Drugs nervous system diseases. Medical search. Frequent questions

His clinical interest include Alzheimer's disease and other neurodegenerative disorders. (stanford.edu)
In October 2020, Amira was appointed Instructor of Neurodegenerative Disease Research at Stanford Neurology, to help develop improved and more powerful approaches that will better reveal key synaptic mechanisms and candidate modules associated with neuroplasticity and affected in AD mouse models, by identifying activity-dependent gene expression signatures that will ultimately serve as a platform for potential therapeutics and animal to human translation. (stanford.edu)
The overall theme of her current research concentrates on studying the roles and mechanisms of small molecules in neuronal networks, synaptic functions, neural stem cells and neurodegenerative diseases which include Alzheimer's disease (AD), Parkinson's disease (PD) and Charcot-Marie-Tooth (CMT) disease. (stanford.edu)
According to the EMET judges, "Her work opened new directions of research in neuroscience and shed light on incurable neurodegenerative diseases. (jpost.com)
Possible treatment for Alzheimer's disease and other neurodegenerative diseases ( Parkinson's disease , Huntington's disease , etc. (iptq.com)

Asthma is the most common chronic disease among children globally and the number of children affected is increasing in developing countries. (bmj.com)
Drug addiction is a chronic relapsing disorder, accounting for the loss of 18 million years of healthy life in 2019 [ 3 ]. (degruyter.com)
The disease is the most common chronic neurological disorder among young adults, and results from aberrant immune cells destroying the protective coating, called myelin, around nerve cells in the brain and spinal cord. (innovationtoronto.com)
Some studies report that POCD still exists at three months after surgery, and can progress from chronic disease to long-term cognitive impairment [5].At the same time, POCD has the same pathological manifestations as dementia (Alzheimer Dementia, AD). (researchsquare.com)
Thesefindings suggest that shutting down the activity of these THi cellsmight stop chronic inflammatory diseases from developing in the firstplace. (sciencedaily.com)
Iron (non-heme) measurements are used in the diagnosis and treatment of diseases, such as iron deficiency anemia, chronic renal disease, and hemochromatosis (a disease associated with widespread deposit in the tissues of two iron-containing pigments, hemosiderin and hemofuscin, and characterized by pigmentation of the skin). (cdc.gov)
WATERTOWN, Mass.--(BUSINESS WIRE)--SQZ Biotechnologies (NYSE: SQZ), focused on unlocking the full potential of cell therapies for multiple therapeutic areas, today announced that the first clinical translation of the company's Tolerizing Antigen Carrier (TAC) platform in autoimmune diseases will be for celiac disease, a chronic autoimmune disorder that afflicts millions of patients and has no approved drug treatment. (pharmiweb.com)
Celiac disease is a chronic autoimmune disorder that occurs in genetically predisposed people. (pharmiweb.com)

Infectious diseases are transmitted in several ways. (wikipedia.org)
Apart from endangering the health of individuals, drug addiction can also lead to crime and violence, and speed up the spread of infectious diseases, seriously affecting social stability and safety [ 3 ]. (degruyter.com)
This could explain how the bacteria are able to enter the brain in certain circumstances," said lead investigator Daniel Brown, an associate professor of infectious diseases at the UF College of Veterinary Medicine. (ufl.edu)

In testimony before a meeting of the Food and Drug Administration's (FDA's) Peripheral and Central Nervous System Drugs Advisory Committee, Public Citizen urged the committee to recommend that the FDA not approve aducanumab for treatment of Alzheimer's disease because there is not substantial evidence of effectiveness. (citizen.org)
The spinal cord transmits sensory reception from the peripheral nervous system. (wikipedia.org)
The spinal cord is protected by vertebrae and connects the peripheral nervous system to the brain, and it acts as a "minor" coordinating center. (wikipedia.org)
This review summarizes the current literature on the pathogenesis and clinical manifestations of neurological injuries associated with HIV in the brain, spinal cord, and peripheral nervous system. (nih.gov)
Treatments for HIV-associated pain and peripheral sensory neuropathies currently consist of symptomatic management, but a greater understanding of their pathogenesis can lead to the development of targeted molecular therapies and disease-modifying therapies. (nih.gov)
Development of central nervous system (CNS) is regulated by both intrinsic and peripheral signals. (biomedcentral.com)
And IPT probably carries out all these functions in the peripheral nervous system as well. (iptq.com)

Reviva's current pipeline focuses on the central nervous system, respiratory and metabolic diseases. (biospace.com)
The in-license is part of Cerecin's pipeline expansion and further strengthens its position as a leader in neurometabolism, addressing metabolic targets and bioenergetics in disease. (wkrn.com)
Cerecin is a clinical-stage biotechnology company focused on developing drugs that target the metabolic bases of central nervous system diseases. (wkrn.com)
Together with pH determination, bicarbonate measurements are used in the diagnosis and treatment of numerous potentially serious disorders associated with acid-base imbalance in the respiratory and metabolic systems. (cdc.gov)
BUN measurements are used in the diagnosis of certain renal and metabolic diseases. (cdc.gov)

New diagnostic criteria have been introduced for neuromyelitis optica, now called neuromyelitis optica spectrum disorder, which is an inflammatory disease of the central nervous system that is sometimes mistaken for multiple sclerosis. (sciencedaily.com)
Two FDA approved drugs were found to stimulate stem cells in the brain and spinal cord to regenerate to the protective coating around neurons that is damaged in diseases such as multiple sclerosis. (innovationtoronto.com)
The two most potent drugs-one that currently treats athlete's foot, and the other, eczema-were capable of stimulating the regeneration of damaged brain cells and reversing paralysis when administered systemically to animal models of multiple sclerosis. (innovationtoronto.com)
We know that there are stem cells throughout the adult nervous system that are capable of repairing the damage caused by multiple sclerosis, but until now, we had no way to direct them to act," said Paul Tesar, the Dr. Donald and Ruth Weber Goodman Professor of Innovative Therapeutics, and associate professor in the Department of Genetics & Genome Sciences at the Case Western Reserve School of Medicine. (innovationtoronto.com)
Our approach was to find drugs that could catalyze the body's own stem cells to replace the cells lost in multiple sclerosis. (innovationtoronto.com)
Current multiple sclerosis therapies aim to slow further myelin destruction by the immune system, but the Case Western Reserve team used a new approach to create new myelin within the nervous system. (innovationtoronto.com)
The molecular roots of inflammatory and autoimmune diseases such as asthma, arthritis, and multiple sclerosis (MS) have been discovered by a team of researchers led by The University of Texas M. D. Anderson Cancer Center. (sciencedaily.com)
We then discuss the contribution of microbiota in CNS and pathogenesis of CNS disorders such as Parkinson's disease (PD), Alzheimer's disease (AD), multiple sclerosis (MS), and gliomas. (biomedcentral.com)
Nervous system problems, such as multiple sclerosis and Guillain-Barré syndrome . (medicalnewstoday.com)

These neurological conditions arise due to complex interactions between HIV viral proteins and neuronal and glial cells that lead to the activation of various inflammatory and neurotoxic pathways across the nervous system. (nih.gov)
In the current review, we describe the astrocytic involvement in the operation of the CNS, and then focus on how astrocytes contribute to drug addiction through diversified pathways. (degruyter.com)
His research team is developing new drugs that are focused on the modulation of fundamental cell signaling pathways that are involved in neurodegeneration. (stanford.edu)
These pathways can be regulated by known protein growth factors but such proteins cannot be used as drugs. (stanford.edu)
Her projects involve neuronal plasticity, RNA-sequencing, molecular biochemistry, signaling mechanisms, target validation and drug development strategies for Alzheimer's disease with the objective of investigating neurotrophin receptor signaling pathways that contribute to synaptic degeneration and preservation. (stanford.edu)
In this review, we first discuss recent findings related to the interaction between gut microbiota and immune system, particularly key innate and adaptive immunity and signaling pathways. (biomedcentral.com)
Previous immunotherapy (e.g. anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CTLA-4 antibody, or any other antibody or drug specifically targeting T-cell co-stimulation or immune checkpoint pathways). (who.int)

Central nervous system diseases, also known as central nervous system disorders, are a group of neurological disorders that affect the structure or function of the brain or spinal cord, which collectively form the central nervous system (CNS). (wikipedia.org)
Disorders exhibiting altered energy substrate utilization, such as Alzheimer's disease, epilepsy, diabetes, and cancer may be of interest for PET imaging studies using CER-022. (wkrn.com)
This study evaluates the behavioral and electroencephalographic effects of LSD in 14 patients with sensory disorders due to focal cerebral diseases. (erowid.org)
Finally, we discuss the role of gut-brain interactions during development of nervous system and neurodegeneration, as well as potential approaches for treating CNS disorders. (biomedcentral.com)
Several psychiatric and neurological disorders, including drug addiction, neuropathic pain syndromes and fragile X syndrome, are associated with abnormal or deficient synaptic plasticity. (nature.com)

They actually went to court to try to challenge and prevent the South African government from issuing a license to create lower cost generic versions of antiretroviral drugs. (fivethirtyeight.com)

BALTIMORE , June 30, 2017 /PRNewswire/ -- AgeneBio , a pharmaceutical company developing innovative therapeutics for unserved patients battling neurodegeneration, today announced that the Company has received an additional $750,000 grant from the Alzheimer's Drug Discovery Foundation (ADDF). (prnewswire.com)
JERSEY CITY, N.J.-The Alzheimer's Drug Discovery Foundation (ADDF) and OnDeckBiotech have announced the launch of ADDF ACCESS, a new and improved open-access platform to connect scientists with a virtual network of contract research organizations (CROs), drug development experts and educational resources. (drugdiscoverynews.com)
The mission of the Alzheimer's Drug Discovery Foundation is to accelerate the discovery of drugs to prevent, treat and cure Alzheimer's diseases, related dementias and cognitive aging. (drugdiscoverynews.com)

Atopic dermatitis (AD) and inflammatory bowel disease (IBD) can lead to alterations in the microbiome, and disruptions in the skin and gut barrier. (medindia.net)

Hypercapnia and respiratory acidosis ensue when impairment in ventilation occurs and the removal of carbon dioxide by the respiratory system is less than the production of carbon dioxide in the tissues. (medscape.com)
Hypercapnia typically occurs late in the disease process with severe pulmonary disease or when respiratory muscles fatigue. (medscape.com)

While there are many advances in Parkinson's Disease (PD), such as identification of new biomarkers to measure disease progression, valuable insights in study design coming from Alzheimer's Disease trials, and creative approaches for patient recruitment, challenges still remain in this therapeutic area. (iconplc.com)
Reviva believes brilaroxazine has the potential to delay disease progression in PAH and IPF and intends to develop brilaroxazine for these pulmonary indications. (biospace.com)
But these treatments may be more effective at slowing the progression of the disease if they're started before symptoms are obvious. (riversideonline.com)

Problems with the body's immune system can lead to tumors. (wikipedia.org)
The syndromes previously were thought to be caused by a virus or by an attack of the body's own immune system. (ufl.edu)
This test will check your body's ability to metabolize (break down) certain drugs, including Xenazine. (medicalnewstoday.com)
Together, the one-two punch could spur the body's own immune system to attack cancer cells. (genengnews.com)

Centers for Disease Control and Prevention. (cdc.gov)
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
The ADDF has granted more than $65 million to fund over 450 Alzheimer's drug discovery programs in academic centers and biotechnology companies in 18 countries. (drugdiscoverynews.com)
Announcer] This program is presented by the Centers for Disease Control and Prevention. (cdc.gov)

Reviva is a clinical-stage biopharmaceutical company that discovers, develops, and seeks to commercialize next-generation therapeutics for diseases representing unmet medical needs and burdens to society, patients, and their families. (biospace.com)
AgeneBio's novel GABA A α5 small molecule program is in discovery stage with potential to address unmet needs for several diseases of the central nervous system including MCI due to AD, autism and schizophrenia. (prnewswire.com)
There is significant unmet need for patients with celiac disease. (pharmiweb.com)

The two mainstreams of cells that build up the central nervous system are neurons and glia, the latter of which for quite a long time are supposed to act as the background of the former, supporting, nourishing and protecting the neurons [ 1 ]. (degruyter.com)
The central nervous system (CNS) is a complex, sophisticated network of neurons that includes our brain and spinal cord. (roche.com)
One of the most common impairments of the nervous system is degeneration - the progressive loss in function or death of neurons. (roche.com)

For a considerable portion of her career, she has been working in the lab, and contributing to important research to find cures for neurological diseases. (stanford.edu)
In this review, we discuss the biological interplay between gut-brain axis, and further explore how this communication may be dysregulated in neurological diseases. (biomedcentral.com)
In this section, we discuss the interplay between resident microbiota and key immunological signaling, and implications of their relationship in CNS development and neurological diseases. (biomedcentral.com)

Every disease has different signs and symptoms. (wikipedia.org)
In a multinational, multicenter, double-blind Phase 2 study in 234 patients with acute schizophrenia or schizoaffective disorder, brilaroxazine met its primary endpoint, reducing Positive and Negative Syndrome Scale (PANSS) total score and demonstrating statistically significant improvement of overall drug treatment outcomes using Clinical Global Impression (CGI) scale and for secondary endpoints evaluating social functioning, and positive and negative symptoms, and directional improvements for depression and cognition. (biospace.com)
As a result, those recovering from drug use experience withdrawal symptoms. (treesforhealth.org)
The first step in managing drug withdrawals is understanding the symptoms you may experience. (treesforhealth.org)
When you detox from drugs, you may experience uncomfortable and even dangerous withdrawal symptoms. (treesforhealth.org)
While the exact symptoms will vary depending on the individual, the drug being detoxed from, and how severe your conditions were, there are still some common symptoms that many experience. (treesforhealth.org)
The diagnosis of central nervous system disease is largely based on clinical symptoms and cognitive testing. (roche.com)
The diseases affect the central nervous system, causing brain damage and symptoms such as seizures, decreased alertness and difficulty maintaining balance. (ufl.edu)
The symptoms of chorea (uncontrollable movements of the legs, arms, and facial muscles) associated with Huntington's disease may return or get worse within 12 to 18 hours of when you took your last dose of Xenazine. (medicalnewstoday.com)
If you are concerned about tremors or other Parkinson's disease symptoms, talk to your physician or learn more about the programs and services available from the Riverside Neurological and Spine Institute . (riversideonline.com)
These eggs then develop into cysticerci which migrate mostly into muscle (causing cysticercosis) and into the central nervous system where the cysticerci can cause seizures and many other neurological symptoms (cysticercosis of the central nervous system). (who.int)

Parkinson's disease is a progressive nervous system condition that affects movement. (riversideonline.com)
Treatments for Parkinson's disease can include drug therapy, physical, occupational and speech therapy, and deep brain stimulation surgery. (riversideonline.com)
But the evidence is growing that all people with Parkinson's disease at all stages - from early onset to late-stage - can contribute to stabilizing the course of their condition with regular physical, occupational and speech therapy. (riversideonline.com)
Physical and speech therapy programs for Parkinson's disease work best when they're specifically designed for Parkinson's disease patients. (riversideonline.com)
Because the program's effectiveness has been scientifically documented for many years, it is a go-to speech therapy option for many people with Parkinson's disease. (riversideonline.com)
LSVT BIG is a targeted, customized physical and occupational therapy program for the movement problems of Parkinson's disease. (riversideonline.com)
Though sooner is better than later, any time is the right time to access the benefits of physical and speech therapy for Parkinson's disease," Dr. Butler adds. (riversideonline.com)

Advances in biomarker testing, a growing number of dementia-inclusive communities, and open clinical trials for conditions like Alzheimer's disease are transforming future outlooks. (roche.com)
Preclinical studies also suggest INCB059872 could help combat small-cell lung cancer and Ewing Sarcoma, and clinical trials are currently underway to test the drug's efficacy in patients with sickle-cell disease, as well as its safety in patients with advanced malignancies. (genengnews.com)

PD study designs require special thought, especially for therapies that have the potential to modify the course of the disease, since clinical outcomes can be confounded by the symptomatic effect of treatment. (iconplc.com)
Previously untreated or symptomatic central nervous system (CNS) metastases or lepto-meningeal disease. (who.int)
A study in southern India, reported in 2000, found an association between cysticercosis of the central nervous system and localization-related symptomatic epilepsy in 51% of patients. (who.int)
There is also no consensus on whether all cases of cycticercosis of the central nervous system benefit from cestocidal treatment with its associated sophisticated diagnostic assessment, or whether simple symptomatic treatment with antiepileptic drugs alone can provide them sustained comfort and quality of life. (who.int)

However, recent developments in drug delivery systems and treatment strategies are encouraging. (nih.gov)
Your doctor might help you find a treatment program if your DE stems from drug or alcohol use. (upmc.com)
Brilaroxazine has already received Orphan Drug Designation by the U.S. FDA for the treatment of these conditions. (biospace.com)
We hope the 2015 criteria will increase awareness, understanding and earlier, more accurate diagnosis and treatment of NMOSD, leading to better outcomes for people with the disease," says Dr. Wingerchuk. (sciencedaily.com)
In cancer, the development of blood vessels can feed tumors and allow them to grow, and drugs that block angiogenesis are being tested as cancer treatment. (ucsfhealth.org)
Prof. Polina Stepensky is the brains behind an "unprecedented achievement" in the treatment of multiple myeloma cancer - the second-most common hematological disease. (jpost.com)
The innovative treatment uses genetic engineering technology called CAR-T, or Chimeric Antigen Receptor T-Cell Therapy, to boost patients' own immune system to destroy the cancer. (jpost.com)
However, with the right treatment plan, many of the negative effects of drug use can be managed. (treesforhealth.org)
In the press release, Vickers Smith said individuals who abuse gabapentin often mix it with opioids, marijuana, cocaine, and opioid treatment medication, compounding side effects to the central nervous system that include euphoria and sedation. (medscape.com)
18FDG PET has been a transformative diagnostic enabling a better understating of tissue metabolism and the early detection and treatment of diseases, particularly cancers and cardiac function. (wkrn.com)
From informing lifestyle changes that could help to slow the decline in cognitive functions to optimizing treatment, biomarker testing is opening new opportunities for people with CNS disease. (roche.com)
But we are starting to see these therapies play a bigger role in symptom treatment and that they may actually delay or prevent disability," says Jonathan Butler, M.D., Ph.D. , a neurologist with Riverside Health System. (riversideonline.com)
One of the promising features of IPT is its reported effectiveness in treatment of numerous nervous system diseases. (iptq.com)
Senses of smell and taste returned, vertigo and tinnitus eliminated, and hearing and sight improved, by treatment of circulatory and other systems. (iptq.com)
Alanine aminotransferase measurements are used in the diagnosis and treatment of certain liver diseases (e.g., viral hepatitis and cirrhosis) and heart diseases. (cdc.gov)
Albumin measurements are used in the diagnosis and treatment of diseases involving the liver and/or kidneys, and are frequently used to assess nutritional status because plasma levels of albumin are dependent on protein intake. (cdc.gov)
Alkaline phosphatase measurements are used in the diagnosis and treatment of liver, bone, and parathyroid disease. (cdc.gov)
AST measurements are used in the diagnosis and treatment of certain types of liver and heart disease. (cdc.gov)
Creatinine measurements are useful in the diagnosis and treatment of renal diseases. (cdc.gov)
Measurements of creatine kinase are used in the diagnosis and treatment of myocardial infarction, skeletal muscle diseases, and diseases of the central nervous system. (cdc.gov)
We look forward to advancing this promising immune tolerance platform into the clinic for the treatment of celiac disease while in parallel continuing preclinical development for additional autoimmune indications, such as Type 1 diabetes. (pharmiweb.com)
5 6 There is currently no approved drug treatment and patients must therefore maintain a gluten-free diet, which involves strict, lifelong avoidance of exposure to gluten proteins. (pharmiweb.com)
The Food and Drug Administration public sewer systems for treatment. (cdc.gov)
Osteoarthritis (OA) is a socially significant age-associated disease, for the treatment of which a search for new effective drugs is underway. (bvsalud.org)
Prior treatment with canakinumab or drugs of a similar mechanism of action (IL-1ß inhibitor). (who.int)

Postoperative cognitive dysfunction (POCD) is a postoperative central nervous system complication that often occurs hours to days after surgery. (researchsquare.com)
The grant will support drug development of AgeneBio's novel GABA A discovery program to treat mild cognitive impairment due to Alzheimer's disease (MCI due to AD) and delay the onset of Alzheimer's dementia. (prnewswire.com)
Recent studies have shown that diabetes is a risk factor for cognitive deficits and even dementias like Alzheimer's disease. (issuu.com)

Ultrasound mediated, targeted drug delivery is an emerging therapy approach with great potential and we are delighted to be in the forefront of this development. (medindia.net)
Osteoarthritis is a widespread age-related disease, that has no effective targeted therapy. (bvsalud.org)

You'll study in the internationally renowned School of Pharmacy, which conducts world-class research in areas such as cancer, cardiovascular disease, antibiotic resistance and tissue engineering. (uea.ac.uk)

Her discoveries include the key role played by immune system cells in repair processes within the central nervous system, the importance of the immune system to the functioning of the healthy brain and the link between the decline in immune system function and dementia. (jpost.com)
Dementia is not a specific disease but is rather a general term for the impaired ability to remember, think, or make decisions that interferes with doing everyday activities. (roche.com)
The nervous system wracked with tertiary syphilis, causing dementia and paralysis. (iptq.com)

An autoimmune disorder is a condition where in the immune system attacks and destroys healthy body tissue. (wikipedia.org)
Now we have discovered the source of IL-17 and also have solidlydemonstrated that these are the crucial cells that regulate tissueinflammation in autoimmune disease and asthma," he says. (sciencedaily.com)
SQZ Biotechnologies Announces First Autoimmune Disease In. (pharmiweb.com)
The company's celiac disease program may support expansion into additional autoimmune diseases. (pharmiweb.com)
Earlier this year, the company presented preclinical findings at the Antigen-Specific Immune Tolerance Digital Summit and the Federation of Clinical Immunology Societies demonstrating that its engineered TACs can drive antigen-specific immune tolerance in complex models of autoimmune disease. (pharmiweb.com)

neuropathic pain is synonymous with disease or damage to the nervous system, resulting in tissue injury. (syr.edu)

Often these diseases stimulate ventilation and hypocapnia due to reflex receptors and hypoxia. (medscape.com)

A disease that affects central nervous system. (innovationtoronto.com)
Chorea may be caused by Huntington's disease (a genetic condition that affects your brain). (medicalnewstoday.com)
3 Many people who have celiac disease have not been diagnosed, 4 however population-based studies indicate that the disease affects about 2 million people in the United States and approximately 1% of the population worldwide, with regional differences. (pharmiweb.com)

Alzheimer's, Parkinson's, and Huntington's diseases). (wikipedia.org)
Her post-graduate work focused on the role of neurotrophin receptor signaling and neuroinflammation in Huntington's Disease (HD). (stanford.edu)
It's approved to treat chorea that's associated with Huntington's disease in adults. (medicalnewstoday.com)
For uncontrollable movements associated with Huntington's disease , the recommended starting dosage of Xenazine is 12.5 mg taken once per day in the morning. (medicalnewstoday.com)
Xenazine is used to treat chorea that's caused by Huntington's disease. (medicalnewstoday.com)

Public Citizen challenges Big Pharma, device manufacturers and federal regulators to make drugs and medical devices safe, effective and accessible to all. (citizen.org)
In a bid to stop abuse and diversion of the anticonvulsant gabapentin, a watchdog group is petitioning federal regulators to make the drug a controlled substance. (medscape.com)

Subject has prior to starting study drug: received live vaccination =3 months, had major surgery =4 weeks prior to starting study drug, has thoracic radiotherapy: lung fields = 4 weeks, other anatomic sites = 2 weeks, palliative radiotherapy for bone lesions = 2 weeks. (who.int)

Brain degeneration also causes central nervous system diseases (i.e. (wikipedia.org)
Dr. Longo's team has pioneered the development of the first small molecule, drug-type compounds that can mimic key parts of growth factor proteins and achieve their potent effects on preventing or reversing degeneration. (stanford.edu)
She further discovered significant therapeutic properties of those small molecules that prevented neuronal degeneration, dendrites dystrophy and spine loss in both diseases of in vitro cell models and in vivo animal models. (stanford.edu)

However, it appears that their clinical disease is sufficiently similar to that of patients with the antibody to warrant a diagnosis of NMOSD without AQP4-IgG antibodies. (sciencedaily.com)
They are completely different from TH1 and TH2effector cells," says Dong.They then used a mouse model of MS and demonstrated that they couldstop development of the disease with an antibody agent that blockedIL-17. (sciencedaily.com)
2 A clinical trial to test the efficacy of combining the epigenetic cancer drug with pembrolizumab, a humanized antibody that inhibits PD-1, is currently underway. (genengnews.com)

Using whole-genome sequencing on drug-exposed cell lines, researchers saw high mutation rates in control cell lines intermittently treated with a compound called CX-5461. (genomeweb.com)
You'll be taught by academic researchers including pharmacologists, cell biologists, and medicinal and pharmaceutical chemists, whose own research is in pharmacology and drug discovery. (uea.ac.uk)
Led by researchers at Case Western Reserve University , a multi-institutional team used a new discovery approach to identify drugs that could activate mouse and human brain stem cells in the laboratory. (innovationtoronto.com)
Researchers from BRITE are making great strides in fighting various types of cancer, diabetes and other diseases that disproportionately impact communities of color. (nccu.edu)
At BRITE, our researchers utilize biological systems to produce biomolecules for use in therapeutic drugs and vaccines. (nccu.edu)
The researchers found that the bacteria, known as Mycoplasma canis, invade dog's cells and suppress their immune system responses. (ufl.edu)
But University of Georgia researchers Renee Barber, and Scott Schatzberg, and colleagues, including Brown, reported earlier this year that whereas viruses were absent from the brain tissues of dogs with the diseases, the bacterium Mycoplasma canis was unexpectedly common. (ufl.edu)
Interestingly, the researchers also found traces of the bacteria in some dogs that did not have the disease. (ufl.edu)
The researchers are continuing to analyze the effects of bacterial infection on immune system cells known as macrophages to determine how the bacteria could breach the blood-brain barrier. (ufl.edu)
Researchers have begun to home in on these proteins, looking for drugs that inhibit their actions in the cell. (genengnews.com)
Like the developers of LSD1 combination therapies, 4SC AG researchers are pairing an epigenetic drug, in this case an HDAC inhibitor, with immunotherapies. (genengnews.com)
Researchers in the College of Arts and Sciences (A&S) have determined that cannabinoid drugs do not appear to reduce the intensity of experimental pain, but, instead, may make pain feel less unpleasant and more tolerable. (syr.edu)
Researchers are also crafting creative solutions to widespread problems, from glasses that help stop short-sightedness in its tracks, to finding compounds in already available drugs to treat jet lag. (issuu.com)
By leveraging OnDeckBiotech's digital technology, the enhanced ADDF ACCESS platform will streamline links between researchers and CROs specializing in diseases of the central nervous system (CNS) to expedite drug discovery research and development. (drugdiscoverynews.com)
OnDeck provides a cloud-based platform, which has now been customized for the Alzheimer's community, to improve functionality, with enhanced search capabilities to help researchers identify companies that provide specific services relevant to CNS drug discovery and development. (drugdiscoverynews.com)

He found that insulin and glucose allowed him to get larger doses of toxic heavy metal drugs into the brain and spinal cord, kill all the syphilis spirochetes, and get the heavy metals back out without killing the patient. (iptq.com)

Diseases caused by Haemophilus species The gram-negative bacteria Haemophilus species cause numerous mild and serious infections, including bacteremia, meningitis, pneumonia, sinusitis, otitis media, cellulitis, and epiglottitis. (msdmanuals.com)
However, rifabutin is preferred over rifampin for disseminated MAC infections because of its superior activity in vitro and reduced drug interaction potential. (msdmanuals.com)

Central nervous system tumors are the most common forms of pediatric cancer. (wikipedia.org)
It can deliver chemotherapy drugs to melt away tumors. (iptq.com)

The work of this panel was a two-year project, a consensus effort by international experts on all facets of the disease -- clinical, laboratory, imaging, adult and pediatric. (sciencedaily.com)
But here we asked if we could find a faster and less invasive approach by using drugs to activate native stem cells already in the adult nervous system and direct them to form new myelin. (innovationtoronto.com)

and other diseases, including those involving inflammation and the central nervous system. (medindia.net)
In Alzheimer's disease condition, the control and adjustment of ABCA7 levels in response to inflammation and the decrease in the availability of cholesterol. (medindia.net)
Inflammation may be one of the underlying links between depression and coronary heart disease . (medpagetoday.com)
The immune system attacks the myelin, the protective layer around nerve fibers and causes Inflammation and lesions. (innovationtoronto.com)
There is no cure, but drugs can control the brain inflammation by suppressing the immune system. (ufl.edu)

These are just some of the challenges you'll explore on our pharmacology and drug discovery degree. (uea.ac.uk)
Our research-rich environment is pivotal to the Pharmacology and Drug Discovery course, which has been designed to prepare you for a career at the forefront of pharmaceutical research. (uea.ac.uk)
You'll examine the way drugs work to combat disease and, combined with drug discovery, you will learn how new drugs are designed, synthesised and manufactured. (uea.ac.uk)
The Pharmacology Drug Discovery programme is the only MSci of its type in the UK and is innovative in its multidisciplinary approach. (uea.ac.uk)
BRITE's major research areas are drug discovery, cardiometabolic disease, central nervous system, plant genetic engineering, cancer and Drosophila genetics. (nccu.edu)
For the last five years, AgeneBio has partnered with Hager Biosciences , a leading preclinical-stage drug discovery organization with innovative medicinal chemistry capabilities, to advance the chemistry of its GABA A discovery program. (prnewswire.com)
At the 15th annual Discovery on Target conference held in Boston, MA in September 2017, scientists described developments in designing epigenetic cancer drugs. (genengnews.com)
The new ADDF ACCESS platform powered by OnDeckBiotech went live in early September right after the ADDF's 15th International Conference on Alzheimer's Drug Discovery, held Sept. 8-9, in Jersey City, N.J. (drugdiscoverynews.com)
Educational material to support CRO selection and program design, including recommendations for selecting and managing CRO contracts, and access to webinars from the ADDF's Annual Drug Discovery for Neurodegeneration Conference are all part of the package. (drugdiscoverynews.com)
By facilitating quality connections between scientists and top-tier drug discovery experts, ADDF ACCESS removes an enormous hurdle to undertaking drug discovery and development in academia and small biotechnology companies, Culver notes. (drugdiscoverynews.com)

Exploring the role lipids and alcohol play in liver disease and identifying biomarkers of disease. (nccu.edu)
Measuring changes in biomarkers can help us to understand how quickly a person's disease is advancing - and, potentially, predict how it may develop in the future. (roche.com)

According to World Drug Report 2021, it was estimated that about 36.3 million people were suffering from drug use disorder in 2019 and the number had rapidly accelerated year by year [ 3 ]. (degruyter.com)

The optogenetic activation of hippocampal astrocytes can be viewed as a novel therapeutic avenue for addressing Alzheimer's disease. (medindia.net)
We hope that understanding the interaction between addictive drugs and astrocytes may help discover new mechanisms underlying the addiction and produce novel therapeutic treatments. (degruyter.com)
She joined Dr. Frank Longo's laboratory as a Senior Scientist in the Stanford School of Medicine in 2008, where her research has focused on identifying mechanisms underlying HD and Alzheimer's disease (AD) and developing small molecule therapeutic strategies to target these mechanisms. (stanford.edu)
Utilizing Drosophila disease models to find therapeutic drugs. (nccu.edu)
We are excited to apply our TAC platform's broad potential in immune tolerance, coupled with our existing rapid red blood cell-based manufacturing capabilities, to create a therapeutic that could provide a meaningful benefit to patients with celiac disease. (pharmiweb.com)

Cysticercosis of the central nervous system is the most important neurological disease of parasitic origin in humans. (who.int)

Her ultimate goal is to develop better small molecules to treat or prevent these diseases. (stanford.edu)

Our mission is to help clients accelerate the development of drugs and devices that save lives and improve quality of life. (iconplc.com)
While ultrasound has been for decades to image organs, check blood flow, and monitor the development of fetuses, new study tests the use of these pulsed sound waves to direct and focus cancer drug therapies. (medindia.net)
The TGen team led the clinical development of one of the current standard-of-care regimens for this disease -- nab-paclitaxel plus gemcitabine. (medindia.net)
When exposed to drugs of abuse, astrocytes go through a series of alterations, contributing to the development of addiction. (degruyter.com)
One of the most gratifying contributions of her doctoral studies was the development of a new electrophysiology tool to assess synaptopathies and the establishment of long-term synaptic plasticity from prefrontal cortex slices to characterize the pathophysiology of novel mouse models of Alzheimer's disease. (stanford.edu)
Schwartz's work, the committee explained, now forms the basis for the development of drugs to treat diseases of the central nervous system. (jpost.com)
Cerecin's programs leverage its extensive experience in neurology and global drug development. (wkrn.com)
He adds that while such drugs are years away from development andclinical trials, agents that block IL-17 could represent an effectivetreatment, based on these results. (sciencedaily.com)
The maturation and development of human central nervous system (CNS) is regulated by both intrinsic and extrinsic factors. (biomedcentral.com)
This mission drives the company's research and development of prescription drugs, marks its growth and success, and promotes its commitment to social responsibility. (flexjobs.com)
The company will leverage its rapid manufacturing system for the development of SQZ TACs. (pharmiweb.com)
ADDF ACCESS users will see improved functionalities across the ADDF ACCESS platform, including direct communication with CROs and consultants, a suite of project management tools and educational resources focused on drug development for CNS diseases. (drugdiscoverynews.com)
The new platform will streamline the process of identifying and contracting with CROs that have pharmaceutical development expertise for challenging CNS diseases. (drugdiscoverynews.com)
Secretory phenotype associated with the aging (SASP) of chondrocytes forms the conditions for the musculoskeletal system diseases development, in particular, osteoarthritis (OA). (bvsalud.org)

Anatomy13

Organisms1

Diseases18

Chemicals and Drugs1

Analytical, Diagnostic and Therapeutic Techniques and Equipment7

Psychiatry and Psychology1

Phenomena and Processes3

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Information Science1

Named Groups1

Health Care3

Neurodegenerative5

Chronic8

Infectious3

Peripheral7

Metabolic5

Multiple sclerosis9

Pathways7

Disorders5

Antiretroviral Drugs1

Alzheimer's Drug Discovery Foundation3

Inflammatory bowel d1

Respiratory2

Progression3

Body's4

Centers5

Unmet3

Neurons3

Neurological diseases3

Symptoms11

Parkinson's Disease7

Clinical trials2

Symptomatic4

Treatment25

Cognitive3

Therapy2

Cardiovascular disease1

Dementia3

Autoimmune5

Neuropathic pain1

Hypoxia1

Affects3

Huntington's5

Federal regulators to make2

Bone1

Degeneration3

Antibody3

Researchers15

Spinal1

Infections2

Tumors2

Adult2

Inflammation5

Discovery10

Biomarkers2

20211

Therapeutic5

Humans1

Small molecules1

Development14