• dynactin
  • IC phosphorylation directs binding to zw10 rather than dynactin, and this interaction is needed for kinetochore dynein localization. (rupress.org)
  • The depletion of kinetochore dynactin by moderate levels of p50(dynamitin) expression disrupted the ability of dynein to remove checkpoint proteins by streaming at metaphase but not other aspects of kinetochore dynein activity. (rupress.org)
  • Together, these results suggest a new model for localization of kinetochore dynein and the contribution of kinetochore dynactin. (rupress.org)
  • Moreover, Lis1, unlike dynein and dynactin, was absent from moving dynein cargos, further suggesting that Lis1 is not required for dynein-based cargo motility once it has commenced. (rupress.org)
  • On page 2643 , Thomas Hays and colleagues provide evidence that Star-directed transport of Spitz requires the activity of the microtubule-associated motor dynein and its activator dynactin. (biologists.org)
  • The authors show that Star disruption enhances the rough-eye phenotype in a fly strain that is mutant for Glued (a subunit of the dynactin complex), as well as in strains that have mutations in Dhc (which encodes the dynein heavy chain). (biologists.org)
  • Therefore, dynactin and dynein appear to mediate Star-directed trafficking of Spitz, a result that advances our understanding of how EGFR signalling is controlled in development. (biologists.org)
  • Yeast dynein can walk along microtubules without detaching, however in metazoans, cytoplasmic dynein must be activated by the binding of dynactin, another multisubunit protein that is essential for mitosis, and a cargo adaptor. (wikipedia.org)
  • The tri-complex, which includes dynein, dynactin and a cargo adaptor, is ultra-processive and can walk long distances without detaching in order to reach the cargo's intracellular destination. (wikipedia.org)
  • The other tail subunits may also help facilitate this interaction as evidenced in a low resolution structure of dynein-dynactin-BicD2. (wikipedia.org)
  • One major form of motor regulation within cells for dynein is dynactin. (wikipedia.org)
  • distinct dynein
  • In this paper, using the long, highly polarized hyphae of the filamentous fungus Aspergillus nidulans , we show that three morphologically and functionally distinct dynein cargos showed transport defects in the genetic absence of Lis1/ nudF , raising the possibility that Lis1 is ubiquitously used for dynein-based transport. (rupress.org)
  • ATPase
  • Dynein ATPase (EC 3.6.4.2, dynein adenosine 5'-triphosphatase) is an enzyme with systematic name ATP phosphohydrolase (tubulin-translocating). (wikipedia.org)
  • cilia and flagella
  • Dynein transports various cellular cargos, provides forces and displacements important in mitosis, and drives the beat of eukaryotic cilia and flagella. (wikipedia.org)
  • kinesins
  • Three families of cytoskeletal motor protein - the myosins, kinesins and dyneins - have evolved to mediate transport of cells and of structures and materials within cells in eukaryotes. (biologists.org)
  • Kinesins and cytoplasmic dyneins play essential roles in intracellular transport such as axonal transport and in the formation of the spindle apparatus and the separation of the chromosomes during mitosis and meiosis. (wikipedia.org)
  • DYNLL1
  • Auf www.antikoerper-online.de finden Sie aktuell 61 Dynein, Light Chain, LC8-Type 1 (DYNLL1) Antikörper von 12 unterschiedlichen Herstellern. (antikoerper-online.de)
  • interaction
  • Authors demonstrate that the interaction between ebola virus VP35 and dynein LC8 is direct and of high affinity and that binding stabilizes the VP35 N-terminal oligomerization domain and enhances viral RNA synthesis. (antikoerper-online.de)
  • In the current study, applying a proteomic approach of biochemical and cell biological assays combined with time-lapse imaging in live snph (+/+) and (−/−) neurons, we reveal that dynein light chain LC8 regulates axonal mitochondrial mobility through direct binding to the docking receptor SNPH, thus enhancing the SNPH-MT docking interaction. (jneurosci.org)
  • Saïb and co-workers conclude that the cytoplasmic dynein motor transports foamy virus along microtubules, speculating that helical coiled-coil motifs similar to that in Gag might be responsible for interaction of the motor with other cargos. (biologists.org)
  • 1998). "Interaction of Doc2 with tctex-1, a light chain of cytoplasmic dynein. (wikipedia.org)
  • Outer
  • Dyneins connect the outer doublets and force them to slide against each other ( Summers and Gibbons, 1971 ). (biologists.org)
  • The outer-arm dyneins have three motor domains (heads) in protozoans, but only two are retained in metazoans. (biologists.org)
  • molecule
  • Since the first edition, enormous strides have been taken in understanding dynein structure, its organization in the axoneme, single molecule motor mechanics, and the consequences of defects for human biology, disease, and development. (shakes.cz)