OrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesNamed GroupsHealth CareGeographicals
ZidovudineAnti-HIV AgentsDidanosineStavudineLamivudineReverse Transcriptase InhibitorsHIV InfectionsZalcitabineInfectious Disease Transmission, VerticalHIV-1NevirapineDideoxynucleotidesDideoxynucleosidesAIDS-Related ComplexAcquired Immunodeficiency SyndromeDrug Therapy, CombinationHIV Reverse TranscriptasePregnancy Complications, InfectiousIndinavirCD4 Lymphocyte CountHIV Core Protein p24Drug Resistance, ViralBenzoxazinesThymine NucleotidesViral LoadRNA, ViralAntiviral AgentsOxazinesOrganophosphonatesDrug InteractionsAntiretroviral Therapy, Highly ActiveHIV Protease InhibitorsDrug Resistance, Multiple, ViralDrug Resistance, MicrobialBotswanaHIVNelfinavirPregnancyAnti-Retroviral AgentsAdenineDouble-Blind MethodLopinavirRNA-Directed DNA PolymeraseAppetite StimulantsSaquinavirHalf-LifeHIV SeropositivityPyrimidinonesDrug Administration ScheduleThymidine MonophosphateInfant, NewbornNucleosidesRitonavirLeukocyte CountAIDS Dementia ComplexTreatment Failure
RetrovirLamivudine and zidovudine tabletsTabletsAbacavir sulfateTenofovirHepaticTRIZIVIRPharmacist if you are allergicTabletStavudineINTERACTIONSConcomitantHematologic toxicityRegimenInfectionPatientsAzidothymidineDoctor or pharmacistMedicationsMyopathyMedicallyNauseaDoseViral loadDosesNeutropeniaSevereMethadoneCoadministrationDosageIndicationsCombination therapyTreatmentResistanceAIDSIngredientsClinicalInfectionsAdverse effectsAdultsDiseasesCombinationsInteractSupplementsSide effects
Retrovir4
  • Additionally, some physicians and some institutions have offered the option of using zidovudine (azidothymidine, AZT, ZDV, Retrovir) after occupational exposure to HIV (6). (cdc.gov)
  • Zidovudine (Retrovir®, AZT) is a drug used for antiretroviral therapy (ART) . (aids.org)
  • The toxicity of AZT is so well documented that the pharmaceutical company that makes and commercializes it typically writes, "Retrovir (Zidovudine) may be associated with severe hematologic toxicity including granulocytopenia and severe anemia particularly in patients with advanced HIV disease" and they add that, "Myopathy and myositis with pathologic changes similar to that produced by HIV disease, have been associated with prolonged use of Retrovir" (5). (robertogiraldo.com)
  • Zidovudine Retrovir saquinavir Invirase theophylline TheoDur. (njacs.org)
Lamivudine and zidovudine tablets7
Tablets4
  • Zidovudine comes in 100mg capsules and 300mg tablets. (aids.org)
  • Leflunomide oral tablets are a generic drug . (medicalnewstoday.com)
  • A simple, accurate, precise and fully automated method for the simultaneous determination of abacavir, lamivudine and zidovudine in pharmaceutical tablets, human serum samples and drug dissolution studies has been developed. (vu.nl)
  • For situations where discontinuation of therapy with one of the active substances of [HA555 trade name], or dose reduction is necessary, separate preparations of lamivudine and zidovudine are available as tablets and oral solutions. (who.int)
Abacavir sulfate3
  • Trizivir (abacavir sulfate, lamivudine, and zidovudine) is a type of antiviral medication called a reverse transcriptase inhibitor used to treat HIV , which causes the acquired immunodeficiency syndrome ( AIDS ). (rxlist.com)
  • Our Trizivir (abacavir sulfate, lamivudinc, and zidovudinc) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
  • The purpose of this study is to determine the safety of and immune response to CsA when given with abacavir sulfate (ABC), lamivudine (3TC), and zidovudine (AZT), (ABC/3TC/AZT) and lopinavir/ritonavir (LPV/r) to HIV infected adults in the early stages of infection. (drugpatentwatch.com)
Tenofovir4
  • zidovudine, elvitegravir/cobicistat/emtricitabine/tenofovir DF. (medscape.com)
  • Conclusions Patients on a tenofovir regimen have better clinical outcomes and improved general health than patients on the zidovudine regimen. (morainetownshipdems.org)
  • To better understand the impact of a tenofovir-containing regimen in India we examined differences in several clinical outcomes including ADRs opportunistic infections CD4 count BMI weight and morbidity in patients receiving either the zidovudine- or tenofovir-containing regimens at a single private hospital clinic. (morainetownshipdems.org)
  • Cochrane Abstracts , Evidence Central , evidence.unboundmedicine.com/evidence/view/Cochrane/432835/all/Tenofovir_or_zidovudine_in_three_drug_combination_therapy_with_one_nucleoside_reverse_transcriptase_inhibitor_and_one_non_nucleoside_reverse_transcriptase_inhibitor_for_initial_treatment_of_HIV_infection_in_antiretroviral_na��ve_individuals:_Cochrane_systematic_review. (unboundmedicine.com)
Hepatic3
  • In patients with severe hepatic impairment, dose adjustment for zidovudine may be necessary. (who.int)
  • Dogs and rats treated with protease inhibitors develop hepatic cell necrosis 30 minutes after administration of the drug (44). (robertogiraldo.com)
  • The human UDP-glucuronosyltransferase (UGT) enzymes UGT1A9 and UGT2B7 play important roles in the hepatic glucuronidation of many drugs. (aspetjournals.org)
TRIZIVIR6
Pharmacist if you are allergic1
Tablet6
  • Zidovudine comes as a capsule, tablet, and syrup to take by mouth. (medlineplus.gov)
  • The combination of lamivudine and zidovudine comes as a tablet to take by mouth. (epnet.com)
  • Severe acute exacerbations of hepatitis B have been reported in patients who are co-infected with hepatitis B virus (HBV) and human immunodeficiency virus (HIV-1) and have discontinued lamivudine, a component of lamivudine and zidovudine tablet. (nih.gov)
  • Discontinue lamivudine and zidovudine tablet as medically appropriate and consider dose reduction or discontinuation of interferon alfa, ribavirin, or both. (nih.gov)
  • Each film-coated tablet contains 30 mg lamivudine and 60 mg zidovudine. (who.int)
  • Cialis Oral tablet 10mg Drug Medication Dosage information Currently The generic form of Cialis is called tadalafil Et al'The dysbindin gene is required Dosedependent fluconazole hepatotoxicity proven on biopsy and rechallenge However UTI Causes Or viruses Users of brand. (njacs.org)
Stavudine1
INTERACTIONS3
  • These interactions can change the amount of each drug in your bloodstream and cause an under- or overdose. (aids.org)
  • This feature, as well as investigating excipients-drug interactions. (free.fr)
  • No identified drug interactions would preclude coadministration of tecovirimat with antiretroviral therapy (ART) for HIV infection. (cdc.gov)
Concomitant1
  • Agents antagonistic with zidovudine: Concomitant use should be avoided. (nih.gov)
Hematologic toxicity1
  • Hematologic/bone marrow suppressive/cytotoxic agents: May increase the hematologic toxicity of zidovudine. (nih.gov)
Regimen5
  • Data collected in an ongoing CDC surveillance project of health-care workers who have been occupationally exposed to blood from HIV-infected patients (7) indicate that during the period April-December 1989, 13 (8.6%) of 151 newly enrolled participants began a postexposure regimen of zidovudine. (cdc.gov)
  • Following an ART regimen involves taking a combination of drugs each day. (medicalnewstoday.com)
  • Combinations of three antiviral drugs could keep the virus in check for a while, and when one treatment regimen failed to suppress the virus or became too toxic, switching to a different combination often renewed effective viral control. (harvard.edu)
  • In general, the patient should be on a combination regimen consisting of a total of at least three different antiretroviral drugs. (cdc.gov)
  • With the availability of new co-formulated HIV drugs, many patients could benefit from simplification of their ART regimen, guided by HIV DNA archive genotype testing (GenoSure Archive). (msdmanuals.com)
Infection8
  • Zidovudine is used along with other medications to treat human immunodeficiency virus (HIV) infection. (medlineplus.gov)
  • Zidovudine is given to HIV-positive pregnant women to reduce the chance of passing the infection to the baby. (medlineplus.gov)
  • Zidovudine controls HIV infection but does not cure it. (medlineplus.gov)
  • Zidovudine is also used along with other medications in certain situations to treat healthcare workers and other individuals exposed to HIV infection after accidental contact with HIV-contaminated blood, tissues, or other body fluids. (medlineplus.gov)
  • Lamivudine and zidovudine controls HIV infection but does not cure it. (epnet.com)
  • This report reviews Public Health Service (PHS) recommendations for postexposure management of workers who have occupational exposures that may place them at risk of acquiring HIV infection, provides background information on zidovudine and experience with zidovudine postexposure prophylaxis, and presents considerations relevant to a decision to offer postexposure prophylaxis. (cdc.gov)
  • Zidovudine was approved in 1987 as an antiretroviral (ARV) drug for people with HIV infection. (aids.org)
  • Combination drug therapy - also called highly active antiretroviral therapy (HAART) - made a huge difference in the treatment of HIV infection during the 1990s, changing HIV/AIDS into an illness that people could live with for many years. (harvard.edu)
Patients12
  • Exacerbation of anemia has been reported in HIV-1/HCV co-infected patients receiving ribavirin and zidovudine. (nih.gov)
  • Some patients taking zidovudine continue to have nausea, vomiting, headaches and fatigue. (aids.org)
  • Designated an orphan drug by FDA for treatment of PCP associated with acquired immunodeficiency syndrome (AIDS) and prevention of PCP in high-risk HIV-infected patients (i.e., history of ≥1 episode of PCP and/or CD4 + T-cell counts ≤200/mm 2 ). (drugs.com)
  • Assess each patient's risk prior to prescribing oxycodone/acetaminophen, and monitor all patients regularly for the development of these behaviors or conditions .Opioid Analgesic Risk Evaluation and Mitigation Strategy (REMS)To ensure that the benefits of opioid analgesics outweigh the risks of addiction, abuse and misuse, the Food and Drug Administration (FDA) has required a REMS for these products. (drugs.com)
  • By taking a systematic and computational approach to assessing the suitability of known compounds, researchers are able to speed up successful drug discovery and bring treatment options to patients who need them. (nature.com)
  • Therefore, it is recommended that separate preparations of lamivudine and zidovudine be administered in these patients (see section 4.4). (who.int)
  • Since substitution or dose reductions of zidovudine should be considered in patients whose haemoglobin concentrations or neutrophil counts fall to clinically significant levels, it is recommended that separate preparations of lamivudine and (if appropriate) zidovudine be administered (see section 4.4). (who.int)
  • This study is designed to determine whether 6 months of anti-HIV drugs given along with tuberculosis treatment will delay the onset of AIDS in HIV infected African patients. (drugpatentwatch.com)
  • The toxicity of AZT, the drug now prescribed indefinitely to both healthy "HIV-positive" individuals and to AIDS patients, has been solidly documented (1,8-13). (robertogiraldo.com)
  • A new drug for AIDS has begun trials in patients in Australia, Italy and the Netherlands. (newscientist.com)
  • Note: Using pamphlets or booklets with images of antiretroviral drugs and other medications may help patients to recall or identify their medications. (cdc.gov)
  • Because disease-related complications can occur in untreated patients with high CD4 counts and because less toxic drugs have been developed, treatment with antiretroviral therapy (ART) is now recommended for all patients. (msdmanuals.com)
Azidothymidine1
  • Zidovudine (ZDV), also known as azidothymidine (AZT), is an antiretroviral medication used to prevent and treat HIV/AIDS. (wikipedia.org)
Doctor or pharmacist1
Medications8
  • Zidovudine is in a class of medications called nucleoside reverse transcriptase inhibitors (NRTIs). (medlineplus.gov)
  • Lamivudine and zidovudine are in a class of medications called nucleoside reverse transcriptase inhibitors (NRTIs). (epnet.com)
  • Abacavir, lamivudine, and zidovudine are antiviral medications that prevent human immunodeficiency virus (HIV) from multiplying in your body. (cigna.com)
  • A drug-induced reaction should be considered in any patient who is taking medications and who suddenly develops a symmetric cutaneous eruption. (medscape.com)
  • Zidovudine (AZT), the most popular of the AIDS medications, was originally developed for chemotherapy in cancer, but due to its toxicity it was never approved for human use (3). (robertogiraldo.com)
  • Cialis contains the active drug ingredient tadalafil and belongs to a group of medications called phosphodiesterase 5 PDE5 inhibitors. (njacs.org)
  • The images of Food and Drug Administration (FDA)-approved antiretroviral medications can be found at http://aidsinfo.nih.gov/contentfiles/HIV_Pill_Poster.pdf f. (cdc.gov)
  • History of drug allergy and type of reactions--especially ask if there is any history of serious reactions to antiretroviral medications or drugs used for treatment or prevention of OIs, such as trimethoprim-sulfamethoxazole. (cdc.gov)
Myopathy2
Medically2
  • Medically reviewed by Drugs.com on Aug 21, 2023. (drugs.com)
  • Medically reviewed by Drugs.com. (drugs.com)
Nausea1
  • Most commonly reported adverse reactions (incidence greater than or equal to 15%) in clinical trials of combination lamivudine and zidovudine were headache, nausea, malaise and fatigue, nasal signs and symptoms, diarrhea, and cough. (nih.gov)
Dose2
  • The recommended dose of zidovudine for adults is 500mg to 600mg daily. (aids.org)
  • If you get anemia, your health care provider might reduce your dose or switch zidovudine for another ARV. (aids.org)
Viral load1
  • If you take zidovudine with other ARV drugs, you can reduce your viral load to extremely low levels, and increase your CD4 cell counts. (aids.org)
Doses1
Neutropenia1
Severe4
  • If the anemia is severe and you have to keep taking zidovudine, you may need a blood transfusion, or you might take the drug erythropoietin. (aids.org)
  • Newer drugs tend to cause fewer and less severe side effects. (medicalnewstoday.com)
  • Co-trimoxazole is drug of choice for treatment of mild, moderate, or severe PCP in adults, adolescents, and children, including HIV-infected individuals. (drugs.com)
  • Severe skin reactions, which can be life threatening, including Stevens-Johnson syndrome , toxic epidermal necrolysis , and drug reaction with eosinophilia and systemic symptoms . (medicalnewstoday.com)
Methadone2
Coadministration1
Dosage2
  • It is recommended that separate preparations of lamivudine and zidovudine are used for any dosage adjustment (see section 4.2). (who.int)
  • Dosage of drugs is not considered in the study. (ehealthme.com)
Indications2
  • Drug repurposing, or drug repositioning, is an approach which aims to circumvent some of the steps of that process by examining previously approved compounds for their efficacy in new indications. (nature.com)
  • In the pursuit of this goal, the value of a strategy that makes use of existing resources is being recognized: drug repurposing or repositioning of compounds for new indications. (nature.com)
Combination therapy2
  • But zidovudine is used as part of combination therapy for people who are exposed to HIV through a workplace accident (needle stick or splash). (aids.org)
  • The company becomes one of the few companies in the world to offer all three component drugs of retroviral combination therapy.In the year 1999 the company launched Nevirapine antiretroviral drug used to prevent the transmission of AIDS from mother to child. (business-standard.com)
Treatment14
  • Your doctor may test you to see if you have HBV before you begin your treatment with lamivudine and zidovudine. (epnet.com)
  • Your doctor will order certain lab tests during and after your treatment to check your body's response to lamivudine and zidovudine. (epnet.com)
  • As of 2019, the standard is a three-drug once-daily oral treatment that can include AZT. (wikipedia.org)
  • Zidovudine was the first drug approved for the treatment of HIV. (aids.org)
  • Early treatment" with zidovudine was tested in people with no symptoms of HIV disease. (aids.org)
  • In this study, CD4 lymphocyte count is both a time-dependent confounder of the causal effect of zidovudine on survival and is affected by past zidovudine treatment. (nih.gov)
  • Below are some of the classes of HIV treatment drugs . (medicalnewstoday.com)
  • Designated an orphan drug by FDA for primary prophylaxis in HIV-infected individuals at high risk for developing T. gondii encephalitis and for treatment and suppression of T. gondii encephalitis. (drugs.com)
  • HIV infected children and adolescents who have taken many anti-HIV drugs may have limited treatment options and are at high risk for progressing to AIDS. (drugpatentwatch.com)
  • The toxicity of AZT can be potentialized by other DNA chain terminators such as gancyclovir and acyclovir, drugs that are frequently prescribed together with AZT in the treatment and prevention of opportunistic viral infections (36,37). (robertogiraldo.com)
  • Prior to the bone marrow transplant, the patient underwent drug and radiation treatment to destroy virtually all of his already damaged immune system to prevent rejection of the transplant by the body. (org.in)
  • Gorchein A. Drug treatment in acute porphyria. (medscape.com)
  • Treatment of monkeypox with tecovirimat as a first-line agent is available through CDC for compassionate use through an investigational drug protocol. (cdc.gov)
  • If treatment fails, drug susceptibility (resistance) assays can determine the susceptibility of the dominant HIV strain to all available drugs. (msdmanuals.com)
Resistance5
  • This is called "developing resistance" to the drug. (aids.org)
  • Sometimes, if your virus develops resistance to one drug, it will also have resistance to other ARVs. (aids.org)
  • When used with zidovudine (ZDV) may prevent emergence of ZDV resistance, and for ZDV-resistant virus, revision to phenotypic ZDV sensitivity may be observed. (cdc.gov)
  • 1,000 copies/mL, drug-resistance testing may be unsuccessful but should still be considered. (hiv.gov)
  • The report also includes a summary on the status of drug resistance for TB, HIV and malaria. (who.int)
AIDS5
  • Although zidovudine does not cure HIV, it may decrease your chance of developing acquired immunodeficiency syndrome (AIDS) and HIV-related illnesses such as serious infections or cancer. (medlineplus.gov)
  • Although the combination of lamivudine and zidovudine does not cure HIV, it may decrease your chance of developing acquired immunodeficiency syndrome (AIDS) and HIV-related illnesses such as serious infections or cancer. (epnet.com)
  • We describe the marginal structural Cox proportional hazards model and use it to estimate the causal effect of zidovudine on the survival of human immunodeficiency virus-positive men participating in the Multicenter AIDS Cohort Study. (nih.gov)
  • Currently, the HIV-AIDS supporters are prescribing hydroxyurea, an inexpensive drug used for chemotherapy of leukemia (38). (robertogiraldo.com)
  • The trials will compare the effect of Nevirapene with zidovudine on people who are HIV-positive and progressing towards AIDS. (newscientist.com)
Ingredients1
  • Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. (ehealthme.com)
Clinical2
  • Zidovudine also has antibacterial properties, though not routinely used in clinical settings. (wikipedia.org)
  • The process of drug discovery, safety testing, and clinical trials is an extremely long and costly one. (nature.com)
Infections1
  • Therefore, since it is a global public health problem involving several sectors, it also requires a global solution in the context of the One Health approach to achieve adequate control through the prevention, reduction, and mitigation of drug-resistant infections. (who.int)
Adverse effects1
Adults2
  • AN was associated with isotretinoin, anticonvulsants in minors, and antiretroviral drugs in adults. (bvsalud.org)
  • In adults, BN was related to psychotropic and hormonally active drugs. (bvsalud.org)
Diseases1
  • In February 2007 the company entered into a development and supply agreement with Drugs for Neglected Diseases Initiative (DNDi) a global non-profit organization for a new anti-malarial combination drug as a global initiative. (business-standard.com)
Combinations2
  • One specific combination of anti-HIV drugs appears to be more effective for initiating therapy than other drug combinations tested in a large multi-institutional study. (harvard.edu)
  • Combinations of 2, 3, or 4 drugs from different classes are usually necessary to fully suppress replication of wild-type HIV. (msdmanuals.com)
Interact2
  • Zidovudine can interact with other drugs or supplements you are taking. (aids.org)
  • Which drugs or supplements interact with alpha-1-proteinase inhibitor? (hdkino.org)
Supplements1
  • Make sure that your health care provider knows about ALL drugs and supplements you are taking. (aids.org)
Side effects3
  • Zidovudine's side effects may be worse if taken with several other drugs. (aids.org)
  • This article explores the differences between common antiretroviral drugs and outlines how they work, including their potential side effects. (medicalnewstoday.com)
  • The Food and Drug Administration (FDA) tracks side effects of drugs it has approved. (medicalnewstoday.com)