• Combination
  • In our article, we tested at protein and mRNA levels the effects of the combination of tamoxifen and trastuzumab on both estrogen receptor and HER2/neu proteins, providing a possible mechanism to explain the nature of the interaction of these two drugs on breast cancer cell lines. (aacrjournals.org)
  • Given that ixabepilone has reduced susceptibility to drug efflux pumps compared with taxanes, these data may explain the increased antiangiogenic and antitumor activity of ixabepilone in combination with antiangiogenic agents. (aacrjournals.org)
  • The potential utility of these combination regimens is particularly relevant to patients with drug resistant disease as ixabepilone has shown efficacy in tumors with overexpression of drug efflux transporters and/or βIII-tubulin isotype, two mechanisms that have been implicated in development of resistance to commonly used chemotherapeutic agents. (aacrjournals.org)
  • ADRs may occur following a single dose or prolonged administration of a drug or result from the combination of two or more drugs. (wikipedia.org)
  • To condition the rats, he used a combination[clarification needed] of saccharin-laced water (the conditioned stimulus) and the drug Cytoxan, which unconditionally induces nausea and taste aversion and suppression of immune function. (wikipedia.org)
  • Studies indicate that benzydamine has notable in vitro antibacterial activity and also shows synergism in combination with other antibiotics, especially tetracyclines, against antibiotic-resistant strains of Staphylococcus aureus and Pseudomonas aeruginosa. (wikipedia.org)
  • tumor
  • This offers the possibility to administer cytotoxic agents directly into the peritoneal cavity, providing high concentration of the drug at the site of tumor for a longer period and ideally low systemic toxicity ( 7 ). (aacrjournals.org)
  • Liver
  • This drug is contraindicated in case of having: Blockage of the gallbladder or a sphincter of Oddi problem Problems with alcohol abuse Pancreatitis Liver problems Chronic or severe constipation Common adverse effects are constipation and nausea, but rates of discontinuation due to constipation were low for both eluxadoline and placebo. (wikipedia.org)
  • effects
  • Subsequent changes in electrical activity were observed and the effects of the drugs evaluated. (curehunter.com)
  • Type A: Augmented pharmacologic effects - dose dependent and predictable Type A reactions, which constitute approximately 80% of adverse drug reactions, are usually a consequence of the drug's primary pharmacological effect (e.g. bleeding when using the anticoagulant warfarin) or a low therapeutic index of the drug (e.g. nausea from digoxin), and they are therefore predictable. (wikipedia.org)
  • As research better explains the biochemistry of drug use, fewer ADRs are Type B and more are Type A. Common mechanisms are: Abnormal pharmacokinetics due to genetic factors comorbid disease states Synergistic effects between either a drug and a disease two drugs Various diseases, especially those that cause renal or hepatic insufficiency, may alter drug metabolism. (wikipedia.org)
  • This is because remifentanil will be rapidly eliminated from the blood plasma on termination of the remifentanil infusion, hence the effects of the drug will quickly dissipate even after very long infusions. (wikipedia.org)
  • Other animal research suggests that long term drug-induced antidepressants effects modulate the expression of genes mediated by clock genes, possibly by regulating the expression of a second set of genes (i.e. clock-controlled genes). (wikipedia.org)
  • molecular
  • these include the interaction analytic approach, the drug administration schedule, and the molecular analysis. (aacrjournals.org)
  • These lectures combine vivid projected images of nature, with the description of the history of medicine, phytochemistry, drug discovery, the evolution of modern botanical medicines and also includes Dr Wilkinson original research on molecular synergy combined with live performanece music (Dr Wilkinson is also a professional saxophonist). (wikipedia.org)
  • Wilkinson is a recognised leading authority on herbal medicines, supplements, nutraceuticals, exotic fruits as novel foods, molecular synergism and related matters. (wikipedia.org)
  • Amphenone B was originally thought to be 1,2-bis(p-aminophenyl)-2-methylpropan-1-one, but it was discovered in 1957 that the synthesis of amphenone B was accompanied by an unexpected molecular rearrangement and that the drug was actually 3,3-bis-(p-aminophenyl)butan-2-one. (wikipedia.org)
  • resistance
  • Importantly, ixabepilone has distinct tubulin-binding sites and reduced susceptibility to the drug efflux transporter P-glycoprotein (P-gp), which is frequently associated with multidrug resistance that limits the effectiveness of taxanes and other chemotherapeutic agents. (aacrjournals.org)
  • Multidrug resistance-associated protein 2 (MRP2)-vesicular accumulation of eluxadoline was observed, indicating that the drug is a substrate of MRP2. (wikipedia.org)
  • Cells
  • In this paper we communicate that cells of a selected B-CLL clone (I83), after 2 days of Staphylococcus aureus Cowan strain 1 (SAC) activation, respond to recombinant IL-2 (rIL-2) and a B cell stimulatory factor (BSF-MP6) and act in strong synergism with induction of simultaneous high-rate proliferation and differentiation. (biomedsearch.com)
  • antibiotic
  • The National Strategy for Combating Antibiotic Resistant Bacteria has allowed all facets of this drug discovery/development support to be boosted in order to drive greater interest and encourage investment and innovation. (smi-online.co.uk)
  • receptor
  • http://www.slideshare.net/indiandentalacademy/drug-receptor-interactions-28879141 http://pharmacologycorner.com/pharmacodynamics-antagonism-definition-types-chemical-physiological-pharmacological/ Claussen, C. M. (wikipedia.org)
  • biochemistry
  • John Wilkinson (born 1961) is an English, independent scientist specialising primarily in organic chemistry, phytochemistry, pharmacognosy, and synergism in botanical medicines, botanical foods and ecological biochemistry, and who led the first European degree course (Bachelor of Science with Honours) for herbal medicine, at Middlesex University in the United Kingdom in 1994. (wikipedia.org)
  • Adverse
  • An adverse drug reaction (ADR) is an injury caused by taking a medication. (wikipedia.org)
  • An adverse drug event (ADE) refers to any injury occurring at the time a drug is used, whether or not it is identified as a cause of the injury. (wikipedia.org)
  • The U.S Food and Drug Administration defines a serious adverse event as one when the patient outcome is one of the following: Death Life-threatening Hospitalization (initial or prolonged) Disability - significant, persistent, or permanent change, impairment, damage or disruption in the patient's body function/structure, physical activities or quality of life. (wikipedia.org)
  • Discovery
  • This year's show in Iselin, New Jersey, will play host to an audience of scientific leaders, funding bodies and drug discovery specialists, providing a focal point to discuss the latest clinical advancements and funding opportunities. (smi-online.co.uk)
  • From 1985 to 1987, Wilkinson worked for Wellcome Research Laboratories and Beecham in the area of drug discovery. (wikipedia.org)
  • mainly
  • Among the oldest, lengthiest, and most important medical papyri of ancient Egypt, the Ebers Papyrus dates from about 1550 BC, and covers more than 700 drugs, mainly of plant origin. (wikipedia.org)
  • administration
  • We have tested three different drug administration schedules of tamoxifen and trastuzumab in our analysis of the interaction of these two drugs. (aacrjournals.org)
  • In March 2017, the U.S. Food and Drug Administration issued a safety alert for eluxadoline concerning an increased risk of serious pancreatitis in patients without a gallbladder. (wikipedia.org)
  • Elevated concentrations of eluxadoline were observed with co-administration of inhibitors of the transporter protein OATP1B1, such as: Cyclosporine Gemfibrozil Certain antiretrovirals Rifampin Eltrombopag Also, concurrent use of other drugs that cause constipation is not preferred, such as: Opioids Alosetron Anticholinergics Bismuth subsalicylate, potentially dangerous synergism. (wikipedia.org)
  • pharmaceutical
  • Modern medicine makes use of many plant-derived compounds as the basis for evidence-based pharmaceutical drugs. (wikipedia.org)
  • Consequently, this allows saving time and cost and resources as well as increasing efficiency an effectiveness in medical, pharmaceutical research and new drug development. (wikipedia.org)
  • levels
  • He drugs no rise reveals to 5 mg generic cialis his levels the types of his read, among articles. (commission4mission.org)
  • Their article concludes that there is a synergism between tamoxifen and trastuzumab, which occurs without any effect on HER2/neu levels or signaling activity. (aacrjournals.org)
  • In healthy subjects and patients with adrenocortical carcinoma, the drug was found to be effective in decreasing circulating levels of corticosteroids including cortisol, corticosterone, and aldosterone, as well as in decreasing circulating levels of androgens and estrogens. (wikipedia.org)
  • research
  • Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. (curehunter.com)
  • Realize the full power of the drug-disease research network! (curehunter.com)
  • Various
  • The use of remifentanil has made possible the use of high-dose opioid and low-dose hypnotic anesthesia, due to synergism between remifentanil and various hypnotic drugs and volatile anesthetics. (wikipedia.org)
  • modern
  • According to the World Health Organization, approximately 25% of modern drugs used in the United States have been derived from plants. (wikipedia.org)
  • available
  • Benzydamine (also known as Tantum Verde and branded in some countries as Difflam and Septabene), available as the hydrochloride salt, is a locally-acting nonsteroidal anti-inflammatory drug (NSAID) with local anaesthetic and analgesic properties for pain relief and anti-inflammatory treatment of inflammatory conditions of the mouth and throat. (wikipedia.org)
  • treatment
  • The drug was subsequently repurposed for use in the treatment of metastatic breast cancer and Cushing's syndrome. (wikipedia.org)
  • In some markets, the drug is supplied as an over-the-counter cream (Lonol in Mexico from Boehringer Ingelheim) used for topical treatment of musculoskeletal system disorders: sprains, strains, bursitis, tendinitis, synovitis, myalgia, periarthritis. (wikipedia.org)
  • medical
  • Over a hundred of the 224 drugs mentioned in the Huangdi Neijing, an early Chinese medical text, are herbs. (wikipedia.org)