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  • India
  • Using information from CDSCO on FDC formulations approved between 1961 and 2013, and FDC sales data between 2007 and 2012 from PharmaTrac (a database of drug sales in India), the researchers analyzed approval status and sales volumes of FDCs in four therapeutic areas. (medindia.net)
  • In 2012, the Parliamentary Standing Committee on Health & Family Welfare has tabled before Parliament a unanimous 118-page report on the state of drug regulation in India and the manner in which it severely compromises the safety of Indian patients. (medindia.net)
  • Our research wholly supports the need for a complete overhaul of the new Drugs Bill and we urge the government of India to make this a priority," noted professor Allyson Pollock, global health expert and study co-author. (medindia.net)
  • NRTIs
  • Subsequently, several more NRTIs were developed but even in combination were unable to suppress the virus for long periods of time and patients still inevitably died. (wikipedia.org)
  • Cancer
  • Cancer researchers have devised a way to rapidly screen combinations of drugs to identify pairs of agents most likely to work synergistically against some of the most difficult to treat forms of leukemia. (ohsu.edu)
  • A drug that cuts off the blood supply feeding tumours may boost the survival of patients with glioblastoma multiforme (GBM), a deadly form of brain cancer . (netdoctor.co.uk)
  • Nasdaq: CPXX), a biopharmaceutical company that is transforming the science of combination therapy and developing products to improve patient outcomes in cancer, announced their successful R&D efforts to apply the CombiPlex technology platform to optimize the efficacy of anticancer drug combinations incorporating molecularly targeted agents (MTAs). (thefreedictionary.com)
  • With our platform, you can profile your compounds as single agents or combinations across hundreds of well-annotated cancer cell lines, and gain actionable insights in a short period of time. (horizondiscovery.com)
  • Researchers were hopeful that the combination treatment could extend survival times of patients with this aggressive cancer. (asbestos.com)
  • Furthermore, researchers from the University of Sydney have found that other anti-cancer drugs may also provide the key to treating aggressive diseases and cancers. (asbestos.com)
  • The study , conducted by professor Des Richardson of the Sydney Medical School, illustrate that drugs can control the spread and growth of cancer cells. (asbestos.com)
  • Now, NCI has released a new, easy-to-use resource to help researchers identify potentially promising combinations of cancer drugs. (cancer.gov)
  • Yet, based on further mechanistic and animal model studies for two of these combinations, NCI investigators have launched two phase I clinical trials to test these respective drug pairs in patients with advanced cancer. (cancer.gov)
  • So, when a novel compound is tested against cell lines in the NCI-60, it's possible to determine not just whether it kills the cells, but how it affects the molecular machinery of a cancer cell-information that is critical for understanding how a drug works. (cancer.gov)
  • The report from our NCI group in Cancer Research provides an ideal case report of what the NCI ALMANAC results might mean for advancing new drug combinations into human trials. (cancer.gov)
  • Data in the NCI ALMANAC showed that the combination of nilotinib and paclitaxel had robust cell-killing effects in blood cancer and triple-negative breast cancer cell lines. (cancer.gov)
  • However, with 300 FDA-approved cancer drugs on the market, there almost 45,000 possible two-drug combinations and almost 4.5 million three-drug combinations for to choose from. (wikipedia.org)
  • The National Cancer Institute has recently highlighted combination therapy as a top research priority in oncology. (wikipedia.org)
  • The majority of drugs used in cancer chemotherapy are cytostatic, many via cytotoxicity. (wikipedia.org)
  • therapies
  • Combination therapies are emerging as superior treatment options for many diseases, including oncology. (horizondiscovery.com)
  • Typically, these terms refer to using multiple therapies to treat a single disease, and often all the therapies are pharmaceutical (although it can also involve non-medical therapy, such as the combination of medications and talk therapy to treat depression). (wikipedia.org)
  • On 23 April 2009, The National Institute for Health and Clinical Excellence (NICE) issued a Final Appraisal Determination (FAD) approving lenalidomide, in combination with dexamethasone, as an option to treat patients with multiple myeloma who have received two or more prior therapies in England and Wales. (wikipedia.org)
  • On 5 June 2013 the FDA designated lenalidomide as a specialty drug requiring a specialty pharmacy distribution for "use in mantle cell lymphoma (MCL) in patients whose disease has relapsed or progressed after 2 prior therapies, 1 of which included bortezomib. (wikipedia.org)
  • researchers
  • In total, the researchers tested 18,278 combinations. (medicalnewstoday.com)
  • Researchers at Duke University found that Bevacizumab (Avastin), a drug that stunts the growth of blood vessels that feed a tumour's growth and spread, may increase the amount of time that patients can survive without tumour growth if given in conjunction with a standard chemotherapy drug. (netdoctor.co.uk)
  • Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while. (innovations-report.com)
  • With this new resource, we've done some heavy lifting for the research community, performing a resource-intensive, robust drug screen to generate data that can provide researchers with new hypotheses to advance to the next stage of investigation. (cancer.gov)
  • AIDS
  • Zalcitabine was the third antiretroviral to be approved by the Food and Drug Administration (FDA) for the treatment of HIV/AIDS. (wikipedia.org)
  • CS1 maint: Uses authors parameter (link) Oral account of the history of AZT, d4T and ddC by Jerome Horwitz and Hiroaki Mitsuya in the documentary film I am alive today - History of an AIDS drug. (wikipedia.org)
  • Midazolam
  • Intravenous midazolam is indicated for procedural sedation (often in combination with an opioid, such as fentanyl), for preoperative sedation, for the induction of general anesthesia, and for sedation of people who are ventilated in critical care units. (wikipedia.org)
  • citation needed] Midazolam, in combination with an antipsychotic drug, is indicated for the acute management of schizophrenia when it is associated with aggressive or out-of-control behaviour. (wikipedia.org)
  • Wood was scheduled to be executed with a combination of midazolam and hydromorphone, which had only been used once previously for the January 2014 execution of Dennis McGuire in Ohio. (wikipedia.org)
  • patients
  • Sellerberg also cautions patients that food too can have an effect on the drugs they are taking. (medindia.net)
  • To allay their fears, patients should look carefully at the insert that comes with the drug that explains how the medicine should be taken. (medindia.net)
  • Publishing their findings in the Journal of Clinical Oncology, they reveal that out of 35 patients given the drug combination, almost half saw no tumour progression after six months, and nearly 80 per cent were still alive six months after being diagnosed. (netdoctor.co.uk)
  • Results from a recent Phase II clinical trial found that adding bevacizumab to the common mesothelioma treatment combination of gemcitabine and cisplatin did not improve survival times for malignant mesothelioma patients. (asbestos.com)
  • For example, mesothelioma experts like Raffit Hassan have stated that breakthrough drugs like SS1 may be able to add months to patients' lives if correct combinations are discovered. (asbestos.com)
  • When we looked at how well the high-risk patients were doing on ibrutinib - even though it was a small number - we saw a great opportunity to find out if combining the two drugs would have a positive impact on these patients," Burger said. (innovations-report.com)
  • Combining these drugs with ribavirin enhances their efficacy and is the standard treatment for hepatitis C. "It looks as though Pegasys is more potent during the early phase of treatment, which is critical for patients with chronic hepatitis C," said Adrian M. Di Bisceglie, M.D., professor of internal medicine in Saint Louis University School of Medicine s division of gastroenterology and hepatology, and the study s lead investigator. (innovations-report.com)
  • Eight weeks into this trial we noticed lower viral levels in patients on the combination of Pegasys and ribavirin. (innovations-report.com)
  • There may not be an FDC available with the appropriate drugs and/or in the most appropriate respective strength(s) for a given patient, which can lead to some patients getting too much of an ingredient and others getting too little, as the AAO notes that FDCs "limit clinicians' ability to customize dosing regimens. (wikipedia.org)
  • On 29 June 2006, lenalidomide received U.S. Food and Drug Administration (FDA) clearance for use in combination with dexamethasone in patients with multiple myeloma who have received at least one prior therapy. (wikipedia.org)
  • Perindopril and amlodipine were found to be so effective, the trial was stopped early so all patients could receive the combination. (wikipedia.org)
  • Later, the term combination antiretroviral therapy (cART) gained favor with some physicians as a name more accurate for the current era, not conveying to patients any misguided idea of the nature of the therapy. (wikipedia.org)
  • treat
  • Similarly, the pain reliever paracetamol, when taken with drugs that treat epilepsy, glaucoma or tuberculosis, can cause serious liver damage. (medindia.net)
  • It is estimated that people over 65 take an average of seven drugs at any one time to treat a variety of illnesses. (diabetesselfmanagement.com)
  • orphan drug one that has limited commercial appeal because of the rarity of the condition it is used to treat. (thefreedictionary.com)
  • Lenalidomide is one of the novel drug agents used to treat multiple myeloma. (wikipedia.org)
  • Chlordiazepoxide/clidinium bromide (marketed as Librax) is a drug consisting of chlordiazepoxide (marketed separately under the trade name Librium) and clidinium bromide and used to treat peptic ulcers, irritable bowel syndrome (IBS), and gastritis. (wikipedia.org)
  • There are six classes of drugs, which are usually used in combination, to treat HIV infection. (wikipedia.org)
  • toxicity
  • Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a drug, reaction to a drug or drug abuse. (medindia.net)
  • Along with several other drugs developed in recent years, lenalidomide has significantly improved overall survival in myeloma (which formerly carried a poor prognosis), although toxicity remains an issue for users. (wikipedia.org)
  • diabetes
  • So in addition to insulin or diabetes pills, other drugs are often needed to control these problems - statins for high cholesterol , diuretics or beta-blockers for high blood pressure, antidepressants for depression or neuropathy pain, and a daily aspirin to prevent a heart attack. (diabetesselfmanagement.com)
  • Empagliflozin/linagliptin is a drug combination used for the treatment of type II diabetes. (wikipedia.org)
  • doses
  • The synergy score S = ln f X ln f Y Σ doses max(0, Z data ) ( Z data − Z model ) sums up the excess inhibition over the HSA model with weights to account for drug dilution factors f X , f Y , and favor synergy at high inhibition levels. (nih.gov)
  • And each drug in each pair was tested at different doses, producing nearly 3 million data points. (cancer.gov)
  • multiple
  • Once the effect of each compound as a single agent is removed, an Excess Matrix is generated that provides a simple visual representation of information about combination activity at the multiple concentrations and ratios of the two drugs and where synergies or antagonism can be seen. (horizondiscovery.com)
  • Multiple formulations included drugs which are restricted, banned or were never approved in other countries because of associations with serious adverse events including death. (medindia.net)
  • Recent precision medicine approaches have focused on targeting multiple biomarkers found in individual tumors using combinations of drugs. (wikipedia.org)
  • The use of multiple drugs that act on different viral targets is known as highly active antiretroviral therapy (HAART). (wikipedia.org)
  • medication
  • In the search for medication against Alzheimer's disease, scientists have focused - among other factors - on drugs that can break down Amyloid beta (A-beta). (medindia.net)
  • Combination therapy or polytherapy is therapy that uses more than one medication or modality (versus monotherapy, which is any therapy taken alone). (wikipedia.org)
  • dosages
  • Ability to compose combined profiles of for example pharmacokinetics, effects and adverse effects that may be specific for the relative dosages in a given FDC product, providing a simpler overview compared to when looking at the profiles of each single drug individually. (wikipedia.org)
  • adverse drug e
  • Why this is so is not well understood but may include underreported or unrecognized adverse drug events by the people taking them or their physicians, people simply not taking their medicines consistently, individual differences in tolerance of drug effects, and individual variations in the blood levels of any of the potential interacting drugs. (diabetesselfmanagement.com)
  • FDCs
  • In 2012, the Parliamentary Standing Committee on Health & Family Welfare reported that a very large number of FDCs had been licensed by state drug authorities without approval by the Central Drugs Standard Control Organization (CDSCO). (medindia.net)
  • Perindopril
  • The Anglo-Scandinavian Cardiac Outcomes Trial showed the benefits of taking the two drugs perindopril and amlodipine together. (wikipedia.org)
  • pairs
  • The NCI ALMANAC includes data on more than 5,000 pairs of FDA-approved drugs that were tested against the NCI-60-a total of 300,000 experiments. (cancer.gov)
  • We began by conducting follow-up experiments on a subset of drug pairs identified in the database that exhibited potent cell-killing effects. (cancer.gov)
  • pharmaceutical
  • This ban is likely to affect many leading pharmaceutical drug manufacturers such as Pfizer, Abbott, Macleods Pharma and Glenmark Pharmaceuticals. (medindia.net)
  • FDC drug products may be developed by a pharmaceutical company as a way to in effect extend proprietary rights and marketability of a drug product. (wikipedia.org)
  • Sometimes "polymedicine" is used to refer to pharmaceutical combination therapy. (wikipedia.org)
  • however
  • It is however to be noted that combining two or more drugs can lead to disastrous consequences, including death. (medindia.net)
  • Caution should be used when administering this drug however due to a possible shift in tropism which allows HIV to target an alternative co-receptor such as CXCR4. (wikipedia.org)
  • interact
  • With this amount of medicine use, the probability that a person will take two prescribed drugs that may interact with one another is very high. (diabetesselfmanagement.com)
  • In a recent study done in six European countries, investigators reviewed the medicines taken by about 1600 people and found that 46% were taking at least one pair of drugs that could interact. (diabetesselfmanagement.com)
  • regimens
  • There may not be an FDC available with the appropriate drugs and/or in the most appropriate respective strength(s) for a given patient, which can lead to some patients getting too much of an ingredient and others getting too little, as the AAO notes that FDCs "limit clinicians' ability to customize dosing regimens. (wikipedia.org)
  • Chemotherapy regimens are often identified by acronyms, identifying the agents used in the drug combination. (wikipedia.org)
  • perindopril
  • The Anglo-Scandinavian Cardiac Outcomes Trial showed the benefits of taking the two drugs perindopril and amlodipine together. (wikipedia.org)
  • research
  • New research has revealed that, contrary to traditional beliefs in the medical community, four- or five-drug combinations can be effective in treating infection with treatment-resistant bacteria. (medicalnewstoday.com)
  • New research led by scientists at the University of California, Los Angeles (UCLA) reveals that combining four or five antibiotics can prove surprisingly effective in killing off or slowing down the progression of drug-resistant bacteria. (medicalnewstoday.com)
  • The treatment, based loosely on the research of Spanish psychologist Juan Jose Legarda, involves a combination of three medications as well as therapy. (wikipedia.org)