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  • Cyproheptadine, sold under the brand name Periactin among others, is a first-generation antihistamine with additional anticholinergic, antiserotonergic, and local anesthetic properties. (wikipedia.org)
  • First of all, Quality Prescription Drugs strives to provide a generic alternative for each brand Periactin in order to provide additional savings to Americans. (qualityprescriptiondrugs.com)
  • In addition, you can always purchase Cyproheptadine - Generic, the generic alternative, instead of Periactin. (qualityprescriptiondrugs.com)
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  • Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Periactin (Cyproheptadine). (qualityprescriptiondrugs.com)
  • Cyproheptadine is a generic drug also sold under the brand name Periactin. (optionrx.com)
  • Periactin (cyproheptadine), an antihistamine, and Depakote (divalproex sodium), which is normally used to stop the seizures associated with epilepsy, can help. (xshotpix.com)
  • Periactin should be used only by the patient to whom the drug is prescribed. (quickshiprx.com)
  • Antiserotonin and antihistamine drugs appear to compete with serotonin and histamine, respectively, for receptor sites. (nih.gov)
  • Cyproheptadine is a very potent antihistamine or inverse agonist of the H1 receptor. (wikipedia.org)
  • Apetamin, which contains the antihistamine cyproheptadine, is an appetite stimulant not regulated by the Food and Drug Administration. (medicalnewstoday.com)
  • Cyproheptadine is an antihistamine, in many ways similar to other antihistamines with which we are more familiar, but it is rarely used for its antihistamine effects. (vin.com)
  • Common side effects of cyproheptadine stem from its antihistamine nature. (vin.com)
  • Apetamin is an illegal product containing cyproheptadine, an antihistamine rarely prescribed to treat allergic reactions because of its potential side effects. (healthnews.com)
  • Cyproheptadine is an antihistamine medicine that is sometimes used to treat frequent migraines in children under 12. (xshotpix.com)
  • Cyproheptadine hydrochloride USP is a white to slightly yellowish crystalline solid, with a molecular weight of 350.89, which is soluble in water, freely soluble in methanol, sparingly soluble in ethanol, soluble in chloroform, and practically insoluble in ether. (nih.gov)
  • Cyproheptadine hydrochloride USP is available for oral administration in 4 mg tablets. (nih.gov)
  • Our offered 200 ml Cyproheptadine Hydrochloride and Tricholine Citrate Syrup has gained exceptional value in the market for its various properties like effectiveness, longer shelf life and very effective for the treatment of under nutrition or anorexia in infants and children. (adelinalifesciences.co.in)
  • Recently, the authorities concerned in Jammu and Kashmir blacklisted the said company's Cyproheptadine Hydrochloride Syrup IP for its substandard quality. (com.pk)
  • Side Effects & Drug Interactions. (apsia.org)
  • Care was taken to exclude the possibility that some drug effects could be due to interactions with ACh by recording from spontaneousl active cells and by comparing drug effects on some cells in the presence and absence of ACh leakage effects. (erowid.org)
  • It can cause dangerous drug interactions leading to serious side effects. (quickshiprx.com)
  • For instance, Apetamin is an illegally marketed weight-gain syrup banned by the Food and Drug Administration (FDA). (healthnews.com)
  • Apetamin claims to be a weight gain syrup containing cyproheptadine, L-lysine, and B vitamins. (healthnews.com)
  • This syrup having Cyproheptadine and Tricholine Citrate help revives appetite. (lycona.com)
  • Cyproheptadine comes as a tablet and a solution (liquid) to take by mouth. (medlineplus.gov)
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  • Cyproheptadine is in a class of medications called antihistamines. (medlineplus.gov)
  • tell your doctor and pharmacist if you are allergic to cyproheptadine, other antihistamines, or any other medications. (medlineplus.gov)
  • Cyproheptadine has sedative effects and can be used to treat insomnia similarly to other centrally-acting antihistamines. (wikipedia.org)
  • Antihistamines, in general, also produce what are called anticholinergic effects at higher doses or in overdoses, and cyproheptadine is no different. (vin.com)
  • Cyproheptadine belongs to a class of medications called antihistamines. (optionrx.com)
  • Cyproheptadine also is used for the treatment of Cushing's Syndrome (an abnormal condition that is caused by excess hormones [corticosteroids]) and to treat certain types of headache such as migraine.Talk to your doctor about the possible risks of using this medication for your condition. (medlineplus.gov)
  • Cyproheptadine is a medication used to treat allergy symptoms such as runny nose, itchy eyes, sneezing, hives, and itching. (optionrx.com)
  • While akathisia is most commonly expressed following the use of antipsychotic medication, often it may be observed resulting from the use of antidepressant therapy, in particular drugs of the selective serotonin reuptake inhibitor (SSRI) class expressing serotonin-2A (5-HT 2A ) stimulatory effects. (antidepressantsfacts.com)
  • After a single 4 mg oral dose of 14 C-labelled cyproheptadine HCl in normal subjects, given as tablets, 2 to 20% of the radioactivity was excreted in the stools. (nih.gov)
  • Only about 34% of the stool radioactivity was unchanged drug, corresponding to less than 5.7% of the dose. (nih.gov)
  • After a single 4 mg oral dose of 14 C-labelled Cyproheptadine HCl in normal subjects, given as tablets, 2-20% of the radioactivity was excreted in the stools. (nih.gov)
  • Cyproheptadine had no effect on fertility in a two-litter study in rats or a two generation study in mice at about 10 times the human dose. (nih.gov)
  • Cyproheptadine has been reported to block 85% of 5-HT2 receptors in the human brain at a dose of 4 mg three times per day (12 mg/day total) and to block 95% of 5-HT2 receptors in the human brain at a dose of 6 mg three times per day (18 mg/day total) as measured with positron emission tomography (PET). (wikipedia.org)
  • The dose of cyproheptadine recommended to ensure blockade of the 5-HT2 receptors for serotonin syndrome is 20 to 30 mg. (wikipedia.org)
  • If a medicine is causing increased appetite and weight gain, your health care provider may decrease your dose or have you try another drug. (adam.com)
  • Do not take double dose of the drug, unless prescribed by your doctor. (quickshiprx.com)
  • You are not to take cyproheptadine, or you may require a lower dose or special monitoring during treatment, if you have any of the conditions listed above. (quickshiprx.com)
  • Cyproheptadine is a serotonin and histamine antagonist with anticholinergic and sedative effects. (nih.gov)
  • Examination of cyproheptadine in radioligand receptor-binding assays shoed that it was some five orders of magnitude more active in displacing appropriate radioligands from central histamine, 5-HT-2 and muscarinic cholinergic receptor sites than in inhibiting depolarization dependent calcium fluxes (Donatsch et al 1980). (erowid.org)
  • Cyproheptadine is mostly used because of its strong appetite-stimulating side effect, though it also is used in inflammatory conditions which involve histamine. (vin.com)
  • Cyproheptadine is a histamine and serotonin antagonist used to treat allergic reactions. (healthnews.com)
  • Cyproheptadine is a tricyclic benzocycloheptene and is closely related to pizotifen and ketotifen as well as to tricyclic antidepressants. (wikipedia.org)
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  • Cyproheptadine is also sometimes used to treat allergic reactions in people who have received blood products as part of medical treatment and to treat life-threatening allergic reactions after the symptoms have been brought under control with other medications. (medlineplus.gov)
  • Cyproheptadine is used to treat allergic reactions (specifically hay fever). (wikipedia.org)
  • Cyproheptadine interferes with the activity of several anti-anxiety medications, including clomipramine and fluoxetine . (vin.com)
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  • Cyproheptadine is:widely used experimentally as an anti-5-hydroxytrytaminergic, antihistaminic and antiacetylcholine drug, these intrinsic properties being well established (Stone et al 1961). (erowid.org)
  • The ingredients in Apetamin, including cyproheptadine, can have potential side effects and risks when used without medical supervision. (healthnews.com)
  • Cyproheptadine will help relieve symptoms but will not treat the cause of symptoms or speed recovery. (medlineplus.gov)
  • It is also used off-label in the management of moderate to severe cases of serotonin syndrome, a complex of symptoms associated with the use of serotonergic drugs, such as selective serotonin reuptake inhibitors (and monoamine oxidase inhibitors), and in cases of high levels of serotonin in the blood resulting from a serotonin-producing carcinoid tumor. (wikipedia.org)
  • In the treatment of allergy symptoms, cyproheptadine use is common. (optionrx.com)
  • Serotonin syndrome ( SS ) is a group of symptoms that may occur with the use of certain serotonergic medications or drugs . (wikipedia.org)
  • [6] (Many of these symptoms may be side effects of the drug or drug interaction causing excessive levels of serotonin rather than an effect of elevated serotonin itself. (wikipedia.org)
  • Cyproheptadine HCl USP, is an antihistaminic and antiserotonergic agent. (nih.gov)
  • Treatment is as with amphetamines, but antiserotonergic drugs (e.g., cyproheptadine) may be necessary. (vin.com)
  • No detectable amounts of unchanged drug were present in the urine of patients on chronic 12 to 20 mg daily doses. (nih.gov)
  • In the Indian state of Haryana, the company was prosecuted by a central government drug inspector for quality violations under the Drugs and Cosmetics Act in 2017. (com.pk)
  • The company was fined in Kerala in 2017 in a case filed by the Drugs Inspector office of the Drugs Controller. (com.pk)
  • One of the effects of the drug is increased appetite and weight gain, which has led to its use (off-label in the USA) for this purpose in children who are wasting as well as people with cystic fibrosis. (wikipedia.org)
  • Cyproheptadine is used in cats as an appetite stimulant: 1371 and as an adjunct in the treatment of asthma. (wikipedia.org)
  • Examples include fluid therapy such as intravenous fluids ("IV") or subcutaneous fluids (injections of fluid given under the skin), hand feeding or coaxing to eat, appetite-stimulating drugs, and others. (petplace.com)
  • The appetite stimulating effect of cyproheptadine is probably a consequence of serotonin antagonism. (lycona.com)
  • It is also prescribed in anaphylaxis, a life-threatening allergic reaction, after treating with another drug called epinephrine. (quickshiprx.com)
  • Alcohol can make the side effects of cyproheptadine worse. (medlineplus.gov)
  • Cyproheptadine may cause side effects. (medlineplus.gov)
  • Receiving this diagnostic test with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. (mayoclinic.org)
  • Did you experience many side effects while taking this drug? (rxwiki.com)
  • Serious side effects or death can occur if you use drugs on your pet without your veterinarian's advice. (vin.com)
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  • The database is based on Region Stockholm's work in Sweden and may mean, for example, that information about the Wise list, the drug formulary of recommended essential medicines for the entire Stockholm healthcare region, has been included. (janusinfo.se)
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  • Characteristics of the drugs themselves (e.g., generic ingredients, composition status, etc.) are obtained from the Drug Product Information File, maintained and marketed by the American Druggist Blue Book Data Center, and from the National Drug Code Directory, produced by the National Center for Drugs and Biologics of the U.S. Public Health Service. (cdc.gov)
  • There have been some trials to see if cyproheptadine could reduce sexual dysfunction caused by SSRI and antipsychotic medications. (wikipedia.org)
  • Reserve concomitant prescribing of these drugs for when alternative treatment options are inadequate. (pdr.net)
  • talk to your doctor about the risks and benefits of taking cyproheptadine if you are 65 years of age or older. (medlineplus.gov)
  • Assess each patient's risk prior to prescribing oxycodone/acetaminophen, and monitor all patients regularly for the development of these behaviors or conditions .Opioid Analgesic Risk Evaluation and Mitigation Strategy (REMS)To ensure that the benefits of opioid analgesics outweigh the risks of addiction, abuse and misuse, the Food and Drug Administration (FDA) has required a REMS for these products. (drugs.com)
  • Assess patients for risks of addiction, abuse, or misuse before drug initiation, and monitor patients who receive benzodiazepines routinely for development of these behaviors or conditions. (pdr.net)
  • Emergency clinics and selected veterinary diagnostic laboratories have quick screening tests that can detect the most commonly abused drugs (including metabolites) in body fluids (e.g., amphetamines, barbiturates, benzodiazepines, cocaine, marijuana, and opiates). (vin.com)
  • They are designed to detect drug metabolites in the urine and can detect most commonly available illicit or recreational drugs such as amphetamines, cocaine, marijuana, opiates, and barbiturates. (merckvetmanual.com)
  • Cyproheptadine may interfere with the effectiveness of tramadol , a pain reliever. (vin.com)
  • Studies in adults have demonstrated the effectiveness of many drug classes in prophylactic treatment of migraines, but studies in children have provided insufficient evidence for recommendations because of small sample size and high placebo response rates. (clinicaladvisor.com)
  • The principle metabolite found in human urine has been identified as a quaternary ammonium glucuronide conjugate of cyproheptadine. (nih.gov)
  • The presence of a parent drug or its metabolites in blood or urine may help confirm exposure in suspect cases. (merckvetmanual.com)
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  • Cyproheptadine should not be used in nursing mothers as it may interfere with milk production. (vin.com)
  • Cyproheptadine is best avoided in patients with glaucoma , recovering from urinary blockage , seizure disorders, hyperthyroidism , and/or heart failure patients. (vin.com)
  • You should not take cyproheptadine if you are breastfeeding, or have glaucoma, stomach ulcers, bladder or intestine problems, or an enlarged prostate. (optionrx.com)
  • Do you use any illicit drugs? (adam.com)
  • Illicit drugs are often adulterated with other pharmacologically active substances, making the diagnosis even more difficult. (merckvetmanual.com)
  • Most human hospitals, emergency clinics, and some veterinary diagnostic laboratories have illicit drug screens available and can check for the presence of illicit drugs or their metabolites in different body fluids. (merckvetmanual.com)
  • Cyproheptadine has been studied for the treatment of post-traumatic stress disorder. (wikipedia.org)
  • Cyproheptadine is a second line treatment for pituitary pars intermedia dysfunction in horses. (wikipedia.org)
  • Cyproheptadine is also used (rarely and not very reliably) in the treatment of Cushing's disease , the hormone imbalance involving excess cortisone production in the body. (vin.com)
  • Overdosing on cyproheptadine can lead to serious adverse events, such as decreased breath, low blood pressure, sedation, and even death. (healthnews.com)
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  • Avoid coadministration with other drugs that cause constipation. (medscape.com)
  • Cyproheptadine is well-absorbed following oral ingestion, with peak plasma levels occurring after 1 to 3 hours. (wikipedia.org)
  • Long-term carcinogenic studies have not been done with cyproheptadine. (nih.gov)
  • More recently, studies on cyproheptadine inhibition of insulin secretion (Donatsch et al 1980) have led to the suggestion that the drug interacts with calcium channels and in so doing produced its in vivo pharmacological effects. (erowid.org)
  • Observational studies have demonstrated that concomitant use of opioid analgesics and benzodiazepines increases the risk of drug-related mortality compared to the use of opioids alone. (pdr.net)
  • There are no well-done studies that have been done in humans with Cyproheptadine. (rxwiki.com)
  • Agents used include cyproheptadine, propranolol, and topiramate, although studies involving young children are lacking. (clinicaladvisor.com)