DiseasesChemicals and DrugsPsychiatry and Psychology
LoxapineAmoxapinePsychomotor AgitationAntipsychotic AgentsBasal Ganglia DiseasesReceptors, Serotonin
LoxitaneAntipsychoticsResearchers have arguedAtypicalSchizophreniaClozapineAcuteReceptorFormulationAntipsychotic drugsGrapefruit juiceBenzodiazepinesInteractionsLikelihoodTopiramateEvaluationClinicalAnticholinergicPharmacologicDosePsychosisPhysicalReactionsSolubilityMetabolismChemicalDiseasesTypicalSubstanceTreatmentPeopleEffectsMeasurement2023VivoAvoidCautionLeadRiskBloodMouthMakesHigherMedicationDevelopmentOpticalThoughtModuleTransmission
Loxitane2
  • Loxapine, sold under the brand names Loxitane and Adasuve (inhalation only) among others, is a tricyclic antipsychotic medication used primarily in the treatment of schizophrenia. (wikipedia.org)
  • We know that, Loxapine ( Loxapac , Loxitane ) is a typical antipsychotic medication, used primarily in the treatment of schizophrenia. (med-chemist.com)
Antipsychotics1
  • The U.S. Food and Drug Administration (FDA) approved typical (first-generation) antipsychotics and their indications are summarized in the table below. (medscape.com)
Researchers have argued2
  • Several researchers have argued that loxapine, initially classified as a typical antipsychotic, behaves as an atypical antipsychotic. (wikipedia.org)
  • Several researchers have argued that Loxapine may behave as an atypical antipsychotic. (med-chemist.com)
Atypical3
  • Loxapine is a dibenzoxazepine and is structurally very similar to clozapine, an atypical antipsychotic. (wikipedia.org)
  • Does loxapine have "atypical" properties? (wikipedia.org)
  • There are many conventional and atypical anti-psychotic drugs currently available for the treatment of schizophrenia, and choosing the appropriate antipsychotic for the acute episode and long-term maintenance treatment can be a matter of trial and error until an acceptable balance is achieved between maximisation of efficacy and minimisation of adverse effects. (medscape.com)
Schizophrenia4
  • The US Food and Drug Administration (FDA) has approved loxapine inhalation powder for the acute treatment of agitation associated with schizophrenia or bipolar I disorder in adults. (wikipedia.org)
  • A brief review of loxapine found no conclusive evidence that it was particularly effective in patients with schizophrenia. (wikipedia.org)
  • Controversy over the growing list of indications for these powerful drugs initially approved for schizophrenia and bipolar disorder stems from aggressive clinical trials by the drug makers as well as likely publication bias. (medscape.com)
  • Psychosis is a broad term, which covers schizophrenia and manic behaviour, but people may also experience brief episodes during severe depression, or a physical illness, or sometimes because of taking street drugs. (findmedarticle.com)
Clozapine2
  • The higher likelihood of EPS with loxapine, compared to clozapine, may be due to its higher affinity for the D2 receptor compared to clozapine, which has one of the lowest binding affinities at the D2 receptor of any antipsychotic. (wikipedia.org)
  • Iloperidone acts on both dopamine and serotonin receptors, making it a favorable choice against competing drugs clozapine and olanzapine. (bionity.com)
Acute2
  • Maintenance therapy with antipsychotic drugs reduces the risk for acute relapse but may fail to prevent long-term deterioration. (clinicalgate.com)
  • If agitation is present in the acute episode, use of sedative drugs in combination with aripiprazole is highly recommended because aripiprazole does not have sedative effects at therapeutic doses. (medscape.com)
Receptor2
  • Q.1 Which one of the following drug is selective β1 receptor agonist? (pdfmedarticles.com)
  • However, the onset of action varies significantly and clinical efficacy is not always directly related to only the H 1 receptor potency, as concentration of free drug at the receptor must also be considered. (cloudfront.net)
Formulation2
  • The inhaled formulation of loxapine carries a low risk for a type of airway adverse reaction called bronchospasm that is not thought to occur when loxapine is taken by mouth. (wikipedia.org)
  • The main improvements in process monitoring, formulation analysis, proquin automation, rapid analysis and drug-excipient distribution. (kurashi-kyoiku.com)
Antipsychotic drugs3
  • Who should avoid taking antipsychotic drugs? (findmedarticle.com)
  • This booklet is for people who are prescribed antipsychotic drugs, and for their friends, relatives and carers, or anyone else who has an interest in this type of medication. (findmedarticle.com)
  • What are antipsychotic drugs? (findmedarticle.com)
Grapefruit juice1
  • Fexofenadine is not to be taken with apple, orange, or grapefruit juice because they could decrease absorption of the drug. (mdwiki.org)
Benzodiazepines1
  • Lorazepam belongs to a class of drugs known as benzodiazepines which act on the brain and nerves (central nervous system) to produce a calming effect. (plusukmeds.com)
Interactions2
  • review drug interactions. (pdr.net)
  • They may be more aware of possible side effects, and alsopossible interactions with other drugs. (findmedarticle.com)
Likelihood1
  • This allows us to characterize the association between prediction score and likelihood of successful drug repurposing (see Daniel's post below for citations). (github.io)
Topiramate1
  • The glucocorticoids lymphocytopenic actions make them softer and easier to control measurement of drug disposition, or drug agencies, counsellors, other drug users may be possible to effect death, either by slow injection play a critical role in drug strategy topiramate, divalproex, gabapentin, pizotifen, flunarizine, verapamil refractory patient strategy concomitant use with specific receptors is stereoselecciviry. (themauimiracle.org)
Evaluation1
  • Investigation of the photolysis and TiO 2, SrTiO 3, no recoil battlefield 2042 2 O 2 -mediated photocatalysis of an antipsychotic drug loxapine - Evaluation of kinetics, identification of photoproducts, and in silico estimation of properties. (maxtorque.com.br)
Clinical2
  • I believe it is important for drug-predictions within a given disease to be evaluated by an appropriate clinical specialists. (github.io)
  • Halofuginone (see structure, below) has been in clinical trials for cancer, but the high-resolution picture of the molecule suggests it has a modularity that would make it useful as a template to create new drugs for numerous other diseases. (med-chemist.com)
Anticholinergic6
  • Comment: Coadministration of anticholinergic drugs and glucagon increase the risk of gastrointestinal adverse reactions due to additive effects on inhibition of gastrointestinal motility. (medscape.com)
  • Concomitant use of anticholinergic drugs may cause a hyporesponse to stimulation testing with secretin. (medscape.com)
  • Discontinue anticholinergic drugs at least 5 half-lives before administering secretin. (medscape.com)
  • Concomitant use with other anticholinergic-containing drugs may lead to additive anticholinergic adverse effects. (medscape.com)
  • Use of anticholinergic drugs after administration of botulinum toxin-containing products may potentiate systemic anticholinergic effects. (medscape.com)
  • a Consider previous antipsychotic withdrawal after switching antipsychotic agents and use antihistaminic or anticholinergic drug as appropriate. (medscape.com)
Pharmacologic2
  • Given the relatively inexpensive (time and money) nature of pharmacologic testing in epilepsy, drug companies have already attempted drug-repurposing experiments on vast arrays of drugs. (github.io)
  • In this section we discuss pharmacologic properties shared by all FGAs. (clinicalgate.com)
Dose5
  • If concurrent use of codeine and buspirone is imperative, reduce the dose of one or both drugs. (pdr.net)
  • If hydrocodone is used with buspirone, the dose of one or both drugs should be reduced. (pdr.net)
  • Examination of the safety and tolerability of iloperidone have shown that at a 5mg/day dose in healthy male volunteers, the drug was fairly well tolerated, although hypotension, dizziness, and somnolence were very common side effects ranging from mild to moderate in severity. (bionity.com)
  • it is also greater in people with a history of alcohol or drug abuse.If you miss a dose, take the missed dose as soon as you remember. (plusukmeds.com)
  • Substances that act as inhibitors of the CYP3A4 enzyme such as ketoconazole , erythromycin , cimetidine , and furanocoumarin derivatives (found in grapefruit) lead to increased plasma levels of loratadine - that is, more of the drug was present in the bloodstream than typical for a dose. (cloudfront.net)
Psychosis2
  • Neuroleptics are also used as sedatives, tranquilizers, for their antiemetic properties, to control hiccups, and in the treatment of drug-induced psychosis. (medscape.com)
  • These drugs can help people who are experiencing psychosis, either as a one-off episode or as part of an ongoing illness. (findmedarticle.com)
Physical4
  • Physical properties also influence the separation column can healthy joints become blocked or damaged with prolonged use. (marketypik.pl)
  • However the variance plot will also depend spastic colon to some bulk physical property of the technique. (marketypik.pl)
  • In order to avoid manufacturing problems, physical and chemical properties of solid dosage forms are presented. (kurashi-kyoiku.com)
  • Although its physical properties imply that anaesthesia can be induced more rapidly than with halothane , [8] its pungency can irritate the respiratory system, negating any possible advantage conferred by its physical properties. (mdwiki.org)
Reactions1
  • Antihistamines should be discontinued 48 hours prior to skin allergy tests , since these drugs may prevent or diminish otherwise-positive reactions to dermal activity indicators. (cloudfront.net)
Solubility1
  • Furthermore, the realisation in the blood, and the drug demonstrates high aqueous solubility is a potential to promote renal clear- injection in adults strongly alkaline solutions. (themauimiracle.org)
Metabolism2
  • Drug metabolism principles- Phase I and Phase II. (amrita.edu)
  • Factors affecting drug metabolism including stereo chemical aspects. (amrita.edu)
Chemical1
  • This drug works by enhancing the effects of a certain natural chemical in the body (GABA). (plusukmeds.com)
Diseases3
  • It would also be prudent to evaluate whether diseases with a large number of high-scoring predictions are the same diseases which had a large number of input disease-drug connections (which is certainly true in epilepsy). (github.io)
  • I personally find it extremely difficult to evaluate drug predictions for non-neurologic diseases, I would estimate it requires 10x more time for me to research and evaluate each prediction in a non-neurologic disease. (github.io)
  • Repurposing is more advanced in epilepsy than the majority of other human diseases, we know whether most drugs improve or exacerbate epilepsy. (github.io)
Typical1
Substance3
  • vasotec Similarly, in chiral claramax drug substance. (marketypik.pl)
  • If the drug substance will be deemed adulterated with respect to where quality fluocinolone and conformation in stationary phase is pressurised. (kurashi-kyoiku.com)
  • High quality motorised stages are required to scrutinise for both drug substance and drug products, and others. (kurashi-kyoiku.com)
Treatment4
  • In reality, drug cochemical properties prior to or treatment overdose alprazolam tachycardia. (themauimiracle.org)
  • In March 2013, canagliflozin became the first in a new class of drugs for diabetes treatment to be approved. (med-chemist.com)
  • My beloved Border Collie - named Mickey - was recently diagnosed with a form of plasmacytoma cancer and is on both Melphalan and Prednisone drugs as part of his monthly treatment. (rxgo.com)
  • I was able to buy the Melphalan chemotherapy drug for $34 less than the last 2 months, since we started treatment! (rxgo.com)
People2
  • Amoxapine is further metabolized to its 8-hydroxy metabolite (8-hydroxyamoxapine), which is also found in the blood of people taking loxapine. (wikipedia.org)
  • Many people would like to have the information about their proposedtreatment before they are given the prescription for it, and not afterthey have obtained the drugs. (findmedarticle.com)
Effects3
  • Loxapine can cause side effects that are generally similar to that of other antipsychotic medications. (wikipedia.org)
  • Such technologies could be useful for screening the effects of drugs, valuable as replacement therapies for damaged tissues, and relevant to this article on creating disease models. (psychiatrictimes.com)
  • This is when a drug interactswith other drugs and changes their effects, makes them less effective,or causes additional side effects. (findmedarticle.com)
Measurement1
  • Vibrational spectroscopy of polymorphs, one form is used to describe the measurement property population. (hotpod.net.au)
20231
  • Friedman, Yali, "United States: These 36 Drugs Face Patent Expirations and Generic Entry From 2023 - 2024" DrugPatentWatch.com thinkBiotech, 2023 www.drugpatentwatch.com/p/expiring-drug-patents-generic-entry/ . (drugpatentwatch.com)
Vivo1
  • In vivo interaction studies with these drugs have not been performed. (pdr.net)
Avoid1
Caution1
  • Use with caution in patients with a history of drug dependence. (syrianclinic.com)
Lead1
  • Intramuscular injections of loxapine lead to higher blood levels and area under the curve of loxapine than when it is taken by mouth. (wikipedia.org)
Risk1
  • Frailty yes no step 2 high risk of birth usually prevents double counting if clients use of population modeling may be excreted in the world health organization , health is allocating 5.4 million for research on drugs and tend to spread supervised patients they can be expressed example, in the, su -life expectancy sulfonylurea, bot basal -comorbidities. (themauimiracle.org)
Blood1
  • The quantification of antipsychotic levels in blood, also known as therapeutic drug monitoring (TDM), is a potentially useful tool of modern personalized therapy that can be applied to augment antipsychotic use and dosing decisions. (psychiatrist.com)
Mouth1
Makes1
Higher2
  • It is the only disease where 1% of drugs had a prediction score higher than 0.35. (github.io)
  • This represents the top 7% of drugs predicted for epilepsy (93rd percentile and higher). (github.io)
Medication1
  • Furthermore, within the same experiment, one can determine whether a medication would exacerbate epilepsy, these are the drugs that lower the seizure threshold. (github.io)
Development4
  • addictive download Nuclear Organization in Development and drug of championship 1. (turgon.com)
  • Download the download Nuclear Organization in Development and Disease to insert you through each drug. (turgon.com)
  • The thermal microscope is best applied adefovir dipivoxil when the progression of drug development. (hotpod.net.au)
  • spastic colon The recent development in chiral drug bioanalysis, stereoselective separative methods are applicable to determine a structure analytically. (marketypik.pl)
Optical1
  • Every solidstate form has different optical properties such as the exercise is completed by the spinning speed. (hotpod.net.au)
Thought1
  • DMF is thought to haveimmunomodulatory properties without significant immunosuppression. (med-chemist.com)
Module1
  • Trying to get property of non-object in user_node_load() (line 3691 of /home/gammafunsu/www/modules/user/user.module ). (gamma-fundlab.lu)
Transmission1