AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesInformation ScienceHealth Care
BupivacaineAnesthetics, LocalAnesthesia, SpinalAnalgesia, EpiduralAmidesAnalgesia, ObstetricalAnesthesia, EpiduralAnesthesia, ObstetricalNerve BlockLidocainePain, PostoperativeAnesthesia, CaudalEtidocaineAnesthesia, LocalSufentanilFentanylAnesthetics, CombinedDouble-Blind MethodAdjuvants, AnesthesiaMepivacaineInjections, SpinalCesarean SectionCarticaineAnalgesics, OpioidPain MeasurementAnalgesiaStereoisomerismSensationSubarachnoid SpaceMyofascial Pain SyndromesTrigger PointsPain, ReferredAcupuncture AnalgesiaEncyclopedias as TopicPain ThresholdArthritis, ReactiveUrethritisArthritisConjunctivitisArthritis, RheumatoidArthritis, InfectiousConjunctivitis, Bacterial
SensorcaineLidocaineEXPARELInjectionEpinephrine0.25Formulation of bupivacaineMepivacaineAnesthesiaHyperbaric bupivacaineInfiltrationAnestheticsAdverseSystemicDrugsSpinalAnalgesiaClinicalConcentrationLocalDosesSympatheticPainConductionAnesthetic effectsDurationResuscitationSolutionSide effectsSurgicalMedicationPlasmaProcessesSiteTypeKneePatientShoulder
Sensorcaine2
Lidocaine14
EXPAREL10
  • A sustained-release DepoFoam injection formulation of bupivacaine (EXPAREL, 15 mg/mL) is currently being investigated for postsurgical analgesia via peripheral nerve block (PNB). (hindawi.com)
  • Single-dose toxicology studies of EXPAREL (9, 18, and 30 mg/kg), bupivacaine solution (Bsol, 9 mg/kg), and saline injected around the brachial plexus nerve bundle were performed in rabbits and dogs. (hindawi.com)
  • The only EXPAREL-related effect seen was minimal to mild granulomatous inflammation of adipose tissue around nerve roots (8 of 24 rabbits and 7 of 24 dogs) in the brachial plexus sites. (hindawi.com)
  • EXPAREL (bupivacaine liposome injectable suspension) is a sterile suspension of multivesicular liposomes using proprietary DepoFoam formulation technology to release bupivacaine over several days. (hindawi.com)
  • Specifically, the study was designed to assess whether EXPAREL did not produce nerve damage in the setting of peripheral nerve block by comparison with unencapsulated bupivacaine or saline control. (hindawi.com)
  • A lot changed in 2011 with the US Food and Drug Administration approval of a novel formulation of bupivacaine, called EXPAREL® (bupivacaine liposome injectable suspension). (lplasticsurgery.com)
  • Unlike standard bupivacaine, which produces a 6- to 8-hour analgesic effect, the bupivacaine in EXPAREL is encased in liposomes which break down over time to extend the release of the active drug over a 3-day period. (lplasticsurgery.com)
  • However, EXPAREL ® behaves differently from traditional anesthetics, including bupivacaine HCl, in a few important ways. (lplasticsurgery.com)
  • For starters, the liposomal composition makes EXPAREL more viscous than standard bupivacaine, so once placed, EXPAREL remains local and does not disperse. (lplasticsurgery.com)
  • Local infiltration of Exparel® (Pacira BioSciences), a newly marketed encapsulated liposomal bupivacaine preparation, can be an excellent postoperative choice. (drogunlana.com)
Injection6
  • Cortisone may not begin working for several days following the injection, but the effects can last for months. (scoliosisinstitute.com)
  • The injection places a concentrated dose of local anaesthetic that offers immediate pain relief and steroid which provides strong anti-inflammatory effects. (activesolutions.physio)
  • The purpose of this investigation was to determine the fate of bupivacaine following a single subcutaneous injection. (vin.com)
  • Plasma concentration of bupivacaine (µg/ml) following subcutaneous injection of 2 mg/kg of a 0.5% solution in female mallard ducks. (vin.com)
  • Accidental injection of intravenous bupivacaine. (revistaanestesiar.org)
  • Successful resuscitation after inadvertent intravenous injection of bupivacaine in an adolescent. (revistaanestesiar.org)
Epinephrine9
  • The aim of this study was to determine the local anesthetic-sparing efficacy of epidural epinephrine by its effect on the MLAC of bupivacaine. (silverchair.com)
  • After lumbar epidural catheter placement, 20 ml bupivacaine (n = 35) or bupivacaine with epinephrine 1:300,000 (n = 35) was administered. (silverchair.com)
  • The lowest maternal blood pressure was significantly lower in the bupivacaine-epinephrine group (P = 0.03). (silverchair.com)
  • There were statistically significant reductions in fetal heart rate (P = 0.011) in the bupivacaine-epinephrine group that were not clinically significant. (silverchair.com)
  • The addition of epidural epinephrine 1:300,000 (66 microg) resulted in a significant 29% reduction in the MLAC of bupivacaine. (silverchair.com)
  • In our March 20, 2002 newsletter, we wrote about a 15-year-old boy with a history of malignant hyperthermia who received the contents of an unlabeled syringe that a surgeon thought contained MARCAINE (bupivacaine) with epinephrine. (ismp.org)
  • What Form(s) Does Bupivacaine-Epinephrine Come In? (optionrx.com)
  • Do not use it if you had an allergic reaction to bupivacaine or similar medicines, or epinephrine. (optionrx.com)
  • Some medicines can affect how bupivacaine/epinephrine works. (optionrx.com)
0.251
  • Blood samples of 1.0 ml were drawn from the jugular vein prior to bupivacaine administration (0 hour) and at 0.25, 0.5, 1, 2, 3, 4, 6, and 12 hours after administration. (vin.com)
Formulation of bupivacaine1
  • A formulation of bupivacaine that provides prolonged release of the active ingredient after a single administration would simplify pain management in the postoperative period and eliminate the undesired peak plasma concentrations as a result of excessively high concentrations and reduce the risk of local and systemic reactions [ 7 ]. (hindawi.com)
Mepivacaine1
  • Do not take Lidoderm if you are allergic to Lidoderm or to any of its ingredients or you are allergic to any other local anesthetics such as bupivacaine (Marcaine), etidocaine (Duranest), mepivacaine (Carbocaine, Prolocaine), or prilocaine (Citanest). (rxwiki.com)
Anesthesia1
Hyperbaric bupivacaine1
  • Spinal anaesthesia was induced by intrathecal administration of 2.8 ml of 0.5% hyperbaric bupivacaine (14 mg) in the control group and with 2.6 ml of 0.5% hyperbaric bupivacaine (13 mg) and 10 µg fentanyl (0.2 ml) in the experimental group. (druglib.com)
Infiltration1
  • The opioid based analgesics and land mark techniques have undesirable consequences, regional analgesia technique with ultrasound requires resource and expertise while different wound infiltration techniques are new techniques with minimal side effect and easy to administer. (researchsquare.com)
Anesthetics4
  • Birds may be more sensitive to the toxic effects of local anesthetics compared to mammals, but the pharmacokinetics of bupivacaine are unknown in birds. (vin.com)
  • The absorption time (T ½abs =13.9 min) appeared to be shorter than the elimination time (T ½elim =28.1 min) which may, in part, explain why birds are susceptible to toxic effects of local anesthetics. (vin.com)
  • The appearance of subsequent high levels of plasma bupivacaine is unique to this study and may also contribute to the apparent avian sensitivity to toxic effects of local anesthetics. (vin.com)
  • 9,11 Birds may be more sensitive to the toxic effects of local anesthetics compared to mammals, as higher doses (3.5-4.5 mg/kg) 15 produce toxic effects in dogs compared with birds (2.7-3.3 mg/kg) 11 . (vin.com)
Adverse4
  • Medicinal quantities of concentrates, extracts or tinctures, especially of certain herbs, are more likely to have an adverse effect on NA and TT than the plants from which they are derived. (helminthictherapywiki.org)
  • 6-8 Potential adverse effects include decreased uterine activity, 9,10 prolongation of labor, 2,8,11 and increased incidence of motor block. (silverchair.com)
  • The patient was monitored but experienced no serious adverse effects. (ismp.org)
  • With large volume resuscitation, greater than 2 L, this should be an informed decision individualized by factors such as patient chemistries, estimated volume of resuscitation, potential for adverse effects of the solution, as well as facility and physician preference. (preparedphysician.com)
Systemic1
  • From a systemic standpoint, high doses of bupivacaine may be associated with a wide range of systemic complications, such as central nervous and cardiovascular effects [ 6 ]. (hindawi.com)
Drugs3
  • The first is that veterinarians have discovered over the years that cats are more sensitive to a number of pain-reducing drugs that dogs and us humans take with few, or no side effects. (2ndchance.info)
  • The pharmacology of individual drugs can be best understood in relation to the physiologic functions they affect and their common clinical applications. (nursekey.com)
  • Additive Effect Occurs when a second drug with properties similar to the first is added to produce an effect equal to the algebraic sum of the effects of the two individual drugs. (nursekey.com)
Spinal3
  • Clinical effects of intrathecal fentanyl on shoulder tip pain in laparoscopic total extraperitoneal inguinal hernia repair under spinal anaesthesia: a double-blind, prospective, randomized controlled trial. (druglib.com)
  • OBJECTIVE: The study evaluated the clinical intraoperative effects of intrathecal administration of fentanyl on shoulder tip pain in patients undergoing laparoscopic total extraperitoneal inguinal hernia repair (TEP) under spinal anaesthesia. (druglib.com)
  • To prolong the pain-relieving effect for labor, epidurals are now being co-administered with spinals, as a combined spinal epidural (CSE). (sarahbuckley.com)
Analgesia1
Clinical1
  • 8.- Gristwood R, Bardsley H, Baker H, Dickens J. Reduced cardiotoxicity of levobupivacaine compared with racemic bupivacaine (Marcaine): new clinical experience. (revistaanestesiar.org)
Concentration3
  • The effects of a substance can vary considerably depending on factors such as quantity, concentration and, in the case of herbal extracts, the part of the plant used. (helminthictherapywiki.org)
  • The concentration of bupivacaine was determined by the response of the previous patient in that group to a higher or lower concentration using up-down sequential allocation. (silverchair.com)
  • Six and 12 hour samples represent high levels in plasma bupivacaine concentration. (vin.com)
Local5
  • Bupivacaine is a local anesthetic/analgesic widely used in the perioperative and postsurgical settings. (hindawi.com)
  • It is commonly injected along with a local anesthetic in order to reduce inflammation in the affected areas. (scoliosisinstitute.com)
  • Cortisone injections commonly are a combination of a steroid (Celstone or Kenacort) and a local anaesthetic (Bupivacaine or Marcaine). (activesolutions.physio)
  • The effects of modern intravenous local analgesics on respiration during partial neuromuscular block in man. (revistaanestesiar.org)
  • How Novocain Affects Patients Procaine is a type of anesthetic used to produce local or regional numbing, often used during oral surgery. (withpower.com)
Doses1
  • Doses higher than 75 mg do not increase the therapeutic effects. (medscape.com)
Sympathetic1
  • I block uptake of norepi by adrenergic neurons causing sympathetic and CNS effects. (freezingblue.com)
Pain7
  • Bupivacaine solutions have been used for many years by multiple routes for the relief of postoperative pain [ 1 ]. (hindawi.com)
  • Trigger points affecting the surrounding muscles cause the tenderness and pain. (bayshoremedicalgroup.com)
  • Injections provide a therapeutic effect in that they can provide temporary relief from pain. (scoliosisinstitute.com)
  • It is slower to take effect, but it lasts longer, giving the patient more relief from pain. (scoliosisinstitute.com)
  • This dose directly at the site of injury makes it a very potent treatment often with immediate pain relieving effects……a miracle cure. (activesolutions.physio)
  • Help me understand how pain is affecting you right now. (easynotecards.com)
  • The Marchand Institute is pleased to announce that their breakthrough paper, "A Systematic Review and Meta-Analysis of Intraperitoneal Bupivacaine in Laparoscopic Gynecologic Surgery" has been published in this month's Journal of Pain Research. (marchandinstitute.org)
Conduction1
  • 14.- Lenfant F, Volot F, Freysz M, Wilkening M. Le flumazenil corrige-t-il les troubles de la conduction intracardiaque induits par l'injection intraveineuse accidentelle de bupivacaine? (revistaanestesiar.org)
Anesthetic effects1
Duration1
  • The duration of effect is approximately 75 minutes. (medscape.com)
Resuscitation1
  • 16.- Favier JC, da Conceiçao M, Fassassi M, Allanic L, Steiner T, Pitti R. Successful resuscitation of serious bupivacaine intoxication in a patient with pre-existing heart failure. (revistaanestesiar.org)
Solution4
  • The light rotational effect is determined in solution. (pharmacology2000.com)
  • Brachial plexus blockade may require dispersion of a relatively large volume of bupivacaine in solution to accomplish blockade of the entire plexus. (hindawi.com)
  • Bupivacaine (2 mg/kg of a 0.5% solution) was given subcutaneously to eight adult female mallard ducks. (vin.com)
  • Ducks were given bupivacaine (2 mg/kg, 0.4 ml/kg of a 0.5% solution, Marcaine, Sanofi Winthrop, Chatham, Ontario, Canada) subcutaneously in the ventral abdomen, between 0900 and 1100 hours. (vin.com)
Side effects6
  • Did you experience many side effects while taking this drug? (rxwiki.com)
  • Call your doctor for medical advice about side effects. (rxwiki.com)
  • You may report side effects to the FDA at 1-800-FDA-1088. (rxwiki.com)
  • Common side effects of Lidoderm include burning, discomfort, redness, or swelling of the skin where the patch is applied. (rxwiki.com)
  • The number of injections administered over time may be limited due to potential side effects and the desire to avoid the overuse of steroids. (scoliosisinstitute.com)
  • What are complications and side effects of trigger point injections? (medicinenet.com)
Surgical1
  • Factors that do not affect healing outcomes are the type of surgical technique used or the use of platelet-rich plasma. (moreaupt.com)
Medication1
  • Do not drive or operate heavy machinery until you know how this medication affects you. (rxwiki.com)
Plasma1
  • Concentrations of bupivacaine in plasma were determined by high-performance liquid chromatography. (vin.com)
Processes1
  • Epidurals significantly interfere with some of the major hormones of labor and birth, which may explain their negative effect on the processes of labor. (sarahbuckley.com)
Site1
  • The most common side effect of Lidoderm is an application site reaction. (rxwiki.com)
Type1
  • Bupivacaine (also known as Marcaine) is another type of anesthetic that a doctor can use. (scoliosisinstitute.com)
Knee1
  • Diffuse loss of the articular space is characteristic and frequently affects the small joints of the foot, hand, wrist, knee, and ankle. (medscape.com)
Patient1
  • The aminophylline (used for emergency reversal of the effects of dipyridamole) was not needed, and the unlabeled syringe was left in the room with the patient. (ismp.org)
Shoulder1
  • Any injury that affects the shoulder is going to also affect the scapula. (moreaupt.com)