• incorporation
  • Efforts to improve the retention of vaginal medicines involves the incorporation of "mucoadhesive" excipients or the thickening of gels within the vagina, using pseudoplastic or thixotropic gel systems which shear-thin during application, or using thermogelling materials, which increase in viscosity after warming in the vagina. (pharma-excipients.ch)
  • Drug release from film-forming systems is affected by several factors: active substance physicochemical properties, type and concentration of a polymer and plasticizer, and incorporation of other excipients [ 18 , 19 ]. (hindawi.com)
  • formulation
  • Today we solve unmet formulation needs and offer intelligent solutions for today and tomorrow's challenges in drug formulation. (basf.com)
  • It was demonstrated that the selected Monodose inhaler in combination with the newly developed bi-component drug formulation was able to reproduce the quality of inhalable aerosol obtained from Diskus DPI. (pharma-excipients.ch)
  • Therefore, we conclude that novel S-SuSMEDDS formulations offer great potential for developing solid dosage forms of a liquefied formulation such as SuSMEDDS, while improving oral absorption of drugs with poor water solubility. (pharma-excipients.ch)
  • rapid termination of therapy by removal of the device or formulation, the reduction of fluctuations in plasma levels of drugs, and avoid pain associated with injections. (hindawi.com)
  • The purpose of the present work was to develop transdermal formulation of Repaglinide which increases the patient compliance and also sustain the release of drug to increase the bioavailability by using different grades of HPMC and PVP K30 as polymers. (hindawi.com)
  • permeation
  • Although bioavailability of peptides administered through nasal route is still under 1% because of low membrane permeability, a short local residence time and a high metabolic turnover in the nasal epithelium but the richly supplied vascular nature of the nasal mucosa coupled with its high drug permeation makes the nasal route of administration attractive for many drugs including proteins and peptides. (pharma-excipients.ch)
  • commonly
  • The processibility of 15 carbohydrates, more or less commonly used, was investigated as excipients in supercritical fluid drying. (leidenuniv.nl)
  • Moreover, the effect of three commonly used excipients, microcrystalline cellulose, dibasic calcium phosphate dihydrate, and lactose monohydrate, were investigated with the expectation of enhancing the mechanical properties of microgranules. (pharma-excipients.ch)
  • Together, three commonly used excipients were added and evaluated for the improvement in mechanical properties of the microgranules. (pharma-excipients.ch)
  • The effects of serotonin and norepinephrine on pain, while not completely understood, have had causal links established and drugs in the SNRI class are commonly used in conjunction with opioids (especially tapentadol and tramadol) with greater success in pain relief. (wikipedia.org)
  • Excipient
  • citation needed] Allergy to macrogol is rare, and usually appears as an allergy to an increasing number of seemingly unrelated products, including cosmetics, drugs that use it as an excipient, and peri-procedural substances such as ultrasound gel. (wikipedia.org)
  • delivery system
  • We are all very excited about how this new drug-delivery system can potentially help patients with HIV/AIDS, as well as many other diseases," said Robert Langer, the David H. Koch Institute Professor at MIT. (pharma-excipients.ch)
  • In order to improve the dissolution and oral bioavailability of valsartan (VST), and reduce the required volume for treatment, we previously formulated a supersaturable self-microemulsifying drug delivery system (SuSMEDDS) composed of VST (80 mg), Capmul® MCM (13.2 mg), Tween® 80 (59.2 mg), Transcutol® P (59.2 mg), and Poloxamer 407 (13.2 mg). (pharma-excipients.ch)
  • Transdermal drug delivery system (TDDS) has been an increased interest in the drug administration via the skin for both local therapeutic effects on diseased skin (topical delivery) as well as for systemic delivery of drugs. (hindawi.com)
  • Hence, it can be concluded that the developed OLM loaded SLNs can represent better and effective drug delivery system than conventional drug delivery system in hypertension. (pharma-excipients.ch)
  • The successful topical therapy of onychomycosis depends on effective drug release and penetration into nail, which can be achieved by using an adequately developed delivery system. (hindawi.com)
  • vitro
  • In this study, hydroxypropylmethylcellulose (HPMC), hydroxypropylmethylcellulose acetate succinate (HPMCAS) types L, M and H and polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer (SOL) were evaluated by in vitro supersaturation studies regarding their anti-precipitant ability on the poorly soluble drug candesartan cilexetil (CC) under two different media, including biorelevant conditions. (pharma-excipients.ch)
  • In vitro supersaturation studies are used to evaluate their performance in achieving and maintaining drug supersaturation.In this study, different polymers were tested regarding their CC precipitation inhibition performance. (pharma-excipients.ch)
  • In vitro release data were fitted to various models to ascertain kinetic of drug release. (hindawi.com)
  • polymer
  • With our unique expertise in polymer chemistry, our research & development capabilities and our clear commitment to developing excipients, BASF has continuously created solutions that contribute to our customers' success and to more efficient pharmaceuticals. (basf.com)
  • Among the strategies to improve the biopharmaceutic properties of poorly soluble drugs, Supersaturating Drug Delivery Systems like polymer-based amorphous solid dispersions (SD) have been successfully applied. (pharma-excipients.ch)
  • Unexpectedly, however, the addition of excipients resulted in a rather negative effect on the friability of microgranules owing to the inhomogeneous distribution of the binder polymer. (pharma-excipients.ch)
  • peptides
  • M. M. Dhar, born on 13 January 1927, secured a PhD from Manchester University in 1952 for his thesis on peptides and joined Central Drug Research Institute (CDRI) where he worked as a deputy director, heading the Division of Medicinal Chemistry and Botany and subsequently, as the director of the institute. (wikipedia.org)
  • novel
  • Tapentadol, with some structural similarities to tramadol, presents what is believed to be a novel drug working through two (and possibly three) different modes of action in the fashion of both a traditional opioid and as a SNRI. (wikipedia.org)
  • treatment
  • however, it has significant disadvantages: long systematic treatment can cause serious side effects, liver damage, and only tiny drug fraction could reach a target because of limited blood circulation [ 2 ]. (hindawi.com)
  • This leads to achieving continuous penetration of drug substance, required for an effective treatment [ 13 - 15 ]. (hindawi.com)
  • Amodiaquine has become an important drug in the combination therapy for malaria treatment in Africa. (wikipedia.org)
  • study
  • In the present study, by using Florite® PS-10 (119.1 mg) and Vivapur® 105 (105.6 mg) as solid carriers, VST-loaded solidified SuSMEDDS (S-SuSMEDDS) granules were successfully developed, which possessed good flow properties and rapid drug dissolution. (pharma-excipients.ch)
  • Samples were collected before study drug administration using the nebulizer method and sent to a central laboratory for analysis. (clinicaltrials.gov)
  • Spirometry was used to measure post-bronchodilator FEV1 at Baseline and before study drug administration at Weeks 1, 2, 3, and 4. (clinicaltrials.gov)
  • This study focuses on understanding the physicochemical principles for the preparation of high drug-loaded microgranules with a desired size distribution and mechanical properties. (pharma-excipients.ch)
  • In this study, the overall processes for the preparation of high drug-loaded microgranules using an extruder and conical screen mill were investigated. (pharma-excipients.ch)
  • widely
  • Premarin soon superseded Emmenin and has since become not only a very widely used estrogen, but one of the most widely prescribed drugs in North America. (wikipedia.org)
  • properties
  • SuSMEDDS composed of VST, Capmul® MCM, Tween® 80, Transcutol® P, and Poloxamer 407 was efficiently solidified with Florite® PS-10 and Vivapur® 105, and the resultant granules showed good flow properties and rapid drug dissolution. (pharma-excipients.ch)
  • efficient
  • Equipped with an in-depth understanding of multiple industries, technologies and applications, we have the skills and resources to make drug manufacturing more efficient, robust, and cost-effective. (basf.com)
  • This system is considered to be efficient for onychomycosis therapy as a film creates a reservoir of the drug substance in the infected nail plate. (hindawi.com)
  • classes
  • and Reviews of the uses and applications for individual drug substances, classes of drug substances, or excipients. (elsevier.com)
  • Analgesic choice is also determined by the type of pain: For neuropathic pain, traditional analgesics are less effective, and there is often benefit from classes of drugs that are not normally considered analgesics, such as tricyclic antidepressants and anticonvulsants. (wikipedia.org)
  • Together
  • Nonsteroidal anti-inflammatory drugs (usually abbreviated to NSAIDs), are a drug class that groups together drugs that decrease pain and lower fever, and, in higher doses decrease inflammation. (wikipedia.org)
  • control
  • Moxidectin is an anthelmintic drug used in animals to prevent or control parasitic worms (helminths), such as heartworm and intestinal worms, in dogs, cats, horses, cattle and sheep. (wikipedia.org)
  • United Nations International Drug Control Programme. (wikipedia.org)
  • increase
  • The OLM loaded SLNs following oral administration in rat showed an almost 2.3 fold increase in plasma exposure of the drug. (pharma-excipients.ch)
  • The increase of drug concentration depends on the volatile fraction in the nail lacquer [ 12 ]. (hindawi.com)
  • After widespread adoption of the COX-2 inhibitors, it was discovered that most of the drugs in this class increase the risk of cardiovascular events by 40% on average. (wikipedia.org)
  • Macrogols are also attached to biopharmaceutical drugs to slow down their degradation in the human body and increase their duration of action, as well as to reduce immunogenicity. (wikipedia.org)
  • better
  • The drug has largely been replaced by newer and improved NSAAs, namely bicalutamide and enzalutamide, due to their better efficacy, tolerability, safety, and dosing frequency (once per day), and is now relatively little-used. (wikipedia.org)
  • available
  • The most prominent members of this group of drugs, aspirin, ibuprofen and naproxen, are all available over the counter in most countries. (wikipedia.org)
  • route of administrat
  • There are a number of emerging areas in intravaginal drug delivery, but the vagina is a challenging route of administration, due to the clearance mechanisms present which result in poor retention of dosage forms, and the potential for irritation and other adverse reactions. (pharma-excipients.ch)
  • oral
  • Repaglinide is an oral blood-glucose-lowering drug of the meglitinide class use to treat NIDDM (noninsulin-dependent diabetes mellitus). (hindawi.com)
  • pain
  • An analgesic or painkiller is any member of the group of drugs used to achieve analgesia, relief from pain. (wikipedia.org)
  • make
  • This advance could make it much easier for patients to adhere to the strict schedule of dosing required for the drug cocktails used to fight the virus, the researchers say. (pharma-excipients.ch)