• tumors
  • CSCs may generate tumors through the stem cell processes of self-renewal and differentiation into multiple cell types. (wikipedia.org)
  • Because they do not bind directly to tubulin, taccalonolides have shown efficacy in cell lines and tumors with taxane-resistance mediated by overexpression of P-glycoprotein (Pgp) multidrug transporter or expression of class III β-tubulin. (wikipedia.org)
  • Particularly, lipophilic titanocene dichloride derivatives derived from fulvenes were synthesised in structural diversity and this led to the development of bis[(p-methoxybenzyl)cyclopentadienyl]titanium(IV) dichloride, which became better known in the literature under its trivial name of Titanocene Y. Titanocene Y is a cytotoxic apoptosis-inducing and anti-angiogenic drug candidate targeting renal-cell cancer and other solid tumors. (wikipedia.org)
  • proteins
  • Intestinal MDR transport proteins and P-450 enzymes as barriers to oral drug delivery. (springer.com)
  • Meanwhile, by MACS and FACS sorting of CD138+ subpopulation, we found that Notch activation could up-regulates anti-apoptotic proteins (Bcl-xL, Mcl-1 and Bcl-2) in CD138+ MM subpopulation, which also contribute to Notch activation mediated drug resistance. (currentscience.org)
  • on the other hand, Notch activation mainly up-regulates several anti-apoptotic proteins in CD138+ subpopulation, thus resulting in drug resistance to bortezomib in murine and human MM cells. (currentscience.org)
  • Focal adhesion proteins g130Cas (Cas) is normally a multi-domain docking proteins, with an N-terminal SH3 domains, a central "substrate domains" consisting of multiple SH2-domains presenting motifs (Tyr-x-x-Pro), and a "Src-binding domains" near the C-terminus . (elevateblogconference.com)
  • ABC transporters often consist of multiple subunits, one or two of which are transmembrane proteins and one or two of which are membrane-associated ATPases. (wikipedia.org)
  • bacteria
  • Community acquired urinary tract infections (UTI) are highly prevalent in developing countries and are usually difficult to eradicate because the pathogenic bacteria have acquired resistance to most of the drugs. (scielo.br)
  • Due to indiscriminate use of drugs in developing countries, the pathogenic bacteria are much more dynamic, versatile and 'battle-hardened' as compared with developed countries. (scielo.br)
  • Inhibitors
  • Tubulin inhibitors are drugs that interfere directly with the tubulin system, which is in contrast to those drugs acting on DNA for cancer chemotherapy. (wikipedia.org)
  • Pseudomonas
  • The lack of newly emerging antimicobrial drugs have resulted in the revisit of old antibiotic drugs such as colistin and fosfomycin (Polymyxins), which are traditionally considered to be toxic but have gained a principal role in the treament of the most problematic MDR Gram-negative pathogens including Pseudomonas aeruginosa, Acinetobacter baumannii, Klebsiella pneumoniae and Stenotrophomonas maltophilia. (wikipedia.org)
  • 2016
  • The global multiple drug resistance bacterial infection treatment market was valued at US$ 26,169.09 Mn in 2016, and is expected to reach US$ 44,060.77 Mn by 2025 expanding at a CAGR of 6.01 % from 2017 to 2025. (abnewswire.com)
  • pumps
  • Exporters or effluxers, which are present both in prokaryotes and eukaryotes, function as pumps that extrude toxins and drugs out of the cell. (wikipedia.org)
  • Molecular Biology
  • Stuart B. Levy, M.D., Professor of Molecular Biology and Microbiology and of Medicine, is the Director of the Center for Adaptation Genetics and Drug Resistance at Tufts University School of Medicine and staff physician at the Tufts Medical Center. (wikipedia.org)
  • taxanes
  • First drug belong to the taxanes and paclitaxel, discovered in extracts from the bark of the yew tree, Taxus brevifolia, in 1967 by Monroe Wall and Mansukh Wani but, its tubulin inhibition activity was not known until 1979. (wikipedia.org)
  • treatment
  • New tools for monitoring drug resistance and treatment response in visceral leishmaniasis in the Indian subcontinent. (uantwerpen.be)
  • New Market Research Reports Title "Multiple Drug Resistance Bacterial Infection Treatment Market Is Expected To Reach US$ 44,060.77 Mn By 2025 - Credence Research" Has Been Added to Credenceresearch.com Report Database. (dovernewsnow.com)
  • Little is known about how variations in fungicide treatment affect the selection pressure to evolve resistance to that fungicide. (wikipedia.org)
  • Titanocene Y is not patent protected and would therefore benefit from non-commercial sponsoring to develop it into a cytotoxic drug candidate for the treatment of advanced renal-cell cancer - an area in need of better therapies. (wikipedia.org)
  • paclitaxel
  • One possibility is the encapsulation of a drug into a carrier molecule, which has been successfully done with several hydrophobic drugs, including paclitaxel. (wikipedia.org)
  • human
  • Arsenic trioxide in the mechanism of drug resistance reversal in MCF-7/ADM cell line of human breast cancer. (biomedsearch.com)
  • OBJECTIVE: To investigate the effect of drug resistance by arsenic trioxide (As(2)O(3)) and its possible mechanism in human breast cancer cell line MCF-7/ADM. (biomedsearch.com)
  • METHODS: Cytotoxicity of As(2)O(3) and the sensibility to adriamycin (ADM) in MCF-7/ADM cell line, a ADM-resistance cell line of human breast cancer, were studied through MTT assay. (biomedsearch.com)
  • CONCLUSION: As(2)O(3) is able to enhance the cytotoxicity of ADM and partly reverse the ADM resistance of MCF-7/ADM cell line of human breast cancer, which may be related to the variation of GST-pi enzyme. (biomedsearch.com)
  • Some of these exporters in humans are involved in tumor resistance, cystic fibrosis and a range of other inherited human diseases. (wikipedia.org)
  • Very encouraging is the fact that Titanocene Y is breaking platinum-resistance in human colon and human lung cancer cells, which might make it attractive as a cytotoxic component of future 2nd or 3rd line cancer treatments. (wikipedia.org)
  • parasites
  • We demonstrate a multiplicity of scenarios, clearly resulting from the biological diversity of the different organisms, but also from the different modes of action of the drugs used, the specific within- and between-host ecology of the parasites, and environmental factors that may have direct or indirect effects. (uantwerpen.be)
  • mechanism of act
  • Finally, it is imperative to elucidate the mechanism of action of taccalonides to further both drug development and identification of other molecules capable of producing taccalonolide-like effects. (wikipedia.org)
  • cell
  • Therefore, Cas may possess a regulatory part in cell loss of life signaling in response to multiple different stimuli. (elevateblogconference.com)
  • This functional heterogeneity among cancer cells has led to the creation of multiple propagation models to account for heterogeneity and differences in tumor-regenerative capacity: the cancer stem cell (CSC) and stochastic model. (wikipedia.org)