• lipid-lower
  • Guidelines from the American College of Cardiology/American Heart Association (ACC/AHA) and the U.K. National Institute for Health and Care Excellence (NICE) indicate that lipid-lowering drugs have benefit for primary and secondary prevention of atherosclerotic cardiovascular disease (ASCVD) events. (aafp.org)
  • Other lipid-lowering drugs (e.g., bile acid sequestrants, ezetimibe) can be considered if patients do not tolerate statins. (aafp.org)
  • They are called lipid-lowering drugs. (wikipedia.org)
  • therapy
  • Disorders of lipid metabolism in patients with HIV disease treated with antiretroviral agents: frequency, relationship with administered drugs, and role of hypolipidaemic therapy with bezafibrate. (nih.gov)
  • Lowered TC, either by behavioral intervention or-much more potently-by drug therapy, is a question distinct from naturally low TC. (onlinejacc.org)
  • In only two clinical trials has the issue of the most relevant lipid measure change been addressed, and change in either the TC/HDL ratio ( 5 ) or the apolipoprotein (apo) B/apoA1 ratio ( 6 ) accounted for all the benefit from drug therapy. (onlinejacc.org)
  • The benefits of statins and other dyslipidemic drugs appear proportional to the degree of improvement in the TC/HDL ratio, and by far the largest reductions in event rates reported to date occurred with combination statin and niacin therapy, with the attendant profound lowering of the TC/HDL ratio ( 7 ). (onlinejacc.org)
  • pharmacology
  • If you've ever wondered how drugs work, the role that pharmacology plays in human health, or the kinds of personal skills you'll need to discover and develop the next generation of drugs (including. (purzuit.com)
  • In part 1 of 3, Picmonic's content director Kendall Wyatt MD, RN will help you understand how using drug endings can help you master Pharmacology faster alongside Picmonic's research proven. (purzuit.com)
  • Professor Fink introduces the subject of Pharmacology, including the most prescribed categories of drugs, subdisciplines of Pharmacology, Drug Nomenclature (generic names vs. registered brand. (purzuit.com)
  • Cholesterol
  • The combination of a cholesterol-lowering drug, bezafibrate, and a contraceptive steroid, medroxyprogesterone acetate, could be an effective, non-toxic treatment for a range of cancers, researchers at the University of Birmingham have found. (wikipedia.org)
  • 2016
  • In early 2016, the U.S. Food and Drug Administration withdrew approvals for extended-release niacin and delayed-release fenofibric acid (fibrate) in combination with statins based on lack of cardiovascular benefit. (aafp.org)
  • bile
  • Bile acid sequestrants may cause gastrointestinal problems and may also reduce the absorption of other drugs and vitamins from the gut. (wikipedia.org)
  • toxicity
  • A significant advantage of drug repositioning over traditional drug development is that since the repositioned drug has already passed a significant number of toxicity and other tests, its safety is known and the risk of failure for reasons of adverse toxicology are reduced. (wikipedia.org)
  • fatty
  • Polyunsaturated fatty acids, especially formulation rich in omega-3, are widely accepted and endorsed in the medical community for their beneficial effects on hyperlipidemia and coronary disease risk reduction. (clinicaltrials.gov)
  • pharmaceutical
  • An oral pharmaceutical composition is provided for treating hypercholestereolemia or hyperlipidemia containing an advantageous formulation for stabilizing the HMG-CoA coenzyme A inhibitor, CI-981 Hemi-Calcium, of formula (IA) ##STR1## with effective amounts of calcium carbonate. (google.co.uk)
  • While these drugs are useful for patients with hyperlipidemia, Tangier's disease patients do not benefit from these pharmaceutical interventions. (wikipedia.org)
  • More than 90% of drugs fail during development, and this is the most significant reason for the high costs of pharmaceutical R&D. In addition, repurposed drugs can bypass much of the early cost and time needed to bring a drug to market. (wikipedia.org)
  • Whilst there are clear advantages to pharmaceutical companies in pursuing the licensing of repurposed drugs there are risks and costs associated with this, for example the introduction of thalidomide for multiple myeloma was seen by many analysts at the time as high risk and even dangerous but has been hugely successful for patients and the company. (wikipedia.org)
  • blood
  • Reduce triglyceride levels Reduce very low density lipoprotein (VLDL) levels Modest reduction of low density lipoprotein (LDL) levels Moderate increase in high density lipoprotein (HDL) levels GI distress Musculoskeletal pain Increased incidence of gallstone Hypokalemia (low blood potassium) Increased risk of cancer Hyperlipidemia (Type III): Gemfibrozil is the drug of choice for therapy. (wikipedia.org)
  • high
  • Computational approaches based on virtual screening of comprehensive libraries of approved and other human use compounds against large numbers of protein targets simultaneously have been developed to enhance the efficiency and success rates of drug repositioning, particularly in terms of high-throughput shotgun repurposing. (wikipedia.org)
  • TOPIC
  • Drug repositioning is seen by some as a controversial topic as the costs of an unlicensed product are often much less than a licensed one, especially in the rare disease market. (wikipedia.org)
  • Compounds
  • This s tructure, together with the structures of complexes with substrate and inhibitors, will provide a better understanding of the catalytical mechanism and will make it possible that 'lead compounds', identified via 'random screening' can be optimised into physiologically active drugs. (ugent.be)
  • issues
  • On the other hand, drug repositioning faces some challenges itself since the intellectual property issues surrounding the original drug may be complex and from a commercial point of view it may not always make sense to take such a drug to market. (wikipedia.org)
  • Food and Drug Admin
  • The first two PCSK9 inhibitors, alirocumab and evolocumab, were approved as once every two week injections, by the U.S. Food and Drug Administration in 2015 for lowering LDL-particle concentrations when statins and other drugs were not sufficiently effective or poorly tolerated. (wikipedia.org)
  • advantages
  • An upbeat, creative, and informative overview that outlines the advantages of working at the FDA's Center for Drug Evaluation and Research. (purzuit.com)