• tertiary
  • Phentermine (contracted from phenyl-tertiary-butylamine), also known as α,α-dimethylphenethylamine, is a psychostimulant drug of the substituted amphetamine chemical class, with pharmacology similar to amphetamine. (wikipedia.org)
  • Glucuronidation of imipramine in rabbit and human liver microsomes: assay conditions and interaction with other tertiary amine drugs. (semanticscholar.org)
  • Characterization of rabbit UDP-glucuronosyltransferase UGT1A7: tertiary amine glucuronidation is catalyzed by UGT1A7 and UGT1A4. (semanticscholar.org)
  • It is a tertiary amine TCA, with its side chain-demethylated metabolite norbutriptyline being a secondary amine. (wikipedia.org)
  • Contraindications include: Recent myocardial infarction Any degree of heart block or other cardiac arrhythmias Mania Severe liver disease During breastfeeding Hypersensitivity to trimipramine or to any of the excipients The side effects of trimipramine have been said to be similar to those of other tertiary amine TCAs, with a preponderance of anticholinergic and sedative effects. (wikipedia.org)
  • If the amine is primary or secondary, it will have direct action, but if the amine is tertiary, it will have poor direct action. (wikipedia.org)
  • secondary
  • Thus original protocol by Prakash, Olah, and co-workers is applicable to Boc-protected secondary amines bearing 1,1-disubstituted, tri- or tetrasubstituted double bonds, and the corresponding products including spirocyclic compounds were obtained on a gram scale in good to excellent yields. (sciencetrends.com)
  • If these treatments do not address the symptoms, it would be reasonable to try noradrenergic drugs, secondary amine tricyclic antidepressants, or a monoamine oxidase inhibitor. (wikipedia.org)
  • A primary or secondary aliphatic amine separated by 2 carbons from a substituted benzene ring is minimally required for high agonist activity. (wikipedia.org)
  • monoamine
  • Moclobemide (sold as Amira, Aurorix, Clobemix , Depnil and Manerix) is a reversible inhibitor of monoamine oxidase A (RIMA) drug primarily used to treat depression and social anxiety. (wikipedia.org)
  • No significant rise in blood pressure occurs when moclobemide is combined with amines such as tyramine-containing foods or pressor amine drugs, unlike with the older nonselective and irreversible monoamine oxidase inhibitors (MAOIs), which cause a severe rise in blood pressure with such combination. (wikipedia.org)
  • Compounds
  • Modern drug discovery relies heavily on the ability of chemists to produce good starting points for producing high-quality lead compounds. (sciencetrends.com)
  • The commercial products, which contain amine fluoride or compounds of this with tin-fluoride in their formula, are present under different forms: - gels, - fluids, - dentifrice, - mouth rinse. (wikipedia.org)
  • effects
  • Furthermore, when VYVANSE was administered orally and intravenously in two clinical human drug abuse studies, VYVANSE produced subjective responses on a scale of "Drug Liking Effects" (DLE) that were less than d-amphetamine at equivalent doses. (biospace.com)
  • However it doesn't cause central nervous system side effects like other drugs of its class. (wikipedia.org)
  • Side effects are typical of gastrointestinal effects of anticholinergic drugs, and include dry mouth, indigestion, and constipation. (wikipedia.org)
  • These are commonly repeated by organizations which oppose all classified drug use, often causing the true effects and dangers of drugs to be misunderstood and less scrutinized. (wikipedia.org)
  • citation needed] However, drugs described as LSD in the 1970s occasionally actually contained PCP, amphetamine, or other drugs that have quite different effects from LSD. (wikipedia.org)
  • rapidly
  • Due to their surface activity the amine fluorides are rapidly dispersed in the oral cavity and wet all surfaces. (wikipedia.org)
  • dosulepin
  • There is clear evidence of the efficacy of dosulepin in psychogenic facial pain, though the drug may be needed for up to a year. (wikipedia.org)
  • synthesize
  • The false claim states that it is possible to synthesize LSD or some similar hallucinogenic drug called "bananadine" from banana peels or other common household foods and chemicals. (wikipedia.org)
  • chemical
  • Although this chemical reaction is known for more than 50 years, it represented merely academic interest until recently, and gem -difluorocyclopropane building blocks were rarely utilized in drug discovery programs due to their limited synthetic and commercial availability. (sciencetrends.com)
  • The chemical name of butriptyline is 3-(10,11-dihydro-5H-dibenzo[a,d]cycloheptene-5-yl)-N,N,2-trimethylpropan-1-amine and its free base form has a chemical formula of C21H27N with a molecular weight of 293.446 g/mol. (wikipedia.org)
  • The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. (wikipedia.org)
  • Aprepitant (brand name: Emend (the brand name used in all English-speaking countries)) is an antiemetic chemical compound that belongs to a class of drugs called substance P antagonists (SPA). (wikipedia.org)
  • include
  • The symptoms of physical withdrawal from stimulants can include fatigue, dysphoric mood, increased appetite, vivid or lucid dreams, hypersomnia or insomnia, increased movement or decreased movement, anxiety, and drug craving, as is apparent in the rebound withdrawal from certain substituted amphetamines. (wikipedia.org)
  • dose
  • One possible reason people believe that they had "bad acid" could be because they were simply sold a much higher dose than usual, which is not uncommon due to the inherent lack of quality control of illicit drugs. (wikipedia.org)
  • cytotoxic
  • Moreover, it is used in combination with chemotherapy, where drugs such as cisplatin, and other cytotoxic agents, are highly emetic . (issuu.com)
  • Aprepitant has been shown to inhibit both the acute and delayed emesis induced by cytotoxic chemotherapeutic drugs by blocking substance P landing on receptors in the brain's neurons. (wikipedia.org)
  • citation needed
  • citation needed] This is an unverifiable drug-scare story dating to the 1960s of a hippie babysitter girl putting a baby in the oven and a turkey in the bassinet. (wikipedia.org)
  • hydrochloride
  • The drug has been used commercially both as the free base and as the hydrochloride salt. (wikipedia.org)
  • Butriptyline is the English and French generic name of the drug and its INN, BAN, and DCF, while butriptyline hydrochloride is its BANM and USAN. (wikipedia.org)
  • activity
  • Taxol is a naturally occurring diterpenoid which has great potential as an anti-cancer drug, and which has shown activity in several tumor systems. (google.com)
  • He observed that amine fluoride had a pronounced affinity regarding enamel, by raising the quantity of fluoride in the enamel and also having an antienzyme effect on the microbial activity of dental plaque. (wikipedia.org)
  • Detailed understanding of their structure-activity relationship is expected to aid in drug discovery. (wikipedia.org)
  • symptoms
  • These large multi-site studies showed that the drug significantly reduced ADHD symptoms throughout the day with a predictable tolerability profile. (biospace.com)
  • involve
  • There are a limited number of cases reported in which babies were put into microwaves, though these cases were not known to involve any drugs. (wikipedia.org)
  • agent
  • found taxol to be an active agent against drug-refractory ovarian cancer. (google.com)
  • A transdermal drug delivery device for the controlled transdermal delivery of an active pharmaceutical agent. (google.com)
  • This invention relates to a transdermal drug delivery device for the controlled release of a pharmaceutical agent which contains a silicone skin contact pressure-sensitive adhesive made from an adhesive composition which contains a well defined concentration of silanol such that it remains adherent to the skin. (google.com)
  • known
  • Ephedrine, a well-known drug, is derived from the ma huang plant. (reference.com)
  • Basingstoke, U.K., Philadelphia, PA and Radford, VA - FEBRUARY 23, 2007 - Shire plc (LSE: SHP, NASDAQ: SHPGY, TSX: SHQ) and its collaborative partner New River Pharmaceuticals Inc. (NASDAQ: NRPH) announced today that the U.S. Food and Drug Administration (FDA) has granted marketing approval for VYVANSE (lisdexamfetamine dimesylate, formerly known as NRP104), for the treatment of Attention Deficit Hyperactivity Disorder (ADHD). (biospace.com)
  • However, there have been no known cases of microwaving (or baking) babies involving LSD specifically, or any other psychedelic drug (including cannabis) alone. (wikipedia.org)
  • effect
  • The label we received with the approval letter includes information about the extended duration of effect and abuse-related drug liking characteristics of VYVANSE which illustrate benefits that differentiate this compound from other ADHD medicines. (biospace.com)
  • applications
  • The polymer is useful in making hydrolytically degradable hydrogels which can be used in drug delivery and related biomedical applications. (google.com)