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Plasma CellsParaproteinemiasLeukemia, Plasma CellCell ProliferationAmyloidosisMultiple MyelomaPOEMS SyndromeImmunoglobulin Light ChainsNeoplasms, Plasma CellMonoclonal Gammopathy of Undetermined SignificanceParaproteinsOsteosclerosisCell DivisionImmunoglobulin lambda-ChainsHematologic DiseasesPlasmacytomaAgranulocytosisImmunoglobulin kappa-ChainsPlasmaCells, CulturedDibenzazepinesCell DifferentiationSignal TransductionCell Line, TumorPolyneuropathiesBone MarrowApoptosisImmunohistochemistryCell CycleGranuloma, Plasma CellB-LymphocytesMelphalanNeoplasmsRNA, MessengerCell SurvivalCell LineFlow CytometryMice, Inbred C57BLPancreatic NeoplasmsBromodeoxyuridineLymphocyte ActivationTime FactorsBlotting, WesternReverse Transcriptase Polymerase Chain ReactionCell MovementTumor Cells, CulturedGene Expression Regulation, NeoplasticAmyloidMice, KnockoutSyndecan-1PhosphorylationDose-Response Relationship, DrugKi-67 AntigenT-LymphocytesGene Expression RegulationProliferating Cell Nuclear AntigenMolecular Sequence DataDown-RegulationMice, TransgenicMice, Inbred BALB CCell CountGene ExpressionTranscription FactorsRNA, Small InterferingNeoplasm ProteinsTransfectionSkin NeoplasmsUp-RegulationEpithelial CellsCell Growth ProcessesAntigens, CDBone Marrow CellsCyclin D1Base SequenceMutationTreatment OutcomeCell MembraneSpleenCell Transformation, NeoplasticImmunoglobulin GNeoplasms, Cystic, Mucinous, and SerousImmunoglobulinsMice, NudeStem CellsFibroblastsThymidineDNA-Binding ProteinsPhenotypeLung NeoplasmsAntineoplastic AgentsHyperplasiaAntibodies, MonoclonalGerminal CenterBreast NeoplasmsDisease Models, AnimalRats, Sprague-DawleyNeoplasm InvasivenessRNA InterferenceLiver NeoplasmsLiver

Bone marrowNeoplasticSmoldering myelomaHematologicTumorDifferentiationApoptosisLymphoidLymphomasLymphocytesHEMATOPOIETIC STEMMalignantSurface antigenMonoclonal immunoglobulinGenesCellularClinicalProliferateChronicDisordersCloneMultipleImmunoglobulinsProteinsPeripheral bloodChainsStemTissueAbnormalPatientsGeneticAdultDecreaseCancerDrugNormalVarious typesBlood cellsTherapyProcess

Bone marrow10

• These neoplastic plasma cells proliferate and produce monoclonal immunoglobulin in the bone marrow causing skeletal damage, a hallmark of multiple myeloma. (jnccn.org)
• urgent intervention indicated Definition:A dysfunction characterised by insufficiently wholesome hematapoietic cell manufacturing by the bone marrow. (ehd.org)
• Any discrete, presumably solitary, mass of neoplastic PLASMA CELLS either in BONE MARROW or various extramedullary sites. (lookformedical.com)
• Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells. (lookformedical.com)
• Solitary extramedullary plasmacytoma (SEP) is a neoplastic proliferation of a single clone of plasma cells that occur outside of the bone and bone marrow. (scielo.org.za)
• A normocellular microscopical appearance, with no plasma cell dyscrasia, was displayed on the bone marrow aspirate. (scielo.org.za)
• The repair of the damaged mesangium is difficult due to the absence of enough mesangial cells that can participate in the process and also the damage can be so extensive that the intrinsic processes that are available for repair (i.e. recruitment of stem cells from bone marrow and precursor stem cells in renal niches) cannot effectively carry out the recovery. (heraldopenaccess.us)
• Multiple myeloma (MM) is a hematological malignancy characterized by the proliferation of transformed monoclonal plasma cells in the bone marrow (BM) [ 1 ]. (biomedcentral.com)
• The paradox of proliferative bone marrow together with peripheral blood cytopenias in MDS may be explained by increased intramedullary myeloid precursor cell apoptosis [ 6 ]. (medilib.ir)
• Multiple myeloma (MM) is a malignant neoplasm of plasma cells in the bone marrow. (haematologica.org)

Neoplastic2

• Multiple myeloma (MM) is caused by the neoplastic proliferation of plasma cells. (jnccn.org)
• Clonal studies in the chronic myeloid disorders - Genetic and enzyme studies based upon X-chromosome inactivation patterns have revealed a multipotent progenitor cell origin for the neoplastic clone in both MDS [ 8 ] and MPN [ 9 ]. (medilib.ir)

Smoldering myeloma1

• The NCCN Multiple Myeloma Panel members have developed guidelines for the management of patients with various plasma cell dyscrasias, including solitary plasmacytoma, smoldering myeloma, multiple myeloma, systemic light chain amyloidosis, and Waldenström's macroglobulinemia. (jnccn.org)

Hematologic2

• It is usually due to an underlying immunoproliferative disorder or hematologic neoplasms, especially multiple myeloma. (wikipedia.org)
• CLASSIFICATION OF HEMATOLOGIC MALIGNANCIES - The hematopoietic pluripotent stem cell is capable of both self-renewal and stepwise differentiation into either the lymphoid or myeloid lineage (which appears to be determined stochastically) [ 1 ]. (medilib.ir)

Tumor6

• These properties are not found in the normal adult cell from which the tumor is derived. (mhmedical.com)
• A cell line derived from cultured tumor cells. (lookformedical.com)
• Our study demonstrates that losing one copy of the MIR15A/MIR16-1 gene promotes tumor cell proliferation in both mice and patients," said Chesi. (aacr.org)
• BCMA, a member of the tumor necrosis factor (TNF) superfamily, is exclusively expressed in a subpopulation of B cells, normal plasma cells, and malignant plasma cells. (biomedcentral.com)
• Two main advantages of BCMA as an antigen for CAR-T therapy are the potential reduction of on-target/off-tumor toxicity and the lack of antigen-dependent reduction in CAR-T cell expansion [ 16 ]. (biomedcentral.com)
• Here we show that the murine antibody, mKap, binds specifically to a range of kappa-type multiple myeloma (MM) cell lines and mediates in vivo anti-tumor activity in a SCID mouse human myeloma xenograft model. (slideserve.com)

Differentiation2

• However, the vast majority of human cancers are characterized by a multiple-step process involving many genetic abnormalities, each of which contributes to the loss of control of cell proliferation and differentiation and the acquisition of capabilities, such as tissue invasion, the ability to metastasize, and angiogenesis. (mhmedical.com)
• Moreover, BCMA plays an essential role in regulating B cell maturation and differentiation into plasma cells. (biomedcentral.com)

Apoptosis1

• In both cases there is enhancement of mesangial cell apoptosis and the altered mesangium has a marked decrease of mesangial cells, most undergoing apoptosis. (heraldopenaccess.us)

Lymphoid1

• Acute and chronic inflammation, with lymphocytic and giant cell perivascular infiltrates, and lymphoid follicles are the most common histologic findings in oral and GI Crohn disease. (medscape.com)

Lymphomas2

• Causes of paraproteinemia include the following:[citation needed] Leukemias and lymphomas of various types, but usually B-cell non-Hodgkin lymphomas with a plasma cell component. (wikipedia.org)
• Cancers are named based on their origin: those derived from epithelial tissue are called carcinomas , those derived from mesenchymal tissues are sarcomas , and those derived from hematopoietic tissue are leukemias , lymphomas , and plasma cell dyscrasias (including multiple myeloma ). (mhmedical.com)

Lymphocytes2

• AL amyloidosis These are characterized by the presence of any abnormal protein that is involved in the immune system, which are most often immunoglobulins and are associated with the clonal proliferation of lymphocytes. (wikipedia.org)
• The clonal process may develop at different progenitor cell levels in individual patients, and the clonal progenitor cell may or may not involve T and B lymphocytes [ 10 ]. (medilib.ir)

HEMATOPOIETIC STEM1

• BCMA is not present in other hematological cells like hematopoietic stem cells or other tissues. (biomedcentral.com)

Malignant3

• The presence of unregulated growth and tissue invasion is characteristic of malignant neoplasms. (mhmedical.com)
• However, because a wide variety of genetic and epigenetic changes can occur in different cells within malignant tumors over time, most cancers are characterized by marked heterogeneity in the populations of cells. (mhmedical.com)
• 7 6 In MM bone disease, the interaction between malignant plasma cells and the bone microenvironment leads to osteoclastic bone destruction, reduced osteoblast function, and blocking of bone repair. (haematologica.org)

Surface antigen1

• However, with the exception of idiotype, few antigen targets have been identified that would facilitate specific immunotherapy of MM. We have previously described a murine monoclonal antibody that recognizes a conformation-dependent epitope on free human kappa light chains and a cell surface antigen, KMA, expressed on kappa MM (MM) plasma cells 1,2. (slideserve.com)

Monoclonal immunoglobulin1

• A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. (lookformedical.com)

Genes4

• The genes that can promote cell growth when altered are often called oncogenes . (mhmedical.com)
• it was subsequently found that the viral genes had normal counterparts with important functions in the cell and had been captured and mutated by viruses as they passed from host to host. (mhmedical.com)
• Furthermore, deleting one copy of miR15a/miR16-1 in mice with multiple myeloma significantly enhanced the aggressiveness of their disease and led to increased expression of genes that promote cellular proliferation. (aacr.org)
• Consistent with these results, analysis of a genetic dataset of multiple myeloma patients revealed that single-copy deletion of MIR15A/MIR16-1 in patient tumors was associated with increased expression of the same cellular proliferation genes that were upregulated in the mouse experiments. (aacr.org)

Cellular2

• The glomerulopathic light chains interact with mesangial cells where purported receptors regulate the downstream cellular mechanisms that will be activated and result in glomerular alterations. (heraldopenaccess.us)
• Thus, during normal hematopoiesis, there exists a cellular hierarchy headed by a stable population of pluripotent stem cells that generate lineage-specific progenitors, which differentiate into the various types of mature blood cells [ 2 ]. (medilib.ir)

Clinical3

• Conditions characterized by the presence of M protein (Monoclonal protein) in serum or urine without clinical manifestations of plasma cell dyscrasia. (lookformedical.com)
• There is an unmet need to develop novel therapies for refractory/relapsed MM. In the past few years, chimeric antigen receptor (CAR)-modified T cell therapy for MM has shown promising efficacy in preclinical and clinical studies. (biomedcentral.com)
• He also spearheaded an international effort to identify the first Mendelian germline predisposition gene in testicular germ cell tumors, CHEK2, with potentially immediate clinical and mechanistic implications. (the-asci.org)

Proliferate1

• This heterogeneity significantly complicates the treatment of most cancers because it is likely that there are subsets of cells that will be resistant to therapy and will therefore survive and proliferate even if the majority of cells are killed. (mhmedical.com)

Chronic1

• INTRODUCTION - An overview of the four classic myeloproliferative neoplasms (MPN): polycythemia vera, essential thrombocythemia, primary myelofibrosis, and chronic myeloid leukemia will be presented here. (medilib.ir)

Disorders1

• Myelodysplastic/myeloproliferative neoplasms (MDS/MPN) include disorders that manifest both dysplastic and proliferative features. (medilib.ir)

Clone1

• A group of related diseases characterized by an unbalanced or disproportionate proliferation of immunoglobulin-producing cells, usually from a single clone. (lookformedical.com)

Multiple4

• The NCCN Guidelines for Multiple Myeloma provide recommendations for diagnosis, initial workup, treatment, follow-up, and supportive care for patients with various plasma cell neoplasms, including multiple myeloma. (jnccn.org)
• A rare, aggressive variant of MULTIPLE MYELOMA characterized by the circulation of excessive PLASMA CELLS in the peripheral blood. (lookformedical.com)
• Multiple myeloma is a cancer of antibody-producing cells-called plasma cells-that accounts for approximately 1.8 percent of new cancer cases in the United States. (aacr.org)
• Multiple myeloma is preceded by a premalignant condition known as monoclonal gammopathy of undetermined significance (MGUS) , in which abnormal plasma cells accumulate but do not expand. (aacr.org)

Immunoglobulins1

• Abnormal immunoglobulins synthesized by atypical cells of the MONONUCLEAR PHAGOCYTE SYSTEM. (lookformedical.com)

Proteins3

• Local blood flow increases to transport the polymorphonuclear leukocytes, macrophages, and plasma proteins to the injured area. (medscape.com)
• The resulting infiltration of tissues by the leukocytes, plasma proteins, and fluid causes the redness, swelling, and pain that are characteristic of inflammation. (medscape.com)
• Approximately 85% of the monoclonal proteins in patients with plasma cell dyscrasia are associated with renal disease. (heraldopenaccess.us)

Peripheral blood2

• Myeloproliferative neoplasms (MPN), unlike MDS, usually exhibit terminal myeloid cell expansion in the peripheral blood [ 7 ]. (medilib.ir)
• Furthermore, cKap satisfies the therapeutic criteria of being able to trigger ADCC MMusing human peripheral blood-derived effector cells. (slideserve.com)

Chains2

• Several antigens have been used as targets for CAR-T cell therapy against MM, including B cell maturation antigen (BCMA), CD19, CD138, signaling lymphocytic activation molecule 7 (SLAM7), and immunoglobulin light chains. (biomedcentral.com)
• 2Department of Cell and Molecular Biology, University of Technology Sydney, Broadway, NSW, 2007, Australia JJN3 MMk cells (IgAk) were incubated with mKap or cKap alone or in the presence of competing free kappa light chains (kBJP). (slideserve.com)

Stem3

• Introducing exogenous mesenchymal stem cells represents a novel therapeutic avenue that has been experimentally tested with promising results. (heraldopenaccess.us)
• The article addresses how mesangial injury occurs in LCDD and AL-amyloidosis as examples of generic mesangiopathies and summarizes existing data regarding the experimental use of exogenous mesenchymal stem cells in mesangial healing. (heraldopenaccess.us)
• This book also has a dedicated section on Regenerative Medicine with chapters on platelet rich plasma, stem cell therapy, and intradiscal regenerative therapy. (nshealth.ca)

Tissue3

• Cancers are characterized by unregulated cell division, avoidance of cell death, tissue invasion, and the ability to metastasize. (mhmedical.com)
• A neoplasm is benign when it grows in an unregulated fashion without tissue invasion. (mhmedical.com)
• Release of damaged cells and tissue debris occurs upon injury. (medscape.com)

Abnormal1

• These cells frequently secrete a structurally homogeneous immunoglobulin (M-component) and/or an abnormal immunoglobulin. (lookformedical.com)

Patients2

• Mesangial injury represents a crucial event in the pathogenesis of light chain-associated glomerulopathies in patients with plasma cell dyscrasias. (heraldopenaccess.us)
• The findings that have been elucidated have paved the way for the design of novel therapeutic interventions aimed at stopping, slowing down or avoiding renal damage in patients with plasma cell dyscrasias. (heraldopenaccess.us)

Genetic1

• Cancers nearly always arise as a consequence of genetic alterations, the vast majority of which begin in a single cell and therefore are monoclonal in origin. (mhmedical.com)

Adult1

• They are also present in many adult organs and in brain and endocrine neoplasms. (lookformedical.com)

Decrease1

• Two compounds which have been proven to afect mitochonlease elevated signifcantly alongside a signifcant decrease in cell viability to drial function have been examined to determine whether or not the culture media would 34 mens health 082013 [url=https://livrobranco.gov.ao/rx-pills/buy-online-cenforce-cheap-no-rx/][/url]. (ehd.org)

Cancer2

• Immunotherapy utilizing T cell immunity has become a new treatment to eliminate cancer cells. (biomedcentral.com)
• non-small cell lung cancer) mit einer BRAF-V600E Mutation nach einer vorausgegangenen Chemotherapie. (oncoletter.ch)

Drug1

• The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. (lookformedical.com)

Normal1

• Indeed, normal cells have a large number of safeguards against uncontrolled proliferation and invasion. (mhmedical.com)

Various types1

• The mucous lining of the LARYNX, consisting of various types of epithelial cells ranging from stratified squamous EPITHELIUM in the upper larynx to ciliated columnar epithelium in the rest of the larynx, mucous GOBLET CELLS, and glands containing both mucous and serous cells. (lookformedical.com)

Blood cells1

• Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. (lookformedical.com)

Therapy1

• Furthermore, the toxicities of CAR-T cell therapy are manageable. (biomedcentral.com)

Process1

• The influx of leukocytes facilitates the process of phagocytosis and the removal of damaged cells and other particulate matter. (medscape.com)