• acute lymphoid leukemia
  • In addition to Wilms tumor and hepatoblastoma, children with BWS have been shown in individual case reports to develop ganglioneuroma, adrenocortical carcinoma, acute lymphoid leukemia, liver sarcoma, thyroid carcinoma, melanoma, rhabdomyosarcoma, and mesoblastic nephroma. (wikipedia.org)
  • In a 2010 study by the University of California, Berkeley's School of Public Health, researchers found that children with acute lymphoid leukemia (ALL) had almost twice the chance of having been exposed to three or more X-rays compared with children who did not have leukemia. (wikipedia.org)
  • CD10
  • CD10 is of use in hematological diagnosis since it is expressed by early B, pro-B and pre-B lymphocytes, and by lymph node germinal centers. (wikipedia.org)
  • transgenic
  • Present investigations aim to identify mechanisms of cooperativity between these factors, to identify additional factors which regulate the MPO and NE enhancers, to identify biochemical pathways which link myeloid cell surface receptors, such as the G-CSF Receptor, to these factors, and to assess the ability of these enhancers to direct early myeloid-specific expression in transgenic mice. (searlescholars.net)
  • hematopoiesis
  • KMT2A gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. (wikipedia.org)
  • lymphoproliferative
  • Similar problems are encountered in the diagnosis of lymphoproliferative disorders, although certain disorders such as hairy cell leukemia (HCL) can be quite distinctive morphologically. (thefreelibrary.com)
  • malignancy
  • Leukemia is a hematological malignancy or a cancer of the blood. (wikipedia.org)
  • The term leukemoid reaction describes an increased white blood cell count, or leukocytosis, which is a physiological response to stress or infection (as opposed to a primary blood malignancy, such as leukemia). (wikipedia.org)
  • adults
  • Chronic myeloid leukemia in pediatric patients is rare, making it difficult to study, and is often more aggressive in children and young adults," said Jonathan Leith, PhD, hematology development lead, Bristol-Myers Squibb. (businesswire.com)
  • clinical
  • The precise findings will vary depending on the type of chronic leukemia and often requires special stains, cytogenetic analysis, and clinical correlation for accurate interpretation. (thefreelibrary.com)
  • PRINCETON, N.J.--( BUSINESS WIRE )-- Bristol-Myers Squibb Company (NYSE: BMY) today announced the first presentation of data from two cohorts of the Phase 2 CA180-226 clinical trial evaluating Sprycel (dasatinib) in imatinib-resistant or -intolerant (R/I to IM) and newly diagnosed (ND) pediatric patients with chronic phase chronic myeloid leukemia. (businesswire.com)
  • whereas
  • We observed positive associations between 1,3-butadiene and childhood leukemia in single and co-pollutant models whereas effect estimates from single pollutant models were diminished for benzene and POM in co-pollutant models. (biomedcentral.com)
  • survival
  • citation needed] Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. (wikipedia.org)
  • patients
  • CA180-226 is an ongoing Phase 2, open-label, nonrandomized study evaluating Sprycel in patients aged 18 years or younger with newly diagnosed chronic myeloid leukemia (CML) or Philadelphia chromosome-positive (Ph+) leukemias resistant to or intolerant of imatinib. (businesswire.com)
  • FOSTER CITY, Calif. --(BUSINESS WIRE)--Oct. 9, 2013-- Following a recommendation by an independent Data Monitoring Committee (DMC), Gilead Sciences , Inc. (Nasdaq:GILD) today announced that its Phase 3 study (Study 116) evaluating idelalisib in previously-treated chronic lymphocytic leukemia (CLL) patients who are not fit for chemotherapy will be stopped early. (gilead.com)