• Prognosis
  • Given early diagnosis is critical to prognosis in ovarian cancer, development of an appropriate screening test for ovarian cancer is an important research goal. (aacrjournals.org)
  • Proteomics may have important applications in cancer diagnosis, prognosis and predictive clinical outcome that could directly change clinical practice by affecting critical elemen-ts of care and management. (wiley.com)
  • Monitoring CA-125 blood serum levels is also useful for determining how ovarian cancer is responding to treatment (with the duration of disease-free survival correlating with the rate of fall of CA-125) and for predicting a patient's prognosis after treatment. (wikipedia.org)
  • patients
  • Bast obtained annual blood samples from ovarian cancer patients up to seven years before diagnosis through a collaboration with Drs. Usha Menon and Ian Jacobs in the United Kingdom Collaborative Trial of Ovarian Cancer Screening. (healthcanal.com)
  • A "symptom index" was considered positive if patients had experienced pelvic or abdominal pain, bloating, or feeling full at least daily for at least once a week, with onset during the year prior to cancer diagnosis (or prior to a reference date for women without cancer). (unm.edu)
  • Early detection of recurrence or progression disease in patients with ovarian cancer after primary debulking surgery. (minervamedica.it)
  • Cancer patients often turn to alternative treatments to improve their quality of life. (womenhealthzone.com)
  • Mortality is mainly because of the fact that majority of the patients attending oncology clinics present too late when the primary cancer has disseminated to distant organs with the presence of micro- or macro-metastases. (wiley.com)
  • After unblinding the tests, the algorithm correctly identified 96 of 100 patients (96%) with ovarian cancer, including 23 of 24 patients with stage I or stage II disease. (medpagetoday.com)
  • Background: Although overall 5-year survival rates for ovarian cancer are poor (10-30%), stage I/IIa patients have a 95% 5-year survival. (aacrjournals.org)
  • Temporal microRNA dynamics: A complication with designing and developing tumour suppressor drugs for cancer patients is that the molecular environment within and around the tumour does not seem to be constant throughout the process of tumour development. (wikipedia.org)
  • Legislation that improves quality of life and access to care for cancer patients. (wikipedia.org)
  • Abagovomab is currently under clinical development in patients with advanced ovarian cancer, as consolidation of the remission status obtained following surgery and standard platinum and taxane first line chemotherapy. (wikipedia.org)
  • In a Phase II study on 119 patients with advanced ovarian cancer in which the standard therapies had already been ineffective, treatment with abagovomab led to a prolongation of survival time (23.4 months compared to 4.9 months) in those patients who responded to the vaccination, i.e. those in whom the formation of antibodies against the tumour was proven (almost 70% of patients). (wikipedia.org)
  • A multicenter clinical trial, internationally known as MIMOSA (Monoclonal antibody Immunotherapy for Malignancies of the Ovary by Subcutaneous Abagovomab), in which Abagovomab will be administered as maintenance therapy (after first line therapy with surgery and chemotherapy), is ongoing in patients with ovarian cancer. (wikipedia.org)
  • Noting that some cancer patients had relatives and ancestors with the same type of cancer, Lynch postulated that cancer could be hereditary. (wikipedia.org)
  • genetic
  • Testing may be appropriate, the USPTF concluded, in women who have a family history of ovarian cancer or who have a genetic predisposition for the disease. (yourmedicalsource.com)
  • Women at familial/genetic ovarian cancer risk often undergo screening despite unproven efficacy. (aacrjournals.org)
  • In some animal cancers, there also appears to be the same genetic changes associated as in humans. (wiley.com)
  • Henry T. Lynch (born January 4, 1928) is an American physician noted for his discovery of familial susceptibility to certain kinds of cancer and his research into genetic links to cancer. (wikipedia.org)
  • He defined the necessary criteria for a genetic cancer: early age of onset of the disease, specific pattern of multiple primary cancers, and Mendelian patterns of inheritance in hundreds of extended families worldwide. (wikipedia.org)
  • diagnosis
  • For many cancers, a simple blood test, often combined with an imaging test such as an ultrasound, computed tomography (CT), or magnetic resonance imaging (MRI) scan, can lead to early diagnosis - and cure. (yourmedicalsource.com)
  • The recent dramatic advances in molecular medicine, genomics, proteomics and translational research will allow biomarker identification, which may provide the best strategies for veterinarians and clinicians to combat disease by early diagnosis and administration of effective treatments. (wiley.com)
  • Educating medical and other healthcare professionals about ovarian cancer diagnosis and the need to provide referral to gynecologic oncologists. (wikipedia.org)
  • recurrent
  • To find the right proteins for the new test, the researchers screened blood samples from 28 healthy women, 18 women with newly diagnosed ovarian cancer, and 40 women with recurrent disease. (medpagetoday.com)
  • markers
  • An accompanying editorial notes that the results of this study "highlight the urgent need to develop better molecular markers and improved imaging modalities for ovarian cancer screening. (unm.edu)
  • Methods We evaluated cross-sectional relationships between lifestyle and reproductive factors and these markers among controls (n = 1910) from a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC). (cam.ac.uk)
  • Conclusions This study provides insights into sources of variation in ovarian cancer early detection markers in healthy women and informs about the utility of individualizing marker cutpoints based on epidemiologic factors. (cam.ac.uk)
  • Mor G. Serum Protein Markers for Early Detection of Ovarian Cancer. (medpagetoday.com)
  • Methods: To evaluate these markers in an independent study population, postdiagnostic/pretreatment serum samples were collected from women hospitalized at the Mayo Clinic from 1980 to 1989 as part of the National Cancer Institute Immunodiagnostic Serum Bank. (aacrjournals.org)
  • Together with Dirk Bauerschlag and Garret Hampton, he identified additional markers suitable as serum markers for early detection of ovarian cancer subgroups. (wikipedia.org)
  • prevention
  • Women who are at increased risk of ovarian cancer based on family or personal medical history who are participating in the Northwestern Ovarian Cancer Early Detection and Prevention Program clinic. (clinicaltrials.gov)
  • This finding may lead to earlier detection, as well as better treatment and perhaps even prevention of ovarian cancer. (blogspot.com)
  • During that time Philippe Autier launched and coordinated the first Early Warning Systems for famine prevention in Mali and Chad, projects funded by the European Commission. (wikipedia.org)
  • In 1988 he received a Fulbright fellowship with a grant from the Frank Boas Foundation to study at Harvard School of Public Health, Cambridge, Massachusetts, where he was awarded a M.P.H. Going back to Europe in 1989, Autier joined Institut Jules Bordet, an oncology centre in Brussels, as head of the Epidemiology and Prevention Unit, and the Oeuvre Belge du Cancer, an agency active in cancer prevention. (wikipedia.org)
  • He returned to the Institut Jules Bordet for two more years and finally moved to Lyon, France, to join the International Agency for Research on Cancer, IARC, as Head of the Unit of Prevention Evaluation(former Epidemiology Methods and Support Group) and Cluster Coordinator of the Biostatistics and Epidemiology Cluster until 2009. (wikipedia.org)
  • Autier's main field of research is the study of environmental factors for cancer and the evaluation of cancer prevention technologies. (wikipedia.org)
  • For the first field he is known for his work on causes and prevention of skin cancers, mainly the cutaneous melanoma, where he has the goal to evaluate exposure to solar and artificial ultraviolet radiation (see also his work on cancer risks with sunbeds). (wikipedia.org)
  • He is sometimes described as "the father of hereditary cancer detection and prevention" or the "father of cancer genetics", although Lynch himself said that title should go to the early 20th century pathologist Aldred Scott Warthin. (wikipedia.org)
  • In 1984 he established the Hereditary Cancer Prevention Clinic at Creighton, which focuses on identifying risk factors, promoting early detection, and preventing the onset of familial cancers. (wikipedia.org)
  • Lynch Syndrome: An Interview With the Father of Hereditary Cancer Detection and Prevention, Henry T. Lynch, MD". Interview with the Innovators. (wikipedia.org)
  • cervical
  • Since the development of the Papanicolou smear or Pap smear in 1941, cervical cancer has been highly preventable. (wikipedia.org)
  • The implementation of Pap smear screening programs has resulted in a steady decline in incidence and mortality rates from cervical cancer since the mid-1970s. (wikipedia.org)
  • Human papilloma virus (HPV) is consistently present in almost all cervical cancer cases across the world and is the main etiologic factor in cervical cancer. (wikipedia.org)
  • ovary
  • Rarely, it may cause the ovary to twist around the ovarian ligament and can cut off the blood flow to the ovary. (wikipedia.org)
  • cysts
  • Gynecologic sonography is used extensively: to assess pelvic organs, to diagnose acute appendicitis to diagnose and manage gynecologic problems including endometriosis, leiomyoma, adenomyosis, ovarian cysts and lesions, to identify adnexal masses, including ectopic pregnancy, to diagnose gynecologic cancer in infertility treatments to track the response of ovarian follicles to fertility medication (i.e. (wikipedia.org)
  • serous
  • With these findings Meinhold-Heerlein contributed to the contemporary understanding of serous ovarian cancer in discriminating two significant types: low grade versus high grade. (wikipedia.org)
  • tumour
  • 6-8 Individuals with the same type of cancer vary in their tumour location, size, histology, grade and stage. (wiley.com)
  • Moreover, an individual organ can harbour a tumour that contains several stages in the same tissue (for example, in situ and invasive cancer). (wiley.com)
  • researchers
  • The Ovarian Cancer National Alliance educates the public by hosting an Annual Conference, which offers forums and lectures with renowned clinicians and researchers. (wikipedia.org)
  • Obstetrics
  • He is currently deputy director of the Department of Gynaecology and Obstetrics at the University Hospital RWTH Aachen as well as head of the gynaecological cancer centre and the endometriosis centre of the University Hospital RWTH Aachen. (wikipedia.org)
  • In 1985 he began one of the largest trials for ovarian cancer screening, and began training in the field of obstetrics and gynaecology at the Addenbrooke's Hospital, which he completed in 1990. (wikipedia.org)
  • Risk
  • Cancer is an intractable disease and the risk of human and companion animal cancers increases dramatically with age. (wiley.com)
  • Under his leadership Creighton also hosts a High Risk Registry, part of the Early Detection Research Network sponsored by the National Cancer Institute. (wikipedia.org)
  • Genetics
  • In 1990-91 he received a fellowship from the Medical Research Council to research cancer genetics at Duke University, followed by a Cambridge Regional College fellowship in 1992-94. (wikipedia.org)
  • Cancer Genetics. (wikipedia.org)