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Peptide Initiation FactorsEukaryotic Initiation Factor-2Eukaryotic Initiation Factor-4EEukaryotic Initiation FactorsEukaryotic Initiation Factor-4GEukaryotic Initiation Factor-4FEukaryotic Initiation Factor-3Eukaryotic Initiation Factor-2BProtein BiosynthesisEukaryotic Initiation Factor-4APeptide Chain Initiation, TranslationaleIF-2 KinaseReticulocytesEukaryotic Initiation Factor-1RibosomesEukaryotic Initiation Factor-5PhosphorylationRNA CapsRNA, Transfer, MetEukaryotic CellsMolecular Sequence DataRNA Cap AnalogsRNA, MessengerTOR Serine-Threonine KinasesProtein KinasesProkaryotic Initiation Factor-2Poly(A)-Binding ProteinsRNA-Binding ProteinsRibosomal Protein S6 KinasesAmino Acid SequencePolyribosomesRabbitsPhosphoproteinsGuanosine TriphosphateProtein BindingBase SequenceCodon, InitiatorCarrier ProteinsRibosomal Protein S6RNA Cap-Binding ProteinsProteinsActivating Transcription Factor 4Saccharomyces cerevisiaeRibosome Subunits, Small, EukaryoticProkaryotic Initiation Factor-3Guanosine DiphosphateRibosomal Protein S6 Kinases, 70-kDaSirolimusHeLa CellsRNA, Transfer, Amino AcylProtein-Serine-Threonine KinasesBinding Sites5' Untranslated RegionsRNA, Double-StrandedCell-Free SystemKineticsCell LineMutationGuanine Nucleotide Exchange FactorsSignal TransductionSaccharomyces cerevisiae ProteinsMacromolecular SubstancesProtein Structure, TertiaryHeminSequence Homology, Amino AcidRNA, TransferProtein Synthesis InhibitorsEndoplasmic ReticulumNucleic Acid ConformationProtein SubunitsHemeRibosome Subunits, Large, EukaryoticPotyvirusRibosomal ProteinsTranscription Factor CHOPTranscription, GeneticAdaptor Proteins, Signal TransducingNuclear Cap-Binding Protein ComplexCloning, MolecularEdeineSequence AlignmentEscherichia coliRecombinant ProteinsLysineProkaryotic Initiation FactorsLeucineRNA, ViralTriticumMolecular WeightMethionineMultiprotein ComplexesGene Expression RegulationAmino AcidsPicornaviridaeEnzyme ActivationBlotting, WesternSerineGuanine NucleotidesPeptide Elongation Factor 2Models, Molecular
EIF4gMRNAsBindsMRNA cap-bindingProteinsSubunitEIF4FPhosphorylationTranslationIncreased eIF4E-dependentEIF4AEIF2Protein synthesisMTORGeneGenes4EBP1InhibitSubunitsRegulatorsCellularOncogenicCytoplasmDownstreamAbundanceKinaseComplexNuclearRecombinantMediatesMutationsInfluencesHumansRolesFunctionalClinicalTranscription factorsSynthesisGuanosineEpidermalBodiesResistanceTargetExpressionRibavirinPotyviruses
EIF4g11
  • Some viruses cut eIF4G in such a way that the eIF4E binding site is removed and the virus is able to translate its proteins without eIF4E. (wikipedia.org)
  • The RNA helicase eIF4A and the scaffold protein eukaryotic translation initiation factor 4G (eIF4G) and the capping protein eIF4E are part of the complex that loads the mRNAs onto the 40 S ribosomal subunit, together with eIF3. (biosyn.com)
  • 4E-binding proteins (4E-BPs) block the interaction of eIF4E with eIF4G to negatively regulate the formation of the eIF4F complex. (biosyn.com)
  • The 'closed-loop' model explains that the induction of 5'- to 3'-proximity of mRNAs requires the initiation factors eIF4E, eIF4G, and PABP. (biosyn.com)
  • The model proposes the cap's interactions, with eIF4E, eIF4G, PABP, and the poly(A) tail and that the disruption of these interactions leads to functional effects. (biosyn.com)
  • PABP binding to poly(A) increases PABP's affinity to eIF4G and the affinity of eIF4E for the cap as well. (biosyn.com)
  • eIF4G is an essential translation factor that exerts strong control over protein synthesis. (nih.gov)
  • Engineered changes in eIF4G abundance amplify noise, demonstrating that minimum stochasticity coincides with physiological abundance of this factor. (nih.gov)
  • Plasmid-mediated synthesis of eIF4G imposes increased global gene expression stochasticity and reduced viability because the intrinsic noise for this factor influences total cellular gene noise. (nih.gov)
  • Phosphorylation also enhances the interaction of eIF4E with eIF4G, which form a complex known as eIF4F. (affbiotech.com)
  • This complex recognizes the mRNA by interacting with initiation factors eIF4E bound to the 5' cap, and eIF4G bound to the poly(A) tail-binding proteins. (jove.com)
MRNAs12
  • Most eukaryotic cellular mRNAs are blocked at their 5'-ends with the 7-methyl-guanosine five-prime cap structure, m7GpppX (where X is any nucleotide). (wikipedia.org)
  • eIF4E is a eukaryotic translation initiation factor involved in directing ribosomes to the cap structure of mRNAs as well as other steps in RNA metabolism that require cap-binding. (wikipedia.org)
  • Many cellular mRNAs require eIF4E in order to be translated into protein. (wikipedia.org)
  • Heterogeneous population of RNA granules serve as motile units to translocate, store, translate, and degrade mRNAs in the dendrites contain cis -elements and trans -acting factors such as RNA-binding proteins and microRNAs to convey stimulus-, transcript-specific local translation. (frontiersin.org)
  • however, mRNAs encoding a subset of factors important for error-free replication and chromosome segregation, including TIPIN, PLK2 and PLK3, remain at low abundance. (babraham.ac.uk)
  • The oncogenic potential of eIF4E arises from its ability to bind the 7-methyl guanosine (m7G) cap on mRNAs, thereby selectively enhancing eIF4E-dependent nuclear mRNA export and translation. (mcmaster.ca)
  • eIF4E, a protein modulates translation of maternal mRNAs in early embryos before the onset of zygotic transcription. (affbiotech.com)
  • eIF4E binds to the 7 methyl GTP cap structure of eukaryotic mRNAs. (affbiotech.com)
  • Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. (affbiotech.com)
  • Most eukaryotic mRNAs are monocistronic, that is, they encode only a single protein. (jove.com)
  • Translational control of mRNAs is mediated in part by eukaryotic initiation factor 4E (eIF4E). (ecu.edu)
  • Further mechanistic studies revealed that these functions were controlled by the eukaryotic initiation factor (eIF) 4E and the mitogen-activated protein kinase (MAPK) interacting protein kinase (MNK) signaling pathways, which regulate which mRNAs will be translated. (lu.se)
Binds9
  • For its RNA export function, eIF4E directly binds to the leucine rich pentatricopeptide repeat protein (LRPPRC) which directly binds the dorsal surface of eIF4E and simultaneously to the 4ESE RNA thereby acting as a platform for assembly for the RNA export complex. (wikipedia.org)
  • Even though EIF4EBP2 protein binds eIF4E and inhibits translation initiation, growth factors can release this inhibition by a phosphorylation-dependent disruption. (prospecbio.com)
  • Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. (affbiotech.com)
  • Together with eIF2 and GTP, the initiator tRNA binds the P site of the small ribosomal subunit forming the eukaryotic pre-initiation complex. (jove.com)
  • Before the preinitiation complex binds the mRNA, to make sure that a correctly processed mRNA is translated, the cell uses initial recognition of the 5' cap of the mRNA by the eIF4E subunit of eIF4F. (jove.com)
  • Phosphorylation by mTOR of 4E-BP1 disrupts its binding to eIF4E, a protein that binds the 5'-cap structure of mRNA. (biomedcentral.com)
  • 4E-BP1 binds to eIF4E, preventing its assembly into the EIF4F complex and inhibiting cap-dependent translation. (affbiotech.cn)
  • Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. (affbiotech.cn)
  • eIF4E binds the methylated 5' cap of mRNA and recruits it to the ribosome. (ecu.edu)
MRNA cap-binding2
  • An essential E box in the promoter of the gene encoding the mRNA cap-binding protein (eukaryotic initiation factor 4E) is a target for activation by c-myc. (idrblab.net)
  • eIF4E is an mRNA cap-binding protein which recruits another translation factor to start protein synthesis in cells. (uw.edu)
Proteins10
  • Also some cellular proteins, the most notable being heat shock proteins, do not require eIF4E in order to be translated. (wikipedia.org)
  • Both viruses and cellular proteins achieve this through an internal ribosome entry site in the RNA or through other RNA translation mechanisms such as those going through eIF3d eIF4E plays roles outside of translation and other cap-binding proteins can engage in cap-dependent translation in an eIF4E-independent manner including factors such as eIF3D, eIF3I, PARN, the nuclear cap-binding complex CBC. (wikipedia.org)
  • In all, the nuclear functions of eIF4E can have potent impacts on the proteome allowing eIF4E to both re-write the message as well as to increase production of proteins based on increased accumulation in the cytoplasm due to increased export as well as to increased number of ribosomes per transcript in some cases. (wikipedia.org)
  • Regulation of eIF4E may be achieved at the levels of transcription, RNA stability phosphorylation, subcellular localization and partner proteins. (wikipedia.org)
  • AKT proteins also participate in the mammalian target of rapamycin (mTOR) signalling pathway which controls the assembly of the eukaryotic translation initiation factor 4F (eIF4E) complex and this pathway, in addition to responding to extracellular signals from growth factors and cytokines, is disregulated in many cancers. (senescence.info)
  • Moreover, mTORC1 also phosphorylates eukaryotic translation initiation factor 4E-binding protein 1 (4EBP1), which will result in the separation of 4EBP1 from eukaryotic translation initiation factor 4E (eIF4E) for the translation of viral proteins in shrimp. (genscript.com)
  • Nuclear export factor 1 (NXF1) exports mRNA to the cytoplasm after recruitment to mRNA by specific adaptor proteins. (uni-frankfurt.de)
  • The initiator tRNA also contains conserved nucleotides that are recognized by proteins called eukaryotic initiation factors, or eIFs. (jove.com)
  • Plants contain two distinct cap-binding proteins, eIF4E and eIFiso4E, that assemble into different eIF4F complexes. (le.ac.uk)
  • AKT prevents cell death by inactivating proapoptotic factors including BAD, procaspase-9 and Forkhead transcription factor family proteins (FOXOs), activates transcription factors that upregulate antiapoptotic genes, including NF-kB, inactivates p53 through Mdm2, and phosphorylates the cell cycle inhibitors p21 CIP1/WAF1 and p27 KIP1 , thus increasing cell proliferation (Hennessy et al. (ebrary.net)
Subunit4
  • In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap. (affbiotech.com)
  • Upon codon-anticodon recognition, GTP is hydrolyzed and the initiation factors dissociate, allowing the large ribosomal subunit to join the complex and form an intact ribosome. (jove.com)
  • Now, the 50S ribosomal subunit can bind to the initiation complex, with the complete ribosome ready to begin translation. (jove.com)
  • As a component of the ternary eIF4F complex, eIF4E interacts with the mRNA cap structure to facilitate recruitment of the 40S ribosomal subunit onto mRNA. (le.ac.uk)
EIF4F1
  • It is a 24-kD polypeptide that exists as both a free form and as part of the eIF4F pre-initiation complex. (wikipedia.org)
Phosphorylation8
  • ISRIB (integrated stress response inhibitor) as a drug, imparts resistance to the cells against the downstream effects of eukaryotic initiation factor 2 (eIF2)α phosphorylation such as activating transcription factor 4 (ATF4) and eukaryotic translation initiation factor 4E (eIF4E)-binding protein 1 (4E-BP1) induction. (sigmaaldrich.com)
  • Phosphorylation of additional residues also occurs, for example, in response to insulin growth factor-1 and epidermal growth factor. (senescence.info)
  • This inhibition is associated with the increased phosphorylation of eukaryotic initiation factor (eIF2) α, increased association of eIF4E with the inhibitory eIF4E-binding protein (4E-BP1), and specific cleavages of eIF4B and eIF2α. (gla.ac.uk)
  • However, our data suggest that neither increased phosphorylation of eIF2α nor increased [eIF4E.4E-BP1] complex formation is essential for the inhibition of overall translation by the DNA-damaging agent. (gla.ac.uk)
  • Phosphorylation of eIF4E on serine 209 regulates the affinity of this protein for the 7 methyl GTP cap and/or RNA. (affbiotech.com)
  • eIF4E phosphorylation is correlated with increased translational rate in a number of cell types. (affbiotech.com)
  • Phosphorylation at Thr-37, Thr-46, Ser-65 and Thr-70, corresponding to the hyperphosphorylated form, is regulated by mTORC1 and abolishes binding to EIF4E. (affbiotech.cn)
  • Lang and Frost 106 demonstrated that leucine induced activation of eukaryotic initiation factor eIF4E is abrogated in endotoxin-treated rats and that endotoxin treatment antagonized the leucine-induced phosphorylation of ribosomal protein S6 and mTOR, hgh recombinant dna. (artaredecor.ir)
Translation22
  • Eukaryotic translation initiation factor 4E, also known as eIF4E, is a protein that in humans is encoded by the EIF4E gene. (wikipedia.org)
  • The eIF4E polypeptide is considered by some to be the rate-limiting component of the eukaryotic translation apparatus and is involved in the mRNA-ribosome binding step of eukaryotic protein synthesis. (wikipedia.org)
  • Translation elongation factor 1A2 (TEF1A2) is a tumor marker and an inhibitor of cadmium -induced apoptosis. (cdc.gov)
  • Eukaryotic translation initiation factor 4E (eIF4E) is a cellular target for cadmium toxicity. (cdc.gov)
  • EIF4EBP2 belongs to the eukaryotic translation initiation factor 4E binding protein family. (prospecbio.com)
  • EIF4EBP2 mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase pathway. (prospecbio.com)
  • The eukaryotic translation initiation factor eIF4E unexpectedly acts in splicing thereby coupling mRNA processing with translation: eIF4E induces widescale splicing reprogramming providing system-wide connectivity between splicing, nuclear mRNA export and translation. (iric.ca)
  • 3 In that clinical trial, some clinical responses associated with the reduction of eukaryotic translation initiation factor 4E (eIF4E) levels were seen. (haematologica.org)
  • eIF4E has a crucial role in the regulation of translation. (biosyn.com)
  • It is also expressed in embryonic and adult olfactory neuroepithelia where it complexes with eukaryotic translation initiation factor 4E (eIF4E) and possibly regulates mRNA transport or translation. (abnova.com)
  • This model also correctly predicts a plateau-like response of translation to super-physiological increases in abundance of the other cap-complex factors, eIF4E and eIF4A. (nih.gov)
  • In MCF-7 breast cancer cells, tumor necrosis factor α (TNFα) and TNF-related apoptosis-inducing ligand inhibit overall translation by a mechanism that requires caspase (but not necessarily caspase-3) activity. (gla.ac.uk)
  • The eukaryotic translation initiation factor eIF4E is elevated in 30% of malignancies including M4/M5 subtypes of acute myeloid leukemia (AML). (mcmaster.ca)
  • eIF4E also influences the overall rate of translation. (affbiotech.com)
  • In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. (affbiotech.cn)
  • Eukaryotic initiation factor eIF4E plays a pivotal role in translation initiation. (le.ac.uk)
  • The antisense depletion of both NteIF4E and NteIFiso4E resulted in plants with a semi-dwarf phenotype and an overall reduction in polyribosome loading, demonstrating that both eIF4E and eIFiso4E support translation initiation in planta, which suggests their potential role in the regulation of plant growth. (le.ac.uk)
  • Bean common mosaic virus Isolate Exhibits a Novel Pathogenicity Profile in Common Bean, Overcoming the bc-3 Resistance Allele Coding for the Mutated eIF4E Translation Initiation Factor. (oregonstate.edu)
  • bc-3 was identified as the eIF4E allele carrying mutated eukaryotic translation initiation factor gene. (oregonstate.edu)
  • Ribavirin is an mRNA cap-mimetic that can compete with eIF4E to inhibit mRNA translation. (uw.edu)
  • Subsequently, mTOR phosphorylates key eukaryotic translation regulators, including p70-S6 kinase (p70S6K) and the eukaryotic translation initiation factor 4E binding protein 1 (4E-BP1) (Hay and Sonenberg 2004). (ebrary.net)
  • The latter overrides the repressing activity of 4E-BP1 on the eukaryotic initiation factor 4E (eIF4E), resulting in enhanced translation of a subset of growth promoting genes (Hay and Sonenberg 2004). (ebrary.net)
Increased eIF4E-dependent1
  • Increased nuclear accumulation of eIF4E as well as increased eIF4E-dependent RNA export, m7G capping and splicing of selected transcripts is characteristic of high-eIF4E AML patient samples. (wikipedia.org)
EIF4A1
  • It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. (affbiotech.com)
EIF21
  • First, the initiator tRNA must be selected from the pool of elongator tRNAs by eukaryotic initiation factor 2 (eIF2). (jove.com)
Protein synthesis2
  • Jeffrey, I. W. , Bushell, M. , Tilleray, V. J. , Morley, S. and Clemens, M. J. (2002) Inhibition of protein synthesis in apoptosis: differential requirements by the tumor necrosis factor alpha family and a DNA-damaging agent for caspases and the double-stranded RNA-dependent protein kinase. (gla.ac.uk)
  • This pathway converges on and activates the apparatus necessary to start protein synthesis through a protein called the eukaryotic initiation factor 4E (eIF4E). (uw.edu)
MTOR2
  • Markedly, we found that suppression of HIF-1α accumulation by celastrol correlated with strong dephosphorylation of mammalian target of rapamycin (mTOR) and its effectors, ribosomal protein S6 kinase (p70S6K) and eukaryotic initiation factor 4E (eIF4E) and extracellular signal-regulated kinase (ERK), pathways known to regulate HIF-1α expression at the translational level. (spandidos-publications.com)
  • BDNF), glial fibrillary acidic protein (GFAP), excitatory amino acid transporter 1 (EAAT1), mTOR, eukaryotic initiation factor 4E (eIF4E)-binding protein 1 (4E-BP1), p70 ribosomal S6 kinase (p70S6K) and glyceraldehyde-3-phosphate dehydrogenase (GAPDH). (biographysoftware.com)
Gene5
  • Regulation of eIF4E by Gene Expression and RNA stability The mechanisms responsible for eIF4E transcriptional regulation are not entirely understood. (wikipedia.org)
  • The basis of this relationship was further established by the characterization of two myc-binding sites (CACGTG E box repeats) in the promoter region of the eIF4E gene. (wikipedia.org)
  • This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. (cancerindex.org)
  • This gene encodes a homeobox-containing transcription factor that is the homolog to the 'empty spiracles' gene in Drosophila. (abnova.com)
  • This latter finding is likely to preclude the existence of cryptic transcription factor binding site(s) in the 5'-untranslated region of p27 gene. (biomedcentral.com)
Genes1
  • This compound markedly decreased the hypoxia-induced accumulation of HIF-1α protein dose-dependently, whereas it did not affect the expressions of HIF-1β and topoisomerase-I (topo‑I). Furthermore, celastrol prevented hypoxia-induced expression of HIF-1 target genes for vascular endothelial growth factor (VEGF) and erythropoietin (EPO). (spandidos-publications.com)
4EBP11
  • Figure 3 shows molecular models of the cystal structure of eIF4E, in complex with the cap m7GpppA, and a 4EBP1 peptide. (biosyn.com)
Inhibit1
  • The company is also developing Zotatifin, a small molecule designed to inhibit eukaryotic initiation factor 4A (eIF4E), which is in phase 1/2 clinical trial to treat patients with solid tumors. (tradingview.com)
Subunits1
Regulators1
  • Several kinases are currently being investigated as potential regulators of eIF4E including PKC and/or the MAP kinase activated Mnk. (affbiotech.com)
Cellular2
  • Hypoxia-inducible factor-1 (HIF-1) is the central mediator of cellular responses to low oxygen and vital to many aspects of cancer biology. (spandidos-publications.com)
  • Low power laser irradiation (LPLI) promotes proliferation of multiple cells, which (especially red and near infrared light) is mainly through the activation of mitochondrial respiratory chain and the initiation of cellular signaling. (biomedcentral.com)
Oncogenic2
  • In the nucleus, eIF4E plays well defined roles in the export of selected RNAs which contributes to its oncogenic phenotypes. (wikipedia.org)
  • 2006). In turn AKT plays a key role in the transmission of pro-proliferative and transforming pathways initiated by EGFR and multiple growth factor receptors, as well as by oncogenic active PI3K mutants (Luo et al. (ebrary.net)
Cytoplasm1
  • Ribavirin-induced relocalization of nuclear eIF4E to the cytoplasm and reduction of eIF4E levels were associated with clinical response. (mcmaster.ca)
Downstream1
  • Activated TPKR could activate its downstream signaling elements, like Ras/Raf/MEK/ERK, PI3K/Akt/eIF4E, PI3K/Akt/eNOS and PLC-gamma/PKC pathways. (biomedcentral.com)
Abundance1
  • Since eIF4E is an initiation factor that is relatively low in abundance, eIF4E can be controlled at multiple levels. (wikipedia.org)
Kinase2
  • Hepatocyte growth factor receptor (c-Met), a member of tyrosine protein kinase receptors (TPKR), is phosphorylated during LPLI-induced proliferation, but tumor necrosis factor alpha (TNF-alpha) receptor has not been affected. (biomedcentral.com)
  • The class I PI3Ks are activated by growth factor tyrosine kinase receptors (class IA), such as EGFR, or by G protein coupled receptors (GPCRs) (class IB). (ebrary.net)
Complex1
  • In addition to the cis -elements in its 3′UTR and trans -acting factor Staufen, posterior localization of oskar mRNA requires deposition of exon junction complex (EJC) in its first exon through splicing ( Hachet and Ephrussi, 2004 ). (frontiersin.org)
Nuclear3
  • eIF4E is found in nuclear bodies a subset of which colocalize with PML nuclear bodies, and eIF4E is additionally found diffusely in parts of the nucleoplasm in mammalian. (wikipedia.org)
  • Nuclear eIF4E has been shown to play other roles in RNA processing including in m7G capping, alternative polyadenylation and splicing. (wikipedia.org)
  • Lack of response or relapse coincided with continued or renewed nuclear localization of eIF4E. (mcmaster.ca)
Recombinant1
  • Purified recombinant fragment of human EIF4E expressed in E. Coli. (affbiotech.com)
Mediates1
  • For several years, researchers have focused on the role of insulin-like growth factor (IGF)-1 as a primary signaling molecule that mediates skeletal-muscle growth in response to resistance exercise, given that resistance exercise stimulates the secretion of IGF-1. (humankinetics.com)
Mutations1
  • The IVT7214 cultivar supporting the replication of BCMV-1755a was found to have the intact homozygous bc-3 cleaved amplified polymorphic sequences marker and corresponding mutations in the eIF4E allele that confer resistance to BCMV isolates from all other pathogroups as well as to other potyviruses. (oregonstate.edu)
Influences1
  • The expression of eIF4E influences cell growth and phenotype. (biosyn.com)
Humans1
  • eIF4E is found in the nucleus of many mammalian cell types as well as in other species including yeast, drosophila and humans. (wikipedia.org)
Roles3
  • Its multiple roles in RNA processing require its association of RNAs through the m7G cap, and thus eIF4E can be considered a cap-chaperone protein. (wikipedia.org)
  • To study the functional roles of eIF4E and eIFiso4E in tobacco, we isolated two corresponding cDNAs, NteIF4E1 and NteIFiso4E1, and used these to deplete cap-binding protein levels in planta by antisense downregulation. (le.ac.uk)
  • Our data indicate two unique roles for eIF4E (IFE-1 isoform) in late oogenesis and spermatogenesis. (ecu.edu)
Functional1
  • Inclusion criteria included elevated eIF4E levels compared to healthy volunteers and functional equilibrative nucleoside transporter 1 (ENT1). (haematologica.org)
Clinical2
  • We tested the clinical efficacy of targeting eIF4E in M4/M5 AML patients with a physical mimic of the m7G cap, ribavirin. (mcmaster.ca)
  • This first clinical study to target eIF4E in human malignancy demonstrates clinical activity and associated molecular responses in leukemic blasts. (mcmaster.ca)
Transcription factors2
Synthesis1
  • Furthermore, LPLI induces the synthesis or release of many molecules, like growth factors, interleukins, inflammatory cytokines and others, which are related to promotive effects of LPLI. (biomedcentral.com)
Guanosine1
Epidermal2
  • Meanwhile, this DNA-PKcs-SIN1 complexation by UVB was dependent on epidermal growth factor receptor (EGFR) activation, and was disrupted by an EGFR inhibitor (AG1478) or by EGFR depletion. (biomedcentral.com)
  • UVB-induced activation of Akt signaling has been shown to be dependent on epidermal growth factor receptor (EGFR) trans-activation [ 8 ]. (biomedcentral.com)
Bodies1
  • These granules are physically associated with stabilized microtubules and are spatially segregated from eIF4E-enriched granules and P-bodies. (frontiersin.org)
Resistance2
  • Researchers demonstrated that ENT1 removal from the cell surface was induced by bone marrow stroma cell-secreted factors, and this contributed to cytarabine resistance in AML cells. (haematologica.org)
  • It is well known that the primary factor determining the hypertrophic response to contractile activity is the load across the muscle or the mechanical stretch/strain imposed on the muscle fibers, which is higher in resistance exercise than in endurance exercise. (humankinetics.com)
Target1
  • eFFECTOR has a global collaboration with Pfizer to develop inhibitors of a third target, eIF4E. (tradingview.com)
Expression1
  • SRSF5 depletion reduces and overexpression increases their cytoplasmic mRNA levels, suggesting that enhanced mRNA export by SRSF5 is required for the expression of pluripotency factors. (uni-frankfurt.de)
Ribavirin1
Potyviruses1
  • Due to frequent host switching during their evolution, host-specific adaptation of potyviruses may have been shaped by numerous host factors. (bvsalud.org)