Effect phosphorylation. Medical search. Frequent questions

The co-occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific. (duke.edu)
The main contribution of this work has been to show that the control of mitochondrial metabolic fluxes can be shared among several steps of the oxidative phosphorylation process, and that this distribution can vary according to the steady state and the tissue. (nih.gov)
It was therefore assumed that cancer cells were generating energy using glycolysis rather than mitochondrial oxidative phosphorylation, and that the mitochondria were dysfunctional. (researchgate.net)
reduced oxidative phosphorylation. (cdc.gov)
are structures within cells that use oxygen to convert the energy from food into a form cells can use through a process called oxidative phosphorylation . (medlineplus.gov)
These proteins perform the steps of oxidative phosphorylation. (medlineplus.gov)
Cellular respiration (oxidative phosphorylation) occurs in the mitochondria, where a series of enzymes catalyze the transfer of electrons to molecular oxygen and the generation of energy-storing adenosine triphosphate (ATP). (msdmanuals.com)
Tissues with a high energy demand (eg, brain, nerves, retina, skeletal and cardiac muscle) are particularly vulnerable to defects in oxidative phosphorylation. (msdmanuals.com)
Increase in the lactate:pyruvate ratio distinguishes oxidative phosphorylation defects from other genetic causes of lactic acidosis. (msdmanuals.com)

β-PMA-induced phosphorylation of SERT occurs initially on serine residues(s) and then on threonine residue(s). (aspetjournals.org)
Phosphorylation on tyrosine residues, which are localized on membrane proteins, stimulates a cascade of signaling pathways that control cell proliferation, migration, and adhesion. (wikipedia.org)
One of the regulatory mechanisms that modulate the Cdk5 kinase activity is phosphorylation of conserved residues ( Dhavan and Tsai, 2001 ). (frontiersin.org)
Cytokine binding to the cell surface leads to phosphorylation of the receptor complex by receptor associated Janus kinases (JAKs) at tyrosine residues. (nature.com)
Looking upstream the kinase cascade, the identity of the kinase (s) that brings about the phosphorylation of the tyrosine residues remains to be elucidated. (umass.edu)
Surprisingly, Src inhibitors down regulates the phosphorylation of serine/threonine residues that correlate on earlier events in the capacitation, as assayed by western blot with PKA substrates antibody. (umass.edu)

Two important classes of tyrosine kinase in tyrosine phosphorylation are receptor tyrosine kinase and nonreceptor tyrosine kinase. (wikipedia.org)
Binding of PLCγ to the activated receptor facilitates its efficient tyrosine phosphorylation by the RTK. (wikipedia.org)
Glutamate inputs activate Cdk5, which inhibits postsynaptic dopamine D1 receptor (D1R)-mediated signaling by phosphorylating DARPP-32 at Thr75 (Thr75-DARPP-32) in the striatum, since DARPP-32 with Thr75 phosphorylation (DARPP-32-pThr75) functions as an inhibitor of cAMP-dependent protein kinase A (PKA). (frontiersin.org)
Here, we show that in the mouse striatum, dopamine receptor stimulation negatively regulates phosphorylation of Tyr15-Cdk5 most likely through a D2R-mediated mechanism. (frontiersin.org)
Analysis of the primary protein structure of the human serotonin1B (5-HT1B) receptor reveals consensus sites for phosphorylation and a putative site for palmitoylation. (nih.gov)
This study investigated in a pancreatic alpha-cell line the effects of chronic exposure to palmitate on the insulin and IGF-I receptor (IGF-IR) and intracellular insulin pathways. (unict.it)
Insulin-stimulated insulin receptor phosphorylation was greatly reduced by exposure to palmitate. (unict.it)
Here we showed that social defeat stress enhanced plantar incision-induced AMPA receptor GluA1 phosphorylation at the Ser831 site in the spinal cord and greatly prolonged plantar incision-induced pain. (jneurosci.org)
In addition, stress hormones enhanced GluA1 phosphorylation and AMPA receptor-mediated electrical activity in the spinal cord. (jneurosci.org)
Therefore, spinal AMPA receptor phosphorylation contributes to the mechanisms underlying stress-induced pain transition. (jneurosci.org)
Here, we define a phosphorylation-dependent binding site on the receptor that mediates agrin-induced clustering. (jneurosci.org)
Together, these findings suggest that agrin-induced phosphorylation of the β subunit motif increases the stoichiometry of rapsyn binding to the AChR, thereby helping to stably cluster the receptor and anchor it at high density in the postsynaptic membrane. (jneurosci.org)
Microdomains or lipid rafts greatly affect the distribution of proteins and peptides in the membrane and play a vital role in the formation and activation of receptor/protein complexes. (frontiersin.org)
To analyze whether and how the quantitative ratio between receptor and rafts affects LRP6 phosphorylation and WNT/β-catenin pathway activation, we present a computational modeling study, that for the first time employs realistic raft numbers in a compartment-based pathway model. (frontiersin.org)
Our simulation experiments indicate, that for receptor/raft ratios smaller than 1, i.e., when the number of raft compartments clearly exceeds the number of pathway specific membrane proteins, we observe significant decrease in LRP6 phosphorylation and downstream pathway activity. (frontiersin.org)
Here, we apply computational modeling to analyze whether and how the quantitative ratio between receptor and rafts affects LRP6 phosphorylation and WNT/β-catenin pathway activation. (frontiersin.org)
It is hypothesized that arsenic's diabetogenic effect may be related to its ability to bind and inhibit the insulin receptor [Rossman 2007]. (cdc.gov)
Biphasic changes in airway epithelial cell EGF receptor binding and phosphorylation induced by components of hogbarn dust. (cdc.gov)
Epidermal growth factor receptor (EGFR) phosphorylation and activation has been identified as one important mediator of inflammatory cytokine release from these cells. (cdc.gov)
It has been suggested that the non receptor tyrosine kinase Src family is involved in the capacitation associated phosphorylation cascade. (umass.edu)
Effects of insulin and the glucagon-like peptide 1 receptor agonist liraglutide on the kidney proteome in db/db mice. (lu.se)

Ushiro and Cohen (1980) discovered the important role of the phosphorylation of tyrosine as a regulator of intracellular processes and revealed changes in the tyrosine kinase activity of proteins in mammalian cells. (wikipedia.org)
Tyrosine phosphorylation of certain target proteins is required for ligand stimulation of their enzymatic activity. (wikipedia.org)
The insulin-stimulated phosphoinositide 3-kinase (PI 3-kinase)/3-phosphoinositide-dependent kinase-1 (PDK1)/protein kinase B (PKB) kinase cascade is believed to play a critical role in metabolic control and cell survival, largely mediated through PKB phosphorylation of many proteins. (dundee.ac.uk)
15 The dynamic addition and removal of O-GlcNAc has been described for multiple cytoplasmic and nuclear proteins and it affects the function of various signaling molecules and transcription factors. (nature.com)
Acute RE and EE increased the phosphorylation of proteins in the Akt-mTOR-p70S6K pathway with comparatively minor differences between two exercise stimuli. (mcmaster.ca)
Phosphorylation of Akt-mTOR-p70S6K proteins was increased after 10 weeks of RE training but not by EE training. (mcmaster.ca)
Chronic RE or EE training modifies the protein synthetic response of functional protein fractions, with a shift toward exercise phenotype-specific responses, without an obvious explanatory change in the phosphorylation of regulatory signalling pathway proteins. (mcmaster.ca)
In this work we used a combination of two dimensional gel electrophoresis and mass spectrometry to identify proteins that undergo tyrosine phosphorylation during capacitation. (umass.edu)
Some of the identified proteins are the mouse orthologues of human sperm proteins known to undergo tyrosine phosphorylation. (umass.edu)
In addition to previously described proteins, we identified two testis-specific aldolases as substrates for tyrosine phosphorylation. (umass.edu)
Because of the importance of glycolysis for sperm function, we hypothesize that tyrosine phosphorylation of these proteins can play a role in the regulation of glycolysis during capacitation. (umass.edu)

The phosphorylation of MLC primarily regulates the force production and maintenance in the smooth muscle [ 6 ]. (hindawi.com)
We demonstrate that the phosphorylation of GLUT1 on S226 regulates glucose transport and propose that this modification is important in the physiological regulation of glucose transport. (elsevierpure.com)
Protein phosphorylation is a biological process that regulates most aspects of cellular life, and the enzymes that catalyze this reaction - protein kinases - constitute the largest family of enzymes encoded by the human genome. (lu.se)

These results indicate that regulation of synthase activity in the hepatocyte involves changes in phosphorylation at multiple sites. (umn.edu)
HDE stimulated EGFR phosphorylation at both 15 min and 18 hr in BEAS-2B cells and primary cells, but only at 15 min in H292 cells, indicating that the different EGFR binding changes among these cell types is likely related to their different time-dependent changes in phosphorylation. (cdc.gov)

Previously published data have shown an allele-specific variation in the in vitro binding of apolipoprotein E (apoE) to tau, which prompted the hypothesis that apoE binding may protect tau from phosphorylation, apoE3 being more efficient than apoE4. (ox.ac.uk)
We have, therefore, investigated the effects of apoE on tau phosphorylation in vitro by the proline-directed kinase, glycogen synthase kinase (GSK)-3 beta. (ox.ac.uk)
Through in vitro kinase assays, mass spectrometry, and phosphospecific antibodies, we identify serine 226 in GLUT1 as a PKC phosphorylation site. (elsevierpure.com)
Several naturally occurring, pathogenic mutations that cause GLUT1 deficiency syndrome disrupt this PKC phosphomotif, impair the phosphorylation of S226 in vitro, and block TPA-mediated increases in glucose uptake. (elsevierpure.com)
However, in vitro kinase activity of PKA showed no effect of Src inhibitors in the phosphorylation of the PKA specific substrate, kemptide. (umass.edu)
The in vitro effects of metronidazole on the production of reactive oxygen species by polymorphonuclear (PMN) cells were studied by means of nitroblue tetrazolium and luminol-dependent chemiluminescence. (who.int)

Beurel, E., Song, L. & Jope, R. S. Inhibition of glycogen synthase kinase-3 is necessary for the rapid antidepressant effect of ketamine in mice. (nature.com)
Protein kinase C (PKC)-mediated phosphorylation of SERT occurs on the plasma membrane during the initial phase of rapid transporter inhibition, and later, the phosphorylated SERT enters the intracellular pool. (aspetjournals.org)
The initial serine phosphorylation corresponded to the first phase of rapid inhibition mediated by changes in intrinsic activity and/or silencing of SERT. (aspetjournals.org)
The later phosphorylation on threonine residue(s) corresponded to the later phase of sustained inhibition mediated by an enhanced endocytosis of SERT. (aspetjournals.org)
The effect of promethazine was concentration dependent, with concentrations of 5-12 μM (mean 8μM) causing 50% inhibition. (johnshopkins.edu)
Comment: Mechanism: inhibition of phosphorylation process. (medscape.com)

Metabolic control analysis has often been used for quantitative studies of the regulation of mitochondrial oxidative phosphorylations (OXPHOS). (nih.gov)

Tyrosine phosphorylation is a key step in signal transduction and the regulation of enzymatic activity. (wikipedia.org)
Phosphorylation thus plays positive and negative roles in regulation of MRTF-A. (elifesciences.org)
Suggestion of a role for protein phosphorylation in the regulation of intestinal active NaCl transport was found by studying the effects of low concentrations of promethazine on Ca 2+ -calmodulin (CaM)-dependent protein phosphorylation of ileal microvillus membranes and on active ileal electrolyte transport. (johnshopkins.edu)
The similar, and unusual sensitivity to low concentrations of promethazine on ileal microvillus membrane phosphorylation increased by Ca 2+ -CaM and on ileal electrolyte transport is consistent with Ca 2+ -CaM-dependent microvillus membrane phosphorylation being involved in the regulation of active electrolyte transport in ileal absorptive cells. (johnshopkins.edu)
Cohen, ME, Sharp, GWG & Donowitz, M 1986, ' Suggestion of a role for calmodulin and phosphorylation in regulation of rabbit ileal electrolyte transport: Effects of promethazine ', American Journal of Physiology - Gastrointestinal and Liver Physiology , vol. 251, no. 5, pp. 14/5. (johnshopkins.edu)
Background: The phosphorylation of NF-kappaB inhibitor alpha (IκBα) protein is pivotal to the regulation of NF-κB transcription factor activity in the cell. (researchsquare.com)
Evidence presented in this review implicated that Rhizoma coptidis exerted beneficial effects on various diseases by regulation of NF-κB/MAPK/PI3K-Akt/AMPK/ERS and oxidative stress pathways, which support the clinical application of Rhizoma coptidis and offer references for future researches. (springer.com)
An overall aim of our research is to study the regulation and function of protein phosphorylation cascades that are important for the maintenance of a normal energy metabolism and that might be involved in the pathophysiological changes that ultimately lead to type 2 diabetes. (lu.se)

The key of these miraculous healing effects relies in the fact that fat metabolism and its generation of ketone bodies (beta-hydroxybutyrate and acetoacetate) by the liver can only occur within the mitochondrion, leaving chemicals within the cell but outside the mitochondria readily available to stimulate powerful anti-inflammatory antioxidants. (sott.net)

activation of Ras phosphorylation and activation of MAP kinases transmission of signal into genome. (wikipedia.org)
The phosphorylation of IκBα by IκB kinase family have been so many identified, but the phosphorylation sites of IκBα by other kinases remain poorly understood. (researchsquare.com)
Cyclin-dependent kinases are regulated by phosphorylation and dephosphorylation events. (bvsalud.org)

We here report that Cdk5 with Tyr15 phosphorylation (Cdk5-pTyr15) is enriched in the mouse striatum, where dopaminergic stimulation inhibited phosphorylation of Tyr15-Cdk5 by acting through the D2 class dopamine receptors. (frontiersin.org)
Upon cytokine stimulation, STAT5 tyrosine phosphorylation (pYSTAT5) is transient, while in diverse neoplastic cells persistent overexpression and enhanced pYSTAT5 are frequently found. (nature.com)
Adenosine inhibited both the phosphorylation of PI and the stimulation of the (Ca2+ + Mg2+)-ATPase by G-kinase. (portlandpress.com)
The promethazine effect on microvillus membrane phosphorylation was specific, since neither cAMP- and cGMP-induced phosphorylation in the microvillus membrane nor the stimulation by Ca 2+ -CaM of myosin light chain kinase phosphorylation of myosin light chain were affected by promethazine. (johnshopkins.edu)

The level of myosin light chain (MLC) phosphorylation is an important determinant of smooth muscle contraction. (hindawi.com)
Evidence is presented showing that the apparent phosphorylation occurs in a contaminant protein, possibly myosin light-chain kinase. (portlandpress.com)

Although homozygous Cx50D47A lenses have increased levels of p62, a specific reduction in p62 phosphorylation at T269/S272, and a specific increase in p62 phosphorylation at S349, this protein is not a critical determinant of the severity of the abnormalities of these lenses (reduced growth or differentiation and cataracts). (molvis.org)

We map multiple sites of serum-induced phosphorylation, most of which are S/T-P motifs, and show that S/T-P phosphorylation is required for transcriptional activation. (elifesciences.org)

Differential effects of apolipoprotein E isoforms on phosphorylation at specific sites on tau by glycogen synthase kinase-3 beta identified by nano-electrospray mass spectrometry. (ox.ac.uk)
In vivo phosphorylation of liver glycogen synthase. (umn.edu)
Dive into the research topics of 'In vivo phosphorylation of liver glycogen synthase. (umn.edu)

Fig. 6: Pirenzepine upregulates MeCP2 phosphorylation and increases release probability. (nature.com)
Promethazine inhibited the Ca 2+ -CaM-induced increases in each of these phosphorylations. (johnshopkins.edu)
In addition, in contrast to the current belief that β-catenin Y654 phosphorylation increases tumour progression to a more invasive phenotype, these results show that it rather increases tumour initiation by enhancing Wnt signalling. (eur.nl)

This study investigates the relevance of β-catenin tyrosine phosphorylation for Wnt signalling and intestinal tumorigenesis in vivo. (eur.nl)
Results: This study provided in vivo evidence that β-cateninE654 is characterised by reduced affinity for cadherins, increased signalling and strongly increased phosphorylation at serine 675 by protein kinase A (PKA). (eur.nl)
The capacitation associated tyrosine phosphorylation is greatly reduced in the presence of Src specific inhibitors (SU6656 and SKI606) in vivo. (umass.edu)

Akt pathways have effects on apoptosis, protein synthesis, metabolism and cell cycle. (springer.com)

ERK-mediated S98 phosphorylation inhibits assembly of G-actin complexes on the MRTF-A regulatory RPEL domain, promoting nuclear import. (elifesciences.org)
Conclusively, WPE inhibits H. pylori -induced STAT3 phosphorylation in a PPAR-γ and SOCS1-dependent manner. (nuthealth.org)

Conclusions: A thus far unknown mechanism was uncovered in which Y654 phosphorylation of β-catenin facilitates additional phosphorylation at serine 675 by PKA. (eur.nl)

The phosphorylation of smooth muscle regulatory light chain by MLCK is the basic requirement for smooth muscle contraction and hollow organ physiological activities [ 10 ]. (hindawi.com)
01J09219) Investigating the effects of regulatory phosphorylation and linear ubiquitination on Pyrin-mediated auto-inflammatory disorders. (ugent.be)

EA caused a significant increase in the MLC dephosphorylation and MLCK phosphorylation levels in the group compared to the sham EA and model groups. (hindawi.com)
It is suggested that the phosphorylation of MLC catalyzed by Ca 2+ -calmodulin- (CAM-) dependent MLCK and dephosphorylation catalyzed by MLCP help regulate the contraction and relaxation of smooth muscle [ 8 , 9 ]. (hindawi.com)

Conclusions: These studies extend the evidence for EGFRs as important cellular targets for components of HDE and they reveal novel patterns of EGFR phosphorylation and binding changes that vary among airway epithelial cell types. (cdc.gov)
Conclusions: Therefore, we identified novel phosphorylation site of IκBα by AURK, and its site was related to apoptosis and necroptosis pathway in breast cancer cells. (researchsquare.com)

Erk 44/42 and p38 phosphorylation (P) (MAPK pathway markers) were also measured. (unict.it)

Moreover, in the 1-methyl-4-phenyl-1,2,4,6-tetrahydropyridine (MPTP) mouse model, dopamine deficiency caused increased phosphorylation of both Tyr15-Cdk5 and Thr75-DARPP-32 in the striatum, which could be attenuated by administration of L-3,4-dihydroxyphenylalanine and imatinib (STI-571), a selective c-Abl inhibitor. (frontiersin.org)
The effect of the FAK inhibitor was AM-4668 confirmed by analyzing FAK phosphorylation levels at Y396 (data not shown). (lavoixdesrroms.org)

Here we show that methyl-CpG-binding protein 2 (MeCP2) phosphorylation at Ser421 (pMeCP2) is essential for the sustained, but not the rapid, antidepressant effects of ketamine and scopolamine in mice. (nature.com)
We investigated whether levels of p62 and its phosphorylation were altered in the lenses of Cx50D47A mice, which express a mutant of connexin50 (Cx50) that leads to cataracts and impaired lens differentiation. (molvis.org)
To evaluate the importance of p62 in the lens defects caused by a connexin50 mutant, we also examined the effect of deleting p62 in homozygous Cx50D47A mice. (molvis.org)
However, deletion of p62 did not affect the sizes of the lenses or the severity of their cataracts in homozygous Cx50D47A mice. (molvis.org)
In testis extracts from mice lacking Cdk2, there are changes in expression of PMS2, MSH2, and HEI10, which may be reflective of the loss of CDK2 phosphorylation. (lu.se)

and (ii) the liver, the kidney and the brain, controlled mainly at the phosphorylation level by ATP synthase and the phosphate carrier. (nih.gov)
Tyrosine phosphorylation is the addition of a phosphate (PO43−) group to the amino acid tyrosine on a protein. (wikipedia.org)
Effect of glucose and glucagon treatment of liver cells on the distribution of the [32P]phosphate. (umn.edu)
G-kinase, but not A-kinase, stimulated the phosphorylation of PI to phosphatidylinositol phosphate (PIP) in a preparation of (Ca2+ + Mg2+)-ATPase obtained by calmodulin affinity chromatography from smooth muscle, but not in a similar preparation from erythrocytes. (portlandpress.com)
Molecular docking further demonstrated that the phosphate group introduced by phosphorylation enhanced the calcium -binding capacity of LTF by ionic bonds and coordination bonds. (bvsalud.org)

Our data show that O-GlcNAcylation of STAT5 is an important process that contributes to oncogenic transcription through enhanced STAT5 tyrosine phosphorylation and oligomerization driving myeloid transformation. (nature.com)

Walnut polyphenol extracts inhibit Helicobacter pylori -induced STAT3 Tyr705 phosphorylation through activation of PPAR-γ and SOCS1 induction. (nuthealth.org)
Fresh walnut polyphenol extracts (WPE) were found to suppress the phosphorylation and nuclear translocation of signal transducer and activator of transcription 3 (STAT3) induced by H. pylori infection in RGM-1 gastric mucosal cells. (nuthealth.org)
Notably, H. pylori infection significantly decreased suppressor of cytokine signaling 1 (SOCS1), but WPE induced expression of SOCS1, by which the suppressive effect of walnut extracts on STAT3 Tyr705 phosphorylation was not seen in SOCS1 KO cells. (nuthealth.org)
WPE induced significantly increased nuclear translocation nuclear translocation of PPAR-γ in RGM1 cells, by which PPAR-γ KO inhibited transcription of SOCS1 and suppressive effect of WPE on p-STAT3 Tyr705 was not seen. (nuthealth.org)
Expression of the mutants differentially affected insulin-induced phosphorylation of IRS1, AKT, ERK, and STAT3. (scielo.br)

abstract = "Protein kinase C has been implicated in the phosphorylation of the erythrocyte/brain glucose transporter, GLUT1, without a clear understanding of the site(s) of phosphorylation and the possible effects on glucose transport. (elsevierpure.com)

What are possible effects of electron transport inhibitors? (quizlet.com)

These findings suggested that mutations in subunits of the OXPHOS complex I had a beneficial effect on longevity, while the simultaneous presence of mutations in complex I and III (which also occurs in J subhaplogroups involved in LHON) and in complex I and V seemed to be detrimental, likely explaining previous contradictory results. (duke.edu)

Basal glucagon secretion was increased and the inhibitory effect of acute insulin exposure reduced in alpha-TC1 cells cultured with palmitate. (unict.it)
We show that Rho-dependent MRTF-A phosphorylation reflects relief from an inhibitory function of nuclear actin. (elifesciences.org)
The inhibitory effect was in a dose-dependent pattern. (who.int)

About one year later, researchers discovered an important role for tyrosine phosphorylation in growth factor signaling and proliferation, and by extension in oncogenesis through hijacking of growth factor tyrosine phosphorylation signaling pathways. (wikipedia.org)
GABA has an essential relaxing influence and its favored production by ketosis also reduces the toxic effects of excitatory pathways in our brains. (sott.net)
In this review, we studied on the effects and molecular mechanisms of Rhizoma coptidis on NF-κB/MAPK/PI3K-Akt/AMPK/ERS and oxidative stress pathways. (springer.com)
In this review, we sorted out the relationship of Rhizoma coptidis among components, diseases and NF-κB/MAPK/PI3K/Akt/AMPK/ERS/oxidative stress pathways, systematically studying on how Rhizoma coptidis exerts beneficial effects to various diseases, which supported the clinical application of Rhizoma coptidis and provided references for the future researches. (springer.com)

PDGF-induced activation of phospholipase C activity is abrogated in cells expressing PLCγ mutated in the tyrosine phosphorylation sites. (wikipedia.org)
We found that O-GlcNAcylation and tyrosine phosphorylation act together to trigger pYSTAT5 levels and oncogenic transcription in neoplastic cells. (nature.com)
Indeed, we have shown previously that mutation of a tyrosine phosphorylation site in the long cytoplasmic loop of the β subunit impairs agrin-induced cytoskeletal anchoring and aggregation of mutant AChR in muscle cells ( Borges and Ferns, 2001 ). (jneurosci.org)
It is proposed that G-kinase stimulates the plasmalemmal Ca2+ pump of smooth-muscle cells indirectly via the phosphorylation of an associated PI kinase. (portlandpress.com)
Phosphorylation modification of bovine bone collagen peptide enhanced its effect on mineralization of MC3T3-E1 cells via improving calcium-binding capacity. (bvsalud.org)
When the muscle cells of affected individuals are stained and viewed under a microscope, these cells usually appear abnormal. (medlineplus.gov)
ultra- + L. sonus, sound, + G. grapho, to write] Doppler u. application of the Doppler effect in ultrasound to detect movement of scatterers (usually red blood cells) by the analysis of the change in frequency of the returning echoes.In many settings, ultrasound has supplanted x-radiography as the imaging method of choice, because it poses no known risk to patients and is noninvasive and of moderate cost. (theodora.com)
We investigated the new phosphorylation site for IκBα and identified its biological function in breast cancer cells. (researchsquare.com)
Besides, S63A and/or S262A of IκBα regulated apoptotic and necroptic effects in breast cancer cells. (researchsquare.com)
Also, our mutants induced proliferation, glucose uptake, inhibited the migration of 293T cells and affected the responsiveness of the cells to cisplatin and radiation. (scielo.br)
Radiosensitizers are chemical agents that have the potential to increase the lethal effect of radicals induced during irradiation [1-6].The extent of radiation damage to cells is dependent on the amount of oxygen available to the cell [1,2,7,8]. (who.int)
Our aim is to determine if and how SIK2 affects insulin sensitivity in adipose cells - specifically in humans. (lu.se)
bronchoalveolar lavage cells from control and CBD subjects to evaluate the beryllium salt-specific production of endogenous IL-10 and the effects of exogenous human rIL-10 (rhIL-10) on HLA expression, on the production of IL-2, IFN- , and TNF- , and on T lymphocyte proliferation. (cdc.gov)

Homozygous deletion of p62 led to an 84% increase in the levels of ubiquilin 2, but did not significantly affect the levels of ubiquilin 1 or ubiquilin 4. (molvis.org)
Interestingly, targeted mutation of the GluA1 phosphorylation site Ser831 significantly inhibited stress-induced prolongation of incisional pain. (jneurosci.org)
The results showed that phosphorylation of LTF significantly enhanced its calcium -binding capacity. (bvsalud.org)

Either decreases effects of the other by Other (see comment). (medscape.com)
doxorubicin decreases effects of stavudine by Other (see comment). (medscape.com)
doxorubicin liposomal decreases effects of stavudine by Other (see comment). (medscape.com)

Surprisingly, the expression of β-cateninE654 did not affect histological grade or induce tumour invasiveness. (eur.nl)

The sequence contains a conserved tyrosine (Y390) whose phosphorylation is induced by agrin and whose mutation abolished clustering of β loop chimeras and their ability to inhibit agrin-induced clustering of the endogenous AChR. (jneurosci.org)

There was no effect on plasma lipids or uric acid, but there was a lower glucose and insulin peak concentration after consumption of the FVPD compared with the sugar-matched control. (cambridge.org)

During the first half of the 20th century, the concept of beriberi heart disease (ie, thiamine deficiency) was present throughout the medical literature, and the idea that alcohol had any direct effect on the myocardium was doubted. (medscape.com)

Phosphorylation of S226 is required for the rapid increase in glucose uptake and enhanced cell surface localization of GLUT1 induced by the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA). (elsevierpure.com)

7 The JAKs also trigger the activation and tyrosine phosphorylation of STAT5, causing parallel dimerization, nuclear translocation and tetramerization of STAT5. (nature.com)
The MRTFs also undergo Rho- and ERK-dependent phosphorylation, but the function of MRTF phosphorylation, and the elements and signals involved in MRTF-A nuclear export are largely unexplored. (elifesciences.org)

A prominent example for the decisive impact of lipid rafts on signaling is LRP6, whose localization to the same lipid rafts domain as the kinase CK1γ is crucial for its successful phosphorylation and the subsequent activation of the signalosome, hence WNT/β-catenin signaling. (frontiersin.org)
EGFR phosphorylation, expression, and localization were assessed with anti-EGFR antibodies and either blotting or confocal microscopy. (cdc.gov)

The molecular mechanisms underlying the maintenance of these antidepressant effects are unknown. (nature.com)
Therefore, we explored the effects and mechanisms of EA on DBD in streptozotocin-high-fat diet- (STZ-HFD-) induced diabetic rats. (hindawi.com)
Together, these data reveal that in platelets, SERT function is regulated by PKC in a biphasic manner involving both trafficking-dependent and independent mechanisms and that these two events occur at distinct phases of transporter phosphorylation. (aspetjournals.org)
In this project, we will investigate the mechanisms by which Pyrin signaling is regulated by phosphorylation and linear ubiquitination, and how this modulates Pyrin-mediated auto-inflammation in FMF and ORAS mouse models. (ugent.be)
However, although these mechanisms may play a role in selected patients, most evidence in the literature indicates that the effects of alcohol on the myocardium are independent of these factors and that the effect is a direct toxic result of ethanol or its metabolites. (medscape.com)
As a traditional Chinese medicine, Rhizoma coptidis has excellent therapeutic effects on various diseases, but the underlying systematic molecular mechanisms are still far from being fully elucidated. (springer.com)

The effect of phosphorylation by cyclic GMP-dependent protein kinase (G-kinase) on the activity of the plasmalemmal Ca2+-transport ATPase was studied on isolated plasma membranes and on the ATPase purified from pig erythrocytes and from the smooth muscle of pig stomach and pig aorta. (portlandpress.com)
How would taking this 'prescription' affect the excitability of your muscle? (fsu.edu)
particularly affecting the central nervous system, retina, and muscle. (msdmanuals.com)

Indeed, we found that rapsyn associated with CD4-β loop chimeras in a phosphorylation-dependent manner, and that agrin increased the ratio of rapsyn binding to wild type AChR but not to AChR-β 3F/3F , which lacks β loop tyrosine phosphorylation sites. (jneurosci.org)
Results: We identified two novel sites of serine phosphorylation at S63 and S262. (researchsquare.com)

This study aimed to investigate the effect of phosphorylation modification of collagen peptide on its calcium -binding capacity and pro-mineralization activity. (bvsalud.org)

MERRF is part of a group of conditions known as mitochondrial disorders, which affect an estimated 1 in 5,000 people worldwide. (medlineplus.gov)
These disorders can appear in every generation of a family and can affect both males and females, but fathers do not pass traits associated with changes in mtDNA to their children. (medlineplus.gov)

To identify the essential domains of IκBα for phosphorylation of IκBα by AURK, kinase assay was performed with a series of IκBα truncation mutants. (researchsquare.com)

Anatomy25

Organisms9

Chemicals and Drugs159

Analytical, Diagnostic and Therapeutic Techniques and Equipment14

Phenomena and Processes45

Information Science3

Oxidative phosphorylation9

Residues6

Receptor21

Proteins11

Regulates3

Changes in phosphorylation2

Vitro6

Inhibition6

Mitochondrial oxidative1

Regulation8

Mitochondria1

Kinases3

Stimulation4

Myosin2

Determinant1

Transcriptional1

Glycogen synthase3

Increases3

Vivo3

Protein synthesis1

Inhibits2

Mechanism1

Regulatory2

Dephosphorylation2

Conclusions2

Pathway1

Inhibitor2

Mice5

Phosphate5

Contributes1

STAT35

ABSTRACT1

Inhibitors1

Occurs1

Inhibitory3

Pathways4

Cells13

Significantly3

Decreases3

Tumour1

Endogenous1

Insulin1

Deficiency1

Glucose uptake1

Nuclear2

Localization2

Mechanisms6

Muscle3

Sites2

Calcium1

Disorders2

Mutants1