• Candida
  • Tabbene, Olfa 2017-08-01 00:00:00 The present study aimed to investigate the anti-Candida activity of ten essential oils (EOs) and to evaluate their potential synergism with conventional drugs. (deepdyve.com)
  • antibacterial
  • 1997). Historically, the majority of the natural product-based drugs including cyclosporine, paclitaxel, and camptothecin derivatives were first discovered by traditional cell-based in vitro assays (antibacterial, antifungal, antiviral, antiparasitic, or cytotoxic assays) before their real molecular biological targets were identified (Shu, 1998). (scielo.br)
  • Fungal asthma is often misdiagnosed as COPD (chronic obstructive pulmonary disease) and treated with antibacterial drugs and steroids. (shorenewstoday.com)
  • The close link between fungal diagnostics and antibacterial prescribing needs a great deal more attention. (shorenewstoday.com)
  • Diseases
  • Furthermore, the study - published in the prestigious journal Clinical Infectious Diseases - discovered azole-resistance markers in three-quarters of the small number of aspergillosis patients (eight) who had never been treated with an azole, suggesting widespread dissemination of resistance. (healthcanal.com)
  • The search for new pharmacologically active agents obtained by screening natural sources such as microbial and plant extracts has led to the discovery of many clinical useful drugs that play a major role in the treatment of human diseases (Shu, 1998). (scielo.br)
  • Poor diagnosis worldwide of fungal disease causes doctors to over-prescribe antibiotics, increasing harmful resistance to antimicrobial drugs, according to a paper published in Emerging Infectious Diseases. (shorenewstoday.com)
  • Fungal disease diagnostics are critical in the AMR fight and will improve survival from fungal disease across the world," said David Denning, GAFFI president and a professor of infectious diseases in global health at the University of Manchester. (shorenewstoday.com)
  • spores
  • Eventually, the dispersed fungal spores come into contact with either liquid or solid material and settle onto it, but only when the conditions are right do the spores germinate. (wikipedia.org)
  • mechanisms
  • C. glabrata represents the second most prevalent cause of candidemia and a better understanding of its virulence and drug resistance mechanisms is thus of high medical relevance. (mdpi.com)
  • In this comprehensive review, we want to emphasize and discuss the mechanisms underlying virulence and drug resistance of C. glabrata , and discuss its ability to escape from the host immune surveillance or persist inside host cells. (mdpi.com)
  • In the present study, a collection of fungal clinical isolates were analyzed for the known molecular mechanisms of resistance. (escrs.org)
  • Study of fungal prions has led to a characterisation of the sequence features and mechanisms that enable prion domains to switch between functional and amyloid-forming states. (wikipedia.org)
  • clinical
  • Of a total of 400+ clinical trials initiated by big pharma towards the development of anti-Alzheimers drugs over the past 14 years, 99.7% of these trials have failed utterly. (stanford.edu)
  • There is a need for new therapeutic antibiofilm strategies that focus on the use of combination therapy, since biofilm formation poses an important clinical problem due to their resistance to antifungal agents. (asmscience.org)
  • albicans
  • In C. albicans, resistance occurs by way of mutations in the ERG11 gene, which codes for 14α-demethylase. (wikipedia.org)
  • Another resistance mechanism employed by both C. albicans and C. glabrata is increasing the rate of efflux of the azole drug from the cell, by both ATP-binding cassette and major facilitator superfamily transporters. (wikipedia.org)
  • organisms
  • Narrow-spectrum antibiotics are preferred over broad-spectrum antibiotics when possible, as effectively and accurately targeting specific organisms is less likely to cause resistance. (wikipedia.org)
  • Methenamine silver stains are used for staining in histology, including the following types: Grocott's methenamine silver stain, used widely as a screen for fungal organisms. (wikipedia.org)
  • diagnosis
  • Professor Denning added, "Not only is molecular testing much more sensitive than conventional culture for diagnosis, but it enables testing for resistance, which until now has been impossible if cultures are negative. (healthcanal.com)
  • Perlin
  • This innovative approach to drug resistance detection was made possible because of the application of molecular beacon technology, which was invented by scientists at New Jersey Medical School ," said study co-author David Perlin, Executive Director and Professor at New Jersey Medical School , whose laboratory designed and performed the advanced tests. (healthcanal.com)
  • Perlin is a world-renowned expert in fungal research. (healthcanal.com)
  • lanosterol
  • These mutations prevent the azole drug from binding, while still allowing binding of the enzyme's natural substrate, lanosterol. (wikipedia.org)
  • asthma
  • Of more than 200 million asthma sufferers, an estimated 6 million to 15 million have fungal asthma, which can be diagnosed with skin testing or blood tests and responds to antifungal agents, not antibiotics, the report notes. (shorenewstoday.com)
  • secondary
  • Transcriptomic analysis employing both biofilm models showed upregulation of genes coding for proteins involved in the biosynthesis of secondary metabolites, adhesion, and drug resistance. (asmscience.org)
  • enzyme
  • In addition, isavuconazole induces CYP2B6 and can decrease the amount of drugs that are metabolized by the enzyme. (wikipedia.org)
  • proteins
  • Fungal prions are naturally occurring proteins that can switch between multiple, structurally distinct conformations, at least one of which is self-propagating and transmissible to other prions. (wikipedia.org)
  • isavuconazonium will increase the amount of drugs that are affected by those proteins and may increase their toxicities. (wikipedia.org)
  • toxicity
  • In order to overcome limitations such as sub-optimal spectra of activity, drug-drug interactions, toxicity, development of resistance and unfavorable pharmacokinetics, analogues were developed. (wikipedia.org)
  • molecular
  • Today, with the advent of genomics research and newer molecular biology tools for developing bioassays, more sophisticated biological assays in addition to cell-based assays are being employed routinely in the drug discovery paradigm. (scielo.br)
  • cause
  • The drug was infused into the bloodstream and could cause kidney damage and other side effects. (wikipedia.org)
  • treat
  • Since 2014, acriflavine has been undergoing testing as an antimalarial drug to treat parasites with resistance to quinine and modern anti-parasitic medicines. (wikipedia.org)
  • culture
  • Fungal isolates were grown in solid culture medium for normal growth, in RPMI 1640 liquid medium to allow biofilm formation, and after biofilm formation dispersed again with vortexing in liquid medium. (escrs.org)
  • The solid medium normal fungal culture was considered as control. (escrs.org)
  • known
  • Many people diagnosed with tuberculosis of the lungs don't have TB - known as smear negative cases - but are treated ineffectively with costly TB drugs anyway. (shorenewstoday.com)