Metoclopramide and cisaprideErythromycinMosaprideGastroparesisDomperidonePropulsidDrugsEsophagusReceptorsCardiacIntestinalGastricStomachConstipationSignificantlyDoseFunctionalAgentsDosagePregnancyFrequencyConjunctionIntestineTabletClinicalTherapiesSide effectsDisordersDrugAgentLongerResearchGroupTotal effective rateLowerSafe
Metoclopramide and cisapride2
- Present management involves the empirical use of prokinetic drugs such as domperidone, metoclopramide, and cisapride. (bmj.com)
- Prokinetic drugs like metoclopramide and cisapride are used in conjunction with other measures in patients who are suffering from nausea or bloating in addition to heartburn. (web-gerd.com)
Erythromycin6
- Erythromycin, a macrolide antibiotic, has been shown to have gastric prokinetic effects and has been proposed as an alternative therapeutic option for diabetic gastroparesis. (nih.gov)
- The purpose of the present study was to compare the effects of erythromycin (250 mg 60 min before meals) and cisapride (10 mg 30 min before meals) on gastric emptying of healthy subjects and insulin-dependent diabetics. (nih.gov)
- Three scintigraphic studies, spaced at least 3 days apart, were carried out on each subject, basally and after erythromycin or cisapride. (nih.gov)
- Erythromycin may represent an effective therapeutic alternative to more established forms of treatment in patients with diabetic gastroparesis, especially when other drugs have failed. (nih.gov)
- Other molecules, including macrolides such as mitemcinal and erythromycin, have affinity for the motilin receptor where they act as agonists resulting in prokinetic properties. (wikipedia.org)
- However, Cisapride can cause life threatening cardiac arrhythmias, especially in patients with cardiac or renal diseases, those with prolonged QT interval on their EKG, patients who are on anti-fungal, anti-viral and Mycin types of antibiotics like erythromycin and clarithromycin. (web-gerd.com)
Mosapride2
- Some of these prokinetic agents, such as mosapride and cisapride, classic benzamides, have only moderate affinity for 5HT4 receptors. (wikipedia.org)
- The researchers add that acupuncture is effective without significant adverse effects whereas mosapride may cause loose stools, dizziness, headaches, insomnia, abdominal pain, and borborygmus. (affinityacupuncture.com)
Gastroparesis1
- Diabetic gastroparesis is a disabling condition with no consistently effective treatment. (bmj.com)
Domperidone2
- AEPIO DSR CAPSULE is a combination of Domperidone and Esomeprazole which belongs to the group of medicines called Prokinetic Drugs and Proton pump inhibitors respectively. (netmeds.com)
- Domperidone is a prokinetic medicine with anti-emetic properties. (netmeds.com)
Propulsid3
- Propulsid (cisapride) is a "prokinetic" agent that increases muscle contractions of the lower esophagus and the lower esophagus sphincter used to treat gastric reflux (the regurgitation of stomach acid into the esophagus), which is usually experienced as heartburn . (rxlist.com)
- Our Propulsid (cisapride) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
- Cisapride (Propulsid) causes less diarrhea and extra-pyramidal side effects than Metoclopropamide (Reglan). (web-gerd.com)
Drugs13
- However, its efficacy has not yet been compared with that of other prokinetic drugs. (nih.gov)
- Activation of a wide range of serotonin receptors by serotonin itself or by certain prokinetic drugs results in enhanced gastrointestinal motility. (wikipedia.org)
- Other prokinetic drugs may increase acetylcholine concentrations by stimulating the M1 receptor which causes acetylcholine release, or by inhibiting the enzyme acetylcholinesterase which metabolizes acetylcholine. (wikipedia.org)
- Researchers are examining ways to improve reflux control by developing better acid suppressors with more rapid onsets and longer durations, by testing prokinetic drugs, and by searching for ways to reduce esophageal sensitivity. (pharmacytimes.com)
- We conclude that the isolated perfused pig intestine is an effective model for studying the pharmacological effects of drugs and their routes of delivery. (annals.edu.sg)
- The direct intraluminal (IL) administration of drugs into the intestine may have an important regional action and therefore clinical implications in the effective management of functional bowel disorders. (annals.edu.sg)
- We have previously published findings in the anaesthetised in vivo pig, that cisapride and mebeverine when infused IL into the sigmoid colon resulted in a pharmacological dose dependent responses, which was more efficacious and localised than systemic administration of these drugs. (annals.edu.sg)
- While it was originally developed for use in humans, cisapride has since been withdrawn from the human market in many countries due to the risk of reactions with other drugs causing heart arrhythmias and death. (wagwalking.com)
- Many of these patients also took drugs expected to increase cisapride blood levels by inhibiting the cytochrome P450 3A4 enzymes that metabolize cisapride. (rxlist.com)
- Cisapride is contraindicated in patients taking any of these drugs. (rxlist.com)
- QT prolongation, torsades de pointes (cisapride removed from us market) (sometimes with syncope), cardiac arrest, and sudden death have been reported in patients taking cisapride without the above-mentioned contraindicated drugs. (rxlist.com)
- Protonix , the currently least expensive, and in my clinical experience the least effective of PPIs, is reported to have the least effect on other drugs metabolized by the cytochromeP-450. (web-gerd.com)
- AEPIO DSR CAPSULE is effective in treating peptic ulcer caused either due to stomach infection (H. pylori infection) or due to prolong use of non-steroidal anti-inflammatory drugs (such as ibuprofen, Aceclofenac etc. (netmeds.com)
Esophagus1
- Use of prokinetics along with Nexium sachets may provide better relief for GERD for children, as excess stomach acid is expelled more quickly and there's less chance of it burning or irritating the esophagus. (canadadrugsdirect.com)
Receptors1
- As such, the relatively poor selectivity profile of cisapride versus other receptors (especially hERG [human ether-a-go-go K+] channels) contributes to its potential to cause cardiac arrhythmias. (wikipedia.org)
Cardiac2
- metoclopramide has been associated with extrapyramidal side effects and movement disorders, and cisapride with serious cardiac events. (pharmacytimes.com)
- Serious cardiac arrhythmias including ventricular tachycardia, ventricular fibrillation, torsades de pointes, and QT prolongation have been reported in patients taking cisapride. (rxlist.com)
Intestinal3
- Isolated perfused segments of pig ileum and sigmoid colon were used as an extrinsically denervated model of intestinal fluid propulsion to compare the effects of intraluminal (IL) with intraarterial (IA) administration of cisapride and mebeverine. (annals.edu.sg)
- Do not give cisapride for dogs to pets who are allergic to the drug or have an intestinal obstruction or perforation. (wagwalking.com)
- if necessary, these can be followed by intestinal secretagogues and/or prokinetic agents. (medscape.com)
Gastric1
- PPIs permanently inhibit proton pump and suppress gastric acid for several days, not taking it daily still effective. (web-gerd.com)
Stomach1
- As a result, cisapride treats vomiting caused by megaesophagus, as well as a range of other conditions associated with the stomach emptying too slowly. (wagwalking.com)
Constipation4
- Lactobacillus reuteri in infants and Lactobacillus casei and Bifidobacterium breve in children have been found to be effective in the treatment of constipation. (wikipedia.org)
- Chengdu University of Traditional Chinese Medicine researchers find true acupuncture more effective than sham acupuncture for the relief of constipation. (affinityacupuncture.com)
- Chengdu University of Traditional Chinese Medicine) conclude that acupuncture is safe and effective for the treatment of functional constipation, often referred to as chronic idiopathic constipation (CIC). (affinityacupuncture.com)
- In a prior meta-analysis, acupuncture had a 72.8% total effective rate for the treatment of constipation. (affinityacupuncture.com)
Significantly1
- IL cisapride produced a dose-dependent response in the dose range 1 × 10 -9 M to 3 × 10 -1 & l-3 × 10 -7 M in the ileum, and 3 × 10 -11 to 3 × 10 -9 M in the colonic segments, IL cisapride was significantly more effective than IA delivery of equivalent doses. (annals.edu.sg)
Dose1
- The starting dose of cisapride is one 10 mg tablet or 10 ml of the suspension 4 times daily at least 15 minutes before meals and at bedtime. (rxlist.com)
Functional1
- The findings from FDSU24 conclusively reaffirm the safety and tolerability profile of FDgard as an effective, safe, and well-tolerated option in the management of Functional Dyspepsia, where few options are available. (pharmiweb.com)
Agents3
- Most prokinetic agents are grouped under the Anatomical Therapeutic Chemical Classification System (a World Health Organization drug classification system), as ATC code A03F. (wikipedia.org)
- We propose that analogues of ghrelin may represent a new class of prokinetic agents. (bmj.com)
- The development of new and effective pharmacologic agents for the treatment of ACPO would substantially reduce the need for surgical intervention, which is associated with considerable morbidity and mortality. (medscape.com)
Dosage4
- Keep reading for more information on the dosage, efficacy, and drug interactions of cisapride for dogs. (wagwalking.com)
- In terms of dosage amount and cisapride toxicosis, severe clinical signs have been reported in acute exposures as low as 18 mg per kg . (wagwalking.com)
- The cost of cisapride for dogs depends on the dosage strength and form prescribed. (wagwalking.com)
- Some studies suggest that there is evidence for an association between paracetamol during pregnancy and autism spectrum disorder and attention deficit hyperactivity disorder, while making clear further research is required to establish any causal link, which has prompted some calls to limit its use in pregnancy to the lowest effective dosage for the shortest possible time. (worldsbest.rehab)
Pregnancy1
- During pregnancy, cisapride should be taken only if prescribed. (rxlist.com)
Frequency2
- A prokinetic agent (also gastroprokinetic agent, gastrokinetic agent or propulsive) is a type of drug which enhances gastrointestinal motility by increasing the frequency or strength of contractions, but without disrupting their rhythm. (wikipedia.org)
- True acupuncture had better frequency of bowel movement scores, difficulty of bowel movement scores, and a higher total effective rate. (affinityacupuncture.com)
Conjunction1
- Cisapride is one of the more common Prokinetics that a physician may recommend be used in conjunction with Nexium sachets. (canadadrugsdirect.com)
Intestine2
- SSRIs have been found to have prokinetic actions on the small intestine. (wikipedia.org)
- These effects make the small intestine more effective at propelling food, bacteria and luminal secretions into the colon. (wikipedia.org)
Tablet1
- Cisapride is available as a compounded tablet, capsule, or liquid . (wagwalking.com)
Clinical1
- However, according to the Merck Veterinary Manual , there haven't been reports of similar adverse reactions to the clinical use of cisapride in veterinary medicine. (wagwalking.com)
Therapies1
- SYNOPSISThere is not enough evidence that anti-reflux therapies are effective in treating hoarsenessHoarseness is a common disorder. (fliphtml5.com)
Side effects2
- If your dog has been prescribed cisapride, it's important to know how the drug works and what potential side effects it could have on your dog. (wagwalking.com)
- Consult your veterinarian if you're concerned about any of the side effects of cisapride. (wagwalking.com)
Disorders1
- Most patients had disorders that may have predisposed them to arrhythmias with cisapride. (rxlist.com)
Drug2
- Cisapride for dogs is a prokinetic drug that supports the proper functioning of the digestive tract. (wagwalking.com)
- A prokinetic drug, cisapride speeds up the passage of food through the digestive tract. (wagwalking.com)
Agent1
- BENZTROPINE MESYLATE TABLETS USP is a powerful anticholinergic agent which is mainly effective in relieving tremor and rigidity. (sgpharma.com)
Longer1
- Beacause of this side-effect, Cisapride is no longer availabe in the US. (web-gerd.com)
Research1
- Research into the prokinetic effects of probiotics on the gastrointestinal tract has also been conducted in humans. (wikipedia.org)
Group1
- The active sham control group had a 67.65% total effective rate compared with the 82.56% total effective rate of the true acupuncture group. (affinityacupuncture.com)
Total effective rate2
- Acupuncture plus herbs produced a high total effective rate and very low relapse rate. (affinityacupuncture.com)
- In this study, the classic front mu and back shu combination achieved an 82.56% total effective rate. (affinityacupuncture.com)
Lower1
- Studies show that cisapride is more effective than metoclopramide hydrochloride at increasing lower esophageal sphincter resting pressure . (wagwalking.com)
Safe1
- In the short term, paracetamol is safe and effective when used as directed. (worldsbest.rehab)