AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation Science
GlycosaminoglycansChondroitin SulfatesDermatan SulfateHeparitin SulfateHeparinChondroitinHyaluronic AcidSulfatesMucopolysaccharidosesProteoglycansKeratan SulfateChondroitinases and Chondroitin LyasesHeparin LyaseElectrophoresis, Cellulose AcetateUronic AcidsMucopolysaccharidosis IDisaccharidesChondroitin LyasesHyaluronoglucosaminidasePolysaccharide-LyasesChondroitin ABC LyaseIduronic AcidGlucosamineHeparin Cofactor IIHeparan Sulfate ProteoglycansHexosaminesNitrous AcidMucopolysaccharidosis IIAlcian BlueExtracellular MatrixChloratesSulfur RadioisotopesRenal Tubular Transport, Inborn ErrorsN-Acetylgalactosamine-4-SulfataseSulfuric AcidsCartilageUridine Diphosphate Glucose DehydrogenaseMucopolysaccharidosis IVGlucuronidaseChromatography, GelGlycocalyxCollagenSulfotransferasesIduronidaseCartilage, ArticularCattleCells, CulturedChromatography, Ion ExchangeChondroitin Sulfate ProteoglycansGlycomicsGlycosidesSepharoseOligosaccharidesProtein BindingElectrophoresisCHO CellsCricetinaeCarbohydrate SequenceOculocerebrorenal SyndromeMucopolysaccharidosis VIIIduronate SulfataseMucopolysaccharidosis VIExtracellular Matrix ProteinsSulfatasesBinding SitesSilver ProteinsKineticsCarbohydrate ConformationFibroblastsSurface Plasmon ResonanceChromatography, PaperPolysaccharidesMonosaccharidesXyloseMucopolysaccharidosis IIISkinMolecular Sequence DataCell LineChromatography, AffinityGlycoproteinsAggrecansHymecromoneSyndecansMolecular WeightChromatographyRecombinant ProteinsCorneaPronaseArylsulfatasesFibrocartilageAmino Acid SequenceBiglycanPentosan Sulfuric PolyesterDecorinGlucuronatesFibronectinsComb and WattlesGlycoside HydrolasesSyndecan-4Virus Attachment
GAGsExtracellular matrixCartilageChondroitin sulfateOsteoarthritisBiosynthesisHeparinHeparan sulfateSynthesisHyaluronicInflammationAdequanSubstancesPSGAGCharacterizationProteinsAdverseAssayPolysaccharidesCollagen peptidesPleiotropic effectsJointCellularMolecularAnticoagulantExposure2020SulfationInhibitorsProliferationIncreasesComponentRoleContentEffectivenessReverseIncludeProcessStudiesResultsSkinHumanPresenceSide
GAGs13
  • Glycosaminoglycans (GAGs) are essential functional components of the extracellular matrix (ECM). (degruyter.com)
  • Although sulfated GAGs (sGAGs) appear intracellularly, the knowledge about intracellular effects and putative interaction partners is scarce. (degruyter.com)
  • Glycosaminoglycans (GAGs) are multifunctional polysaccharides of the extracellular matrix (ECM) responsible for ECM hydration and binding of cations and proteins due to their negative charge. (degruyter.com)
  • Glycosaminoglycans (GAGs) have been implicated in the regulation of outflow resistance of aqueous humor flow through the trabecular meshwork (TM). (elsevierpure.com)
  • We quantitatively and structurally characterize primary stored HS and other glycosaminoglycans (GAGs) possibly accumulated through a secondary storage in brain, liver, kidney and lung of MPS IIIA mouse model. (unimore.it)
  • Cartilage extracted glycosaminoglycans (GAGs) concentration was assessed after agarose gel electrophoresis. (usp.br)
  • Peptan IIm contains glycosaminoglycan matrix components (GAGs) and hydrolyzed collagen type II, matrix elements similar as found in human cartilage, in one single ingredient. (nutraceuticalsworld.com)
  • Articular cartilage undergoes severe loss of proteoglycan and its constituent glycosaminoglycans (GAGs) in osteoarthritis. (cardiff.ac.uk)
  • Among the factors potentially involved in the process are molecules belonging to the family of glycosaminoglycans, or simply GAGs. (neurodegenerationresearch.eu)
  • Interestingly, in the co-culture system, vVECs-VIC co-culturing enhanced the amount of both collagen and glycosaminoglycans (GAGs) whereas aVECs did not affect the ECM proteins. (bl.uk)
  • Aortic VECs exposed to oscillatory flow had higher content of collagen and GAGs while vVECs did not share this effect. (bl.uk)
  • During postnatal heart valve development, glycosaminoglycan (GAG)-rich valve primordia transform into stratified valve leaflets composed of GAGs, fibrillar collagen , and elastin layers accompanied by decreased cell proliferation as well as thinning and elongation. (bvsalud.org)
  • GALNS deficiency induces the accumulation of glycosaminoglycans (GAGs), keratan sulfate (KS) and chondroitin-6-sulfate (C6S) in multiple tissues, particularly bone, cartilage, heart valves, and cornea, whereas β-galactosidase deficiency induces the accumulation of only KS in those tissues. (medscape.com)
Extracellular matrix4
Cartilage3
  • Illustration of the sites from which articular cartilage was obtained from a middle carpal joint for histologic evaluation of the effects of treatment with ESWT and PSGAG in horses. (avma.org)
  • The bioactive multitasker has been shown to promote healthy cartilage, enabling easy joint movement and reducing the effects of inflammation. (nutraceuticalsworld.com)
  • Chondroitin Sulfate Chondroitin sulfate is a glycosaminoglycan, a natural component of cartilage. (msdmanuals.com)
Chondroitin sulfate5
Osteoarthritis1
  • Glucosamine is claimed to relieve pain due to osteoarthritis, possibly with both analgesic and disease-modifying effects. (msdmanuals.com)
Biosynthesis1
  • SYN®-HYCAN has a firming and remodeling effect by stimulation of GAG (glycosaminoglycan) biosynthesis. (lotioncrafter.com)
Heparin3
  • Sulodexide is a mixture of glycosaminoglycans: heparin and dermatan sulphate, which on one hand suppresses the intravascular inflammation and on the other hand have protective effect towards the endothelium. (viamedica.pl)
  • Plasma must be separated from cellular components within 1 hour (platelet factor 4, released by platelets, neutralizes the effect of heparin). (medscape.com)
  • Heparin is a mixture of negatively charged glycosaminoglycans (sulfated mucopolysaccharides) that have anticoagulant properties due to their interaction with the natural anticoagulant antithrombin. (medscape.com)
Heparan sulfate2
  • The glycosaminoglycan (heparan sulfate) component of glomerular basement membranes from human kidneys of diabetic and nondiabetic subjects has been quantitated after isolation from protease digests of the membranes on OEAE-cellulose microcolumns. (diabetesjournals.org)
  • Heparan sulfate was identified as the predominant glycosaminoglycan in both diabetic and control subjects and the extent of its sulfation appeared to be similar. (diabetesjournals.org)
Synthesis4
  • Inhibition of glycosaminoglycan synthesis. (caringmedical.com)
  • CS is the glycosaminoglycan (GAG) constituent of the human intervertebral disc that stimulates synthesis of the disc. (coxtechnic.com)
  • Glucosamine plays a very important role in the synthesis of glycosaminoglycans, proteoglycans, and glycolipids, which are all important in various functions but mostly related to anti-inflammatory processes, connective tissue growth, and maturation, and tissue repair and rebuilding. (mypetneedsthat.com)
  • Mechanism for glucosamine sulfate may be related to improved glycosaminoglycan synthesis as a result of the sulfate moiety. (msdmanuals.com)
Hyaluronic2
Inflammation2
  • Since all tissues heal by inflammation, one can see why long-term use of these medications will have harmful effects. (caringmedical.com)
  • It is this combination of effects that make chondroitin one of the most sought-after supplements in the management of osteoarthritic pain and inflammation. (mypetneedsthat.com)
Adequan1
  • AQHA releases ineligibility list for the Level 2 Championships, presented by Adequan® (polysulfated glycosaminoglycan), held in conjunction with the 2020 AQHA World Championship Show. (oqha.com)
Substances1
  • Glycosaminoglycans are substances that function as very efficient shock absorbers and as lubricant for the joints. (mypetneedsthat.com)
PSGAG1
  • There are no known contraindications to the use of intramuscular Polysulfated Glycosaminoglycan (PSGAG). (adequan.com)
Characterization1
Proteins2
  • By identifying many sGAG-specific interacting proteins, our data provide a resource for upcoming studies aimed at molecular mechanisms and understanding of sGAG cellular effects. (degruyter.com)
  • Researchers have discovered that a gene regulator active during fetal brain development, called REST, switches back on later in life to protect aging neurons from various stresses, including the toxic effects of abnormal proteins. (neurodegenerationresearch.eu)
Adverse8
  • This is not a complete list of all side effects or adverse reactions that may occur from the use of this drug. (medicinenet.com)
  • Call your doctor for medical advice about serious side effects or adverse reactions. (medicinenet.com)
  • This material has improved many adverse effects experienced by contact lens wearers. (news-medical.net)
  • The advancements in materials used to manufacture contact lenses reduced the adverse effects linked to their use, preserved a regular corneal metabolism, and maintained tear film stability. (news-medical.net)
  • Epidemiological studies provide evidence for an association between prenatal and postnatal exposure to lead and adverse effects on neurodevelopment in infants and young children, and support the use of PbB as an index of toxicological effect. (cdc.gov)
  • 40 :g/dL also may be associated with adverse effects on sperm counts and morphology (ATSDR 1999). (cdc.gov)
  • There no published reports of unacceptable adverse effects on chronic use. (ndtv.com)
  • First, potential adverse effects of anesthesia, radiation, and surgery often complicate traditional diagnostic and treatment modalities. (medscape.com)
Assay3
  • Type I mucopolysaccharidosis was diagnosed in a fetus by assay of the glycosaminoglycans of the amniotic liquor. (bmj.com)
  • Factor Xa assay is indicated to monitor anticoagulant effects. (medscape.com)
  • For monitoring LMWH, the anti-Xa assay plays an essential role since it is the only assay offered for this purpose, since LMWH has minimal effect on PTT. (medscape.com)
Polysaccharides1
  • In addition to the aforementioned, acidic polysaccharides-specifically sulfated glycosaminoglycans-whose presence has been shown by using electrophoretic and chromatographic methods in Eisenia andrei [ 13 ] also fulfil important biological functions. (hindawi.com)
Collagen peptides3
  • The latest results of a new clinical study on the effect of type I Peptan collagen peptides on recovery from exercise will be revealed during the " Nutritional Strategies for Exercise Recovery " workshop on Thursday, Nov. 8. (nutraceuticalsworld.com)
  • Two placebo-controlled clinical trials were run to assess the effect of a daily oral supplementation with Peptan® collagen peptides on skin hydration. (naturalproductsinsider.com)
  • Ex vivo experiments demonstrated that collagen peptides induce collagen as well as glycosaminoglycan production, offering a mechanistic explanation for the observed clinical effects. (naturalproductsinsider.com)
Pleiotropic effects1
  • The evidence suggests that the liver is more severely affected than the central nervous system at this stage of gestation, and this finding agrees with the recent demonstration of the underlying enzyme defect of this disorder, with the corollary that many biochemical abnormalities previously noted in gargoylism must be pleiotropic effects of the mutant genotype. (bmj.com)
Joint1
  • Polysulphate glycosaminoglycan is recommended for the intramuscular treatment of non-infectious, degenerative, and/or traumatic joint dysfunction and associated lameness of the carpal and hawk joints in horses. (adequan.com)
Cellular1
  • With this in mind, three decellularization protocols were compared in terms of their effectiveness to extract cellular materials, their effect on glycosaminoglycan (GAG) content and, finally, their effect on tensile biomechanical behavior. (upm.es)
Molecular7
  • The effect of different molecular weight hyaluronan on macrophage physiology. (nel.edu)
  • In contradiction, the biological effects of fragmented low molecular weight hyaluronan are suggested to be pro-angiogenic and pro-inflammatory. (nel.edu)
  • The effects of highly purified pharmacological grade hyaluronan of defined molecular weights 11, 52, 87, 250 and 970 kilodaltons were tested on mouse macrophage cell lines RAW 264.7 and MHS. (nel.edu)
  • Similarly, hyaluronan of any molecular weight neither exerted stimulatory nor inhibitory effects on macrophages pre-treated by lipopolysaccharide. (nel.edu)
  • Further studies are necessary to clarify the effects of different molecular weight hyaluronan on phagocytes. (nel.edu)
  • Krejcova D, Pekarova M, Safrankova B, Kubala L. The effect of different molecular weight hyaluronan on macrophage physiology. (nel.edu)
  • These glycosaminoglycans markedly prevented thrombosis formation and thrombin-induced platelet aggregation in a dose- and molecular weight-dependent manner in vitro and in vivo. (myjournals.org)
Anticoagulant2
  • The aim of this study was to further evaluate the anticoagulant and antithrombic activity of AHG and DAHGs, as well as reveal the dynamic relationship between exposure and effect in vivo. (myjournals.org)
  • Antithrombin's anticoagulant effect results from its inactivation of certain coagulation factors, for the most part IIa and Xa, by enzymatic cleavage (serine protease). (medscape.com)
Exposure1
  • The effects of lead are similar across inhalation and oral routes of exposure. (cdc.gov)
20201
  • Earlier this spring, the AQHA Executive Committee waived the qualification requirements for the 2020 AQHA World Championship Show due to effects of the worldwide coronavirus pandemic on the showing industry. (oqha.com)
Sulfation1
  • Their role was further investigated by assessment of the effects of chlorate, an inhibitor of sulfation, and β-xyloside, which provides a competitive nucleation point for addition of disaccharide units, in anterior segment perfusion culture. (elsevierpure.com)
Inhibitors1
  • Augmented excretion of urolithiasis inhibitors, such as citrate, magnesium, and glycosaminoglycans, neutralize these phenomena in pregnant patients, who are no more likely to form urinary calculi than nonpregnant patients. (medscape.com)
Proliferation1
  • The effects of hypoxia on late embryonic valve ECM composition, Sox9 expression, and cell proliferation were examined in chicken embryo aortic valve organ cultures . (bvsalud.org)
Increases1
Component1
  • The reduced level of glycosaminoglycan in the diabetic glomerular basement membrane was accompanied by a significant elevation of hexoses, which are primarily associated with the collagen component, suggesting that a redistribution of basement membrane macromolecules occurs in the diabetic state. (diabetesjournals.org)
Role1
  • Chrondroitin sulfate is an important glycosaminoglycan that plays a role in tissue repair by promoting the faster growth of cells. (mypetneedsthat.com)
Content2
  • 0.005) in the glycosaminoglycan content of diabetic membranes was observed. (diabetesjournals.org)
  • Poor nutritional supply has a long-term effect on disc degeneration with low CS and water content in the human intervertebral disc. (coxtechnic.com)
Effectiveness1
  • All listed effects of sulodexide may explain its effectiveness in therapy in a group of patients with the cardiovascular disorders. (viamedica.pl)
Reverse1
  • They can actually reverse the effects of aging by improving skin health and rejuvenating its appearance. (selfgrowth.com)
Include1
  • Other possible side effects include bloating, diarrhea, and constipation. (medlineplus.gov)
Process2
  • Adifyline® peptide is the perfect ingredient to diminish the effects that the aging process causes in the skin. (lotioncrafter.com)
  • The need for a second surgical site makes the surgical process more complex with side effects to the patient 27 . (bvsalud.org)
Studies2
  • However, while some studies point to these molecules as the culprit for prion conversion, others suggest an opposite effect in which the molecules protect against prion conversion. (neurodegenerationresearch.eu)
  • Outside Latin America, a few studies reported the effect of pregnancy-associated malaria in unstable malaria settings in Africa and Asia ( 9 - 12 ), and described increased risks for low birthweight and for maternal anemia as consequences of P. vivax infection during pregnancy ( 13 , 14 ). (cdc.gov)
Results1
  • Treatment of the isolated bovine granules with 0.2% Lubrol PX results in the solubilization of most membranes present in the fractin but has only a limited effect on the matrices, which remain aggregated and can be recovered and purified by gradient centrifugation. (rupress.org)
Skin2
  • It helps in retaining the moisture of the skin making it moist and soft with a glowy effect [2] . (thebeautyinsiders.com)
  • Both activities of SYN®-HYCAN work nicely together: Fresh hyaluronan and stronger collagen fibrils result in a visible remodeling effect and a firmer skin. (lotioncrafter.com)
Human1
  • We tested our hypothesis by examining the effects of silencing C/EBPβ, DDIT4, Trib3 or α-syn with small interfering ribonucleic acid (siRNA) on METH-induced autophagy and apoptosis in the human neuroblastoma SH-SY5Y cells. (cancerindex.org)
Presence1
  • Although the concentration of glycosaminoglycans and glycoproteins is relatively low in membraneless granules, the possibility that their presence in the fraction is largely due to cross-contamination and/or artifactual adsorption could be excluded on two grounds. (rupress.org)
Side4