The pathologic effect of AGEs is caused by its ability in inducing oxidative stress and inflammation through binding with the receptor on the cell surface and body protein cross-linking, thus altering the cell structure and function. (hindawi.com)
Epithelial3
We demonstrated adhesive and significant pathogen inhibitory efficacies among the swine intestinal L. amylovorus strains studied, pointing to their potential use as probiotic feed supplements, but no independent role could be demonstrated for the major S-layer proteins in adherence to epithelial cells. (biomedcentral.com)
The results indicate that many intestinal bacteria may coexist with and confer benefits to the host by mechanisms not attributable to adhesion to epithelial cells or mucus. (biomedcentral.com)
Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. (lookformedical.com)
Pathogen1
Adhesiveness to intestinal epithelium, beneficial immunomodulating effects and the production of pathogen-inhibitory compounds are generally considered as beneficial characteristics of probiotic organisms. (biomedcentral.com)
Intracellular1
Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and is thought to regulate lipid metabolism in response to phosphorylation by protein kinase A (PKA). (uci.edu)
Regulate1
Tenascins are a family of glycoproteins found primarily in the extracellular matrix of embryos where they help to regulate cell proliferation, adhesion and migration. (biomedcentral.com)
Bacterial2
In brain tissue, primary microglia cells showed an enhanced response towards lysates from bacteria lacking capsules and pneumolysin as they moved rapidly to areas with an abundance of bacterial factors. (biomedcentral.com)
Furthermore, we demonstrate for the first time that the bacterial capsule affects cellular behaviors such as motility and taxis. (biomedcentral.com)
Peripheral2
Recurrent, unabated ischemia is the underlying cause of tissue loss in peripheral arterial disease (PAD) or peripheral vascular disease (PVD). (frontiersin.org)
In T2DM, peripheral tissue insulin sensitivity and β -cell pancreas insulin secretion are disrupted. (hindawi.com)
Protein1
This pore-forming toxin has been reported as an important protein that mediates tissue damage promoted by S. aureus . (nature.com)
Mechanisms1
Diabetes mellitus affects the skin with several mechanisms where hyperglycemia and advanced glycation end-products (AGEs) are the two main factors. (hindawi.com)
Host1
As adhesion to host tissues is essential for many gastro-intestinal pathogens, the paradigm of competitive exclusion through competition for binding sites has evolved. (biomedcentral.com)
Growth2
We report here that myricetin, but not its glycosylated form, can remarkably decrease the production of several S. aureus virulence factors, including adhesion, biofilm formation, hemolysis and staphyloxanthin production, without interfering with growth. (nature.com)
The culture supernatants of all of the strains exerted inhibitory effects on the growth of E. coli , Salmonella , Listeria and Yersinia , and a variable, strain-dependent induction was observed of both pro- and anti-inflammatory cytokines in human DCs. (biomedcentral.com)
Factors3
Human-perceived temperature (HPT) describes the joint effects of multiple climatic factors such as temperature and humidity. (bvsalud.org)
We utilized live imaging and immunostaining of glial cells in dissociated and acute brain slice cultures to study the effect of pneumococcal factors, including the cholesterol-dependent cytolysin pneumolysin and the pneumococcal capsule, on microglial motility and taxis. (biomedcentral.com)
In this work, we examined the effect of Streptococcus pneumoniae and its major pathogenic factors (the capsule and PLY) on microglial tissue migratory behavior in acute brain slices and in primary cultures. (biomedcentral.com)
Highly2
However, the effects of β1 are highly dependent on the experimental system in which they are studied, and different effects on the kinetics and voltage dependence of gating of brain sodium channels are observed on expression in Xenopus oocytes, Chinese hamster lung and ovary cells, and human embryonic kidney cells (Isom et al. (jneurosci.org)
Apart from the pro-inflammatory effects of PLY on microglia [ 14 ], the migratory behavior of this highly motile surveillance phagocyte of the brain in the presence of pneumococcal infection remains unknown. (biomedcentral.com)
Expression4
Certain studies show that P. gingivalis lipopolysaccharide (LPS) could induce the expression of intercellular adhesion molecule 1 and vascular cell adhesion molecule 1 in human umbilical vein endothelial cells (HUVECs) ( 13 , 14 ), which significantly enhances trans-endothelial migration of inflammatory cells. (spandidos-publications.com)
Sodium channel β1 subunits modulate α subunit gating and cell surface expression and participate in cell adhesive interactions in vitro . (jneurosci.org)
β1 subunits affect sodium channel gating and cell surface expression when expressed in heterologous cells in vitro . (jneurosci.org)
These results suggest that effects of β1 on sodium channel gating are dependent on the genetic background and signal transduction pathways present in the cell type used in heterologous expression and emphasize the importance of analyzing the effects of β1 in vivo . (jneurosci.org)
Damage1
Although skeletal muscle is the major carnosine depot, the role of the dipeptide in preventing skeletal muscle injury has not been studied, and it is unclear whether carnosine affects ischemic damage or post injury events underlying wound healing and tissue angiogenesis. (frontiersin.org)
Loss1
To investigate the effects of loss of β1 function in vivo , we have used gene-targeting methods to produce β1(-/-) mice, and we have analyzed their neuronal phenotypes. (jneurosci.org)
Cells2
In contrast, pretreatment of hypoxic C2C12 cells with methylcarcinine, a carnosine analog, lacking Fe 2+ chelating capacity, had no effect on HIF-1α levels and VEGF release. (frontiersin.org)
The effects on microglia were not mediated by astrocytes because pure microglial cells responded to various pneumococcal lysates similarly with distinct cell shape changes as seen in mixed cultures. (biomedcentral.com)
Response1
β1 also recruits ankyrin to the plasma membrane at sites of cell-cell contact in response to homophilic cell adhesion (Malhotra et al. (jneurosci.org)
Lipid1
Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and is thought to regulate lipid metabolism in response to phosphorylation by protein kinase A (PKA). (uci.edu)
Molecules2
Synapses are highly specialized intercellular junctions organized by adhesive and scaffolding molecules that align presynaptic vesicular release with postsynaptic neurotransmitter receptors. (rupress.org)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Liver2
PMID- 5097518 TI - Effects of -amanitin on mouse and rat liver cell nuclei. (nih.gov)
Mitochondrial and peroxisomal palmitoyl-CoA (16:0-CoA) oxidation rates in the liver homogenates were significantly higher in rats fed linseed and perilla oils than in those fed saturated fats and safflower oil. (iospress.com)
Cellular1
It is well known that carbohydrates play a vital role in cellular recognition and adhesive processes. (auburn.edu)
PMID7
PMID- 5097488 TI - The therapeutic effect of dithiocarb (DTC) and potassium chloride on experimental thallium poisoning in guinea pigs. (nih.gov)
PMID- 5097489 TI - Effect of caffeine and phenacetin on thiopental-induced hypothermia and anesthesia. (nih.gov)
PMID- 5097495 TI - Post-mortem changes in tissue levels of sodium secobarbital. (nih.gov)
PMID- 5097498 TI - 52 factors that can affect blood glucose levels. (nih.gov)
PMID- 5097510 TI - Base lines for measuring adverse effects of air pollution: some evidence for weather effects on mortality. (nih.gov)
PMID- 5097516 TI - Polyploidy and gene dosage effects on chloroplasts of fern gametophytes. (nih.gov)
PMID- 5097525 TI - Animalizing effects of Evans blue in embryos of Arbacia punctulata. (nih.gov)
Investigate2
To investigate the possibility of hepatoprotective effect of Nigella sativa (NS) in INH-induced hepatotoxicity. (ijp-online.com)
Therefore, this study will investigate the effects of endogenous and soluble PSA-NCAM on synaptic glutamate receptors. (auburn.edu)
Quality2
Atopic dermatitis (AD) is a chronic, recurrent, inflammatory skin disorder, often accompanied by severe pruritus, which severely affects the life quality of patients. (nature.com)
Background The care of people with skin wounds is an important health problem, that affect the quality of life of patients and their families, and has a great socioeconomic impact. (bvsalud.org)
Study1
Synaptosomes and membrane fractions from rat hippocampi and recombinant receptors, respectively, were used in this study to evaluate the mechanistic effects of PSA on AMPA receptors and the NR2 subunit containing NMDA receptor subtypes?NR2A, NR2B, and NR2A/NR2B, specifically. (auburn.edu)
Activity2
Our results indicate that PSA potentiates synaptic AMPA receptor properties and that cyclothiazide, a known inhibitor of AMPA receptor desensitization does not occlude PSA effects on AMPA receptor activity. (auburn.edu)
Dietary fats rich in \alpha -18:3-CoA relative to safflower oil did not affect the hepatic activity of fatty acid synthase and glucose 6-phosphate dehydrogenase. (iospress.com)
Levels1
Tissue-specific expression analysis indicated high expression levels of dy in the epidermis, head and fat body of late-stage larvae. (sdbonline.org)
Skin2
The test substance was held in contact with skin with a porous gauze dressing and bandaged with non-irritating adhesive tape up to 24 h. (europa.eu)
We show that the adhesive, self-healing and antimicrobial hydrogel is suitable for the unique scratching and bacterial environment of AD skin. (nature.com)