• muscles
  • It appears that dystonia interferes with the brain's ability to inhibit those surrounding muscles, leading to loss of selectivity. (wikipedia.org)
  • The muscles most often affected are usually in the legs and feet (75% of reported cases), but the upper body muscles such as the arms, face, neck, and trunk have also been observed to be affected during the episodes of dystonia. (wikipedia.org)
  • larynx
  • Evidence of a genetic contribution for dystonia involving the larynx is still weak and more research is needed in order to establish a causal relationship between SD and specific genes. (wikipedia.org)
  • eyelids
  • The main concern for this dystonia is that it can cause the eyelids to close involuntarily and for indefinite periods of time. (wikipedia.org)
  • cause
  • It is hypothesized that a deficit in inhibition caused by a genetically mediated loss of inhibitory interneurons may be the underlying cause of the deficits observed in dystonia. (wikipedia.org)
  • patient
  • Lead implantation may take place under local anesthesia or with the patient under general anesthesia ("asleep DBS") such as for dystonia. (wikipedia.org)
  • treatment
  • Addex Therapeutics is also investigating an extended-release formulation of dipraglurant for the treatment of non-parkinsonian dystonia. (wikipedia.org)
  • multiple
  • Her expertise included studies of deep brain stimulation in people with Parkinson disease and multiple studies in people with idiopathic and isolated dystonias. (wikipedia.org)