• tumors
  • Early detection of drug resistant tumor cells may be critical in successful treatment of tumors. (antibody-antibodies.com)
  • CSCs may generate tumors through the stem cell processes of self-renewal and differentiation into multiple cell types. (wikipedia.org)
  • Because they do not bind directly to tubulin, taccalonolides have shown efficacy in cell lines and tumors with taxane-resistance mediated by overexpression of P-glycoprotein (Pgp) multidrug transporter or expression of class III β-tubulin. (wikipedia.org)
  • Particularly, lipophilic titanocene dichloride derivatives derived from fulvenes were synthesised in structural diversity and this led to the development of bis[(p-methoxybenzyl)cyclopentadienyl]titanium(IV) dichloride, which became better known in the literature under its trivial name of Titanocene Y. Titanocene Y is a cytotoxic apoptosis-inducing and anti-angiogenic drug candidate targeting renal-cell cancer and other solid tumors. (wikipedia.org)
  • proteins
  • Intestinal MDR transport proteins and P-450 enzymes as barriers to oral drug delivery. (springer.com)
  • Meanwhile, by MACS and FACS sorting of CD138+ subpopulation, we found that Notch activation could up-regulates anti-apoptotic proteins (Bcl-xL, Mcl-1 and Bcl-2) in CD138+ MM subpopulation, which also contribute to Notch activation mediated drug resistance. (currentscience.org)
  • on the other hand, Notch activation mainly up-regulates several anti-apoptotic proteins in CD138+ subpopulation, thus resulting in drug resistance to bortezomib in murine and human MM cells. (currentscience.org)
  • Focal adhesion proteins g130Cas (Cas) is normally a multi-domain docking proteins, with an N-terminal SH3 domains, a central "substrate domains" consisting of multiple SH2-domains presenting motifs (Tyr-x-x-Pro), and a "Src-binding domains" near the C-terminus . (elevateblogconference.com)
  • ABC transporters often consist of multiple subunits, one or two of which are transmembrane proteins and one or two of which are membrane-associated ATPases. (wikipedia.org)
  • bacteria
  • Community acquired urinary tract infections (UTI) are highly prevalent in developing countries and are usually difficult to eradicate because the pathogenic bacteria have acquired resistance to most of the drugs. (scielo.br)
  • Due to indiscriminate use of drugs in developing countries, the pathogenic bacteria are much more dynamic, versatile and 'battle-hardened' as compared with developed countries. (scielo.br)
  • In 2016, Beta Lactam held the largest market in the drug class segment due to factors such as rising prevalence of multiple drug resistance cases and development of drugs such as Ceftazidime-avibactam and Doripenem which exhibit broad spectrum activity to counteract drug resistance by bacteria. (dovernewsnow.com)
  • 2016
  • The latest market report published by Credence Research, Inc. "Global Multiple Drug Resistance Bacterial Infection Treatment Market - Market Growth, Future Prospects, Competitive Analysis, 2017 - 2025," the global multiple drug resistance bacterial infection treatment market was valued at US$ 26,169.09 Mn in 2016, and is expected to reach US$ 44,060.77 Mn by 2025 expanding at a CAGR of 6.01 % from 2017 to 2025. (dovernewsnow.com)
  • cross-resistance
  • Herpes simplex virus rarely becomes resistant to acyclovir preparations, mostly in the form of cross-resistance to famciclovir and valacyclovir, usually in immunosuppressed patients. (wikipedia.org)
  • Sometimes negative cross resistance occurs, where resistance to one chemical class of fungicides leads to an increase in sensitivity to a different chemical class of fungicides. (wikipedia.org)
  • chemotherapy
  • Our data indicates a potential application of Notch pathway inhibitor to increase drug sensitivity to chemotherapy. (currentscience.org)
  • We conclude that integrated control of drug-resistant vectorborne parasites is not dependent upon chemotherapy only, but also requires a better insight into the ecology of these parasites and how their transmission can be impaired. (uantwerpen.be)
  • clinical
  • Also included in this database are links to relevant databases containing information about target function, sequence, 3D structure, ligand binding properties, enzyme nomenclature and drug structure, therapeutic class, clinical development status. (wikipedia.org)
  • biochemical
  • Target validation normally requires the determination that the target is expressed in the disease-relevant cells/tissues, it can be directly modulated by a drug or drug-like molecule with adequate potency in biochemical assay, and that target modulation in cell and/or animal models ameliorates the relevant disease phenotype. (wikipedia.org)
  • treatment
  • Yeasts such as Candida species can become resistant under long term treatment with azole preparations, requiring treatment with a different drug class. (wikipedia.org)
  • New tools for monitoring drug resistance and treatment response in visceral leishmaniasis in the Indian subcontinent. (uantwerpen.be)
  • New Market Research Reports Title "Multiple Drug Resistance Bacterial Infection Treatment Market Is Expected To Reach US$ 44,060.77 Mn By 2025 - Credence Research" Has Been Added to Credenceresearch.com Report Database. (dovernewsnow.com)
  • In addition, multiple drug resistance has become important for treatment of several other diseases such as tuberculosis, cholera, malaria and HIV-AIDS. (antibody-antibodies.com)
  • Little is known about how variations in fungicide treatment affect the selection pressure to evolve resistance to that fungicide. (wikipedia.org)
  • Titanocene Y is not patent protected and would therefore benefit from non-commercial sponsoring to develop it into a cytotoxic drug candidate for the treatment of advanced renal-cell cancer - an area in need of better therapies. (wikipedia.org)
  • biology
  • Stuart B. Levy, M.D., Professor of Molecular Biology and Microbiology and of Medicine, is the Director of the Center for Adaptation Genetics and Drug Resistance at Tufts University School of Medicine and staff physician at the Tufts Medical Center. (wikipedia.org)
  • molecule
  • One possibility is the encapsulation of a drug into a carrier molecule, which has been successfully done with several hydrophobic drugs, including paclitaxel. (wikipedia.org)
  • taxanes
  • First drug belong to the taxanes and paclitaxel, discovered in extracts from the bark of the yew tree, Taxus brevifolia, in 1967 by Monroe Wall and Mansukh Wani but, its tubulin inhibition activity was not known until 1979. (wikipedia.org)
  • human
  • Arsenic trioxide in the mechanism of drug resistance reversal in MCF-7/ADM cell line of human breast cancer. (biomedsearch.com)
  • OBJECTIVE: To investigate the effect of drug resistance by arsenic trioxide (As(2)O(3)) and its possible mechanism in human breast cancer cell line MCF-7/ADM. (biomedsearch.com)
  • METHODS: Cytotoxicity of As(2)O(3) and the sensibility to adriamycin (ADM) in MCF-7/ADM cell line, a ADM-resistance cell line of human breast cancer, were studied through MTT assay. (biomedsearch.com)
  • CONCLUSION: As(2)O(3) is able to enhance the cytotoxicity of ADM and partly reverse the ADM resistance of MCF-7/ADM cell line of human breast cancer, which may be related to the variation of GST-pi enzyme. (biomedsearch.com)
  • Some of these exporters in humans are involved in tumor resistance, cystic fibrosis and a range of other inherited human diseases. (wikipedia.org)
  • Very encouraging is the fact that Titanocene Y is breaking platinum-resistance in human colon and human lung cancer cells, which might make it attractive as a cytotoxic component of future 2nd or 3rd line cancer treatments. (wikipedia.org)
  • parasites
  • We demonstrate a multiplicity of scenarios, clearly resulting from the biological diversity of the different organisms, but also from the different modes of action of the drugs used, the specific within- and between-host ecology of the parasites, and environmental factors that may have direct or indirect effects. (uantwerpen.be)
  • development
  • Knowledge of developed QSAR models for different molecular scaffolds active against different targets is highly useful for facilitating further drug development and lead optimisation efforts. (wikipedia.org)
  • Finally, it is imperative to elucidate the mechanism of action of taccalonides to further both drug development and identification of other molecules capable of producing taccalonolide-like effects. (wikipedia.org)
  • veterinary
  • Toxoplasma gondii can also become resistant to artemisinin, as well as atovaquone and sulfadiazine, but is not usually MDR Antihelminthic resistance is mainly reported in the veterinary literature, for example in connection with the practice of livestock drenching and has been recent focus of FDA regulation. (wikipedia.org)
  • increasingly
  • Drug resistance in trypanosomes is increasingly being recognised as a constraint to livestock production in many parts of Africa. (cgiar.org)
  • Multi-target agents directed at selected multiple targets have been increasingly explored for enhanced therapeutic efficacies, improved safety profiles, and reduced resistance activities by simultaneously modulating the activity of a primary target and the counteractive elements. (wikipedia.org)
  • pumps
  • Exporters or effluxers, which are present both in prokaryotes and eukaryotes, function as pumps that extrude toxins and drugs out of the cell. (wikipedia.org)
  • cells
  • This kit contains protocols and reagents for use in the detection of Multiple Drug Resistance within cells. (antibody-antibodies.com)
  • As CSCs form a small proportion of the tumor, this may not necessarily select for drugs that act specifically on the stem cells. (wikipedia.org)
  • This functional heterogeneity among cancer cells has led to the creation of multiple propagation models to account for heterogeneity and differences in tumor-regenerative capacity: the cancer stem cell (CSC) and stochastic model. (wikipedia.org)
  • disease
  • Evidence shows that the doses that provide the most control of the disease also provide the largest selection pressure to acquire resistance, and that lower doses decrease the selection pressure. (wikipedia.org)
  • Therefore, TTD collects three types of target validation data: experimentally determined potency of drugs against their primary target or targets, observed potency or effects of drugs against disease models (cell-lines, ex-vivo, in-vivo models) linked to their primary target or targets, and the observed effects of target knockout, knockdown, RNA interference, transgenetic, antibody or antisense treated in-vivo models. (wikipedia.org)