• zero tolerance
  • The National Police launched a zero tolerance drug program at Soekarno-Hatta International Airport on Wednesday as part of an effort to crack down on drug trafficking and drug abuse across the country. (kemlu.go.id)
  • Ahead of the first special session of the United Nations General Assembly on global drug policy in nearly two decades health officials from around the world have formed a commission and authored a report to persuade officials to walk back the zero-tolerance policies of the past 50 years, which they say have harmed public health instead of protecting it. (vice.com)
  • The tolerance is even lower for commercial drivers (0.04 percent) and drivers under the age of 21, for whom "zero tolerance" is given (0.02 percent). (oklahoma-criminal-defense.com)
  • The amendment to 47 O.S. ยง 11-902 (a) adds a clause pertaining to zero tolerance for driving under the influence of drugs. (oklahoma-criminal-defense.com)
  • FARK.com: (8300283) More and more concert promoters vow to enforce a zero-tolerance policy on drug use at their summer fest. (fark.com)
  • National Insti
  • The National Institute on Drug Abuse has said that an increase in prescription opioid abuse in the US has led to a corresponding increase in heroin use because heroin is a cheaper, readily available alternative. (vice.com)
  • Amphetamine
  • Tolerance is expected to develop with regular substituted amphetamine use. (wikipedia.org)
  • It is a prescription drug in many countries, and unauthorized possession and distribution of amphetamine are often tightly controlled due to the significant health risks associated with recreational use. (wikipedia.org)
  • Adderall, Adderall XR, and Mydayis are combination drugs containing four salts of the two enantiomers of amphetamine, a central nervous system (CNS) stimulant of the phenethylamine class. (wikipedia.org)
  • cross tolerance
  • In a study in rats cross-tolerance between the benzodiazepine drug chlordiazepoxide and bretazenil has been demonstrated. (wikipedia.org)
  • In a primate study bretazenil was found to be able to replace the full agonist diazepam in diazepam dependent primates without precipitating withdrawal effects, demonstrating cross tolerance between bretazenil and benzodiazepine agonists, whereas other partial agonists precipitated a withdrawal syndrome. (wikipedia.org)
  • Cross-tolerance has also been shown between bretazenil and full agonist benzodiazepines in rats. (wikipedia.org)
  • alcohol
  • For example, heavy drinkers initially develop tolerance to alcohol (requiring them to drink larger amounts to achieve a similar effect) but excessive drinking can cause liver damage, which then puts them at risk of intoxication when drinking even very small amounts of alcohol. (wikipedia.org)
  • I have extensive experience treating people with alcohol and drug use problems. (blogspot.com)
  • David Nutt from the University of Bristol has suggested bretazenil as a possible base from which to make a better social drug, as it displays several of the positive effects of alcohol intoxication such as relaxation and sociability, but without the bad effects such as aggression, amnesia, nausea, loss of coordination, liver disease and brain damage. (wikipedia.org)
  • Amphetamines
  • When substituted amphetamines are abused, drug tolerance develops rapidly. (wikipedia.org)
  • The Cochrane Collaboration's reviews on the treatment of ADHD in children, adolescents, and adults with pharmaceutical amphetamines stated that while these drugs improve short-term symptoms, they have higher discontinuation rates than non-stimulant medications due to their adverse side effects. (wikipedia.org)
  • Efficacy
  • It is thought that improving ethA expression will increase the efficacy of ethionamide and prompting interest by drug developers in EthR inhibitors as a co-drug. (wikipedia.org)
  • It is rarely prescribed due to concerns involving human neurotoxicity and potential for recreational use as an aphrodisiac and euphoriant, among other concerns, as well as the availability of safer substitute drugs with comparable treatment efficacy. (wikipedia.org)
  • acute
  • Acute tolerance refers to a process whereby the brain and central nervous system enact processes to immediately mitigate the effects of a given substance. (recoveryfirst.org)
  • Acute tolerance means that in most cases the effects of these drugs will be minimized by the reduction of receptor sites in the brain for each particular substance, and in some cases for certain classes of substances. (recoveryfirst.org)
  • Inverse tolerance can have a significant impact on subsequent relapses from recovery attempts, resulting in an increase in the severity and duration of symptoms related to withdrawal and post acute withdrawal. (recoveryfirst.org)
  • substance
  • Nerve cells, transmission processes, reuptake and receptor sites can be adjusted by the brain to become desensitized to the drugs, effectively producing an antidote to the substance or increasing the amount of receptor sites in order to diffuse the chemical across a wider spread of sites and thereby lessen its effects. (recoveryfirst.org)
  • doses
  • This reduces the effect of the drug and in general means that in order to achieve the same effects, addicts will need to increase their doses. (recoveryfirst.org)
  • If you consider that the drugs typically called synthetic heroin on the street are usually pharmaceuticals with known safe doses, that also illustrates the nature of the problem. (blogspot.com)
  • tough on cr
  • Politicians have been spewing the "war on drugs" "tough on crime" protecting the "fabric of society" bullshit for the last 40-plus years. (blogspot.com)
  • cocaine
  • People who consume a lot of drugs, like caffeine or cocaine, eventually build up a kind of tolerance, and they need more and more to get the same effect. (physicsforums.com)
  • Part of the problem with many drugs - including cocaine , meth and heroin , is that the brain cannot dispose of the drugs on its own. (recoveryfirst.org)
  • potent
  • While dextromethamphetamine is a more potent drug, racemic methamphetamine is sometimes illicitly produced due to the relative ease of synthesis and limited availability of chemical precursors. (wikipedia.org)
  • commonly
  • Methamphetamine (contracted from N-methylamphetamine) is a strong central nervous system (CNS) stimulant that is mainly used as a recreational drug and less commonly as a second-line treatment for attention deficit hyperactivity disorder and obesity. (wikipedia.org)
  • refers
  • Inverse tolerance is effectively the same as the Kindling Effect , which refers to changes in the brain and central nervous system concerning the way chemicals are processed. (recoveryfirst.org)
  • interactions
  • In most cases the brain relies on the interactions between neurotransmitters and receptors, but drugs interrupt this process, leaving the brain helpless to respond. (recoveryfirst.org)
  • The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. (drugs.com)
  • marijuana
  • You can put any type of spin on it you want - more freedom, freedom from the war on drugs, ability to generate more taxes, ability to treat any problem you might have with medical marijuana, you name it - history shows the outcome will be the same. (blogspot.com)
  • heroin
  • In 2014, prescription pain relievers and heroin killed a record-breaking 28,647 people out of the 47,055 drug overdose deaths that year, according to the CDC. (vice.com)
  • effect
  • 1.0 mM).Combined treatment (Zn+DPA) showed a highly synergistic effect in KO cells as compared to single drug treatment (Fig. 5C). (nih.gov)
  • Would there be a tolerance effect there? (shroomery.org)
  • Much of drug rehabilitation consists of resisting and reversing the ramping effect. (wikipedia.org)
  • Diflunisal also has an antipyretic effect, but this is not a recommended use of the drug. (wikipedia.org)
  • In macaques, after BufferGel's effect on microflora and pH were measured by vaginal colposcopy and rectal lavage researchers determined that it fit the safety profile of a drug which could be tested on humans. (wikipedia.org)
  • largely
  • Today it could largely summed up in a word - "drugs" .The same might be said of my criminal law colleagues. (blogs.com)
  • substances
  • As methamphetamine is associated with a high potential for misuse, the drug is regulated under the Controlled Substances Act and is listed under Schedule II in the United States. (wikipedia.org)
  • increase
  • A medical intervention that has for objective to increase tolerance (e.g., allergen immunotherapy, in which one is exposed to larger and larger amounts of allergen to decrease one's allergic reactions) is called drug desensitization. (wikipedia.org)
  • This may be caused by an increase in induction of the enzymes required for degradation of the drug e.g. (wikipedia.org)
  • people
  • In November's edition of Marie Claire, you can read an interview with television celebrity Graham Norton in which he cheerfully acknowledges having used a variety of drugs, and indicating that the only "downside" is the people you end up mixing with. (blogs.com)
  • The vast majority of people who use drugs - 80 to 90 percent - don't have a problem. (vice.com)
  • The problem with the "war on drugs" and excessive incarceration of people with drug charges in many ways parallels the excessive incarceration of the mentally ill because we have a health care system that is politically managed. (blogspot.com)
  • often
  • National Police chief Gen. Bambang Hendarso Danuri said the program would be the vanguard of the national campaign against drugs, often found to have been smuggled into the country through the airport. (kemlu.go.id)
  • Ethionamide is well absorbed orally with or without food, but is often administered with food to improve tolerance. (wikipedia.org)
  • dosage
  • Increasing its dosage may re-amplify the drug's effects, however this may accelerate tolerance, further reducing the drug's effects. (wikipedia.org)
  • Pharmaceutical dextroamphetamine sulfate is available as both a brand name and generic drug in a variety of dosage forms. (wikipedia.org)
  • fabric
  • Do we truly believe that drugs are undermining the fabric of our society, and are we prepared to take the necessary measures to stop it. (blogs.com)
  • different
  • Flupirtine showed promise for fibromyalgia due to its different action than the three approved by U.S. FDA drugs: pregabalin, milnacipran, and duloxetine. (wikipedia.org)
  • small
  • Phase I trials have shown the drug to be well tolerated, with a small Phase II trial (double-blind, placebo-controlled, 130 patients for 2 years) in 2013 showing a reduced rate of disease progression and preserved quality of life. (wikipedia.org)
  • Multidrug tolerance is caused by a small subpopulation of microbial cells termed persisters. (wikipedia.org)
  • Yeast persisters are triggered in a small subset of unperturbed exponentially growing cells by spontaneously occurring DNA damage, which leads to the activation of a general stress response and protection against a range of harsh drug and stress environments. (wikipedia.org)