• Dermatology
  • Unwanted Effects of Cosmetics and Drugs Used in Dermatology, Issue 282 By Anton C. de Groot, Johan Pieter Nater, J. Willem Weyland Maria V, Albuquerque A, Loureiro A, Sousa A, Victorino R (March 2004). (wikipedia.org)
  • idiopathic
  • Features that distinguish drug-induced LP from the idiopathic variety are the presence of focal parakeratosis instead of the usual hyperkeratosis and the presence of eosinophils and sometimes plasma cells in the inflammatory infiltrate. (clinicaladvisor.com)
  • A number of drugs, most of which contain a thiol (or sulphydryl) group in their molecular structure, has been implicated in causing idiopathic conditions closely resembling pemphigus like eruptions. (rxpgonline.com)
  • Diagnosis
  • The diagnosis of LDE may be made clinically, when a high index of suspicion is present, in the setting of the right drug history and when the typical features of the eruptive, widespread lichenoid rash are present. (clinicaladvisor.com)
  • However, they can mimic a wide range of other conditions, thus delaying diagnosis (for example, in drug-induced lupus erythematosus, or the acne-like rash caused by erlotinib). (wikipedia.org)
  • Diagnosis of this drug reaction is straightforward, but occasionally recognition of the causative drug is not possible. (duhnnae.com)
  • Ibuprofen may be quantified in blood, plasma, or serum to demonstrate the presence of the drug in a person having experienced an anaphylactic reaction, confirm a diagnosis of poisoning in hospitalized patients, or assist in a medicolegal death investigation. (wikipedia.org)
  • NSAIDs
  • Common examples include photodermatitis due to local NSAIDs (such as piroxicam) or due to antibiotics (such as minocycline), fixed drug eruption due to acetaminophen or NSAIDs (Ibuprofen), and the rash following ampicillin in cases of mononucleosis. (wikipedia.org)
  • In addition, the United States Food and Drug Administration and the European Medicines Agency started revision processes of the entire class of both NSAIDs and COX-2 inhibitors. (wikipedia.org)
  • rash
  • About 3% of patients admitted to hospital have rashes due to adverse drug reactions but in others the cutaneous signs are due to the underlying or intercurrent illness (e.g. viral or bacterial exanthemas or internal disease), non-specific reactions to treatment (e.g. sweat- rash due to prolonged bed rest with plastic sheeting) or independent skin disease that has not been recognised by hospital staff. (dermnetnz.org)
  • In general, the rash improves when the drug is withdrawn. (dermnetnz.org)
  • Standard reference handbooks such as the MIMS and manufacturers' data sheets include rash in the list of potential adverse effects for nearly every drug. (dermnetnz.org)
  • The suspected drug or drugs should be discontinued, and the rash usually subsides within a week. (dermnetnz.org)
  • Sometimes the rash clears despite continuing the responsible drug or re-challenge is tolerated without adverse reaction. (dermnetnz.org)
  • The most common type of eruption is a morbilliform (resembling measles) or erythematous rash (approximately 90% of cases). (wikipedia.org)
  • The typical amount of time it takes for a rash to appear after exposure to a drug can help categorize the type of reaction. (wikipedia.org)
  • Leukemia and rash: paraneoplastic or drug-induced? (wikipedia.org)
  • severe
  • For example, the field of pharmacogenomics aims to prevent the occurrence of severe adverse drug reactions by analyzing a person's inherited genetic risk. (wikipedia.org)
  • A 2004 survey of six case reports suggested a link between pyritinol and severe cholestatic hepatitis when on several drugs for certain diseases. (wikipedia.org)
  • concurrent
  • No causative drug was found in some patients, which might be associated with concurrent intake of several drugs, multiple FDE, and peculiarity of the patch test. (duhnnae.com)
  • reactions
  • True drug reactions may mimic other skin diseases. (dermnetnz.org)
  • Although adverse reactions are less likely to arise from drugs that the patient has been on for a long period of time, this is not always the case. (dermnetnz.org)
  • Most drug-induced cutaneous reactions are mild and disappear when the offending drug is withdrawn. (wikipedia.org)
  • This unprecedented rise in pharmaceutical use has led to an increasing number of observed adverse drug reactions. (wikipedia.org)
  • There are two broad categories of adverse drug reactions. (wikipedia.org)
  • Type A reactions are known side effects of a drug that are largely predictable and are called, pharmatoxicologic. (wikipedia.org)
  • Drug reactions have characteristic timing. (wikipedia.org)
  • Fixed drug reactions are common and so named because they recur at the same site with each exposure to a particular medication. (wikipedia.org)
  • occur
  • Large tender well-circumscribed edematous and erythematous plaques that may be symmetrical occur after drug ingestion and fade completely within 2 to 3 weeks. (oncologynurseadvisor.com)
  • Eruptions can occur frequently with a certain drug (for example, with phenytoin), or be very rare (for example, Sweet's syndrome following the administration of colony-stimulating factors). (wikipedia.org)
  • The core side effects of NSAAs such as gynecomastia, sexual dysfunction, and hot flashes occur at similar rates with the different drugs. (wikipedia.org)
  • medication
  • The culprit can be both a prescription drug or an over-the-counter medication. (wikipedia.org)
  • The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. (drugs.com)
  • A published algorithm (ALDEN) to assess drug causality gives structured assistance in identifying the responsible medication. (wikipedia.org)
  • Typically, the symptoms of drug-induced SJS arise within a week of starting the medication. (wikipedia.org)
  • Ibuprofen
  • A single blind oral challenge test (SBOCT) with other propionic acid derivates were performed in order to check for crossreactivity between them: ibuprofen, ketoprofen and nabumetone were administered and all drugs were well tolerated. (semanticscholar.org)
  • In 2006, ibuprofen lysine was approved in the US by the Food and Drug Administration (FDA) for closure of patent ductus arteriosus in premature infants weighing between 500 and 1,500 grams (1 and 3 lb), who are no more than 32 weeks gestational age when usual medical management (such as fluid restriction, diuretics, and respiratory support) is not effective. (wikipedia.org)
  • According to the US Food and Drug Administration (FDA), "ibuprofen can interfere with the antiplatelet effect of low-dose aspirin, potentially rendering aspirin less effective when used for cardioprotection and stroke prevention. (wikipedia.org)
  • patients
  • Certain drugs are less likely to cause drug eruptions (rates estimated to be ≤3 per 1000 patients exposed). (wikipedia.org)
  • This cross-sectional study was carried out on 30 patients with criteria of generalized fixed drug eruption over 9 years. (duhnnae.com)
  • The antibiotic group, especially cotrimoxazole 26.1%, was reported to be the most common offending drug, but the causative drug was not determined in 7 23.3% patients. (duhnnae.com)
  • As many as 7 per cent of patients taking the drug for more than six months develop a pemphigus-like eruption. (rxpgonline.com)
  • Patients usually present with the skin eruption 1-2 weeks after use of the cytotoxic drug. (wikipedia.org)
  • In patients receiving chemotherapy, it has been postulated that a high concentration of the cytotoxic drug in sweat has a direct toxic effect on the eccrine glands. (wikipedia.org)
  • In November 2011, this trial was stopped early after an interim analysis revealed that patients given the drug lived for approximately 5 months longer than those taking placebo. (wikipedia.org)
  • withdrawn
  • Because of these results, some drugs were withdrawn from the market (rofecoxib, in September 2004 and valdecoxib in April 2005). (wikipedia.org)
  • Serum
  • An up to 89% decrease in serum prostate specific antigen (PSA) levels have been reported after a month of taking the drug. (wikipedia.org)
  • exposure
  • However, if the patient developed NEH after chemotherapy, the offending cytotoxic drug has to be discontinued, and the patient must avoid this particular cytotoxic drug in the future, because NEH usually re occurs upon re exposure to the same cytotoxic drug. (wikipedia.org)
  • onset
  • The onset may be within weeks of drug initiation, but LDE is atypical in that it can take up to 12 months to evolve. (clinicaladvisor.com)
  • Drugs discontinued more than 1 month prior to onset of mucocutaneous physical findings are highly unlikely to cause SJS and TEN. (wikipedia.org)
  • cytotoxic
  • The overwhelming majority of neutrophilic eccrine hidradenitis (NEH) is seen in people with cancer, especially leukaemia, who receive chemotherapy with a cytotoxic drug. (wikipedia.org)
  • Food and Drug Admin
  • In August 2012, the United States (U.S.) Food and Drug Administration (FDA) approved enzalutamide for the treatment of CRPC. (wikipedia.org)
  • Etoricoxib (Arcoxia) is a selective COX-2 inhibitor from Merck & Co. Currently it is approved in more than 80 countries worldwide but not in the US, where the Food and Drug Administration (FDA) has required additional safety and efficacy data for etoricoxib before it will issue approval. (wikipedia.org)