• In study B, 23 patients with castration-resistant prostate cancer received probes for CYP3A4 (midazolam), CYP2C9 (warfarin), CYP2C19 (omeprazole), and CYP2C8 (pioglitazone), and transporter substrates for P-glycoprotein (P-gp) (fexofenadine) and breast cancer resistance protein (BCRP)/organic anion transporting polypeptide (OATP) 1B1 (rosuvastatin) at baseline and after repeat once-daily administration of apalutamide 240 mg to steady state. (springer.com)
  • Apalutamide for metastatic, castration-sensitive prostate cancer. (springer.com)
  • An open-label, multicenter, phase Ib study investigating the effect of apalutamide on ventricular repolarization in men with castration-resistant prostate cancer. (springer.com)
  • Efficacy and safety of abiraterone acetate in elderly (75 years or older) chemotherapy naïve patients with metastatic castration resistant prostate cancer. (springer.com)
  • Potential drug-drug interactions with abiraterone in metastatic castration-resistant prostate cancer patients: a prevalence study in France. (springer.com)
  • RARITAN, N.J., February 8, 2021 - The Janssen Pharmaceutical Companies of Johnson & Johnson announced today results from the final analysis of the Phase 3 TITAN study, which demonstrated the continued statistically significant benefit of the addition of ERLEADA ® (apalutamide) to androgen deprivation therapy (ADT) in overall survival (OS) in patients with metastatic castration-sensitive prostate cancer (mCSPC), regardless of extent of disease, when compared to placebo plus ADT. (jnj.com)
  • ERLEADA ® has shown a statistically significant improvement in OS with a consistent safety profile in both approved indications of mCSPC (TITAN) and non-metastatic castration-resistant prostate cancer or nmCRPC (SPARTAN). (jnj.com)
  • Prior chemotherapy treatment for castration-sensitive or castration-resistant prostate cancer (docetaxel or cabazitaxel). (orlandohealth.com)
  • Belinostat is under clinical development by Acrotech Biopharma and currently in Phase I for Metastatic Castration-Resistant Prostate Cancer (mCRPC). (pharmaceutical-technology.com)
  • According to GlobalData, Phase I drugs for Metastatic Castration-Resistant Prostate Cancer (mCRPC) have an 88% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. (pharmaceutical-technology.com)
  • JANX-007 is under development for the treatment of metastatic castration resistant prostate cancer (mCRPC). (globaldata.com)
  • The drug candidate is a bi-specific T cell engager (TCE) which acts by targeting cells expressing prostate specific membrane antigen (PSMA) and T cells. (globaldata.com)
  • New nomograms can predict survival outcomes for patients with metastatic castration-resistant prostate cancer (mCRPC) treated with lutetium-177 prostate-specific membrane antigen ( 177- Lu-PSMA), according to a study published in The Lancet Oncology . (renalandurologynews.com)
  • Pseurotin A Validation as a Metastatic Castration-Resistant Prostate Cancer Recurrence-Suppressing Lead via PCSK9-LDLR Axis Modulation. (bvsalud.org)
  • Metastatic castration -resistant prostate cancer (mCRPC) cells can de novo biosynthesize their own cholesterol and overexpress proprotein convertase subtilisin /kexin type 9 (PCSK9). (bvsalud.org)
  • The purpose of the study is to compare progression-free survival in chemotherapy-naïve, post-abiraterone-treated metastatic castration-resistant prostate cancer patients treated with enzalutamide and LY2157299 versus enzalutamide alone. (hopkinsmedicine.org)
  • Metastatic castration-resistant prostate cancer (mCRPC) is a type of cancer that is resistant to conventional prostate cancer treatments, such as androgen deprivation therapies (ADTs) and other chemotherapies. (oncologynurseadvisor.com)
  • The efficacy and safety of cabazitaxel, as compared with an androgen-signaling-targeted inhibitor (abiraterone or enzalutamide), in patients with metastatic castration-resistant prostate cancer who were previously treated with docetaxel and had progression within 12 months while receiving the alternative inhibitor (abiraterone or enzalutamide) are unclear. (nih.gov)
  • Cabazitaxel significantly improved a number of clinical outcomes, as compared with the androgen-signaling-targeted inhibitor (abiraterone or enzalutamide), in patients with metastatic castration-resistant prostate cancer who had been previously treated with docetaxel and the alternative androgen-signaling-targeted agent (abiraterone or enzalutamide). (nih.gov)
  • This clinical trial is studying a potential treatment for men with metastatic castration resistant prostate cancer. (facingourrisk.org)
  • For men with prostate problems, castration was a treatment method for many years. (liu.se)
  • But in the early 20th century, decisions regarding castration were based on the belief that the prostate was the equivalent of the uterus in the woman. (liu.se)
  • In castration, the testicles are removed in order to address problems relating to prostate enlargement. (liu.se)
  • But by studying castration as a treatment for benign prostate enlargement, Elin Björk discovered that the prevalent notion in medicine of the man as norm is not always accurate. (liu.se)
  • Reading the texts gave her access to narratives about what the prostate was believed to be, and why castration was believed to work - or not to work. (liu.se)
  • Castration as a treatment method for prostate hypertrophy 1893-1910. (liu.se)
  • Patient and Methods: Retrospective analysis of trials using androgen receptor axis-targeted drugs for metastatic castration resistant prostate cancer patients (mCRPC). (lu.se)
  • Janssen Biotech) received FDA approval, in combination with prednisone, for high-risk metastatic castration-sensitive prostate cancer (CSPC). (ahdbonline.com)
  • The abiraterone acetate plus prednisone combination was previously approved for metastatic castration-resistant prostate cancer (CRPC) after chemotherapy and for newly diagnosed metastatic CRPC. (ahdbonline.com)
  • Prostate-specific membrane antigen (PSMA) is an excellent target for radionuclide therapy of metastasized castration-resistant prostate cancer (mCRPC). (snmjournals.org)
  • Despite recent approval of some novel drugs, metastatic castration-resistant prostate cancer (mCRPC) remains a lethal disease and additional treatment options are still needed. (snmjournals.org)
  • There is a need for improved therapeutic approaches for patients with advanced metastatic castration-resistant prostate cancer (mCRPC), whilst on the other extreme, there is a need to accurately identify clinically significant prostate cancer in individuals presenting with elevated PSA levels or inconclusive MRI results. (pcf.org)
  • A recently published international clinical Phase III trial of a promising drug for treating advanced prostate cancer ended with surprising results: the new therapeutic agent failed to achieve any significant improvement in the overall survival of patients compared with the established standard treatment. (sciencedaily.com)
  • In 2012, the team was therefore invited to participate in an international study for a new drug (cabozantinib) for the treatment of advanced -- so-called castration-resistant -- prostate cancer. (sciencedaily.com)
  • Patients with metastasising, castration-resistant prostate cancer, who already had bone metastases, were specifically selected. (sciencedaily.com)
  • Data presented included updated investigational AMG 420 safety and efficacy results in patients with relapsed and/or refractory multiple myeloma (R/R MM), as well as initial results from the investigational AMG 212 (pasotuxizumab) first-in-human trial in patients with metastatic castration-resistant prostate cancer (mCRPC). (amgen.com)
  • Many new treatments for castration resistant prostate cancer (CRPC) have been developed in the past decade. (pcf.org)
  • Its two lead programs target the androgen receptor for castration-resistant prostate cancer and the estrogen receptor for ER+ breast cancer. (biospace.com)
  • Targets that have been identified as having the potential to improve survival in patients with castration-resistant prostate cancer stem from research in angiogenesis, bone metabolism, immunotherapy, androgen metabolism and receptor regulation, and apoptosis. (cancernetwork.com)
  • 1,2] Advances have also been made in supportive care: denosumab (XGEVA) demonstrated improvement in skeletal-related events in patients with castration-resistant prostate cancer compared to the standard of care, zoledronic acid (Zometa). (cancernetwork.com)
  • Since the current gold standard for approval of drugs in castration-resistant prostate cancer is based on overall survival, prospective evaluation of these types of markers as a surrogate for survival is clearly needed, particularly with the plethora of new agents. (cancernetwork.com)
  • Episode 2: Castration-Resistant Prostate Cancer Treatment Options Drs Sandhya Srinivas and Shilpa Gupta discuss castration-resistant prostate cancer and the sequence, method of therapy, and specific patient populations in which these drugs will be most effective. (medscape.com)
  • Those who are treated with medical castration for more severe forms of prostate cancer often develop the disease again within a few years. (lu.se)
  • Response to androgen receptor signaling inhibitors (ARSI) varies widely in metastatic castration resistant prostate cancer (mCRPC). (cdc.gov)
  • Even though other drug classes have shown promise, mCRPC has become extremely complicated to treat because of its universal chemo resistance. (oncologynurseadvisor.com)
  • It's not enough to just murder people with chemotherapy or with toxic medications that actually promote liver disease and promote metabolic disorders and promote cancer, and promote osteoporosis and Alzheimer's and dementia and everything else - they also want their drugs to be given to children as chemical castrations," the Health Ranger says. (medicalviolence.com)
  • Must have been administered ARAT (abiraterone, enzalutamide, darolutamide, or apalutamide) in the castration-sensitive or castration-resistant setting. (orlandohealth.com)
  • In a recent study, researchers addressed the issue of the rise of antifungal drugs-resistant infections and the advent of multidrug-resistant fungal pathogens. (news-medical.net)
  • Some of the approaches incorporating these targets have already translated to measurable clinical benefit: sipuleucel-T (Provenge) and cabazitaxel (Jevtana) have demonstrated improvements in median survival of 4.1 and 2.4 months, respectively, in different populations of men with castration-resistant disease. (cancernetwork.com)
  • Mar Drugs;21(4)2023 Mar 28. (bvsalud.org)
  • The Prescription Drug User Fee Act (PDUFA) date for an anticipated FDA decision is in Q4 2023. (urotoday.com)
  • Two phase I studies assessed the drug-drug interaction potential of apalutamide as a substrate and perpetrator. (springer.com)
  • Previous treatment with at least 1 Novel androgen axis drug (NAAD) (e.g., enzalutamide, apalutamide, darolutamide and/or abiraterone). (who.int)
  • Mississippi banned genital mutilation surgeries and chemical castration drugs for children claiming to be "transgender. (breitbart.com)
  • Until that occurs, we can be encouraged that enzalutamide may play a role here and may be a good way to avoid many of the long-term side effects associated with castration. (medscape.com)
  • Understanding the mechanism of action is helpful to identify those patients who would benefit from traditional therapies and will also help in the discovery of new drug mechanisms that could workaround existing resistance methods. (oncologynurseadvisor.com)
  • Feodoroff M, Mikkonen P, Turunen L, Hassinen A, Paasonen L, Paavolainen L, Potdar S, Murumägi A, Kallioniemi O, Pietiäinen V. Comparison of two supporting matrices for patient-derived cancer cells in 3D drug sensitivity and resistance testing assay (3D-DSRT). (helsinki.fi)
  • Feodoroff M, Mikkonen P, Arjama M, Murumägi A, Kallioniemi O, Potdar S, Turunen L, Pietiäinen V. Protocol for 3D Drug Sensitivity and Resistance Testing of Patient-Derived Cancer Cells in 384-Well Plates. (helsinki.fi)
  • Unlike surgical castration, where the gonads are removed through an incision in the body, chemical castration does not remove organs, nor is it a form of sterilization. (wikipedia.org)
  • In a rat model, we investigated whether surgical and chemical castration affected memory ability through the protein kinase A (PKA)/cyclic adenosine. (koreamed.org)
  • Urovant is a clinical-stage biopharma company focused on developing and commercializing drugs for urologic conditions. (biospace.com)
  • Advanced Accelerator Applications), a radioactive drug, for the treatment of adults with somatostatin receptor-positive gastroenteropancreatic neuroendocrine tumors (GEP-NETs). (ahdbonline.com)
  • The other tells them that they should take drugs and cut themselves up with expensive surgeries in order to find freedom from depression," he continued. (breitbart.com)
  • No child in Mississippi will have these drugs or surgeries pushed upon them. (breitbart.com)
  • No doubt the medical associations object to the characterization of double mastectomies for minors as 'mutilation' or 'cutting healthy breasts off teen girls,' or of hormonal treatments as 'chemical castration,'" the attorneys general wrote. (newstarget.com)
  • Chemical castration is generally reversible when treatment is discontinued, although permanent effects in body chemistry can sometimes be seen, as in the case of bone density loss increasing with length of use of depot medroxyprogesterone acetate (DMPA). (wikipedia.org)
  • The research recorded a continuation of this improved behaviour after the administration of the drug had ended, with no evidence of adverse side effects, and so recommended medroxyprogesterone acetate along with counselling as a successful method of treatment for serial sex offenders. (wikipedia.org)
  • Offering criminals the option of chemical castration for a reduction in sentence is an example of compulsory sterilization as it can leave a subject sterile if they are required to continue treatment for more than 3 years. (wikipedia.org)
  • So there are scientists who argue that it makes no biological sense to assume that any treatment that emulates castration would remove sex drive in men but not in women. (wikipedia.org)
  • Some criminologists argue that the appearance of a lower recidivism rate in male sex offenders who take chemical castration treatment than in those who do not can be explained by factors other than biological effects of the medication. (wikipedia.org)
  • Use of an investigational therapeutic drug within the last 4 weeks prior to start of study treatment or scheduled to receive one during the study period. (orlandohealth.com)
  • In her thesis, Elin Björk investigates the treatment method that was prevalent from the late 19th century to the early 20th century: castration. (liu.se)
  • IGALMI is approved by the U.S. Food and Drug Administration (FDA) for the acute treatment of agitation associated with schizophrenia or bipolar I or II disorder in adults. (globenewswire.com)
  • There are those attempting to push a sick and twisted ideology that seeks to convince our kids they're in the wrong body and the solution is to drug, sterilize, and castrate themselves. (breitbart.com)
  • full development is less common unless chemical castration is combined with feminizing oestrogen therapy. (wikipedia.org)
  • Chemical castration therapy reduces an individual's libido which then makes some offenders more responsive to the introduction of psychotherapy. (wikipedia.org)
  • A number of ferroptosis inducers have been proposed as potential drugs for cancer therapy. (nature.com)
  • Thy- roidectomy for hyperthyroidism was first performed in 1880, and antithyroid drugs and radioiodine therapy were developed in the early 1940s. (who.int)
  • Chemical castration is castration via anaphrodisiac drugs, whether to reduce libido and sexual activity, to treat cancer, or otherwise. (wikipedia.org)
  • In May 2016, The New York Times reported that a number of countries use chemical castration on sex offenders, often in return for reduced sentences. (wikipedia.org)
  • Chemical castration was often seen as an easier alternative to life imprisonment or the death penalty because it allowed the release of the convicted. (wikipedia.org)
  • Leuprolide acetate is an LHRH agonist that is most commonly used in chemical castration today. (wikipedia.org)
  • Psychotherapy has also recently been used in conjunction with chemical castration in order to maximize and prolong the beneficial results. (wikipedia.org)
  • Medical schools in the United States are rapidly trying to normalize "gender affirming care" (mutilation and chemical castration) for children. (naturalnews.com)
  • PURPOSE: Goserelin is a drug used for chemical castration. (koreamed.org)
  • This drug has been observed as having higher rates of success in reducing abnormal sexual urges and fantasies, but is often reserved for those offenders who are at a high risk of reoffending due to the drug's intense effects. (wikipedia.org)
  • After vocally opposing the use of castration drugs to punish convicted sex offenders, the American Civil Liberties Union (ACLU) is now advocating for. (naturalnews.com)
  • Ultimately, the only way we will know whether this could be an alternative to castration is with a prospective randomized trial enrolling a significant number of patients. (medscape.com)
  • GlobalData's report assesses how Belinostat's drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. (pharmaceutical-technology.com)
  • GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. (pharmaceutical-technology.com)
  • Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. (pharmaceutical-technology.com)
  • GlobalData's Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). (pharmaceutical-technology.com)
  • This report provides you with the data that allows you to track and predict the specific likelihood of approval (LOA) and phase transition success rate (PTSR) of a drug using GlobalDatas proprietary machine learning algorithms developed using over 10 years of historical data. (globaldata.com)
  • The data is segmented by drug name per indication and shows the current likelihood of approval for the drug compared to the indication benchmark and the industry benchmark. (globaldata.com)
  • GlobalData's Drug-Specific Likelihood of Approval (LoA) calculates the Phase Transition Success Rate (PTSR) and Likelihood of Approval (LoA) customized to individual drug. (globaldata.com)
  • The model uses a combination of Machine Learning (ML) and a GlobalData proprietary algorithm to process data points from the Drugs, Clinical Trials, Regulatory Milestones, Company, and Financial databases. (globaldata.com)
  • Due to system maintenance, the drug interactions feature you are attempting to access is temporarily unavailable. (medscape.com)
  • Diagnostics, Imaging Agents, Biomarkers, stents and other drug delivery devices (covered in GlobalData's Medical Intelligence Center). (globaldata.com)
  • Despite that, activist doctors, the American medical establishment, and leftist politicians have been pushing hard to force such drugs and procedures on children. (breitbart.com)
  • gAs American medical officials are encouraging gender transitions for children, British doctors are placing heavy restrictions on transition drugs and procedures for all persons under 18 years old. (newstarget.com)
  • castration was indeed considered a solution by the medical profession. (liu.se)
  • Please do not use this form to submit personal or patient medical information or to report adverse drug events. (medscape.com)
  • In this article, my objective is to discuss the dimension of castration in drug abuse: the impact of the narcissistic fracture. (bvsalud.org)
  • There is still no clear indication from authorities as to why transgender shooter Audrey Hale's manifesto must remain hidden from public view, but the Health Ranger thinks it has to do with Big Pharma and its mind-altering pharmaceutical drugs - and particularly the kind that transgenders take to "transition" into another gender. (medicalviolence.com)
  • Will the drug transition to the next phase of its clinical pathway? (globaldata.com)
  • The Regulate Experimental Adolescent Procedures Act bans drugs and procedures to "transition" children, as well as prevents state Medicaid funds from paying for them. (breitbart.com)
  • Based on these data, ADT alone should no longer be considered sufficient for patients with advanced, castration-sensitive disease. (jnj.com)
  • Based in New Haven, Connecticut, Arvinas focuses on drugs based on protein degradation. (biospace.com)
  • However, you have been prescribed this drug because your doctor has judged that the benefit to you is greater than the risk of side effects. (webmd.com)
  • BACKGROUND: The hypoglycemic drugs dipeptidyl peptidase-4 (DPP-4) inhibitors have proven protective effects on diabetic kidney disease, including renal fibrosis. (koreamed.org)
  • Metformin, an anti-diabetic drug, was reported to have ameliorative effects on inflammatory bowel disease. (koreamed.org)
  • There are then drugs available to slow the disease, but no cure. (lu.se)
  • For patients who have partners of childbearing potential: The patient and/or partner must use a method of birth control with adequate barrier protection, deemed acceptable by the principal investigator during the study and for 6 months after the last study drug administration. (orlandohealth.com)
  • A third potential mechanism deals with the limited amount of blood supply and hence, limited cytotoxic drug accessibility to the source of cancer. (oncologynurseadvisor.com)
  • A fourth mechanism suggests that cytotoxic drugs are removed from the source using efflux pumps, and the last mechanism is microtubule alterations that affect cytotoxic drug attachment to cancer cells. (oncologynurseadvisor.com)
  • This drug works by binding to a somatostatin receptor on the tumor, using the radiation to destroy cancer cells. (ahdbonline.com)
  • One example is that drugs are developed based on the male body. (liu.se)
  • My thesis shows that when it comes to the castration of men, the female body has been the norm. (liu.se)
  • Thus, knowledge of how the female body functioned was transferred to the male body, and by extension, knowledge of women's bodies was used as an argument for the castration of men. (liu.se)
  • Spaying is observed to cause female animals to stop mating in the same way as castration causes male animals to stop mating. (wikipedia.org)
  • Previous research has found that there was a very restrictive stance on male castration, although there were few alternatives. (liu.se)