• glaucoma
  • To evaluate whether the amount of glaucomatous optic nerve damage at presentation of the patient and the rate of progression of glaucoma during follow-up are related to central corneal thickness. (arvojournals.org)
  • Based on these preceding investigations, it was the purpose of the present study to reevaluate whether in patients with chronic open-angle glaucoma, central corneal thickness correlates with the amount of optic nerve damage and whether it influences the risk of further progression of the disease. (arvojournals.org)
  • To evaluate a novel automated segmentation algorithm for cup-to-disc segmentation from stereo color photographs of patients with glaucoma for the measurement of glaucoma progression. (arvojournals.org)
  • Stereo color photographs of the optic disc were obtained by using a fixed stereo-base fundus camera in 58 eyes of 58 patients with suspected or open-angle glaucoma. (arvojournals.org)
  • An optimal subset of 12 features was used to segment all pixels in all stereo pairs, and the percentage of pixels assigned the correct class and linear cup-to-disc ratio (LCDR) estimates of the glaucoma fellows and the algorithm were compared to the reference standard. (arvojournals.org)
  • The performance of the disc segmentation and LCDR calculation of the algorithm was comparable to that of glaucoma fellows in training and is promising for objective evaluation of optic disc cupping. (arvojournals.org)
  • Glaucoma is the second leading cause of blindness in the United States, characterized by gradual damage of the optic nerve and resultant visual field loss. (arvojournals.org)
  • One way of determining the amount of cupping is planimetry performed by experienced glaucoma specialists examining stereo color photographs of the optic disc. (arvojournals.org)
  • It is useful for finding evidence corroborating the diagnosis of glaucoma and other optic neuropathies, optic neuritis, anterior ischemic optic neuropathy or papilledema (i.e. optic disc swelling produced by raised intracranial pressure), and optic disc drusen. (wikipedia.org)
  • causes retinal
  • With respect to embolic and hemodynamic causes, this transient monocular visual loss ultimately occurs due to a temporary reduction in retinal artery, ophthalmic artery, or ciliary artery blood flow, leading to a decrease in retinal circulation which, in turn, causes retinal hypoxia. (wikipedia.org)
  • posterior ciliary arteries
  • Giant cell arteritis: Giant cell arteritis can result in granulomatous inflammation within the central retinal artery and posterior ciliary arteries of eye, resulting in partial or complete occlusion, leading to decreased blood flow manifesting as amaurosis fugax. (wikipedia.org)
  • neuritis
  • The purpose of this study is to demonstrate the superiority of MD1003 over placebo in the visual improvement of patients suffering from chronic visual loss resulting from multiple sclerosis related optic neuritis. (clinicaltrials.gov)
  • intracranial pressure
  • It is important to differentiate them from other conditions that present with optic disc elevation, especially papilledema, which could imply raised intracranial pressure or tumors. (wikipedia.org)
  • Women in advanced stage of pregnancy with pre-eclampsia should be screened by an ophthalmoscopic examination of the optic disc for early evidence of rise in intracranial pressure. (wikipedia.org)
  • edema
  • Spontaneous venous pulsations are present in about 80 percent of patients with ODD, but absent in cases of true disc edema. (wikipedia.org)
  • 1) There was moderate optic nerve edema with adjacent flame hemorrhages (Figure 1). (harvard.edu)
  • severity of optic
  • Our patient was treated with a regimen of clindamycin 300 mg 4 times daily, trimethoprim/sulfamethoxazole double strength twice daily for 2 months, and concomitant prednisone 20 mg 4 times daily due to the severity of optic nerve involvement. (harvard.edu)
  • vein
  • Other causes are retinal vein occlusion, angiomas (Von Hippel-Lindau Disease), other vascular dysplasias, and radiation-induced retinal vasculopathy. (ophthnotes.com)
  • artery
  • Unilateral visual loss in bright light may indicate ipsilateral carotid artery occlusive disease and may reflect the inability of borderline circulation to sustain the increased retinal metabolic activity associated with exposure to bright light. (wikipedia.org)
  • fundus
  • These improvements have helped make modern fundus photography a standard ophthalmic practice for documenting retinal disease. (wikipedia.org)
  • The optics of a fundus camera are similar to those of an indirect ophthalmoscope in that the observation and illumination systems follow dissimilar paths. (wikipedia.org)
  • venous
  • For each study participant the retinal arterial oxygen saturation, venous oxygen saturation and the arteriovenous (A-V) difference combined with the measurement of each vessel diameter were analyzed within a ring area concentric to the optic disc. (arvojournals.org)
  • ophthalmic
  • citation needed] Traditional colour-film camera images are the reference standard in imaging, requiring an expert ophthalmic photographer, ophthalmic technician, optometrist or an ophthalmologist for taking standardised pictures of the optic disc. (wikipedia.org)
  • head
  • Optic disc drusen (ODD) or optic nerve head drusen (ONHD) are globules of mucoproteins and mucopolysaccharides that progressively calcify in the optic disc. (wikipedia.org)
  • The optic nerve head, or optic disc is the anterior end of the nerve that is in the eye and hence is visible with an ophthalmoscope. (wikipedia.org)
  • Optical coherence tomography scans of the orbits or head, calcification at the head of the optic nerve without change in size of globe strongly suggests drusen in a middle-age or elderly patient. (wikipedia.org)
  • This may be seen with optic nerve head drusen, astrocytic hamartoma, or calcific scarring. (wikipedia.org)
  • Systemic lupus erythematosus Periarteritis nodosa Eosinophilic vasculitis Hyperviscosity syndromePolycythemia HypercoagulabilityProtein C deficiency Antiphospholipid antibodiesAnticardiolipin antibodies Lupus anticoagulant Thrombocytosis Subclavian steal syndrome Malignant hypertension can cause ischemia of the optic nerve head leading to transient monocular visual loss. (wikipedia.org)
  • patients
  • In most patients, optic disc drusen are an incidental finding. (wikipedia.org)
  • All patients underwent qualitative and morphometric evaluation of color stereo optic disc photographs and white-on-white visual field examination. (arvojournals.org)
  • 14 eyes of 10 patients with GA due to AMD were compared to 20 age-matched eyes of 10 patients with incipient AMD (Drusen only) or 20 eyes of 10 patients with no retinal diseases present (healthy controls). (arvojournals.org)
  • The mean retinal vessel diameter of both venules and arterioles were not significantly different in patients with GA compared to eyes with incipient AMD or healthy controls. (arvojournals.org)
  • morphology
  • Despite the lack of wild-type retinal transferrin production and low levels of retinal transferrin protein, the retinal morphology and retinal iron content in HPX −/− mice treated by systemic salvage transferrin injections are normal until age 2 months. (arvojournals.org)
  • They are useful for baseline and serial follow-up to monitor minute changes in optic disc morphology. (wikipedia.org)
  • neuropathy
  • Anterior ischemic optic neuropathy (AION) is a potential complication. (wikipedia.org)
  • Disorders associated with disc elevation include: Alagille syndrome, Down syndrome, Kenny-Caffey syndrome, Leber Hereditary Optic Neuropathy and linear nevus sebaceous syndrome. (wikipedia.org)
  • choroid
  • The source of the proteins and lipids in drusen is also not clear, with potential contributions by both the RPE and the choroid. (wikipedia.org)
  • protein
  • The protein composition of drusen includes apolipoproteins and oxidized proteins, likely originating from blood, RPE, and photoreceptors. (wikipedia.org)
  • Ocular
  • There is no widely accepted treatment for ODD, although some clinicians will prescribe eye drops designed to decrease the intra-ocular pressure and theoretically relieve mechanical stress on fibers of the optic disc. (wikipedia.org)
  • deposits
  • Zinc in drusen has been suggested to play a role in drusen formation by precipitating and inhibiting the elements of the complement cascade, especially complement factor H. The presence of molecules that regulate inflammation in drusen has led some investigators to conclude that these deposits are product of the immune system. (wikipedia.org)