Effects concanavalin a. Medical search. Frequent questions

Concanavalin A (ConA) is a lectin (carbohydrate-binding protein) originally extracted from the jack-bean (Canavalia ensiformis). (wikipedia.org)
Concanavalin A (Con A) completely inhibits IgG-dependent adhesion of human neutrophils, demonstrating lectin-dependent modulation of cell receptor functions. (consensus.app)
The liver injury was induced by injection of concanavalin A (con-A), a lectin derived from jack beans. (biomedcentral.com)
Metabolic labeling of immature jackbean cotyledons with 14C-amino acids was used to determine the processing steps involved in the assembly of concanavalin A. Pulse-chase experiments and analyses of immunoprecipitated lectin forms indicated a complex series of events involving seven distinct species. (rupress.org)
NH2-terminal sequencing of the abundant precursors confirmed that the intact subunit of concanavalin A was formed by the reannealing of two fragments, since the alignment of residues 1-118 and 119-237 was reversed in the final form of the lectin identified in the chase and the precursor first labeled. (rupress.org)
Effects of phagocytosis and colchicine on the distribution of lectin binding sites on cell surface. (uconn.edu)
Concanavalin A is a lectin found in Canavelia that exhibits immunostimulatory, pro-fibrotic, and anticancer chemotherapeutic activities. (lktlabs.com)
Lectin of Concanavalin A as an anti-hepatoma therapeutic agent. (lktlabs.com)
Noonan KD, Burger MM. The relationship of concanavalin A binding to lectin-initiated cell agglutination. (lktlabs.com)
The researchers of this study initially synthesised a mannose (a type of sugar) derivative of DTC to study its binding properties with the lectin, concanavalin. (researchmatters.in)

The cells subsequently became resistant to apoptosis when exposed to Fas-specific antibody or when co-cultured with concanavalin A (ConA)-stimulated hepatic mononuclear cells. (the-scientist.com)
The researchers looked at E. purpurea root extract and its effects on concanavalin A (ConA)-activated murine splenocytes. (natural.news)
Several lectins like concanavalin (ConA) and wheat germ agglutinin (WGA), from both plants and animals, have been identified and studied. (researchmatters.in)

Aliquots of the PBL suspension were cultured in microtiter plate wells with or without the addition of the mitogens Concanavalin A or phytohemagglutinin. (usda.gov)

Similar to phytohemagglutinin (PHA), it is a selective T cell mitogen relative to its effects on B cells. (wikipedia.org)
While in vitro administration of glucocorticoids may inhibit concanavalin A (Con A)- and phytohemagglutinin (PHA)-induced T-cell proliferation, pokeweed mitogen (PWM)-driven B-cell mitogenesis is relatively resistant to glucocorticoids. (karger.com)

Inhibitory effect of liposomal quercetin on acute hepatitis and hepatic fibrosis induced by concanavalin A. Braz J Med Biol Res. (lktlabs.com)

Glucocorticoid effects were assessed in vivo by depletion of endogenous glucocorticoids after oral administration of 1.5 g metyrapone (MET) and subsequent glucocorticoid replacement, and in vitro by incubation of the cells with different doses of dexamethasone (DEX). (karger.com)
There was a significant decrease in PWM-induced B-cell mitogenesis and a more pronounced effect of DEX administered in vitro on spontaneous lymphocyte proliferation after MET treatment when compared with the DEX plus MET pretreated condition in vivo. (karger.com)
investigated the effects of intravenous siRNA injection targeting Fas on mouse hepatocytes in vivo. (the-scientist.com)
In vivo, concanavalin A induces fibrosis. (lktlabs.com)
This effect of PR3 was confirmed in vivo using zebrafish and was inhibited by niclosamide, a IL-6-STAT3 pathway inhibitor. (bmj.com)

Concanavalin A (Con A) affinity chromatography is the standard procedure to separate cholesterol nucleating biliary proteins from lipids and pigment. (wustl.edu)
Affinity chromatography was employed to separate any mixture of compounds based on their affinity towards Concanavalin A, a mannose specific protein. (montana.edu)

The study investigated the allergenic effects of monellin and brazzein on albino males of guinea pigs and males of outbred mice. (news-medical.net)
In addition, the inflammatory response to concanavalin A was assessed in mice. (news-medical.net)
These effects contributed to a rapid recovery from neutropenia in mice treated with CY. (eurekamag.com)
Curcumin attenuates Concanavalin A-induced liver injury in mice. (greenmedinfo.com)
Curcumin inhibits HMGB1 releasing and attenuates concanavalin A-induced hepatitis in mice. (greenmedinfo.com)
Oral administration of ovalbumin protects mice from concanavalin A-induced hepatitis through suppression of interferon-gamma responses. (bvsalud.org)
Oral administration of OVA at high doses inhibited the development of OVA -specific and concanavalin A (Con A)-induced hepatitis in DO11.10 mice , and these effects were associated with the downregulation of Th1 responses. (bvsalud.org)
To investigate the effect of resveratrol (Res) on colonic movement in mice and its mechanism. (shsmu.edu.cn)
The effects of Res (10, 20, 40, and 80 μmol/L) on spontaneous contraction of colonic smooth muscle in mice and colonic migrating motor complex (CMMC) were recordedusing a multi-channel physiological recorder. (shsmu.edu.cn)

Concanavalin A interacts with diverse receptors containing mannose carbohydrates, notably rhodopsin, blood group markers, insulin-receptor the Immunoglobulins and the carcino-embryonary antigen (CEA). (wikipedia.org)
Removal of Con A with α methyl D mannopyranoside (mannose) led to only partial reversal of these effects after 1 hr although 'unresponsiveness' was reversible at 15 min. (usuhs.edu)
Suppression was not due to cytotoxic or agglutinating effects of the high dose Con A. Two x 10 6 thymocytes exposed to 160 μg of Con A for 1 hr bound 1.7 μg, 86% of which was elutable with mannose. (usuhs.edu)
The mannose-spin labeled functionalized dendrimers were further studied to determine effects of the spin label in hemagglutination inhibition assays. (montana.edu)
Initially, the mannose-bound DTC did not show effects of fluorescence when the light was shone on it. (researchmatters.in)

A study was conducted to determine the effects of several stress-related compounds on porcine (p) lymphocyte function. (usda.gov)
Overall, these results demonstrate that cortisol and cannabinoids, both stress-related compounds, have suppressive effects on porcine lymphocyte function. (usda.gov)
We also found that DAEB significantly stimulated lymphocyte proliferation, especially Concanavalin A-induced lymphocyte proliferation in a dose-dependent manner, and augmented phagocytosis and secretion of NO and TNF-alpha in peritoneal macrophages. (google.com)

The present study is aimed at investigating the anti-inflammatory, antioxidative, and antiapoptotic effects of methane on lipopolysaccharide- (LPS-) induced acute orchitis and its potential mechanisms. (hindawi.com)
Therefore, methane exerts therapeutic effects on acute orchitis and might be a new and convenient strategy for the treatment of inflammation-related testicular diseases. (hindawi.com)
Serious" effects are those that evoke failure in a biological system and can lead to morbidity or mortality (e.g., acute respiratory distress or death). (cdc.gov)
As an example, acute inhalation MRLs may not be protective for health effects that are delayed in development or are' acquired following repeated acute insults, such as hypersensitivity reactions, asthma, or chronic bronchitis. (cdc.gov)
In the current study, the effect of high\dose wogonin within the onset of DSS\induced acute colitis was identified. (findadig.com)

In animal models of hepatoma, concanavalin A induces autophagy and cell death and decreases tumor nodule formation. (lktlabs.com)

2). This lack of effect indicates that these peptides either have no effect on cell proliferation, or that the dosage was insufficient to cause an effect. (usda.gov)

Effects of hydroxyl compounds on the interaction of concanavalin A with polysaccharides. (cdc.gov)
Linebroadening effects in the EPR spectra of these compounds allowed us to determine the distance between spin labels (and thus between carbohydrates). (montana.edu)
The molecular mechanisms by which a variety of naturally-occurring dietary compounds exert chemopreventive effects have been a subject of intense scientific investigations. (koreascience.kr)

7: Marks A, Labourdette G. Succinyl concanavalin A stimulates and antimicrotubular drugs inhibit the synthesis of a brain-specific protein in rat glial cells Proc Natl Acad Sci U S A. 1977 Sep;74(9):3855-8. (moleculardepot.com)

Differential effects of concanavalin A and succinyl concanavalin A on the macromolecular events of platelet activation Biochim Biophys Acta. (moleculardepot.com)

Electrokinetic response of granulocytes to concanavalin A and succinyl-concanavalin A Cell Biophys. (moleculardepot.com)
Interaction with concanavalin A and succinyl-concanavalin A Biochim Biophys Acta. (moleculardepot.com)

However, TEA did not block the inhibitory effect of Res. (shsmu.edu.cn)
In addition, TTX, atropine, L-NAME, NPPB and apamin had no effect on the inhibitory effect of Res on spontaneous contraction of colonic smooth muscle. (shsmu.edu.cn)

An MRL is an estimate of the daily human exposure to a hazardous substance that is likely to be without appreciable risk of adverse noncancer health effects over a specified duration of exposure. (cdc.gov)

In recent years, molecular hydrogen treatment has the potential to preventive and therapeutic applications against many diseases due to its extensive effects, such as antioxidant, anti-inflammatory, antiapoptotic [16, 17]. (researchgate.net)

The points in the figures showing no-observed-adverse-effect levels (NOAELs) or lowest observed-adverse-effect levels (LOAELs) reflect the actual doses (levels of exposure) used in the studies. (cdc.gov)

Co-incubation of rFg-CaBP4 with concanavalin A-stimulated monocytes increased the transcription levels of interleukin (IL)-2, IL-4, interferon gamma and transforming growth factor-β. (biomedcentral.com)
They also investigated E. purpurea root extract's effect on the production of cytokines, such as interferon-gamma, interleukin-2 and tumor necrosis factor, in these cells. (natural.news)

The suppressive effects of MSC-derived exosomes and the MSCs in this injury model were evaluated by the level of plasma alanine aminotransferase (ALT), histopathological examinations, the messenger RNA (mRNA) expression of pro- and anti-inflammatory cytokines, and the population alteration of regulatory T cells (Treg) among non-parenchymal liver cells (NPCs). (biomedcentral.com)
It has been proved that inhalation of methane also modulates leukocyte activation, affects key events of ischemia-reperfusion-induced oxidative stress, and has anti-inflammatory effects against ischemia-reperfusion damage [ 12 ]. (hindawi.com)
Additionally, recent researches have demonstrated that methane exerts microcirculatory and mitochondrial effects in inflammatory states [ 13 , 14 ]. (hindawi.com)
Recent basic and clinical research has revealed that hydrogen is an important physiological regulatory factor with antioxidant, anti-inflammatory and anti-apoptotic protective effects on cells and organs. (researchgate.net)

The effect of blueberry on systemic immune functions has not been examined. (blueberry.org)

nitro-L-arginine methyl ester, a nitric oxide (NO) synthase inhibitor], NPPB[5-nitro-2-(3-phenylpropylamino) benzoic acid, an ANO1 (anoctamin 1) channel inhibitor] and apamin [a small conductance Ca2+-activated K+ channel 3 (SK3) channel inhibitor].elution, the effects of Res on spontaneous contraction of colonic smooth muscle strips before and after pretreatment were recorded and compared. (shsmu.edu.cn)

10: Mandal DK, Brewer CF. Differences in the binding affinities of dimeric concanavalin A (including acetyl and succinyl derivatives) and tetrameric concanavalin A with large oligomannose-type glycopeptides Biochemistry. (moleculardepot.com)
Vyvchennia hastroprotektornoi dii kombinatsii kvertsetynu ta pokhidnykh hliukozaminu na modeli etanol-prednizolonovoho urazhennia shlunka u shchuriv [Study of the gastroprotective effect of the combination of quercetin and glucosamine derivatives on the model of ethanol-prednisone gastric damage in rats]. (edu.ua)

Protektyvnyi efekt kvertsetynu shchodo rozvytku metabolichnoho syndromu, indukovanoho vysokozhyrovoiu diietoiu u ovariektomovanykh shchuriv [Protective effect of quercetin on the development of metabolic syndrome induced by a high-fat diet in ovariectomized rats]. (edu.ua)

The concanavalin A receptor from human erythrocytes in lipid bilayer membranes. (moleculardepot.com)

The effect was due to Con A interaction with neutrophils and could not be reproduced by Con A pretreatment of IgG-sepharose. (consensus.app)
Effects of bovine serum albumin on the interaction of concanavalin A and succinyl-concanavalin A with phospholipid bilayers Can J Biochem Cell Biol. (moleculardepot.com)

In this study, we investigated the immunomodulatory effects of a recombinant tegumental calcium-binding EF-hand protein 4 of F. gigantica (rFg-CaBP4) on goat monocytes. (biomedcentral.com)
It is also inconsistent with the common view of hydration effects on protein hydrodynamics. (lu.se)

However, when bound with concanavalin, it started emitting fluorescence, thereby signalling its bound state with concanavalin. (researchmatters.in)
Also, this effect increased with increasing concentrations of concanavalin saturating at 309 times the initial intensity of fluorescence. (researchmatters.in)
Overhauser effect spectroscopy, dielectric relaxation and fluorescence spectroscopy. (lu.se)

The same effect was demonstrated for the chloroform extract of the G. lucidum culture medium. (researchgate.net)

Concanavalin A Column for Analysis of Glycoprotein. (analyteguru.com)
Addition- ally, glycosylation has profound effects on the properties of a glycoprotein including solubility, immunogenicity, circulatory half-life, and thermostability. (analyteguru.com)

Although the development of cyclosporine A and tacrolimus, which suppress interleukin (IL)-2 expression and T cell-mediated immune responses, was a breakthrough, their adverse effects are still a major problem in the long-term follow-up of transplant recipients. (biomedcentral.com)

MRLs are derived for hazardous substances using the no-observed-adverse-effect level/uncertainty factor approach. (cdc.gov)
They are below levels that might cause adverse health effects in the people most sensitive to such chemical-induced effects. (cdc.gov)
Exposure to a level above the MRL does not mean that adverse health effects will occur. (cdc.gov)
They may also be viewed as a mechanism to identify those hazardous waste sites that are not expected to cause adverse health effects. (cdc.gov)
Public health officials and others concerned with appropriate actions to take at hazardous waste sites may want information on levels of exposure associated with more subtle effects in humans or animals (LOAEL) or exposure levels below which no adverse effects (NOAELs) have been observed. (cdc.gov)

Effect of colchicine and vinblastine on the aggultination of polymorphonuclear leukocytes by Concanavalin A. Nature (New Biology) 238: 120-122. (uconn.edu)

Curcumin has a protective effect on experimentally induced inflammation, hepatotoxicity and cardiotoxicity in rats. (greenmedinfo.com)

However, IFN\ and IL\2 production of T cells co\stimulated by concanavalin A and wogonin offers been shown to be significantly enhanced 23. (findadig.com)

This effect was most significant 12 to 24 hr after addition of high dose Con A. It was not necessary for the cells to remain continuously with high dose Con A, since washing out unbound Con A after 1 hr still led to reduced [ 3 H] thymidine incorporation at 24 or 72 hr. (usuhs.edu)
Dwyer JM, Johnson C. The use of concanavalin A to study the immunoregulation of human T cells. (lktlabs.com)
Finally, the effect of Res on L-type Ca2+ channel currents were recordedusing the whole-cell patch clamp technique in freshly dispersed colonic smooth muscle cells. (shsmu.edu.cn)
The spleen plays an important role in granulocyte homeostasis also by influencing the elimination of senescent cells and regulatory effects on granulocyte renewal in the bone marrow. (medscape.com)

This study aimed to evaluate the effect of mesenchymal stem cell (MSC)-derived exosomes on an immune-induced liver injury model. (biomedcentral.com)
In this study, we investigated the suppressive effect of exosomes on an immune-induced liver injury model. (biomedcentral.com)
Concanavalin A is used in research to study cell adhesion. (lktlabs.com)
Eluted proteins were added to heated abnormal bile at a final concentration of 250 μg/ml to study the effect on cholesterol nucleation. (wustl.edu)

This research is undertaken to evaluate the effect of MSC-derived exosome on concanavalin-A (con-A)-induced liver injury. (biomedcentral.com)
Serious health effects (such as irreparable damage to the liver or kidneys, or birth defects) are not used as a basis for establishing MRLs. (cdc.gov)

The protective effects of blueberry suggest that dietary blueberry can buttress T-cell and systemic immune function against HFD-obesity-associated insults. (blueberry.org)

As these kinds of health effects data become available and methods to assess levels of significant human exposure improve, these MRLs will be revised. (cdc.gov)

A. senticosus polysaccharide has an obvious protective effect on the gut homeostasis of Drosophila melanogaster. (greenmedinfo.com)

In addition to complications seen from exposure to chemotherapy and radiation, patients undergoing allogeneic transplantation can experience unique late effects secondary to graft versus host disease (GVHD) and autoimmunity. (medscape.com)

The results indicated that DAEB had potent anti-tumor activity which may be associated with its potent immunostimulating effect. (google.com)

In 72 hr cultures the lowest supraoptimal dose of Concanavalin (Con A) showing no stimulation of rat thymocytes above background was 160 μg/ml. (usuhs.edu)
LOAELs or NOAELs should also help in determining whether or not the effects vary with dose and/or duration, and place into perspective the possible significance of these effects to human health. (cdc.gov)
Moreover, the effects of high\dose wogonin within the function of the effector T and regulatory T cell were examined. (findadig.com)

Occasionally, the spleen may be removed to address the sheer mass effect of a massive enlargement (such as in storage disorders), which can cause mass effects. (medscape.com)

During the development of toxicological profiles, Minimal Risk Levels (MRLs) are derived when reliable and sufficient data exist to identify the target organ(s) of effect or the most sensitive health effect(s) for a specific duration for a given route of exposure. (cdc.gov)
MRLs are derived when reliable and sufficient data exist to identify the target organ(s) of effect or the most sensitive health effect(s) for a specific duration within a given route of exposure. (cdc.gov)

Succinyl-Concanavalin A is a high quality Succinyl-Concanavalin A. This product has been used as molecular tool for various biochemical applications. (moleculardepot.com)

To stimulate and facilitate further research, the NCI and NHLBI held the First International Consensus Conference on Late Effects after Pediatric Hematopoietic Cell Transplantation on April 28 and 29, 2011. (medscape.com)

The effects of wogonin on T cell function under different micro\environments remain ambiguous. (findadig.com)
9: Kido N, Ohta M, Kato N. Inhibition by succinyl concanavalin A of strong adjuvant activity of lipopolysaccharides which possess mannans as the O-specific polysaccharide chains Cell Immunol. (moleculardepot.com)

Capillary electrophoresis analysis of concanavalin A and its succinyl derivative J Pharm Biomed Anal. (moleculardepot.com)

Effect of glutathione-oxidizing agents on microtubule assembly and microtubule-dependent surface properties of human neutrophils. (uconn.edu)

But, it turns out that the fibers and "nutrients" found in these foods might not be so beneficial after all, leaving their supposed health-promoting effects in question. (jayfeldmanwellness.com)

Since the first large cohort of patients was cured in the 1970s, much has been learned about the long-term effects of exposure to chemotherapy, radiation, and surgery in childhood. (medscape.com)
[ 4 , 5 ] The late effects of exposure to chemotherapy, radiation and surgery make the care of survivors highly complex and mandate structured, coordinated long-term follow-up. (medscape.com)
The distinction between "less serious" effects and "serious" effects is considered to be important because it helps the users of the profiles to identify levels of exposure at which major health effects start to appear. (cdc.gov)

MRLs are based on noncancer health effects only and are not based on a consideration of cancer effects. (cdc.gov)
Most MRLs contain a degree of uncertainty because of the lack of precise toxicological information on the people who might be most sensitive (e.g., infants, elderly, nutritionally or immunologically compromised) to the effects of hazardous substances. (cdc.gov)
Proposed MRLs undergo a rigorous review process: Health Effects/MRL Workgroup reviews within the Division of Toxicology, expert panel peer reviews, and agency-wide MRL Workgroup reviews, with participation from other federal agencies and comments from the public. (cdc.gov)
MRLs are based on noncancerous health effects only and do not consider carcinogenic effects. (cdc.gov)

The effect of specific electrolytes on the release of endogenous pyrogen from polymorphonuclear leukocytes. (uconn.edu)

ATSDR acknowledges that a considerable amount of judgment may be required in establishing whether an end point should be classified as a NOAEL, "less serious" LOAEL, or "serious" LOAEL, and that in some cases, there will be insufficient data to decide whether the effect is indicative of significant dysfunction. (cdc.gov)

Anatomy8

Organisms3

Diseases2

Chemicals and Drugs33

Analytical, Diagnostic and Therapeutic Techniques and Equipment4

Phenomena and Processes12

Information Science1

Lectin10

ConA3

Mitogens1

Phytohemagglutinin2

Hepatic1

Vivo5

Affinity Chromatography2

Mice9

Mannose5

Lymphocyte3

Acute5

Hepatoma1

Proliferation1

Compounds3

Inhibit1

Differential1

Biophys2

Inhibitory2

Appreciable risk of adverse1

Therapeutic1

Doses1

Interferon-gamma2

Inflammatory4

Immune functions1

Spontaneous1

Derivatives2

Quercetin1

Lipid1

Interaction2

Protein2

Fluorescence3

Extract1

Glycoprotein2

Responses1

Adverse5

Biology1

Inflammation1

Significantly1

Cells4

Study4

Liver2

Systemic1

Methods1

Protective effect1

Addition1

Potent1

Dose3

Spleen1

Route of exposure2

Product1

Transplantation1

Cell2

Analysis1

Human1

Found1

Exposure3

MRLs4

Endogenous1

Insufficient1