• JANX-007 is under development for the treatment of metastatic castration resistant prostate cancer (mCRPC). (globaldata.com)
  • Biomarker-Directed Therapy in Black and White Men With Metastatic Castration-Resistant Prostate Cancer. (cdc.gov)
  • In this cohort study of 962 men with metastatic castration-resistant prostate cancer, mismatch repair deficiency or microsatellite instability-high was significantly more frequent in Black men than White men. (cdc.gov)
  • Aim 1: To assess preferences and barriers for de-implementation of chemical castration in prostate cancer. (biomedcentral.com)
  • Although some patients with prostate cancer benefit from ADT in terms of survival and symptom improvement, chemical castration is also commonly performed when there is no high level evidence for use and little to no health benefits to patients raising questions of low value care. (biomedcentral.com)
  • He accepted chemical castration treatment, with DES, as an alternative to prison. (codedocs.org)
  • Guided by the theoretical domains framework (TDF), urologists and patients from facilities with the highest and lowest castration rates across the VA will be interviewed to identify key preferences and de-implementation barriers for reducing castration as prostate cancer treatment. (biomedcentral.com)
  • The investigators will conduct national surveys of urologists to prioritize key barriers identified in Aim 1 for stopping incident castration as localized prostate cancer treatment using a DCE experiment design. (biomedcentral.com)
  • Aim 3: To pilot two tailored de-implementation strategies to reduce castration as localized prostate cancer treatment. (biomedcentral.com)
  • Many students describe studies that show changes in hormone levels affect behaviour, e.g. castration studies when looking at testosterone and aggression. (themantic-education.com)
  • When someone is motivated to deal with a threat and has increased emotional and physiological arousal, there could be a higher chance for them to display aggression because to be aggression one typically requires being angry (emotion) and the display of aggression would defeat the social threat and maintain their social standing. (themantic-education.com)
  • This new topic only requires the introduction of the evolutionary role of aggression in maintaining social standing and how testosterone affects the amygdala when we're motivated to deal with social threat. (themantic-education.com)
  • This observation of intercommunity aggression disproves its hypothesised absence in savannah-dwelling chimpanzees, which by extension, has implications for early hominin evolution. (bvsalud.org)
  • When one partner uses words or phrases that are intended to invalidate and destroy the other partner's pride in his or her gender identification, it is equivalent to emotional castration. (relationshipsactually.org)
  • Most all perpetrators of emotional castration were traumatized in the same way at an earlier time in their own lives. (relationshipsactually.org)
  • Most perpetrators of emotional castration have behaved the way they do in all of their past relationships. (relationshipsactually.org)
  • The women struggle in their confined spaces as they figure out sanitation, share inadequate food, and deal with each other's emotional challenges. (parentpreviews.com)
  • More uneducated, non-working mouths to feed, burdens on society. (anchorrising.com)
  • None of the women are perfect but Annick's gentle kindness provides a safe place as they all work through the burdens they carry. (parentpreviews.com)
  • Acknowledge the differences in the way of working online that color the therapy. (theipi.org)
  • As the days unfold, the women grapple with logistical challenges, recoil from the violence they hear through their tiny window, and learn to work through their differences, while forging an unbreakable bond. (parentpreviews.com)
  • These individuals and their work have changed how urologists and other medical professionals treat and view the human body, inside and out. (urologichistory.museum)
  • Jean Civiale, a surgeon in Paris, worked much of his life to treat bladder calculi. (urologichistory.museum)
  • Anyone who has ever taken a course in 19th-century American literature has heard that the "obscure hurt" amounted to physical castration or at least severe damage to the genitals and that it accounts both for Henry's failure to fight in the Civil War (as did his younger brothers Wilkie and Bob) and, more tellingly, his lifelong disinterest in marriage. (vqronline.org)
  • After the war, Turing worked at the National Physical Laboratory, where he designed the Automatic Computing Engine (ACE), one of the first designs for a stored-program computer. (codedocs.org)
  • Like the original, Munroe's exercise in nausea focuses on a young, attractive novelist named Jennifer (Sarah Butler) who has come out to the country in order to work on her next book. (thefreeradical.ca)
  • But the trend over recent years is to do it much more early in order to tackle more effectively the procreation of unwanted cats. (pictures-of-cats.org)
  • His family had limited finances and lived in a crowded apartment, but his parents made every effort to foster his intellect (often favoring Sigmund over his siblings), which was apparent from an early age. (psychologistanywhereanytime.com)
  • So, if there some leverage that Putin has over Donald Trump, it's becoming quite apparent that that leverage is working. (nakedcapitalism.com)
  • Other priority welfare issues deal with feedlot health and morbidity, weaning methods and environmental and housing issues, including new requirements around mud and snow as a water source. (thecattlesite.com)
  • They wait for "pay day" (welfare check arrives), they wear nice clothes, have big screen tvs, go to clubs and spend money on cigarettes, and have lots of free time b/c they don't work. (anchorrising.com)
  • No housing, no welfare, no food, no free tuition at CCRI where you just take up space b/c you have no intention of ever working. (anchorrising.com)
  • [ 11 ] It was terminated approximately 7 years early because of a lack of efficacy, and even a potential negative impact with these supplements at the dosages used. (medscape.com)
  • Taking an intentionalist view, this thesis ascribes a hypothetical intention to each author which is believed to communicate the core meaning of the literary work. (lu.se)
  • Your assessment of where the Iran deal is at in the wake of Trump decertifying it to Congress? (nakedcapitalism.com)
  • If both partners are willing and able to handle the interaction at the same time, they can work together to stop the negativity between them and heal at the same time. (relationshipsactually.org)
  • While reading a recent issue of Mental Floss Magazine , I came across a way to prevent men from losing their hair that has supposedly been known to work since the time of Aristotle. (beartoons.com)
  • we also see amateur sleuthing by a character in search of their sibling and some rather incompetent undercover work. (thecriticalcritics.com)
  • Our initial close partnership with the Tavistock Clinic, the Tavistock Institute for Marital Studies (now called Tavistock Relationships), and Westminster College in Salt Lake City, Utah, used early shaky technology and unreliable internet to establish distance training. (theipi.org)
  • The diaries, which had previously been thought lost, were discovered in 1987 in a safe that had been rented 50 years earlier. (advocate.com)
  • As all therapeutic work moved online, my colleagues at the International Psychotherapy Institute and I had one advantage: We have been at a distance-learning institution for 25 years. (theipi.org)
  • He gets a job working in the kitchen of a local diner, mainly to demonstrate the success of his rehabilitation to a vocal contingent of skeptics led by Lila Loomis née Crane (Vera Miles, the only other returning Psycho cast member besides Perkins and Virginia Gregg (the voice of Mother)), whose sister Marion was Norman's penultimate victim all those many years ago. (filmfreakcentral.net)
  • [14] However, Professor Jack Copeland has estimated that this work shortened the war in Europe by more than two years and saved over 14 million lives. (codedocs.org)
  • This work will broadly advance de-implementation science for low value cancer care, and foster participation in our de-implementation evaluation trial by addressing barriers, facilitators, and concerns through pilot tailoring. (biomedcentral.com)
  • There were, or perhaps still are, concerns about early neutering. (pictures-of-cats.org)
  • They express fury in whatever way will make them cause the most damage, and ten to attract partners who were victims of the same debasing in their early lives. (relationshipsactually.org)
  • If it is early enough in the damage cycle for me to help them heal themselves and their partners, I can change the direction of the relationship. (relationshipsactually.org)
  • However they have occurred, they must be identified and dealt with, or these people will be doomed to continue behaving that way and never know sustaining love. (relationshipsactually.org)
  • I got a note here from a friend listening intently to the program, all this that we've discussed today, and this is really good: 'The Only Hope the Country Has - The only hope this country has is through the innovations of a free people, a people who are free to benefit from their good ideas and their hard work. (rushlimbaugh.com)
  • Hard work born of free people benefiting from their innovations. (rushlimbaugh.com)
  • Sigmund Freud (1856-1939) is commonly referred to as 'the father of psychoanalysis' and his work has been tremendously influential in the popular imagination, popularizing such notions as the unconscious, defense mechanisms, Freudian slips and dream symbolism, while also making a long-lasting impact on fields as diverse as literature, film, Marxist and feminist theories, literary criticism, philosophy and psychology. (psychologistanywhereanytime.com)
  • Mulvey's essay is brilliant but more useful today as a historic landmark of early 70s feminist film theory than as a heuristic for discerning power frameworks. (metafilter.com)
  • Most prominently, the film is deeply indebted to the work of Alfred Hitchcock right from the start. (thecriticalcritics.com)
  • The themantic model, including building blocks and relationship chains works at a micro and a macro level. (themantic-education.com)
  • Kirsten Hawkes has a BA in Political Science and English and has worked in international development and medical education and marketing. (parentpreviews.com)
  • One minute we are dealing with social realism and addiction, the next we have crime and revenge, then later we have gothic horror. (thecriticalcritics.com)
  • However, until now, the absence of intercommunity attacks - including killings - in communities that live in open, mosaic environments has supported hypotheses of reduced resource competition in drier habitats, and informed referential models of early hominin social dynamics in a similar habitat. (bvsalud.org)
  • If you can't take care of yourself and that baby, don't work, don't have the father supporting the baby, don't live with family so that you can work and support the baby, then you get nothing. (anchorrising.com)
  • The Code of Practice recommends painful procedures be performed by competent personnel using proper, clean, and well maintained tools, and producers seek guidance from their veterinarian regarding optimum castration methods, timing, and pain control options. (thecattlesite.com)
  • We don't have a lot of biblical teaching on it, but in the life of Paul and others in the early church there are examples of those called to lifelong celibacy as a gift from the Lord. (preachingtoday.com)
  • These were the earliest attempts by the church to disguise religion in everyday pop-cultural artifacts. (wfmu.org)
  • If their partners still want the relationship to work, they need to take a back seat for a while, even if it means temporary separation. (relationshipsactually.org)
  • This gets back to what we said earlier, which is that we're beginning to talk in that language about the genomic complexity of the disease. (onclive.com)
  • AARON MATE: You know, I'm going to digress briefly into this sidetrack that you've just raised, but then I want to get back to the Iran deal. (nakedcapitalism.com)
  • I don't know about you but after researching whether early neutering is safe and preferable I have come away slightly confused. (pictures-of-cats.org)
  • It was at a public university in the Midwest in the late 1990s and early 2000s where he first heard about transgenderism, recalling a moment when he read an article in the student newspaper written by someone who said he realized that being effeminate made him a woman despite actually being physiologically male. (christianpost.com)
  • will be led by Jessica Girard and Kris Sawyers-Dowling, two case managers with Aging and Disability Resources who specialize in providing practical help to families in the early stages of the disease. (piercecountywa.gov)
  • His earliest experiences behind the camera came from industrial documentaries, films about "the insides of tractors… notaries… ham…" that were destined for small audiences and often made solely for internal use. (thequietus.com)
  • Django Unchained (Tarantino, 2012) set in Texas in 1858, deals with a variety of issues such as race, slavery, revenge and violence. (ukessays.com)
  • During the Second World War, Turing worked for the Government Code and Cypher School (GC&CS) at Bletchley Park , Britain's codebreaking centre that produced Ultra intelligence. (codedocs.org)
  • That's true, but when we see RB [retinoblastoma] loss and other genomic alterations, we know we're dealing with a different prognostic category. (onclive.com)
  • And for those already bald, sorry it is too late for this method to work. (beartoons.com)
  • We have seen that the ideas of the early radical feminists contained the seeds of the coming sexual revolution. (versobooks.com)
  • I'm trying to find out the optimal age for neutering domestic cats and whether there are potential problems with early neutering. (pictures-of-cats.org)
  • We subtly communicate that marriage and raising a family is the "big deal" of Christianity. (preachingtoday.com)
  • Roundworms are extremely common in kittens, and as they can be infected from the mother's milk it should be assumed they are all infected and you should start worming at an early age. (cottagevet.ie)
  • Despite these accomplishments, he was never fully recognised in his home country during his lifetime because much of his work was covered by the Official Secrets Act. (codedocs.org)