BiosynthesisMRNASynthase geneDevelopmentalEncodesMethylationEmbryonic developmentProteinsDataSetsChromosomeRepressionMembraneDifferentialHumansTranscript variantsViralUpstreamPathwaysAccumulationTranscription factorTransientlyProtein expressionAffectsInvolvementDetectionHumanSpecificInteractionRapidFunctionCellsRole
Biosynthesis1
- Light-triggered degradation of PIFs after interaction with photoactivated phytochromes during deetiolation results in a rapid derepression of PSY gene expression and a burst in the production of carotenoids in coordination with chlorophyll biosynthesis and chloroplast development for an optimal transition to photosynthetic metabolism. (lancs.ac.uk)
MRNA5
- MKP-1, but not MKP-3, mRNA expression was 10-fold up-regulated in both mouse and human osteoblast cell lines within 30 min of Dex treatment and remained elevated for 24 h. (ox.ac.uk)
- This study demonstrates the induction of lysozyme mRNA expression in situ in tissue macrophages (M phi) of mice following in vivo stimulation. (ox.ac.uk)
- Differential regulation of human ALAS1 mRNA and protein levels by heme and cobalt protoporphyrin. (wakehealth.edu)
- Parallel microRNA and mRNA expression profiling of (genotype 1b) human hepatoma cells expressing hepatitis C virus. (wakehealth.edu)
- Thirty-three fresh-frozen HPV-16 positive OPSCC samples with known integration status were analyzed by mRNA expression profiling. (cancer-genetics.org)
Synthase gene2
- Haem repression of the housekeeping 5-aminolaevulinic acid synthase gene in the hepatoma cell line LMH. (wakehealth.edu)
- Direct regulation of phytoene synthase gene exp. (lancs.ac.uk)
Developmental3
- Gene Expression Regulation, Developmental" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (jefferson.edu)
- This graph shows the total number of publications written about "Gene Expression Regulation, Developmental" by people in this website by year, and whether "Gene Expression Regulation, Developmental" was a major or minor topic of these publications. (jefferson.edu)
- Below are the most recent publications written about "Gene Expression Regulation, Developmental" by people in Profiles. (jefferson.edu)
Encodes4
- We have recently identified a hematopoietic cell-specific immediate-early gene, DUB-1, that encodes a growth-regulatory deubiquitinating enzyme. (ox.ac.uk)
- This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. (cancerindex.org)
- from Int J Paediatr Dent 2000 Dec;10(4):328-34) The X-linked form is also known as Zinsser-Cole-Engman syndrome and involves the gene which encodes a highly conserved protein called dyskerin. (lookformedical.com)
- This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. (cancer-genetics.org)
Methylation1
- Inactivation of E2f6 leads to a failure to deposit CpG island DNA methylation at these genes during implantation. (cnrs.fr)
Embryonic development2
- Cloning of a novel phospholipase C-delta isoform from pacific purple sea urchin (Strongylocentrotus purpuratus) gametes and its expression during early embryonic development. (ox.ac.uk)
- In addition to Northern and polymerase chain reaction (PCR) analyses, in situ hybridization experiments further demonstrated that the embryonic regions within which the PLC-deltasu transcript can be detected during early embryonic development are associated with the highest levels of proliferative activity, suggesting a possible involvement with metabolism or cell cycle regulation. (ox.ac.uk)
Proteins1
- HCV proteins increase expression of heme oxygenase-1 (HO-1) and decrease expression of Bach1 in human hepatoma cells. (wakehealth.edu)
DataSets1
- Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
Chromosome1
- This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. (cancer-genetics.org)
Repression2
- Both in vitro and in vivo evidence demonstrate that PIF1 directly binds to the promoter of the PSY gene, and that this binding results in repression of PSY expression. (lancs.ac.uk)
- Our findings elucidate the mechanisms of epigenetic targeting of germline genes and provide a paradigm for how transient repression signals by DNA-binding factors in early embryonic cells are translated into long-term epigenetic silencing during mouse development. (cnrs.fr)
Membrane2
- Vascular endothelial growth factor increases heme oxygenase-1 protein expression in the chick embryo chorioallantoic membrane. (wakehealth.edu)
- Additionally, the expression of several cell wall and membrane degradation-related genes in ySpdSyn transgenic fruits was not correlated with an extension of shelf life, indicating that the Spd-mediated increase in fruit shelf life is independent of the above factors. (ox.ac.uk)
Differential1
- Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in enzyme synthesis. (lookformedical.com)
Humans1
- Intestinal expression of genes involved in iron absorption in humans. (wakehealth.edu)
Transcript variants2
- Alternative splicing of this gene results in multiple transcript variants. (cancerindex.org)
- Three transcript variants encoding different isoforms have been found for this gene. (cancer-genetics.org)
Viral2
- Iron increases HMOX1 and decreases hepatitis C viral expression in HCV-expressing cells. (wakehealth.edu)
- Because we showed that integration neither affects the levels of viral genes, nor those of virally disrupted human genes, a genome-wide screen was performed to identify human genes which expression is influenced by viral integration and have clinical relevance. (cancer-genetics.org)
Upstream1
- Digital expression patterns results suggested that the 4 genes including ODC, ADC, AIH and CPA involved in the upstream pathway of TAs, and the 2 branch pathway genes including SPDS and TRII were found to be expressed in all the detected tissues with high expression level in secondary root. (bvsalud.org)
Pathways2
- Cytokine receptors activate multiple signal transduction pathways, resulting in the induction of specific target genes. (ox.ac.uk)
- What pathways are this gene/protein implicaed in? (cancer-genetics.org)
Accumulation3
- Constitutive expression of ySpdSyn enhanced intracellular levels of Spd in the leaf, and transiently during fruit development, whereas E8-ySpdSyn expression led to Spd accumulation early and transiently during fruit ripening. (ox.ac.uk)
- Here we show that phytochrome-interacting factor 1 (PIF1) and other transcription factors of the phytochrome-interacting factor (PIF) family down-regulate the accumulation of carotenoids by specifically repressing the gene encoding phytoene synthase (PSY), the main rate-determining enzyme of the pathway. (lancs.ac.uk)
- Our results also suggest a role for PIF1 and other PIFs in transducing light signals to regulate PSY gene expression and carotenoid accumulation during daily cycles of light and dark in mature plants. (lancs.ac.uk)
Transcription factor1
Transiently1
- Effects of phenylarsine oxide on expression of heme oxygenase-1 reporter constructs in transiently transfected cultures of chick embryo liver cells. (wakehealth.edu)
Protein expression2
- Scope includes mutations and abnormal protein expression. (cancerindex.org)
- Protein expression and function of organic anion transporters in short-term and long-term cultures of Huh7 human hepatoma cells. (cancerindex.org)
Affects1
- Heme status affects human hepatic messenger RNA and microRNA expression. (wakehealth.edu)
Involvement1
- Coupled with the rapidity of Dex action, this indicates immediate-early gene phosphatase involvement, and we therefore used quantitative, real-time PCR to examine expression profiles of the dual-specificity MAPK phosphatases, MKP-1 and MKP-3. (ox.ac.uk)
Detection1
- Non-coding RNAs in hepatitis C-induced hepatocellular carcinoma: dysregulation and implications for early detection, diagnosis and therapy. (wakehealth.edu)
Human5
- Glucocorticoids induce rapid up-regulation of mitogen-activated protein kinase phosphatase-1 and dephosphorylation of extracellular signal-regulated kinase and impair proliferation in human and mouse osteoblast cell lines. (ox.ac.uk)
- Regulation of expression of the human heme oxygenase-1 gene in transfected chick embryo liver cell cultures. (wakehealth.edu)
- Role of Bach-1 in regulation of heme oxygenase-1 in human liver cells: insights from studies with small interfering RNAS. (wakehealth.edu)
- Reciprocal effects of micro-RNA-122 on expression of heme oxygenase-1 and hepatitis C virus genes in human hepatocytes. (wakehealth.edu)
- Effects of silymarin on hepatitis C virus and haem oxygenase-1 gene expression in human hepatoma cells. (wakehealth.edu)
Specific1
- We have expressed a yeast spermidine synthase (ySpdSyn) gene under constitutive (CaMV35S) and fruit-ripening specific (E8) promoters in Solanum lycopersicum (tomato), and determined alterations in tomato vegetative and fruit physiology in transformed lines compared with the control. (ox.ac.uk)
Interaction1
- This response is also evoked by a noninfectious agent (intravenously injected sheep erythrocytes), and is possibly the result of an early phagocytic interaction. (ox.ac.uk)
Rapid1
- Therefore, MKP-1 up-regulation provides a novel and rapid mechanism, whereby GCs inhibit osteoblast proliferation. (ox.ac.uk)
Function1
Cells2
- Increased heme oxygenase-1 gene expression in liver cells and splanchnic organs from portal hypertensive rats. (wakehealth.edu)
- Furthermore, E2F6 is required to initiate epigenetic silencing in early embryonic cells but becomes dispensable for the maintenance in differentiated cells. (cnrs.fr)
Role1
- Role of Bach1 and Nrf2 in up-regulation of the heme oxygenase-1 gene by cobalt protoporphyrin. (wakehealth.edu)