Loading...
  • excretion
  • The first members of the quinolone antibacterial class were relatively low potency drugs such as nalidixic acid, used mainly in the treatment of urinary tract infections owing to their renal excretion and propensity to be concentrated in urine. (wikipedia.org)
  • medication
  • The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. (drugs.com)
  • Conversely, if the medication is a prodrug, it needs to be metabolised to be converted to the active drug. (wikipedia.org)
  • However, the effect only became well-publicized after being responsible for a number of bad interactions with medication. (wikipedia.org)
  • resistance
  • With multidrug therapy used as the standard treatment of Hansen's disease, rifampicin is always used in combination with dapsone and clofazimine to avoid causing drug resistance. (wikipedia.org)
  • Rifampicin can be used as monotherapy for a few days as prophylaxis against meningitis, but resistance develops quickly during long-term treatment of active infections, so the drug is always used against active infections in combination with other antibiotics. (wikipedia.org)
  • citation needed] The initial approval by the U.S. Food and Drug Administration (FDA) in 1986 encompassed the following indications: Uncomplicated urinary tract infections (including cystitis) Complicated urinary tract infections (restricted use) Uncomplicated urethral and cervical gonorrhea (however this indication is no longer considered to be effective by some experts due to bacterial resistance) Prostatitis due to Escherichia coli. (wikipedia.org)
  • Examples
  • Some classic examples of this type of interaction include that thiopentone and suxamethonium should not be placed in the same syringe and same is true for benzylpenicillin and heparin. (wikipedia.org)
  • concentration
  • Carbamazepine, as a CYP450 inducer, may increase clearance of many drugs, decreasing their concentration in the blood to subtherapeutic levels and reducing their desired effects. (wikipedia.org)
  • infections
  • Other drugs are used to treat worm infections outside the digestive tract, as mebendazole is poorly absorbed into the bloodstream. (wikipedia.org)
  • risks
  • The FDA has added a black box warning for this drug in reference to increased risks of suicidal thoughts and behavior in young adults and children. (wikipedia.org)
  • increased risks of suicide increased risks of hyponatremia and SIADH risk of seizures, if the person stops taking the drug abruptly risks to the fetus in women who are pregnant, specifically congenital malformations like spina bifida, and developmental disorders. (wikipedia.org)
  • cholesterol
  • Lovastatin (Merck's Mevacor) is a statin drug, used for lowering cholesterol in those with hypercholesterolemia to reduce risk of cardiovascular disease. (wikipedia.org)
  • Compactin and lovastatin, natural products with a powerful inhibitory effect on HMG-CoA reductase, were discovered in the 1970s, and taken into clinical development as potential drugs for lowering LDL cholesterol. (wikipedia.org)
  • practice
  • The authors, reviewers, and editors of this material have made extensive efforts to ensure that treatments, drugs, and discussions about medical practice are accurate and conform to the standards accepted at the time of publication. (merckmanuals.com)
  • It is therefore easy to see the importance of these pharmacological interactions in the practice of medicine. (wikipedia.org)
  • take
  • assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. (drugs.com)
  • cause
  • By reducing alpha-1-adrenergic activity of the blood vessels, these drugs may cause hypotension (low blood pressure) and interrupt the baroreflex response. (wikipedia.org)
  • As with all statin drugs, it can rarely cause myopathy, hepatotoxicity (liver damage), dermatomyositis or rhabdomyolysis. (wikipedia.org)
  • active
  • Contraindication : Allergies or hypersensitivity to alpha-1 blockers or any of the active ingredient, that includes angiodema induced by the drug. (wikipedia.org)
  • Cases
  • In certain cases, the presence of a drug in an individual's blood may affect certain types of laboratory analysis (analytical interference). (wikipedia.org)
  • Pregnancy
  • citation needed] If needed in pregnancy, adequate human studies are lacking, therefore the drug should be given in pregnant women only if clearly indicated. (wikipedia.org)
  • increase
  • Bergamottin, dihydroxybergamottin, or synthetic analogs may be developed as drugs that are targeted to increase the oral bioavailability of other drugs. (wikipedia.org)
  • taken
  • When drugs are taken orally, they enter the gut lumen to be absorbed in the small intestine and sometimes, in the stomach. (wikipedia.org)
  • certain
  • Or in certain specific situations a drug may even react with itself, such as occurs with dehydration. (wikipedia.org)
  • action
  • The researchers behind the trial hypothesized that the drug blocks a protein that interferes with the action of lysosomes which normally destroy harmful proteins in the brain. (wikipedia.org)
  • blood
  • In order for drugs to be absorbed, they must pass through the epithelial cells that line the lumen wall before they can enter the hepatic portal circulation to be distributed systemically in blood circulation. (wikipedia.org)
  • primary
  • It is the primary drug used for the treatment and prevention of malignant hyperthermia, a rare, life-threatening disorder triggered by general anesthesia. (wikipedia.org)