• Adipose tissue-derived mesenchymal stem cells (AD-MSC) show great potential to treat inflammatory and degradative processes in OA and have demonstrated paracrine effects in chondrocytes. (karger.com)
  • AD-MSC were isolated by collagenase treatment from adipose tissue from healthy individuals subjected to abdominal lipectomy surgery. (karger.com)
  • Further supporting this hypothesis, accurate predictions have been reported for acidic and neutral drugs in these same tissues and also for the same basic lipophilic drugs in tissues with less abundant lysosomes (e.g., brain, muscle, and adipose tissue). (aspetjournals.org)
  • Nevertheless, adipose tissue thickness and distribution play a critical role with injectable drugs. (bvsalud.org)
  • After equilibrium, drug concentrations in tissues and in extracellular fluids are reflected by the plasma concentration. (msdmanuals.com)
  • It refers to when a drug occurs in disproportionate concentrations and/or has disproportionate effects in specific tissues relative to other tissues. (wikipedia.org)
  • Because CNS tissue levels are higher than in serum, levels may underestimate CNS concentrations of phenytoin. (medscape.com)
  • In patients with ulcerative proctitis treated with CANASA® (mesalamine, USP) 500 mg or 1000 mg rectal suppositories, rectal tissue concentrations for 5-ASA and N-acetyl 5-ASA have not been rigorously quantified. (theodora.com)
  • In the third group, ligation of the large vessels around the heart took place immediately post mortem, but significant differences in blood and tissue MDMA concentrations between rabbits of group 2 and 3 could not be demonstrated. (erowid.org)
  • Validation of the analytical method was performed using different spiked tissues, in a range of concentrations from 2.4 to 475 mg/L or mg/kg, and submitting them to dilution (1:25) to avoid the matrix effect and to bring these concentrations to the range of the aqueous calibration curve (0.19-19 mg/L). Limits of detection and quantitation were 0.02 and 0.1 mg/L, respectively. (fluoridealert.org)
  • Conjugation of hydrophilic polymers with small molecule drugs to produce polymer-drug conjugate systems has been demonstrated to be a viable formulation strategy for utilizing hydrophobic drugs in a water-soluble manner, which may offer advantages over the corresponding parent drugs, including fewer side effects, improved solubility, passive tumor targeting, an improved pharmacokinetic profile, and lower plasma concentrations. (dovepress.com)
  • conversely, food or one of its components may affect bioavailability and half-life, circulating plasma concentrations of drugs resulting in an increased risk of toxicity and its adverse effects, or therapeutic failure. (mdpi.com)
  • Through the use of this approach, it appears that most CNS-active agents freely equilibrate across the blood-brain and blood-CSF barriers such that unbound drug concentrations in brain approximate those in the plasma. (aspetjournals.org)
  • In the event that a drug freely diffuses across the blood-brain and blood-CSF barriers, it is reasonable to expect that CSF concentrations will be reflective of those in the brain extracellular fluid ( de Lange and Danhof, 2002 ). (aspetjournals.org)
  • These patients may exhibit signs of toxicity when drug levels are within the therapeutic range (see Lab Studies). (medscape.com)
  • and DRUG TOXICITY as a function of dosage, and rate of METABOLISM. (umassmed.edu)
  • After the application of common drugs, the toxicity and side effects can be limiting. (frontiersin.org)
  • Research in the Tirona Lab focuses on molecular determinants of drug response and toxicity. (uwo.ca)
  • Currently, the laboratory is investigating the role of drug transporters in the skeletal muscle toxicity of the cholesterol-lowering drugs. (uwo.ca)
  • Hence, inhibition of the active drug uptake into proximal tubular cells may provide an effective strategy to ameliorate the renal toxicity syndromes. (aspetjournals.org)
  • Antiepileptic drugs should be used carefully, with consideration of medication interactions and potential side effects. (medscape.com)
  • The use of checkpoint inhibitors in combination therapy further complicates the safety monitoring of SKM injury due to the potential for drug-drug interactions. (degruyter.com)
  • The potential for interactions between mesalamine, administered as 500 mg or 1000 mg rectal suppositories, and other drugs has not been studied. (theodora.com)
  • Objectives: The objective of this study was to explore potential drug-drug/food interactions of ciprofloxacin and grapefruit juice, known hepatic cytochrome P450 (CYP) 1A2 inhibitors, on single-dose oral pharmacokinetics of riluzole, a substrate of CYP 1A2 enzymes. (researchgate.net)
  • The purpose of this study was to investigate the frequency and potential drug-drug interactions associated with antimicrobials among hospitalized patients. (researchgate.net)
  • The Micromedex® online drug reference system was used to control and describe the interactions. (researchgate.net)
  • RESULTS: Potential drug-drug interactions with antimicrobials were 26.4% of all interactions. (researchgate.net)
  • In multivariate analysis, number of prescribed antimicrobials (odds ratio: 2.3001, 95% CI: 1.6237-3.2582), number of prescribed drugs (odds ratio: 1.2008, 95% CI: 1.0943-1.3177), and hospitalization in the university hospital (odds ratio: 1.7798, 95% CI: 1.0035-3.1564) were independent risk factors for developing drug interactions. (researchgate.net)
  • The binding of ciprofloxacin to serum proteins is 20% to 40%, which is not likely to be high enough to cause significant protein binding interactions with other drugs. (theodora.com)
  • Due to system maintenance, the drug interactions feature you are attempting to access is temporarily unavailable. (medscape.com)
  • However, to date little is known concerning the precise mechanisms of translocation of iron nanoparticle s into targeted tissues and organs from blood circulation, as well as the underlying implications of potential harmful health effects in human. (cdc.gov)
  • Tissue engineering (TE) is a promising strategy for replacing, repairing or regenerating damaged tissues and organs. (nature.com)
  • Overview of Pharmacokinetics Pharmacokinetics, sometimes described as what the body does to a drug, refers to the movement of drug into, through, and out of the body-the time course of its absorption, bioavailability, distribution. (msdmanuals.com)
  • It is important to understand the mechanisms of action and the pharmacokinetics of antiepileptic drugs (AEDs) so that these agents can be used effectively in clinical practice, especially in multidrug regimens (see the image below). (medscape.com)
  • Smith BS, Yogaratnam D, Levasseur-Franklin KE, Forni A, Fong J. Introduction to drug pharmacokinetics in the critically ill patient. (umassmed.edu)
  • In particular, studies are performed to characterize and understand the factors that govern interindividual differences in drug pharmacokinetics. (uwo.ca)
  • In addition, we are studying the interplay between transporters and metabolizing enzymes with respect to quantitative in vitro to in vivo prediction of drug pharmacokinetics. (uwo.ca)
  • It is suitable for biomarker detection, tissue classification, pathology research, and imaging the distributions of drugs and metabolites for drug development. (photonics.com)
  • Unbound fractions in mouse brain and plasma were determined for 31 structurally diverse central nervous system (CNS) drugs and two active metabolites. (aspetjournals.org)
  • Only unbound drug is available for passive diffusion to extravascular or tissue sites where the pharmacologic effects of the drug occur. (msdmanuals.com)
  • Minimally distributed to extravascular tissues. (unboundmedicine.com)
  • One of the potential limitations associated with the use of alginate for in vivo tissue regeneration is that it is in general non-degradable by mammals, as they lack the enzymes needed to break down the polymer chains 21 . (nature.com)
  • Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. (origene.com)
  • These cytosolic enzymes are different in their tissue distributions and substrate specificities. (origene.com)
  • Moreover, the role of nuclear receptors in determining the expression of drug metabolizing enzymes and transporters is also an area of interest. (uwo.ca)
  • Medically reviewed by Drugs.com on Jul 24, 2023. (drugs.com)
  • Medically reviewed by Drugs.com on Feb 8, 2023. (drugs.com)
  • To reduce the development of drug-resistant bacteria and maintain the effectiveness of azithromycin and other bacterial drugs, azithromycin for injection should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. (nih.gov)
  • Metabolism and excretion occur simultaneously with distribution, making the process dynamic and complex. (msdmanuals.com)
  • This study aimed to determine the tissue residue depletion kinetics of trimethoprim and. (cabi.org)
  • However, many of the critical pharmacokinetic implications can be derived from information regarding the overall extent of tissue binding estimated nonspecifically. (aspetjournals.org)
  • Pharmacokinetic studies and tissue distributions were performed and detected by an ultra-high performance liquid chromatography/mass spectrometry system. (dovepress.com)
  • Antihypertensive Drugs. (wikipedia.org)
  • Therefore, we concluded that the use of antihypertensive drugs can treat erythematous limb pain with the clinical manifestation of hypertensive crisis. (frontiersin.org)
  • Relating in vitro to in vivo exposures with physiologically based tissue dosimetry and tissue response models. (cdc.gov)
  • In vivo studies suggest that the concentration in phagocytes may contribute to drug distribution to inflamed tissues. (medscape.com)
  • Unbound fraction data were within 3-fold of in vivo exposure ratios for the majority of the drugs examined (i.e., 22 of 33), indicating a predominately free equilibrium across the blood-brain and blood-CSF barriers. (aspetjournals.org)
  • Previous reports suggest that the dilution, homogenization, and incubation process necessary to determine unbound tissue fraction by equilibrium dialysis may disrupt or destroy intracellular components that contribute to distribution in vivo. (aspetjournals.org)
  • We included patients aged ³18 years who received at least 1 antimicrobial drug and at least 1 of any other drug. (researchgate.net)
  • This project aims to achieve a paradigm shift in antimicrobial drug discovery by finding next generation anti-infectives that prevent disease by blocking pathogen adaptation to host physiology. (nih.gov)
  • In the bloodstream, drugs are transported partly in solution as free (unbound) drug and partly reversibly bound to blood components (eg, plasma proteins, blood cells). (msdmanuals.com)
  • Of the many plasma proteins that can interact with drugs, the most important are albumin , alpha-1 acid glycoprotein, and lipoproteins. (msdmanuals.com)
  • The laboratory is especially interested in transport proteins and their impact on tissue drug distribution and elimination. (uwo.ca)
  • Disposition and tissue distribution of angiopeptin in the rat. (aspetjournals.org)
  • The disposition and tissue distribution of angiopeptin, a long-acting octapeptide analogue of somatostatin, were studied in rats following single iv and sc administration of the drug. (aspetjournals.org)
  • Thank you for sharing this Drug Metabolism & Disposition article. (aspetjournals.org)
  • Message Body (Your Name) thought you would be interested in this article in Drug Metabolism & Disposition. (aspetjournals.org)
  • Zaher H, Meyer Zu Schwabedissen HE, Tirona RG , Cox ML, Obert LA, Agrawal N, Palandra J, Stock JL, Kim RB, Ware JA (2008) Targeted Disruption of Murine Organic Anion-Transporting Polypeptide 1b2 (oatp1b2/Slco1b2) Significantly Alters Disposition of Prototypical Drug Substrates Pravastatin and Rifampin. (uwo.ca)
  • Graduate students in the College of Pharmacy and Health Sciences (CPHS) conduct groundbreaking research in diverse areas of pharmaceutical research, including biotechnology , drug delivery, medicinal chemistry, pharmacology, and toxicology . (stjohns.edu)
  • Systems toxicology, therefore, aims at understanding and exploring the way that different biological components are orchestrated as an ensemble in cells, tissues, and organisms. (brill.com)
  • The extent of drug distribution into tissues depends on the degree of plasma protein and tissue binding. (msdmanuals.com)
  • Mesalamine administered as rectal suppositories distributes in rectal tissue to some extent. (theodora.com)
  • In this perspective the archaeological context of the crypt of Ca' Granda in Milan offers an extraordinary substrate on which to verify the presence in the human remains of drug therapies mentioned in the archives of the hospital (or unexpected ones), but never extracted from skeletal remains, as well as the opportunity to test to what extent modern toxicological techniques can help in the reconstruction of the past. (nature.com)
  • With relatively few assumptions, qualitative insight into the extent of tissue binding is easily obtained by pairing distribution measures with unbound plasma fraction. (aspetjournals.org)
  • NT008 trade name] is indicated in adults and children for the elimination through mass drug administration programmes of schistosoma infections due to various types of blood fluke worms ( Schistosoma mansoni, Schistosoma haematobium, Schistosoma japonicum, Schistosoma mekongi, Schistosoma intercalatum ) following the recommendations of the WHO Global Programme to Eliminate Schistosomiasis. (who.int)
  • Tissue selectivity is a topic in distribution (pharmacology) and property of some drugs. (wikipedia.org)
  • Use is contraindicated in patients with hepatic impairment including hepatic cirrhosis as drug exposure is increased (see Contraindications). (pdr.net)
  • Antibiotic overuse contributes to the emergence of drug-resistant organisms. (medscape.com)
  • Distribution equilibrium (when entry and exit rates are the same) between blood and tissue is reached more rapidly in richly vascularized areas, unless diffusion across cell membranes is the rate-limiting step. (msdmanuals.com)
  • Most of the drug was excreted in the feces via the bile, while approximately 10% was excreted in the urine. (aspetjournals.org)
  • Much of the drug is excreted in the bile as an inactive metabolite, which is then reabsorbed from the intestinal tract and ultimately excreted in the urine. (medscape.com)
  • Since its inception, this conference has been a cornerstone for our industry to learn, share, debate, and collaborate, to face our common challenges, and to drive forward innovation in injectable drug delivery. (pda.org)
  • Significant advances in injectable drug delivery have been made over the past 20 years, and rapid evolution aimed at improving patient experience, health outcomes, and total cost of care is expected to continue. (pda.org)
  • Implementing integrated services for prevention of HIV infection, viral hepatitis, STDs, and TB is intended to provide persons who use drugs illicitly with increased access to services, to improve timeliness of service delivery, and to increase effectiveness of efforts to prevent infectious diseases that share common risk factors, behaviors, and social determinants. (cdc.gov)
  • however, relatively less is known about the determinants of tissue binding. (aspetjournals.org)
  • Many acidic drugs (eg, warfarin , aspirin ) are highly protein-bound and thus have a small apparent volume of distribution. (msdmanuals.com)
  • For example, it has been suggested that disruption of the postnuclear fractions containing the acidic organelles (e.g., lysosomes) may explain reported under-predictions in the distribution of the basic lipophilic drugs imipramine, desipramine, chlorpromazine, and methadone from liver, lung, and kidney homogenates ( Clausen and Bickel, 1993 ). (aspetjournals.org)
  • Acts as a HER2-directed antibody-drug conjugate composed of a humanized IgG1 monoclonal antibody (which has the same amino acid sequence as trastuzumab [and targets HER2]), a cleavable linker, and a topoisomerase I inhibitor (DXd) (the cytotoxic component which causes DNA damage and apoptosis). (unboundmedicine.com)
  • To solve these problems, an amphiphilic polymer-drug conjugate was prepared by attachment of low molecular weight (ie, 2 kDa) methoxy poly(ethylene glycol) methyl ether (mPEG) to gambogic acid (GA-mPEG 2000 ) through an ester linkage and characterized by 1H nuclear magnetic resonance. (dovepress.com)
  • The entry rate of a drug into a tissue depends on the rate of blood flow to the tissue, tissue mass, and partition characteristics between blood and tissue. (msdmanuals.com)
  • Post-mortem redistribution is known to influence blood and tissue levels of various drugs. (erowid.org)
  • Many clinicians recommend that the drug be used in patients with left-sided disease, restricted to the colon. (drugs.com)
  • There is some evidence that concomitant therapy with sulfasalazine and corticosteroids may not be more effective than either drug alone, but some subgroups of patients may have a better response to combined therapy (e.g., those with disease localized in the colon). (drugs.com)
  • In this paper, we present the results of toxicological analyses of preserved brain tissue and bone samples from the remains of the seventeenth century patients of the Ospedale Maggiore , the main hospital in Milan and one of the most innovative hospitals in Europe from the Renaissance period. (nature.com)
  • Such analyses have shed light on the pharmacological therapies administered to the patients near the time of death and have implemented our knowledge of medical treatment and drug administration in the 1600's. (nature.com)
  • Another extraordinary aspect of this context is the presence of historical archives, still preserved, concerning the administration and organization of the hospital, patient care and the pharmacopoeia (drugs) used in the hospital to treat the patients' diseases. (nature.com)
  • Methemoglobinemia may not resolve or may rebound after initial response to therapy with methylene blue in patients with methemoglobinemia associated with aryl amines (e.g., aniline) or sulfa drugs (e.g., dapsone). (drugs.com)
  • Patients who develop angioedema after treatment with Ramelteon Tablets should not be rechallenged with the drug. (nih.gov)
  • If coadministration is necessary, monitor patients closely at frequent intervals and consider a dosage reduction of dihydrocodeine until stable drug effects are achieved. (pdr.net)
  • Minor) Zafirlukast inhibits the CYP2C9 isoenzymes and should be used cautiously should be used cautiously in patients stabilized on drugs metabolized by CYP2C9, such as ibuprofen. (pdr.net)
  • Some drugs distribute mostly into fat, others remain in extracellular fluid, and others are bound extensively to specific tissues. (msdmanuals.com)
  • Skeletal muscle tissue (SKM) may be damaged due to mechanical, metabolic, and exertional causes. (degruyter.com)
  • Moreover, we will discuss mechanisms of drug-induced SKM injury, traditional laboratory testing for SKM injury, and novel skeletal myocyte biomarkers under investigation. (degruyter.com)
  • b ), suggesting that active drug accumulation in renal proximal tubules may play a role in the etiology of the drug-associated nephrotoxicity. (aspetjournals.org)
  • Presumably, the uptake of cidofovir across the basolateral tubular membrane is more efficient than the subsequent secretion into tubular lumen resulting in drug accumulation in renal tubules. (aspetjournals.org)
  • The abuse of synthetic psychoactive substances known as "designer drugs," or "new psychoactive substances" (NPS), is increasing at an alarming rate. (jneurosci.org)
  • NPS are purchased as alternatives to traditional illicit drugs of abuse and are manufactured to circumvent laws regulating the sale and use of controlled substances. (jneurosci.org)
  • What Drugs, Substances, or Supplements Interact with Evoxac? (rxlist.com)
  • TE strategies typically incorporate cells, biomaterials and signals (e.g. growth factors), with the goal of developing a construct that once implanted will promote tissue regeneration. (nature.com)
  • A limitation of current TE strategies is their relatively poor spatial control of the distribution of cells, matrix components and bioactive cues within the engineered construct 1 . (nature.com)
  • They will take this work one step further and create new model systems to determine the 3-D relationships and functions of different epithelial cell types as the basal cells detect and respond to various drugs, hormones, chemicals and pathogens that appear in the cavity of the organ. (nih.gov)
  • This guidance provides establishments that manufacture animal cells, tissues, and cell- and tissue-based products meeting the definition of a new animal drug (ACTPs) with recommendations for meeting current good manufacturing practice (CGMP) requirements. (fda.gov)
  • In the ideal case, drugs would be applied at exactly the therapeutic concentration and would precisely target desired cells or tissues. (europa.eu)
  • Such treatments include allogeneic and xenogeneic transplants and skin substitutes such as tissue-engineered skin, cultured cells, and stem cells. (biomedcentral.com)
  • In recent years, the development in cell therapy and stem cell research has led scientist to engage in the production of cells and tissue product that is of clinical grade. (biomedcentral.com)
  • However, the metabolism of therapeutic drugs in black-bone fowl remains unclear. (cabi.org)
  • He had an organic personality disorder with residual schizophrenia and previous suicide attempts with therapeutic drugs and cleaning products. (fluoridealert.org)
  • All new animal drugs, including ACTPs, must be manufactured in accordance with CGMPs to ensure that such drugs meet the requirements of the Federal Food, Drug, and Cosmetic Act (FD&C Act) as to safety, and have the identity, strength, quality, and purity characteristics which they purport to or are represented to possess. (fda.gov)
  • T(MM) display tissue-itinerant trafficking characteristics, restricted distribution within the FRT microenvironment, and distinct effector responses to infection. (cdc.gov)
  • The main groups include sodium channel blockers, calcium current inhibitors, gamma-aminobutyric acid (GABA) enhancers, glutamate blockers, carbonic anhydrase inhibitors, hormones, and drugs with unknown mechanisms of action (see the image below). (medscape.com)
  • Drug-induced myopathies may result from various mechanisms. (degruyter.com)
  • These include direct myotoxicity (caused by alcohol, cocaine, glucocorticoids, and statins, amongst others), immunologically-induced inflammatory myopathy (caused by D-penicillamine, statins, and anti-cancer drugs), and indirect SKM injury (occurs as a result of a variety of different mechanisms). (degruyter.com)
  • The devices described below provide mechanisms for inserting and driving the drug delivery catheter into the heart, as well as connecting the requisite drug reservoirs to the catheter. (justia.com)
  • In one embodiment, the drug delivery and steerable guide mechanisms are integrated in a single piece handle, and distensible tubing on the proximal end of the drug delivery catheter allows rotation of the drug delivery catheter tube relative to the guide catheter tube and Luer fitting which are in fluid communication with the drug delivery catheter. (justia.com)
  • Blood levels of phenytoin reflect only total serum concentration of the drug. (medscape.com)
  • Phenytoin prevents the electrical spread of a focus of irritable tissue from entering normal tissue. (medscape.com)
  • In 1940, phenytoin (PHT) was found to be an effective drug for the treatment of epilepsy, and since then it has become a major first-line antiepileptic drug (AED) in the treatment of partial and secondarily generalized seizures. (medscape.com)
  • Some degree of distributional impairment at either the blood-CSF or the blood-brain barrier was indicated for 8 of the 11 remaining drugs (i.e., carbamazepine, midazolam, phenytoin, sulpiride, thiopental, risperidone, 9-hydroxyrisperidone, and zolpidem). (aspetjournals.org)
  • Distribution is generally uneven because of differences in blood perfusion, tissue binding (eg, because of lipid content), regional pH, and permeability of cell membranes. (msdmanuals.com)
  • In clinical practice, as well as during drug development and in clinical trials, the diagnosis of SKM injury can be challenging due to the variable symptomology, reliance on patient-self reporting, and lack of highly specific biomarkers, such as those available for cardiac myocyte injury (i.e., cardiac troponins) [ 3 ]. (degruyter.com)
  • After a drug enters the systemic circulation, it is distributed to the body's tissues. (msdmanuals.com)
  • The tablets contain a combination of two types of ciprofloxacin drug substance, ciprofloxacin hydrochloride and ciprofloxacin betaine (base). (theodora.com)
  • The volume of distribution calculated for intravenous ciprofloxacin is approximately 2.1-2.7 L/kg. (theodora.com)
  • Studies with the oral and intravenous forms of ciprofloxacin have demonstrated penetration of ciprofloxacin into a variety of tissues. (theodora.com)
  • However, the complete etiology of drug-induced myopathies remains unclear. (degruyter.com)
  • The long-circulating and higher tumor accumulation of E/PCF-NPs resulted in complete ablation of breast tumor tissue through the enhanced photothermal effect by NIR laser irradiation-mediated cell apoptosis. (dovepress.com)
  • A metabolomic study of brain tissues from aged mice with low expression of the vesicular monoamine transporter 2 (VMAT2) gene. (neurotree.org)
  • This report summarizes current (as of 2011) guidelines or recommendations published by multiple agencies of the U.S. Department of Health and Human Services (DHHS) for prevention and control of human immunodeficiency virus (HIV) infection, viral hepatitis, sexually transmitted diseases (STDs), and tuberculosis (TB) for persons who use drugs illicitly. (cdc.gov)
  • Consolidated guidance can strengthen efforts of health-care providers and public health providers to prevent and treat infectious diseases and substance use and mental disorders, use resources efficiently, and improve health-care services and outcomes in persons who use drugs illicitly. (cdc.gov)
  • Rabbits received 1 mg/kg MDMA intravenously iv and were killed 2 h later in order to simulate the state of complete distribution in the body. (erowid.org)
  • This insolubility makes it very difficult to study Δ 9 -THC in isolated tissue preparations suspended or incubated in the standard electrolyte solutions (such as Krebs Ringer) and obtain dose response curves. (unodc.org)
  • For poorly perfused tissues (eg, muscle, fat), distribution is very slow, especially if the tissue has a high affinity for the drug. (msdmanuals.com)
  • Although epidural administration of all corticosteroids including triamcinolone acetonide is considered "off-label" use and not approved by the US Food and Drug Administration, epidural administration of this medication occurs widely in clinical practice. (hindawi.com)
  • However, various adverse effects may be induced by prolonged administration of antiviral drugs. (aspetjournals.org)
  • Curative direct-acting antiviral therapy is approved by the Food and Drug Administration for persons aged ≥3 years. (cdc.gov)
  • Notably, oral administration of a CCR5 antagonist drug blocked T(MM) trafficking. (cdc.gov)
  • The findings from this study provide new understandings on the effects of nanoparticle s on vascular transport of macromolecules and drugs. (cdc.gov)
  • An example of such drugs are selective estrogen receptor modulators (SERM) like tamoxifen, which show estrogenic effects in some tissues and antiestrogenic effects in other tissues. (wikipedia.org)
  • False color images can be created based on the Raman spectrum - these show the distribution of individual chemical components, and variation in other effects such as phase, polymorphism, stress/strain, and crystallinity. (horiba.com)
  • Our Evoxac (cevimeline hydrochloride) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
  • Recently, much progress has been made in developing nanoparticle (NP)- based DDS with the specific aim to improve site-specific targeting of drugs, thus improving efficacy and reducing side-effects. (europa.eu)
  • Volume of distribution provides a reference for the plasma concentration expected for a given dose but provides little information about the specific pattern of distribution. (msdmanuals.com)
  • Register your specific details and specific drugs of interest and we will match the information you provide to articles from our extensive database and email PDF copies to you promptly. (dovepress.com)
  • Most of the changes of gene loci can be found by whole exon gene sequencing, and the clinical symptoms and patient survival can be improved by specific site-to-site drug treatment. (frontiersin.org)
  • Since developing new DDSs costs much less and is much shorter than developing new drugs, EVO-NANO's focus on accelerating production of new DDSs is in line with one of the key strategic challenges defined in the European Commission's Strategic Plan for Health and Food Safety: (Specific objective 1.3 Achieving greater cost-effectiveness). (europa.eu)
  • The apparent volume of distribution is the theoretical volume of fluid into which the total drug administered would have to be diluted to produce the concentration in plasma. (msdmanuals.com)
  • Many basic drugs (eg, amphetamine , meperidine ) are extensively taken up by tissues and thus have an apparent volume of distribution larger than the volume of the entire body. (msdmanuals.com)
  • BACKGROUND: Improper use of antimicrobials can cause adverse drug events and high costs. (researchgate.net)
  • Gurwitz JH, Avorn J. The ambiguous relation between aging and adverse drug reactions. (umassmed.edu)
  • In addition, checkpoint inhibitors are more frequently being employed in combination with other agents (including with other checkpoint inhibitors) in clinical practice, as well in hundreds of combination drug trials with other novel biological, targeted, and immunotherapies. (degruyter.com)
  • Therefore, the present study proposes a strategy for drug safety monitoring using the available biomarkers of SKM injury. (degruyter.com)
  • This report provides an extensive tissue distribution study of fluoride after a well documented case of acute poisoning. (fluoridealert.org)
  • Justine has developed a very ambitious research study that sheds light on the tissue distribution of novel synthetic opioids. (stjohns.edu)
  • Unfortunately, the available biomarkers for SKM injury do not fully meet the needs for satisfactory detection of drug-induced damage, both in clinical and research settings, mainly due to their low sensitivity and specificity. (degruyter.com)