whereas the ability of insulin to oppose vasoconstrictor actions of NE was absent (versus WKY controls). (diabetesjournals.org)
  • A drug that mimics the effects of stimulating postganglionic adrenergic sympathetic nerves. (ebi.ac.uk)
  • An agent that selectively binds to and activates alpha -adrenergic receptors. (ebi.ac.uk)
  • Metaraminol acts on both α1-adrenergic receptors but appears to have no effect on β-adrenergic receptors. (pharmacycode.com)
  • Beta-blockers inhibit the sympathomimetic nervous system and block alpha1-adrenergic vasoconstrictor activity. (medscape.com)
  • With central neural blockade these changes may be attributable to block of autonomic fibers, a direct depressant effect of the local anesthetic agent on various components of the cardiovascular system, and/or the beta-adrenergic receptor stimulating action of epinephrine when present. (nih.gov)
  • Phentolamine mesylate (OraVerse), a nonselective a-adrenergic blocking drug, is the first therapeutic agent marketed for the reversal of soft-tissue anaesthesia and the associated functional deficits resulting from an intraoral submucosal injection of a local anaesthetic containing a vasoconstrictor. (handlebar-online.com)
  • An adrenergic vasoconstrictor agent used as a decongestant. (nih.gov)
  • also known as tuamine and 2-aminoheptane) is a sympathomimetic agent and vasoconstrictor which was formerly used as a nasal decongestant. (wikipedia.org)
  • Bisgaard HOlsson PBende M Effect of leukotriene D4 on nasal mucosal blood flow, nasal airway resistance and nasal secretions in humans. (jamanetwork.com)
  • In addition, pressing the nasal opening point (in the pupil upward two transverse fingers, equivalent to the "Yangbai" point) has the effect of making the nasal cavity smooth. (motherread.net)
  • Vasopressin is a recent addition that exerts vasodilatory effects on the pulmonary circulation and vasotonic effects on the systemic circulation. (monash.edu)
  • However, when given after methoxamine, Y-27632 had a reduced vasodilatory effect, and Y-27632 had no vasodilatory effect when given after ET-1. (elsevierpure.com)
  • At 1 and 7 d postexposure, the following parameters were monitored: pulmonary inflammation, lung cell toxicity, alveolar air/blood barrier damage, alveolar macrophage activity, blood cell differentials, responsiveness of tail artery to vasoconstrictor or vasodilatory agents, and heart rate and blood pressure in response to isoproterenol or norepinephrine, respectively. (cdc.gov)
  • By restoring phosphatidylinositol 3-kinase-dependent effects, rosiglitazone and/or enalapril therapy of SHRs also significantly improved vasodilator responses to insulin in MVB preconstricted with NE ex vivo. (diabetesjournals.org)
  • Experimental and clinical evidence implicate an imbalance between endogenous vasoconstrictor and vasodilator systems in the development and maintenance of hypertension. (nature.com)
  • Xylocaine (lidocaine HCl) Injections are sterile, nonpyrogenic, aqueous solutions that contain a local anesthetic agent with or without epinephrine and are administered parenterally by injection. (nih.gov)
  • Although most respondents reported being likely to choose local anesthetics at less toxic concentrations (including 2% mepivacaine or lidocaine), they were also likely to have similar vasoconstrictor solutions (epinephrine) as the second choice. (bvsalud.org)
  • Power spectral analysis of the effects of epinephrine, norepinephrine, dobutamine and dopexamine on microcirculation following free tissue transfer. (ox.ac.uk)
  • At maximum epinephrine infusion rates, the control of blood flow moved toward (i.e., proportion of power increased in) the lower frequencies, as smooth muscle mediated (myogenic) control began to dominate blood flow, an effect most marked with norepinephrine. (ox.ac.uk)
  • Hence, among other factors, it is important for local anesthetics to show rapid onset of action, provide adequate duration of anesthesia, and be composed by substances (i.e. local anesthetics, vasoconstrictors) with minimal or no systemic toxicity 1-2 . (bvsalud.org)
  • Tuaminoheptane has been found to act as a reuptake inhibitor and releasing agent of norepinephrine, which may underlie its decongestant and stimulant effects. (wikipedia.org)
  • Effect of Selepressin vs Placebo on Ventilator- and Vasopressor-Free Days in Patients With Septic Shock: The SEPSIS-ACT Randomized Clinical Trial. (eddyjoemd.com)
  • Vasoconstrictor responses to vasopressor agents in human pulmonary and radial arteries: an in vitro study. (eddyjoemd.com)
  • Lidocaine HCl stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses thereby effecting local anesthetic action. (nih.gov)
  • Information derived from diverse formulations, concentrations and usages reveals that lidocaine HCl is completely absorbed following parenteral administration, its rate of absorption depending, for example, upon various factors such as the site of administration and the presence or absence of a vasoconstrictor agent. (nih.gov)
  • Although the incidence of adverse effects with 4% Lidocaine Hydrochloride Injection, USP is quite low, caution should be exercised, particularly when employing large volumes and concentrations of lidocaine since the incidence of adverse effects is directly proportional to the total dose of local anesthetic agent administered. (pfizermedicalinformation.com)
  • Lidocaine (Xylocaine) is the most commonly used agent. (medscape.com)
  • The group of dentists involved in this study showed limited knowledge about the toxicity of local anesthetics, as well as some inconsistent background over the choice of vasoconstrictors. (bvsalud.org)
  • One hundred and twenty-four (124) dentists from private clinics in São Luís (Maranhão, Brazil) answered a questionnaire regarding the choice of solutions, selection criteria for local anesthetics and vasoconstrictors, and side effects associated with these substances. (bvsalud.org)
  • A combination of anesthetic agents and local vasoconstrictors is needed. (intechopen.com)
  • Particular features of these procedures include hemostasis of extended surfaces and wide-awake, conscious patients, and a combination of anesthetic agents and local vasoconstrictors is needed. (intechopen.com)
  • Thus, strategies are required towards improving the knowledge of professionals from private dental clinics regarding local anesthetics and/or vasoconstrictors. (bvsalud.org)
  • In this two-part column, we will explore the pharmacokinetic and pharmacodynamic challenges we face in treating children, with specific emphasis placed on the most frequently used medications in our practice: local anesthetics, analgesics, and antibacterial agents. (rdhmag.com)
  • Younger patients do not need large volumes of a local anesthetic agent for pain control. (rdhmag.com)
  • 2,4 It is strongly recommended to include a vasoconstrictor in the local anesthetic solutions used in children, especially when multiple quadrants are anesthetized in smaller pediatric patients, unless there is a compelling reason to exclude it. (rdhmag.com)
  • Most local anesthetic agents share the same basic chemical structure, which consists of an aromatic ring, linked to an intermediate chain, linked to a hydrophilic amine segment. (medscape.com)
  • For more information, see Local Anesthetic Agents, Infiltrative Administration . (medscape.com)
  • Tumescent solution is injected into the adipose tissue of the fat removal site by mixing the vasoconstrictor and the local anesthetic agents. (evitaclinic.com)
  • An infraorbital nerve block requires 1-3 mL of the chosen anesthetic agent. (medscape.com)
  • Bupivacaine (Marcaine) is another frequently used anesthetic agent. (medscape.com)
  • To reverse the effects of a soft-tissue anesthetic medicine, a dentist or other trained health professional will give you this medicine. (handlebar-online.com)
  • As with other rapidly acting intravenous anesthetic agents, the half-time of the blood-brain equilibration is approximately 1 minute to 3 minutes, accounting for the rate of induction of anesthesia. (guidelinecentral.com)
  • However, propofol is thought to produce its sedative/anesthetic effects by the positive modulation of the inhibitory function of the neurotransmitter GABA through the ligand-gated GABA A receptors. (guidelinecentral.com)
  • However, there are no effective agents or protocols to collectively prevent adverse effects from cancer therapies. (pocketdentistry.com)
  • Locally, low concentration vasoconstrictors and anti-inflammatory agents can be dripped to improve symptoms. (motherread.net)
  • The hemodynamic effects of DIPRIVAN during induction of anesthesia vary. (guidelinecentral.com)
  • Comparative clinical studies have shown that the hemodynamic effects of DIPRIVAN during induction of anesthesia are generally more pronounced than with other intravenous (IV) induction agents. (guidelinecentral.com)
  • The effect that symptomatic suppression has upon the long-term course of the syndrome is unknown. (nih.gov)
  • The effect starts 1-2 min after IV injection, 10 min after IM injection, 5-20 min after subcutaneous injection. (pharmacycode.com)
  • It is a short-acting, amide agent and its onset takes place 2 min after injection. (intechopen.com)
  • To evaluate the effect of a single intravitreal ranibizumab injection in eyes with acute nonarteritic ischemic optic neuropathy (NAION). (openophthalmologyjournal.com)
  • Common side effects of phentolamine include injection site pain, headache, and changes in heart rate. (handlebar-online.com)
  • Selepressin, a novel selective V 1A receptor agonist: Effect on mesenteric flow and gastric mucosa perfusion in the endotoxemic rabbit. (eddyjoemd.com)
  • 100/595/070 Ultraperc Percutaneous Dilation Tracheostomy Kit with Single Stage Dilator with Blue Line Ultra Tracheostomy Tube and Introducer description, usages, side effects, indications, overdosage, supplying and lots more! (drugs-library.com)
  • Theodrenaline is under investigation in clinical trial NCT01311414 (Effect of Cafedrine/Theodrenaline and Urapidil on Cerebral Oxygenation). (drugbank.com)
  • Effect of ubrogepant vs placebo on pain and the most bothersome associated symptom in the acute treatment of migraine: the ACHIEVE II randomized clinical trial. (mdedge.com)
  • An adequate interval (3 minutes to 5 minutes) must be allowed between dose adjustments in order to assess clinical effects. (guidelinecentral.com)
  • Like other phenothiazines, it exerts an antiemetic effect through a depressant action on the chemoreceptor trigger zone. (drugs.com)
  • The mycotoxic tremorgens penitrem, paxilline and lolitrem B had profound effects on electromyographic (EMG) activity of smooth muscle of the reticulorumen in conscious sheep, with a similar time course of action to their respective characteristic effects on the induction (1 to 2, 15 to 20 and 20 to 30 minutes) and the duration (1 to 2, 1 to 2 and 8 to 12 hours) of tremoring. (keyopinionleaders.com)
  • EMG recordings were made concurrently from the abomasal antrum and duodenum to study the effects of these tremorgens on smooth muscle of the gut. (keyopinionleaders.com)
  • Background: A patient is required to be fully relaxed and airway reflexes should be adequately suppressed to allow for smooth insertion of a laryngeal mask airway (LMA).Propofol and a variety of other induction agents and their combinations have been tried to ease its insertion. (bvsalud.org)
  • Arsenicum a., and Lachesis m. did not have the same effect on ROS production and were not dose-dependent. (bvsalud.org)
  • Single-dose ampuls and vials contain no bacteriostat or antimicrobial agent. (drugs-library.com)
  • The chemical structure of this intermediate group classifies the agent into the amide group or the ester group. (medscape.com)
  • Dobutamine and dopexamine had little effect on control of blood flow. (ox.ac.uk)
  • With norepinephrine the control of blood flow shifts toward low frequency vasomotion where blood flow depends mostly on average blood pressure, making it potentially the most suitable agent following free tissue transfer. (ox.ac.uk)
  • These agents are used in heart failure to reduce heart rate and blood pressure. (medscape.com)
  • It may be impossible to give a drug in sufficient doses to raise the blood levels enough to have a beneficial effect on the brain. (patentpc.com)
  • In humans, angiotensin-converting enzyme inhibitors, a potent class of antihypertensive agents, lower blood pressure at least partially by favoring enhanced kinin accumulation in plasma and target tissues. (nature.com)
  • Undesirable side effects, such as cardiorespiratory depression, are likely to occur at higher blood concentrations which result from bolus dosing or rapid increases in infusion rates. (guidelinecentral.com)
  • It also has a clinically useful antipsychotic effect. (drugs.com)
  • Methemoglobinemia can occur with use of these agents, though it is rarely clinically significant. (medscape.com)
  • This is especially true if the drug being administered to the brain causes side effects that are harmful or undesirable to the rest of the body. (patentpc.com)
  • What is the side effect of phentolamine? (handlebar-online.com)
  • These agents have moderate afterload reduction properties and cause slight preload reduction. (medscape.com)
  • A ceiling effect was observed for MAC and MAC-BAR, with 6 ng/ml fentanyl providing only an additional 13% and 9% reduction in MAC and MAC-BAR, respectively. (asahq.org)
  • In the presence of 66 vol% N2O, MAC and MAC-BAR of sevoflurane were reduced with increasing concentrations of fentanyL A ceiling effect was not observed for reduction in MAC and MAC-BAR in the presence of N2O. (asahq.org)
  • MAC and MAC-BAR decreased similarly with increasing concentrations of fentanyl in plasma, showing an initial steep reduction followed by a ceiling effect. (asahq.org)
  • Beneficial effects of the "open lung approach" with low distending pressures in acute respiratory distress syndrome. (aaukr.org)
  • Increased NO production may facilitate administration of drugs not easily absorbed to the brain and/or reduce serum concentrations necessary for desired physiological effects. (patentpc.com)
  • The net effect is normally a modest hypotension when the recommended dosages are not exceeded. (nih.gov)
  • If spontaneous ventilation is maintained, the major cardiovascular effect is arterial hypotension (sometimes greater than a 30% decrease) with little or no change in heart rate and no appreciable decrease in cardiac output. (guidelinecentral.com)
  • The duration of effect is approximately 75 minutes. (medscape.com)
  • The mean elimination half-life is approximately 2 h, and the duration of effect following administration is approximately 1-2 h. (handlebar-online.com)
  • AIM OF THE STUDY: The study was designed to investigate the effect of Arnica montana (A. montana) mother tincture and homeopathic dilutions on inflammation markers, oxidative stress and cell migration in diverse cell culture models. (bvsalud.org)
  • It has previously been shown that rats pre-treated with butylated hydroxyanisole (BHA), a well-known inducer of the enzyme DT-diaphorase, are protected against the toxic effects of 2-methyl-1,4-naphthoquinone but are made more susceptible to the harmful action of 2-hydroxy-1,4-naphthoquinone. (keyopinionleaders.com)
  • cobicistat will increase the level or effect of ergotamine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
  • ergotamine decreases effects of glyceryl trinitrate pr by pharmacodynamic antagonism. (medscape.com)
  • ergotamine decreases effects of nitroglycerin IV by pharmacodynamic antagonism. (medscape.com)
  • Close echocardiographic monitoring was performed to ascertain the haemodynamic effects of vasopressin. (monash.edu)
  • Selepressin in septic shock: sharpening the VASST effects of vasopressin? (eddyjoemd.com)
  • BACKGROUND: The use of pressor drugs after microsurgical free tissue transfer remains controversial because of potential vasoconstrictor effects on the free flap. (ox.ac.uk)
  • This structural difference determines the pathway by which the agent is metabolized and its allergic potential. (medscape.com)
  • These effects are less likely to occur with synthetic derivatives when used in large doses. (recallguide.org)
  • In the present experiments, the effects of BHA have been compared with those of other inducers of DT-diaphorase. (keyopinionleaders.com)