• autonomic
  • The autonomic nervous system's physiological state (see below) leading to loss of consciousness may persist for several minutes, so If sufferers try to sit or stand when they wake up, they may pass out again The person may be nauseated, pale, and sweaty for several minutes or hours Reflex syncope occurs in response to a trigger due to dysfunction of the heart rate and blood pressure regulating mechanism. (wikipedia.org)
  • Raynaud's
  • The most common indications for thoracic sympathectomy are focal hyperhidrosis (that specifically affects the hands and underarms), Raynaud's phenomenon, and facial blushing when accompanied by focal hyperhidrosis. (wikipedia.org)
  • mechanism
  • Prostacyclin's interactions in contrast to thromboxane (TXA2), another eicosanoid, strongly suggest a mechanism of cardiovascular homeostasis between the two hormones in relation to vascular damage. (wikipedia.org)
  • IP 3 contributes to PKC activation by a separate mechanism, through opening of IP 3 -gated Ca 2+ transport channels in the endoplasmic reticulum membrane, thereby increasing [Ca 2+ ] i . (ahajournals.org)
  • 4 An alternative mechanism, producing a more sustained increase in DAG concentration, is through a pathway that begins with hydrolysis of phosphatidylcholine by phospholipase D. 5 Much less is known about the chronic activation of PKC through synthesis of DAG from glucose or lipid metabolites in diabetes and insulin resistance (see next section). (ahajournals.org)
  • Christian de Duve, the chairman of the Laboratory of Physiological Chemistry at the Catholic University of Louvain in Belgium, had been studying the mechanism of action of a pancreatic hormone insulin in liver cells. (wikipedia.org)
  • stroke
  • At fetal surgery, heart rate increased acutely, and combined cardiac output diminished at the time of fetal incision for all groups including those with MMC, which suggests diminished stroke volume. (ahajournals.org)
  • Based on previous studies indicating the presence of ACE2 and Mas in the brain as well as a protective role for ACE2/Ang-(1-7)/Mas axis during cardiovascular disease, we have developed the general hypothesis that activation of the brain ACE2/Ang-(1-7)/Mas axis will have cerebroprotective action during ischemic stroke. (ufl.edu)
  • For the treatment of primary hypertension, meta-analyses of studies which mostly used atenolol have shown although beta blockers are more effective than placebo in preventing stroke and total cardiovascular events, they are not as effective as diuretics, medications inhibiting the renin-angiotensin system (e.g. (wikipedia.org)
  • diabetes
  • To understand the process leading to age-associated alterations is, therefore, of the highest relevance for the development of new treatments for age-associated diseases, such as cancer, diabetes, Alzheimer and cardiovascular accidents. (mdpi.com)
  • Direct Evidence for Insulin-induced Capillary Recruitment in Skin of Healthy Subjects During Physiological Hyperinsulinemia Diabetes. (jove.com)
  • As a result of increased intracellular concentrations of the lipid diacylglycerol (DAG), an intermediary in glucose and fat metabolism, PKC is chronically activated in diabetes and nondiabetic insulin resistance. (ahajournals.org)
  • cardiac surgery
  • Sudden worsening of cardiac function (due to, e.g., acute cardiogenic shock, acute decompensation of chronic heart failure, procedures like coronary angiography, or cardiac surgery) triggers acute renal dysfunction, which consequently leads to humorally mediated damages that involves the activation of both SNS and RAAS systems, as well as to sodium and water retention, and to vasoconstriction. (intechopen.com)
  • diseases
  • According to a recent survey, the prevalence of metabolic diseases increases by approximately 46.7% among people older than 60 years compared to younger individuals ( Sepúlveda and Murray, 2014 ). (frontiersin.org)
  • These genetic defects are related to several neurodegenerative disorders, cancer, cardiovascular diseases, and ageing-related diseases. (wikipedia.org)
  • oxygen
  • 5 Reactive oxygen species (ROS) production by placenta and maternal tissues is increased in preeclamptic women and may be involved. (ahajournals.org)
  • The direct consequence of hypopnea (as well as apnea) is that the CO2 in the blood increases and the oxygen level in the patient's blood decrease is proportionate to the severity of the airway obstruction. (wikipedia.org)
  • However, this closure is still enough to cause a physiological effect i.e., an oxygen desaturation and/or an increase in breathing effort terminating in arousal. (wikipedia.org)
  • Beta blockers cause a decrease in renin secretion, which in turn reduces the heart oxygen demand by lowering extracellular volume and increasing the oxygen-carrying capacity of blood. (wikipedia.org)
  • stressful conditions
  • it may have a genetic, physiological or hormonal origin or be triggered by stressful conditions and/or psychological and social factors [ 1 ] (Figure 1 ). (hindawi.com)
  • Under normal physiological conditions, RYR2 mutation has no discernable effect on calcium induced-calcium release from the sarcoplasmic reticulum (SR). Ryr2 is normally activated by increased cytosolic calcium, but under stressful conditions such as increased beta adrenergic activation, RYR2 is activated by luminal calcium in association with increased SR calcium loading. (wikipedia.org)
  • chronic
  • Type II (chronic cardiorenal syndrome): chronic abnormalities in heart function causing kidney dysfunction. (intechopen.com)
  • Manipulation under anesthesia (MUA) or fibrosis release procedures is a multidisciplinary, chronic pain-related manual therapy modality which is used for the purpose of improving articular and soft tissue movement. (wikipedia.org)
  • cytosolic calcium
  • cAMP goes on to inhibit any undue platelet activation (in order to promote circulation) and also counteracts any increase in cytosolic calcium levels that would result from thromboxane A2 (TXA2) binding (leading to platelet activation and subsequent coagulation). (wikipedia.org)
  • disorders
  • Other significant effects include a slowing of cardiovascular system functions, decreased production of red blood cells, balance disorders, eyesight disorders and a weakening of the immune system. (wikipedia.org)
  • apoptosis
  • It has been demonstrated that lipopolysaccharide (LPS)-induced vascular occlusion is associated with the apoptosis, activating calpain and increased [Ca(2+)]i that are related to NHE1 activity in endothelia cells. (jove.com)
  • prevalent
  • Some other possible signs and symptoms of PVCs: Abnormal ECG Irregular heart beat Dyspnea Dizziness Feeling your heart beat (palpitations) Feeling of occasional, forceful beats Increased awareness of your heart beat Perception of a skipped heartbeat Premature ventricular contractions can occur in a healthy person of any age, but are more prevalent in the elderly and in men. (wikipedia.org)
  • effects
  • Targeted delivery is believed to improve efficacy while reducing side-effects. (wikipedia.org)
  • Increasing developments to novel treatments requires a controlled microenvironment that is accomplished only through the implementation of therapeutic agents whose side-effects can be avoided with targeted drug delivery. (wikipedia.org)
  • frequent
  • In sleep clinics, obstructive sleep apnea syndrome or obstructive sleep apnea-hypopnea syndrome is normally diagnosed based on the frequent presence of apneas and/or hypopneas rather than differentiating between the two phenomena. (wikipedia.org)
  • microenvironment
  • Culturing cells in 3D on appropriate scaffolds is thought to better mimic the in vivo microenvironment and increase cell-cell interactions. (jove.com)
  • blood
  • The National Heart, Lung, and Blood Institute Working Group has postulated the cardiorenal syndrome (CRS) as an interaction between the kidneys and the cardiovascular system in which therapy to relieve congestive heart failure (HF) symptoms is limited by the further worsening renal function. (intechopen.com)
  • enzyme
  • In addition, activation of the ACE2/Ang-(1-7)/Mas axis also attenuates many of the pathophysiological states that involve increased production of Ang II by Angiotensin Converting Enzyme (ACE), and subsequent activation of the AT1R (ACE/Ang II/AT1R axis). (ufl.edu)
  • Surprisingly, the enzyme activity was increased to normal of that of the fresh sample. (wikipedia.org)
  • METHODS
  • Another area for which basic experimental research is lacking to support the efficacy of MUA treatment of the low back, and other spinal regions relates to the two presiding theories that [A] flexibility of the spine may be increased when adhesions are reduced, and [B] MUA is more effective at treating adhesions than office-based manual therapy methods. (wikipedia.org)
  • effect
  • In fact, several small molecule ACE2 activators have been identified that selectively increase ACE2 activity without having an effect on ACE activity. (ufl.edu)
  • activation
  • Since PGI2 is primarily produced in a nucleated endothelial cell, the COX inhibition by NSAID can be overcome with time by increased COX gene activation and subsequent production of more COX enzymes to catalyze the formation of PGI2. (wikipedia.org)
  • A Ryr2 mutation may increase sensitivity to luminal calcium activation, therefore increasing calcium release from the SR under store-overload conditions and thus triggered arrhythmias. (wikipedia.org)