• acute lymphoid leukemia
  • In addition to Wilms tumor and hepatoblastoma, children with BWS have been shown in individual case reports to develop ganglioneuroma, adrenocortical carcinoma, acute lymphoid leukemia, liver sarcoma, thyroid carcinoma, melanoma, rhabdomyosarcoma, and mesoblastic nephroma. (wikipedia.org)
  • In a 2010 study by the University of California, Berkeley's School of Public Health, researchers found that children with acute lymphoid leukemia (ALL) had almost twice the chance of having been exposed to three or more X-rays compared with children who did not have leukemia. (wikipedia.org)
  • cells
  • Moreover, the understanding of the mechanisms that damage the earliest steps of the lymphoid developmental program in ALL is incomplete, and the existence of specialized cancer stem cells is still a debate [ 8 ]. (hindawi.com)
  • Here, we show that transfer of early generated B1 B cells from Eμ-TCL1 transgenic mice resulted in chronic lymphocytic leukemia (CLL) with a biased repertoire, including stereotyped BCRs. (rupress.org)
  • termed B1 B cells (also called B-1 B cells), this prompted the question of whether early generated CD5 + B cells can become CLL in aged mice. (rupress.org)
  • The anti-neoplastic activity of ethylamine-carboxyborane and triphenylphosphine-carboxyborane in L-1210 lymphoid leukemia cells. (docme.ru)
  • In humans, C12orf66 has higher than average expression in a number of tissues such as endocrine glands as well as lymphoid tissues and cells. (wikipedia.org)
  • A number of experiments using different human embryonic stem cell lines, oocytes, as well as erythroblasts found C12orf66 expression was increased in these cells earlier in development and expression decreased as these cells became more differentiated. (wikipedia.org)
  • When a child has leukemia, the cells do not respond to the signals telling them when to stop and when to produce cells, regardless of the available space. (wikipedia.org)
  • ALL is a form of leukemia that affects the lymphocytes, a type of white blood cells which fights infection. (wikipedia.org)
  • Nuclear bodies (NBs) were first seen as prominent interchromatin structures in the nuclei of malignant or hyperstimulated animal cells identified using anti-sp100 autoantibodies from primary biliary cirrhosis and subsequently the promyelocytic leukemia (PML) factor, but appear also to be elevated in many autoimmune and cancerous diseases. (wikipedia.org)
  • The leukemia cells of up to 80 percent of infants with ALL-1 have a chromosomal rearrangement that fuses the MLL1 gene to a gene on a different chromosome. (wikipedia.org)
  • He was the first (1970) to prove the existence of cancer stem cells in a study of leukemia. (wikipedia.org)
  • cancers
  • Additionally, C12orf66 expression is increased in a number of cancers including leukemia, breast cancer, cervical cancer, and a number of gastrointestinal related cancers. (wikipedia.org)
  • These, or similar, bodies have been found increased in the presence of lymphoid cancers and SLE (lupus). (wikipedia.org)
  • lymphoproliferative
  • Similar problems are encountered in the diagnosis of lymphoproliferative disorders, although certain disorders such as hairy cell leukemia (HCL) can be quite distinctive morphologically. (thefreelibrary.com)
  • clinical
  • The precise findings will vary depending on the type of chronic leukemia and often requires special stains, cytogenetic analysis, and clinical correlation for accurate interpretation. (thefreelibrary.com)
  • PRINCETON, N.J.--( BUSINESS WIRE )-- Bristol-Myers Squibb Company (NYSE: BMY) today announced the first presentation of data from two cohorts of the Phase 2 CA180-226 clinical trial evaluating Sprycel (dasatinib) in imatinib-resistant or -intolerant (R/I to IM) and newly diagnosed (ND) pediatric patients with chronic phase chronic myeloid leukemia. (businesswire.com)
  • survival
  • citation needed] Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. (wikipedia.org)
  • patients
  • Chronic myeloid leukemia in pediatric patients is rare, making it difficult to study, and is often more aggressive in children and young adults," said Jonathan Leith, PhD, hematology development lead, Bristol-Myers Squibb. (businesswire.com)
  • CA180-226 is an ongoing Phase 2, open-label, nonrandomized study evaluating Sprycel in patients aged 18 years or younger with newly diagnosed chronic myeloid leukemia (CML) or Philadelphia chromosome-positive (Ph+) leukemias resistant to or intolerant of imatinib. (businesswire.com)
  • FOSTER CITY, Calif. --(BUSINESS WIRE)--Oct. 9, 2013-- Following a recommendation by an independent Data Monitoring Committee (DMC), Gilead Sciences , Inc. (Nasdaq:GILD) today announced that its Phase 3 study (Study 116) evaluating idelalisib in previously-treated chronic lymphocytic leukemia (CLL) patients who are not fit for chemotherapy will be stopped early. (gilead.com)