• species
  • Diagnostic laboratory criteria include: microscopic evidence of septate hyphae and/or arthroconidia on KOH preparation, PAS-stained septate hyphae embedded in nail (hyphae on nail represent colonization), or fungal culture positive for dermatophytes (Trichophyton, Epidermophyton, and Microsporum species). (oncologynurseadvisor.com)
  • systemic
  • Signs of established sepsis include confusion, metabolic acidosis (which may be accompanied by faster breathing and lead to a respiratory alkalosis), low blood pressure due to decreased systemic vascular resistance, higher cardiac output, and dysfunctions of blood coagulation (where clotting may lead to organ failure). (wikipedia.org)
  • diseases
  • Furthermore, the study - published in the prestigious journal Clinical Infectious Diseases - discovered azole-resistance markers in three-quarters of the small number of aspergillosis patients (eight) who had never been treated with an azole, suggesting widespread dissemination of resistance. (healthcanal.com)
  • The increase in average age of the population, more people with chronic diseases, on immunosuppressive drugs, and increase in the number of invasive procedures being performed has led to an increased rate of sepsis. (wikipedia.org)
  • spores
  • Eventually, the dispersed fungal spores come into contact with either liquid or solid material and settle onto it, but only when the conditions are right do the spores germinate. (wikipedia.org)
  • clinical
  • Of a total of 400+ clinical trials initiated by big pharma towards the development of anti-Alzheimers drugs over the past 14 years, 99.7% of these trials have failed utterly. (stanford.edu)
  • lanosterol
  • These mutations prevent the azole drug from binding, while still allowing binding of the enzyme's natural substrate, lanosterol. (wikipedia.org)
  • enzyme
  • In addition, isavuconazole induces CYP2B6 and can decrease the amount of drugs that are metabolized by the enzyme. (wikipedia.org)
  • proteins
  • Fungal prions are naturally occurring proteins that can switch between multiple, structurally distinct conformations, at least one of which is self-propagating and transmissible to other prions. (wikipedia.org)
  • isavuconazonium will increase the amount of drugs that are affected by those proteins and may increase their toxicities. (wikipedia.org)
  • candidiasis
  • In 2013 and 2014 the partners won orphan drug designation in the US for isavuconazonium for treating invasive aspergillosis, mucormycosis, and invasive candidiasis. (wikipedia.org)
  • toxicity
  • In order to overcome limitations such as sub-optimal spectra of activity, drug-drug interactions, toxicity, development of resistance and unfavorable pharmacokinetics, analogues were developed. (wikipedia.org)
  • molecular
  • This innovative approach to drug resistance detection was made possible because of the application of molecular beacon technology, which was invented by scientists at New Jersey Medical School ," said study co-author David Perlin, Executive Director and Professor at New Jersey Medical School , whose laboratory designed and performed the advanced tests. (healthcanal.com)
  • Professor Denning added, "Not only is molecular testing much more sensitive than conventional culture for diagnosis, but it enables testing for resistance, which until now has been impossible if cultures are negative. (healthcanal.com)
  • mechanism
  • This exciting study illuminates a mechanism of transcriptional control that couples cell wall integrity with cell cycle regulation, and uncovers circuitry governing resistance to the cell wall targeting antifungal caspofungin. (nature.com)
  • major
  • For the convenience of the study, the scientists generated a hybrid protein: one of its parts was a major fungal ABC-transporter, and the other one was a green fluorescent protein. (laboratoryequipment.com)
  • cause
  • The drug was infused into the bloodstream and could cause kidney damage and other side effects. (wikipedia.org)
  • treat
  • Since 2014, acriflavine has been undergoing testing as an antimalarial drug to treat parasites with resistance to quinine and modern anti-parasitic medicines. (wikipedia.org)
  • culture
  • Fungal isolates were grown in solid culture medium for normal growth, in RPMI 1640 liquid medium to allow biofilm formation, and after biofilm formation dispersed again with vortexing in liquid medium. (escrs.org)
  • The solid medium normal fungal culture was considered as control. (escrs.org)