AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureInformation ScienceNamed GroupsHealth CareGeographicals
ObesityObesity, MorbidObesity, AbdominalPediatric ObesityBody Mass IndexOverweightBody WeightAdipose TissueRisk FactorsLeptinInsulin ResistancePrevalenceWeight LossAnti-Obesity AgentsAdiposityDietWaist CircumferenceTropaeolaceaeWeight GainMetabolic Syndrome XCross-Sectional StudiesEnergy MetabolismDietary FatsDiabetes Mellitus, Type 2ThinnessObesity Hypoventilation SyndromeMice, ObeseBody CompositionWaist-Hip RatioInsulinAnthropometryHyperphagiaStereoisomerismEatingEnergy IntakeBlood GlucoseFeeding BehaviorBariatric SurgeryAdipocytesReceptor, Melanocortin, Type 4Life StyleAbdominal FatMagnetic Resonance SpectroscopySex FactorsUnited StatesMice, Inbred C57BLIntra-Abdominal FatMetabolic DiseasesExerciseReceptors, LeptinNucleic Acid ConformationAdipokinesDiabetes MellitusAdiponectinMolecular StructureMolecular ConformationModels, MolecularFatty LiverTriglyceridesMotor ActivityAdipose Tissue, WhiteCardiovascular DiseasesCohort StudiesLipid MetabolismAge FactorsCase-Control StudiesGastric BypassGastroplastyHypertensionHypothalamusPlant ExtractsFood HabitsTime FactorsSocioeconomic FactorsIndiaBody HeightLogistic ModelsHydrogen BondingLiverAppetite RegulationGlucose Tolerance TestHealth PromotionGuanineDisease Models, AnimalAdipogenesisProspective StudiesPregnancyHealth SurveysLipidsEuropean Continental Ancestry GroupAntibodies, MonoclonalHeterocyclic Compounds, Bridged-RingInflammationBase PairingOdds RatioDiet, ReducingPachyrhizusSubcutaneous FatHyperinsulinismBody Weights and Measures
Management of obesityPrevalenceTreat obesityObeseType 2 diabetAdipocytesOverweight and obesityExert anti-obesityDyslipidemiaMechanismsClinicalAbdominal obesityTherapeuticOrlistatExhibits anti-obesitySemaglutideImbalance between energy intakeCardiovascularAdultsComes to obesityTreatments for obesityTreatmentSibutramineOxidative stressAMPKDiabetesCombat obesityAdipose tissueSystemicDrugsPandemicMetabolismMedicationsComorbiditiesMultifactorialTherapyHumansInflammationAntioxidantSymptomsAdjunctUnclearExtractSide effectsResearchersHealthTriglyceridesGlucoseEndocrineRimonabantCliniciansWeightUnderweightPatientsAdolescentsDiseasesMechanismIncidence
Management of obesity5
  • As with all chronic medical conditions, effective management of obesity must be based on a partnership between a highly motivated patient and a committed team of health professionals. (medscape.com)
  • Short-term adjunct in the management of obesity in a medically monitored comprehensive regimen of wt reduction based on exercise, diet & behaviour modification in obese patients w/ BMI ≥30 kg/m 2 & in overwt patients (BMI 25-29.9 kg/m 2 ) w/ comorbidity. (mims.com)
  • What is standing in the way of increased use of these medications in the management of obesity? (medscape.com)
  • Thus, there is a tendency to use natural compounds for the management of obesity. (mdpi.com)
  • It is now considered as a valuable source of unique natural products for development of medicines against various diseases and also for the development of industrial products.The aim of the study was to compare the lipid lowering activity of Pterocarpus marsupium wood, a traditional Indian plant, with a standard pharmacological agent sibutramine, in the management of obesity. (omicsonline.org)
Prevalence9
  • Although the prevalence of obesity among adults was fairly steady over a decade, it did increase by 3% between 2011 and 2014. (medscape.com)
  • [ 1 ] Here, the prevalence of obesity has remained fairly steady throughout the decade. (medscape.com)
  • Over the past two decades, the prevalence of metabolic abnormalities such as type 2 diabetes and metabolic syndrome (MetS) has been increasing worldwide together with the escalating obesity pandemic [ 1 - 3 ]. (hindawi.com)
  • Therefore, NAFLD is expected to become a major burden in Asian countries where the prevalence of obesity is less than that in Western countries [ 10 , 11 ]. (hindawi.com)
  • The global prevalence of obesity almost tripled between 1975 and 2016, with 39% of adults classified as overweight and 13% as obese ( Collaboration, 2017 ). (frontiersin.org)
  • In conclusion, the prevalence of obesity is increasing at an alarming rate in many parts of the world. (eurekaselect.com)
  • The prevalence of metabolic syndrome is on the rise in many parts of the world, with the main causes of obesity being associated with overeating and lack of exercise [ 4 ]. (walshmedicalmedia.com)
  • Also, as per a study titled "The Prevalence of Polycystic Ovary Syndrome, Its Phenotypes and Cardio-Metabolic Features in a Community Sample of Iranian Population: Tehran Lipid and Glucose Study," published in the Frontier in Endocrinology in March 2022, PCOS (polycystic ovary syndrome) is the most common endocrine disorder in women of reproductive age, affecting 6-12% of them. (marketresearch.com)
  • Prevalence of obesity and severe obesity among adults: United States, 2017-2018. (msdmanuals.com)
Treat obesity5
Obese11
  • In patients with type 2 diabetes mellitus who are overweight or obese, antidiabetic medications that have additional actions to promote weight loss (such as glucagonlike peptide-1 [GLP-1] analogs or sodium-glucose-linked transporter-2 [SGLT-2] inhibitors) are suggested, in addition to the first-line agent for type 2 diabetes mellitus and obesity, metformin. (medscape.com)
  • This meta-analysis demonstrates the beneficial effects of chronic orange juice consumption on blood pressure and HDL-C in overweight and obese adults. (greenmedinfo.com)
  • Overall, approximately 17% of US children and adolescents are obese, again with a higher rate of obesity among non-Hispanic black and Hispanic children. (medscape.com)
  • Obesity, which is linked to systemic inflammation, is thought to increase the risk of Crohn's disease, rheumatoid arthritis (RA), and psoriasis, and as many as 50% of patients with IMIDs are obese. (medpagetoday.com)
  • Aim: To evaluate the preventive effects of an aqueous extract of Trigonella foenum-graecum seeds (AqE-TFG) on fat deposition and dyslipidemia in monosodium glutamate (MSG)-obese rats. (greenmedinfo.com)
  • The effect of the dietary supplement, chitosan, on body weight: a randomized controlled trial in 250 overweight and obese adults. (medscape.org)
  • Obesity is a growing global health concern associated with high comorbidity rates, leading to an increasing number of patients who are obese requiring medication. (bvsalud.org)
  • We conclude that this decision tree system offers a valuable tool to advance research in obesity pharmacology and personalize drug development for patients who are obese, ensuring safe and effective medication. (bvsalud.org)
  • Moreover, I3C exerts anti-obesity effects by reducing body weight and fat accumulation in epididymal adipose tissue in HFD-induced obese mice and thereby improves hyperglycemia and hyperinsulinemia [126]. (researchgate.net)
  • Although the physiological actions of GALP are yet to be fully elucidated, it is possible, given the anti-obesity effect of GALP seen in relation to food intake and body weight loss in obese mice, that GALP could be applied clinically to combat obesity in humans. (walshmedicalmedia.com)
  • lion adults are obese and 2.1 bil ion attributed to obesity. (who.int)
Type 2 diabet2
  • Obesity can induce type 2 diabetes mellitus, dyslipidemia, cardiovascular disease and other chronic disorders with high social and health costs. (benthamscience.com)
  • Obesity was firstly described in 2000 as a cardiometabolic disease, even before Metabolic Syndrome, type 2 diabetes mellitus and coronary disease were considered as such. (benthamscience.com)
Adipocytes2
  • Last year, Singh and colleagues reported that obesity might contribute to the pathogenesis of IBD through dysbiosis, mucosal barrier dysfunction with bacterial translocation, and activation of adipocytes. (medpagetoday.com)
  • Obesity is characterized by accumulation of triacylglycerol in adipocytes. (omicsonline.org)
Overweight and obesity3
Exert anti-obesity1
Dyslipidemia5
Mechanisms7
  • While awaiting the release of new drugs, topiramate, alone or combined with phentermine, has been proposed as a novel anti-obesity drug, showing relevant effects not only on weight loss but also on cardiometabolic alterations and biomarkers, even though new studies should clarify the mechanisms of these findings. (benthamscience.com)
  • Although notoginsenosides are potential drugs for the treatment of obesity, their effects and mechanisms have not been analyzed in depth. (frontiersin.org)
  • This study evaluated the inhibitory effects and mechanisms of YSY for hyperlipidaemia, atherogenesis, and obesity. (tmu.edu.tw)
  • In this review, we highlight the impact of the most common polyphenols from Mediterranean foods on molecular mechanisms that mediate obesity-related oxidative stress and inflammation. (nih.gov)
  • Further investigations of the mechanisms leading to the effect of raspberry ketone on osteoblast differentiation are required. (ironmagazine.com)
  • Mir Ali , MD, bariatric surgeon and medical director of MemorialCare Surgical Weight Loss Center at Orange Coast Medical Center in Fountain Valley, CA, says there are multiple mechanisms by which obesity increases the risk of cardiovascular disease - primarily, that obesity increases atherosclerotic plaque buildup in arteries, putting people at risk for myocardial infarction. (healthline.com)
  • The history of anti-obesity drugs clearly shows question is to what extent the OELs still perform their function, and the need of human (epidemiological and clinical) data applica- through which mechanisms. (cdc.gov)
Clinical11
  • In the last decade, it has been shown that metformin, thiazolidinediones, vitamin E, ezetimibe, n-3 polyunsaturated fatty acids, renin-angiotensin system (RAS) blockers, and antiobesity drugs may improve hepatic pathophysiological disorders as well as clinical parameters. (hindawi.com)
  • Although clinical evidence for RAS blockers and incretin-based agents (GLP-1 analogs and dipeptidyl peptidase-4 inhibitors) is also lacking, these agents are promising in terms of their insulin-sensitizing and anti-inflammatory effects without causing weight gain. (hindawi.com)
  • Reporting in PLoS One , researchers led by Siddharth Singh, MD , of the University of California San Diego, wrote, "A thorough evaluation of obesity as an effect modifier in clinical trials is warranted, and intentional weight loss may serve as adjunctive treatment in patients with obesity failing anti-TNF therapy. (medpagetoday.com)
  • A number of potential implications for clinical practice are derived from the cardiometabolic state underlying obesity and its comorbidities. (benthamscience.com)
  • Therefore, the development of safe and effective new anti-obesity drugs has great clinical significance and economic value. (frontiersin.org)
  • Furthermore, the antihyperlipidaemic effect of YSY was observed in the clinical trial. (tmu.edu.tw)
  • A research review of 13 clinical trials showed that rose oil could help reduce pain, relax the body and mind, and exert an anti-anxiety effect. (medicalnewstoday.com)
  • Consensus for obesity treatment is that clinical therapy should begin with lifestyle changes focusing on behavioral modification, diet, and exercise. (eurekaselect.com)
  • Analytical characterization of an assay designed to detect and fluid samples confirmed our clinical suspicion of ARDS identify diverse agents of disseminated viral infection. (cdc.gov)
  • EV-D68 infection may help with clinical management for Cheng Gong, Meng Chen, Xiali Yu, Jiang Wu, individual patients and minimize unnecessary use of anti- Ying Deng, Fang Huang microbial drugs within communities. (cdc.gov)
  • [ 12 ] Observational studies and clinical trials point to the substantial protective effects of aspirin on colorectal cancer and other digestive tract cancers, and modest risk reductions for breast and prostate cancers. (medscape.com)
Abdominal obesity5
  • As per a team of Stanford scientists, the underlying reason for abdominal obesity is connected to internal body temperature. (ipsnews.net)
  • Abdominal obesity is an important risk factor for heart disease. (drsharma.ca)
  • STRADIVARIUS , a double-blind randomized controlled trial with over 800 patients conducted at 112 centres in North America, Europe and Australia was designed to determine whether treatment with 20 mg of the CB-1 antagonist rimonabant (an anti-obesity drug now available in many countries but not in Canada or the US) would reduce progression of coronary artery disease (CAD) in patients with abdominal obesity and the metabolic syndrome. (drsharma.ca)
  • OBJECTIVES: Risk factors for Barrett's esophagus include gastroesophageal reflux disease (GERD) symptoms, age, abdominal obesity, and tobacco use. (who.int)
  • Logistic regression models predicting Barrett's esophagus using GERD symptoms alone and together with abdominal obesity, tobacco use, and age were compared. (who.int)
Therapeutic4
Orlistat8
  • For that reason orlistat was chosen over lipstatin for development as an anti-obesity drug. (wikipedia.org)
  • Orlistat has a few adverse effects. (wikipedia.org)
  • These adverse effects of orlistat are more common early in the therapy but usually decrease with time. (wikipedia.org)
  • Cetilistat was developed to overcome the adverse effects on the gastrointestinal tract of orlistat. (wikipedia.org)
  • This effect of orlistat as a FAS-inhibitor was first identified in a high throughput screening for enzymes with prostate cancer inhibition activity. (wikipedia.org)
  • Hauptman J. Orlistat: selective inhibition of caloric absorption can affect long-term body weigh. (medscape.org)
  • Low-dose orlistat effects on body weight of mildly to moderately overweight individuals: a 16 week, double-blind, placebo-controlled trial. (medscape.org)
  • Of the current anti-obesity therapies, orlistat and sibutramine do not raise plasma HDL levels, while rimonabant does directly increase HDL concentrations. (eurekaselect.com)
Exhibits anti-obesity2
  • F. H. Chen exhibits anti-obesity effects. (frontiersin.org)
  • RK], which is one of the major aromatic compounds of red raspberry and exhibits anti-obesity action, could promote osteoblast differentiation in C3H10T1/2 stem cells. (ironmagazine.com)
Semaglutide6
  • In June 2021, the FDA approved the use of semaglutide (Wegovy) for obesity. (medscape.com)
  • Topline results from the Semaglutide Effects on Heart Disease and Stroke in Patients with Overweight or Obesity (SELECT) cardiovascular outcome trial showed that in individuals with obesity without type 2 diabetes, semaglutide led to a 20% reduction in major cardiovascular events, Jastreboff noted, adding that full results will be presented at the American Heart Association meeting on November 11. (medscape.com)
  • The findings, presented at this year's European Congress on Obesity in Dublin, Ireland, found that multiple cardiovascular risk factors , including blood pressure , total cholesterol , and triglycerides , decreased after a year of taking semaglutide. (healthline.com)
  • Though additional research is needed to better understand the effects of semaglutide, the findings suggest that people at risk for heart disease may potentially benefit from taking semaglutide. (healthline.com)
  • To understand the effect semaglutide has on cardiovascular disease in people who are overweight or have obesity , the researchers evaluated the health data of 93 patients with a body mass index (BMI) of 27 kg/m2 or higher who had no history of cardiovascular disease. (healthline.com)
  • The team found that the 10-year ASCVD dropped by 1.38 percent, from 7.64 percent before taking semaglutide to 6.26 percent after 12 months of taking the anti-obesity drug. (healthline.com)
Imbalance between energy intake2
Cardiovascular10
  • Effect of oat supplementation interventions on cardiovascular disease risk markers. (greenmedinfo.com)
  • Since NAFLD is closely associated with obesity, diabetes, and MetS, it is unknown whether the relationship between NAFLD and all-cause mortality and cardiovascular death, if any, is independent of cardiometabolic risk factors (Figure 1 ) such as MetS and type 2 diabetes. (hindawi.com)
  • Obesity often increases the risk of lifestyle diseases, such as cardiovascular disease, diabetes, and cancer. (frontiersin.org)
  • Obesity is dangerous as it can lead to various ailments like cardiovascular diseases , diabetes , sleep apnea, osteoarthritis and cancer. (zovon.com)
  • The l-isomer is more potent than the d-isomer in cardiovascular activity, but much less potent in causing CNS excitatory effects. (nih.gov)
  • NeuroSearch reported a slight increase in heart rate and blood pressure among some patients in its tesofensine trials, though it said these effects weren't clinically significant, and Arena said its drug is far more selective than fenfluramine and won't cause the same cardiovascular effects. (wordnik.com)
  • While the report suggests Ozempic may have positive effects on cardiovascular health, more research with larger sample sizes and longer follow-up periods is needed to better understand the short and long-term impacts. (healthline.com)
  • Medical treatments for obesity should help reduce cardiovascular risk. (drsharma.ca)
  • Not surprisingly, several large studies are examining the effect of anti-obesity drugs, both old (e.g. sibutramine) and new (e.g. rimonabant), on cardiovascular morbidity and mortality. (drsharma.ca)
  • When used according to current guidelines, these agents can indeed markedly reduce the risk of cardiovascular disease (obviously, this risk will never be zero, no matter how good the treatment). (drsharma.ca)
Adults2
  • We investigated the effects of supplementing 20 healthy adults with WKBE for 1 week in a randomised, placebo-controlled crossover trial on the composition of the gut microbiota, gastrointestinal (GI) inflammation (faecal calprotectin), GI symptoms, and stool habits. (cambridge.org)
  • Recent studies linked its presence to a reduced risk of obesity in adults. (org.in)
Comes to obesity2
  • My first choice, and what most people recommend to patients when it comes to obesity management, is a lifestyle change focusing on diet and exercise. (medscape.com)
  • So is reduction in heart disease really the great "unmet need" when it comes to obesity treatment? (drsharma.ca)
Treatments for obesity2
  • With nutrient-stimulated hormone therapies for obesity in phase 3 trials, and activin-receptor inhibitors the next upcoming drug class, highly effective treatments for obesity are on the horizon. (medscape.com)
  • Effective treatments for obesity are required irrespective of whether or not they also help reduce heart disease. (drsharma.ca)
Treatment19
  • Used in the treatment of obesity. (mims.com)
  • The first step in accepting obesity as a disease is to have coverage for the treatment, right? (medscape.com)
  • Doctors are reimbursed pretty poorly for treatment of obesity with lifestyle. (medscape.com)
  • thus laying emphasis on the timely prevention and treatment of obesity. (frontiersin.org)
  • However, currently, there are very few drugs available for obesity treatment. (frontiersin.org)
  • Obesity was induced to each group except the normal control group for 30 days and treatment was given for 15 days. (omicsonline.org)
  • Attention Deficit Disorder with Hyperactivity as an integral part of a total treatment program which typically includes other remedial measures (psychological, educational, social) for a stabilizing effect in children with behavioral syndrome characterized by the following group of developmentally inappropriate symptoms: moderate to severe distractibility, short attention span, hyperactivity, emotional lability , and impulsivity. (nih.gov)
  • Importance: Although the American Academy of Pediatrics has recommended treatment with antiobesity drugs for adolescents, the cost-effectiveness of antiobesity drugs for this population is still unknown. (bvsalud.org)
  • Results: Among the 4 antiobesity drugs currently approved for pediatric use, phentermine-topiramate was the most cost-effective with an incremental cost-effectiveness ratio of $93â ¯620 per QALY relative to no treatment in this simulated cohort of 10â ¯000 adolescents aged 12 to 17 years (mode, 15 years) with severe obesity (62% female). (bvsalud.org)
  • Conclusions and Relevance: In this economic evaluation of weight loss drugs for adolescents with severe obesity, we found phentermine-topiramate to be a cost-effective treatment at a willingness-to-pay threshold of $100â ¯000 to $150â ¯000/QALY. (bvsalud.org)
  • Clinicians need to consider the patient's severity of obesity, overall health, and metabolic profile, and match the obesity treatment to the patient. (medscape.com)
  • phenyltropane drug under development for the treatment of obesity . (wordnik.com)
  • Weight gain is a well-known side effect of treatment with psychotropic drugs. (omicsonline.org)
  • However the absence of this side effect might be explained by the study's finding that two-thirds of the patients were no longer in treatment at the end of twelve months. (omicsonline.org)
  • The polycystic ovarian syndrome (PCOS) treatment market is not immune to the effects of the pandemic, which had ramifications for many surgical procedures, including laparoscopic ovarian drilling. (marketresearch.com)
  • However, the side effects of symptomatic treatment drugs and the lack of approved drugs directly targeting PCOS disease drugs act as among the major restraints to the PCOS treatment market. (marketresearch.com)
  • The ABOM stresses obesity be considered a chronic disorder that requires lifelong treatment and follow-up. (msdmanuals.com)
  • Although the optimal treatment strategy continues to evolve, three agents that target angiogenesis (sunitinib, bevacizumab, and pazopanib) and a mammalian target of rapamycin (mTOR)-targeted therapy (temsirolimus) have been approved as front-line agents. (medscape.com)
  • These agents have largely replaced cytokines (immunotherapy) in treatment-naive patients. (medscape.com)
Sibutramine1
  • The change in the lipid profile was carried out to check the lipid lowering effect of P. marsupium compared to sibutramine the standard most widely recommended for obesity. (omicsonline.org)
Oxidative stress2
  • Nutrients - Red beetroot has the potential to have beneficial effects on "inflammation, oxidative stress, cognition, and endothelial function. (dietspotlight.com)
  • Western dietary patterns serve as a model for studying the impact of nutrition transition on civilization diseases, such as obesity, which is commonly associated with oxidative stress and inflammation. (nih.gov)
AMPK2
  • Alpha lipoic acid exerts these weight management effects by suppressing hypothalamic AMP-activated protein kinase (AMPK) activity which is important in the central regulation of food intake and energy expenditure. (herbalmagic.ca)
  • These findings demonstrate that the anti-obesity effects of TBS may be linked to the activation of AMPK. (biomedcentral.com)
Diabetes7
  • It's more cost-effective for the doctor to treat hypertension and diabetes instead of obesity, because it takes a while to talk about lifestyle change. (medscape.com)
  • Gymnema Sylvestre is claimed to be the primary substance in the supplement that has a number of anti-diabetes properties. (timesofisrael.com)
  • It concluded that sage essential oil could be important in helping manage diabetes and obesity. (medicalnewstoday.com)
  • Tirzepatide "is really the best medicine that we have for diabetes in terms of A1c control without much hypoglycemia ," he said, "and also the best medicine for treating obesity in patients with diabetes. (medscape.com)
  • In May 2022, the FDA approved tirzepatide (Mounjaro), a GIP/GLP-1RA, for type 2 diabetes, and a decision about the use of tirzepatide for obesity is expected by year's end. (medscape.com)
  • The increase in body fat in obesity contributes to other risk factors for heart disease like high blood pressure, diabetes, and obstructive sleep apnea, says Behuria. (healthline.com)
  • In recent years, HCC has also been associated with obesity, diabetes, and the metabolic syndrome. (medscape.com)
Combat obesity1
Adipose tissue1
  • Obesity is characterized by excessive growth in adipose tissue mass and is rapidly becoming a public health problem that affects millions of people worldwide [ 1 ]. (biomedcentral.com)
Systemic2
  • Hence, they do not affect systemic lipases. (wikipedia.org)
  • It is likely that in IBD patients, this local mesenteric fat plays a more important role than systemic obesity," and infliximab and adalimumab doses tend to be higher for IBD than for other IMIDs. (medpagetoday.com)
Drugs20
  • At the same time, there are some new antiobesity drugs. (medscape.com)
  • A recent study [ 3 ] looked at uptake of the four new antiobesity drugs: phentermine/topiramate, liraglutide, naltrexone/bupropion, and lorcaserin. (medscape.com)
  • They found that the rate of SGLT2 inhibitor prescriptions was about five times that of all four drugs for obesity combined. (medscape.com)
  • Accordingly, insulin sensitizers, antioxidative agents, Niemann-Pick C1-like 1 (NPC1L1) inhibitors, RAS blockers, and drugs that target the central nervous system may represent candidate pharmacotherapies for NAFLD and possibly NASH. (hindawi.com)
  • Therefore, it is necessary to find more effective and safer anti-obesity drugs. (frontiersin.org)
  • Synthetic anti-obesity drugs show side effects and variable effectiveness. (mdpi.com)
  • A 2019 study found spearmint essential oil to be an anti-obesity agent that might be safer than synthetic drugs. (medicalnewstoday.com)
  • Drugs in this class used in obesity are commonly known as "anorectics" or "anorexigenics. (nih.gov)
  • It has not been established, however, that the action of such drugs in treating obesity is primarily one of appetite suppression. (nih.gov)
  • Exogenous Obesity as a short term (a few weeks) adjunct in a regimen of weight reduction based on caloric restriction for patients refractory to alternative therapy, e.g., repeated diets, group programs, and other drugs. (nih.gov)
  • Objective: To quantify cost-effectiveness of different antiobesity drugs available for pediatric use. (bvsalud.org)
  • Almost all the Western anti-obesity drugs have adverse effects or body weight is regained upon cessation of therapy. (edu.hk)
  • Recent studies have found that acupuncture had a similar efficacy as the Western anti-obesity drugs with fewer reported adverse effects. (edu.hk)
  • The Lancet, Volume 372, Issue 9653, Pages 1906-1913, 29 November 2008) with the conclusion that tesofensine produces a weight loss at least twice that of currently approved anti-obesity drugs. (wordnik.com)
  • Weight Gain on Psychotropic Drugs: Has the Obesity Community been Paying Attention? (omicsonline.org)
  • More than fifty years ago, drugs such as amitriptyline (Elavil) and lithium were known to be associated with substantial increases in weight and despite new generations of psychotropic drugs, this unwelcome side effect has persisted [ 1 - 3 ]. (omicsonline.org)
  • Mirtazapine (Remeron) and paroxetine (Paxil) are two antidepressants with the greatest weight gain potential among the anti-depressants although except for buproprion (Wellbutrin) weight gain has been reported among all of the other drugs in this category [ 4 ]. (omicsonline.org)
  • Anti-obesity drugs: The role of dieticians in monitoring side that AFM1 levels were detected in 100% of the samples, exceeding effects and toxicity the approved limit for milk, according to Codex Alimentarius and Norma Oficial Mexicana. (cdc.gov)
  • Background Nonsteroidal anti-inflammatory drugs (NSAIDs) have been shown to reduce chronic inflammation and risk of many cancers, but their effect on risk of hepatocellular carcinoma (HCC) and death due to chronic liver disease (CLD) has not been investigated. (medscape.com)
  • Investigating the cancer chemopreventive role of modifiable anti-inflammatory agents, especially the widely used nonsteroidal anti-inflammatory drugs (NSAIDs), is an important prevention research area. (medscape.com)
Pandemic1
  • email: [email protected] swine-origin influenza A(H1N1)pdm09 virus and recogni- tion (in the midst of the pandemic) that younger age and obesity were risk factors for severe disease were also sug- gestive of a viral respiratory infection. (cdc.gov)
Metabolism1
  • Pharmacological factor involved in obesity includes lipoprotein lipase having a central role in metabolism of both triglyceride rich particles and high density lipoprotein. (omicsonline.org)
Medications3
  • Recently, it has been noted that natural herbal medications may be effective in treating obesity. (biomedcentral.com)
  • We are at a watershed [moment] brought on by the recent introduction of highly effective antiobesity medications," said Ania M. Jastreboff, MD, PhD, in a lecture at ObesityWeek. (medscape.com)
  • Also invited to comment, Sean Wharton, MD, PharmD, Wharton Medical Clinic and York University, Toronto, Canada, told Medscape that the recent developments in antiobesity medications are "so exciting that it's difficult to make direct comments," since "maybe there will be something bigger, or maybe something will go wrong with these molecules and we'll have to back-step. (medscape.com)
Comorbidities3
  • Yes, while preventing heart disease (or its progression) is perhaps one benefit of treating obesity, I can think of many other benefits that are relevant to patients battling obesity-related comorbidities for which we currently have no effective medical treatments. (drsharma.ca)
  • Unfortunately, pharma companies, regulators and payors appear obsessed with the cardiometabolic consequences of obesity and fail to see the urgent need for treating obesity-related comorbidities beyond heart disease. (drsharma.ca)
  • So, while the results of STRADIVARIUS are nice, I'd be far more interested in whether or not rimonabant reduces obesity-related comorbidities for which we have no alternative treatments - at least that's where I'd put my research money if I had any say in the matter. (drsharma.ca)
Multifactorial3
  • Obesity is a multifactorial disease that is currently developing a threatening tendency towards becoming the main cause of chronic disease in the world. (benthamscience.com)
  • Obesity is a chronic, multifactorial, relapsing disorder characterized by excess body weight and defined as a body mass index (BMI) of ≥ 30 kg/m2. (msdmanuals.com)
  • Causes of obesity are multifactorial and include genetic predisposition and behavioral, metabolic, and hormonal influences. (msdmanuals.com)
Therapy4
  • Taking alpha-lipoic acid by mouth with or without standard hydration therapy during a coronary angiography doesn't seem to prevent kidney damage caused by contrast agents. (medlineplus.gov)
  • Even though the current meta-analysis found no consistent association between obesity and response to anti-TNF therapy in IBD, most studies in patients with IBD were small and failed to adjust for important covariates," Singh told MedPage Today . (medpagetoday.com)
  • Additionally most studies focused on infliximab, which is administered in a weight-based dosing regime, and some newer studies in patients with IBD suggest a negative impact of obesity on response to anti-TNF therapy. (medpagetoday.com)
  • Targeted therapy and immunomodulatory agents are considered standard of care in patients with metastatic disease. (medscape.com)
Humans1
  • Whether the substance has the same effect in humans is not clear. (ironmagazine.com)
Inflammation2
  • In fact, reactive oxygen species (ROS) overproduction can be associated with nuclear factor-κB (NF-κB)-mediated inflammation in obesity. (nih.gov)
  • There were no significant effects on GI inflammation or symptoms related to constipation, or stool consistency or frequency. (cambridge.org)
Antioxidant4
  • Research suggests alpha lipoic acid is best known for its unique antioxidant properties, free radical scavenging abilities and participation in the effects of other antioxidants. (herbalmagic.ca)
  • Citrus oils, such as sweet orange, bitter orange, lemon, and lime peel, often contain the chemical limonene , which research shows may aid digestion and have an antioxidant effect. (medicalnewstoday.com)
  • and recent studies have shown CLA to be a powerful antioxidant, anti-tumor agent, and fighter of obesity. (padmaresortbali.com)
  • 17-22 The key compound that contributed to these magical effects is a type of natural antioxidant found abundantly in green tea - epigallocatechin gallate (EGCG). (nourished.asia)
Symptoms2
  • The symptoms of obesity have been increased very widely in the recent time period and still increasing. (omicsonline.org)
  • For all but the most severely affected patients, the ultimate goal is to prevent symptoms, minimize morbidity from acute episodes, and prevent functional and psychological morbidity to provide a healthy (or near healthy) lifestyle appropriate to the age of child. (medscape.com)
Adjunct1
  • Obesity is associated with rapid clearance of biologic agents, resulting in low trough concentrations, and could result in suboptimal response to biologics, the researchers noted, so treating obesity could be an adjunct target in IBD patients. (medpagetoday.com)
Unclear3
  • Whether YSY is a potential adjuvant intervention for reducing hyperlipidaemia, atherogenesis, or obesity is unclear. (tmu.edu.tw)
  • However, the extent to which testosterone alleviates sexual dysfunction in older men and men with obesity is unclear, despite the fact that testosterone is being increasingly prescribed to these patient populations. (bvsalud.org)
  • States affected those in China is unclear. (cdc.gov)
Extract8
Side effects10
  • Obesity has definitely become a growing problem, but a lot of anti-obesity educations, with fen-peen as the best example, have proven to have very damaging side-effects like lung hypertension and heart valve condition (Fen Peen, 2010). (directcurrentmusic.com)
  • Royalist is also associated with a number of unpleasant intestinal side effects such as loose stools or an urgent need to go to the bathroom and the inability to control bowel movements. (directcurrentmusic.com)
  • Potentiated CNS side effects w/ alcohol. (mims.com)
  • However cetilistat interacts differently with the fat micelles from digested food, therefore it has less side effects and better tolerability. (wikipedia.org)
  • Should users expect any side effects with these gummies? (dietspotlight.com)
  • No bad side effects were reported in the CLA group either. (padmaresortbali.com)
  • Since CLA has not been studied for a long amount of time, the side-effects of supplementation are still relatively unknown. (padmaresortbali.com)
  • They also need to consider the rate of weight reduction, potential bone loss, vitamin deficiencies, muscle loss and function, and side effects, and be mindful of affordability, bias, and stigma. (medscape.com)
  • Rimonabant was well tolerated although (as expected) there were more psychiatric and gastrointestinal side effects and discontinuations in the rimonabant group. (drsharma.ca)
  • In Sweden, as well as many other countries, acylglycerol lipase inhibitor that works in the intestinal lumen to occupational exposure limits (OELs) are presented as an impor- reduce dietary fat absorption produces gastrointestinal side effects tant tool for managing chemical risks. (cdc.gov)
Researchers3
  • With these information, the researchers hope that snow peas would prove to have significant anti-obesity effects. (directcurrentmusic.com)
  • When researchers found out that it promotes less energy uptake, the focus was switched to obesity. (wikipedia.org)
  • Some researchers believe that essential oils may also help counteract more than 20 chronic diseases and health conditions that obesity may contribute to. (medicalnewstoday.com)
Health14
  • On top of image issues, obesity also poses a number of health-related problems which cannot be taken lightly. (directcurrentmusic.com)
  • Dietary fiber, which is found in snow peas, is undoubtedly one of the most talked about nutrients for health promotion and disease prevention (The George Maternal Foundation, Dietary fibers promote beneficial physiological detects including location, bal cholesterol attenuation and blood glucose attenuation or a combination of the three effects. (directcurrentmusic.com)
  • Obesity is a global health problem needing urgent research. (mdpi.com)
  • Obesity and overweight are defined as an excessive and abnormal accumulation of fat in the body which impairs the health of a person. (zovon.com)
  • Obesity is a condition in which excess body fat is accumulated to an extent that health may be negatively affected. (omicsonline.org)
  • Design, Setting, and Participants: This economic evaluation used a Markov microsimulation model with health states defined by obesity levels. (bvsalud.org)
  • Beyond (just) weight reduction," Jastreboff concluded, clinicians "need to focus on optimizing health as we are treating obesity. (medscape.com)
  • Cardiologists believe that the anti-obesity drug boosts heart health by improving these risk factors, which are proven to contribute to heart disease. (healthline.com)
  • 11-14 Another good news about green coffee bean is its benefit is not merely on reducing body weight and body fat, it possesses blood-pressure-lowering effects which may be beneficial for overweight individuals with a higher risk of heart health issues. (nourished.asia)
  • Numerous studies had linked green tea with fat-burning effect and improvement of obesity-related health issues. (nourished.asia)
  • It significantly affects many aspects of mental, physical and socioeconomic health. (drsharma.ca)
  • Also, obesity is associated with greater job absenteeism, loss of productivity, and higher health care costs. (msdmanuals.com)
  • The annual cost of health care in the United States related to obesity is estimated to be $150 billion. (msdmanuals.com)
  • check also tag CHILD or specific HN - 2008 FX - Adolescent Nutrition FX - Infant Nutrition DH - Maternal Nutrition DI - 052505 MN - SP6.021.072 MS - Nutrition of a mother which affects the health of the INFANT as well as herself. (bvsalud.org)
Triglycerides1
  • Pancreatic lipases do not only affect the hydrolysis of triglycerides but are also necessary for hydrolysis of fat soluble vitamins. (wikipedia.org)
Glucose2
  • Alpha lipoic acid is also known to ameliorate the effects of fructose by improving glucose homeostasis. (herbalmagic.ca)
  • Jastreboff, from Yale University and the Yale Center for Weight Management, New Haven, Connecticut, provided an overview of the many nutrient-stimulated hormone-based antiobesity therapies in late phases of development - including dual and triple therapies with glucagon-like peptide 1 receptor agonists (GLP-1 RAs), glucose-dependent insulinotropic polypeptide (GIP) agonists, glucagon , and amylin. (medscape.com)
Endocrine2
  • PCOS is a common hormonal endocrine disorder that affects women of childbearing age (15 to 49 years). (marketresearch.com)
  • However, many other factors appear to increase a person's predisposition to obesity, including endocrine disruptors (eg, bisphenol A [BPA]), gut microbiome, sleep/wake cycles, and environmental factors. (msdmanuals.com)
Rimonabant1
  • Rimonabant, brand named Acomplia, is an anti-obesity drug that may help treat addiction, the team noted. (wordnik.com)
Clinicians4
  • I certainly don't need to tell you or any of the clinicians out there about the problem of obesity in the United States. (medscape.com)
  • The primary issue is that obesity is not considered to be a disease by most people, clinicians included. (medscape.com)
  • W. Timothy Garvey, MD, from the University of Alabama at Birmingham, told Medscape that clinicians treating patients with obesity are looking forward to the decision from the US Food and Drug Administration (FDA) about tirzepatide (Mounjaro), expected by year's end. (medscape.com)
  • The American Board of Obesity Medicine (ABOM) was established in 2011 to help train clinicians and standardize practices for managing obesity. (msdmanuals.com)
Weight14
  • Finally, our own experience with topiramate is described, focusing on its effects upon weight loss and inflammatory markers. (benthamscience.com)
  • i] Scientific investigations have shown alpha lipoic acid supplementation is effective in helping with weight management, demonstrating positive effects on satiety, weight decrease and changes in fat and lean mass. (herbalmagic.ca)
  • Chromium picolinate supplementation in women: effects on body weight, composition, and iron status. (medscape.org)
  • The potential value and toxicity of chromium picolinate as a nutritional supplement, weight loss agent and muscle development agent. (medscape.org)
  • Kamphiuis MMJW, Lejeune MPGM, Saris WHM, Westerterp-Plantenga MS. Effect of conjugated linoleic acid supplementation after weight loss on appetite and food intake in overweight subjects. (medscape.org)
  • The origins of the increased weight loss due to the various possible drug effects are not established. (nih.gov)
  • A new study from the University of Illinois found that drinking several cups of coffee each day can help curb worries about weight gain because caffeine is considered an anti-obesity agent. (mix106radio.com)
  • This makes it harder to lose weight and creates a vicious cycle in which the more calories are reduced, the less effect it has on weight loss. (lifeextension.com)
  • It has long been of interest as a means to boost the effects of a weight loss program. (lifeextension.com)
  • I've shown you all of these agents that clearly produce substantial weight reduction," she said. (medscape.com)
  • In White, Luthin and Cates 's review of studies looking at weight gain with antipsychotic agents, weight gain with olanzapine was as high as 9.4 kg with an average weight gain of 4.5 kg [ 3 ]. (omicsonline.org)
  • Before buying your supplement, learn about the ingredients used and how it helps to maximize the effects by incorporating into your weight loss regime. (nourished.asia)
  • The active constituent extracted from the peels of the fruit known as hydroxycitric acid (HCA) plays a vital role in weight loss effect. (nourished.asia)
  • If obesity treatments can help alleviate these conditions, perhaps even just limit exacerbation by helping curb further weight gain, a lot would be won. (drsharma.ca)
Underweight1
Patients2
  • Arena Pharmaceuticals Inc. is recruiting about 7,000 patients into three phase III trials to test its antiobesity agent, lorcaserin, while Denmark's NeuroSearch AS is developing tesofensine . (wordnik.com)
  • 709 patients volontaires, âgés de 60 ans et plus, qui avaient consulté à la Faculté de Dentisterie de l'Université de Suleyman Demirel pour des soins dentaires de routine entre mars 2008 et avril 2009 à Isparta, en Turquie, ont été interrogés pour obtenir des données démographiques, ainsi qu'au sujet des maladies systémiques et des listes de médicaments qui les concernaient. (who.int)
Adolescents1
  • Obesity in Adolescents Obesity is now twice as common among adolescents than it was 30 years ago and is one of the most common reasons for visits to adolescent clinics. (msdmanuals.com)
Diseases2
  • A meta-analysis has suggested that obesity is an under-reported predictor of inferior response to tumor necrosis factor blockade (anti-TNF) in a range of inflammatory immune-mediated inflammatory diseases (IMIDs), with the results showing a 60% risk of impaired response to anti-TNF across several IMIDs. (medpagetoday.com)
  • Brown fat tissue is associated with greater calorie burning and protection against obesity and metabolic diseases. (lifeextension.com)
Mechanism2
  • There is neither specific evidence which clearly establishes the mechanism whereby amphetamines produce mental and behavioral effects in children, nor conclusive evidence regarding how those effects relate to the condition of the central nervous system. (nih.gov)
  • The main proposed mechanism for these effects is alpha-amylase inhibition, thereby slowing carbohydrate digestion and absorption. (cambridge.org)
Incidence3