• genes
  • Dunn, R.J., 1977, Studies on transfer RNA and transfer RNA genes in Drosophila melanogaster , Ph.D. Thesis, The University of British Columbia. (springer.com)
  • In order to test the interaction effect of overdominance and random genetic drift on the formation of linkage disequilibria under the condition of multiplicative gene action, linkage disequilibria between isozyme genes, inter se , and between polymorphic inversions and isozyme genes were tested for the second chromosomes of Drosophila melanogaster sampled from two isolated Pacific islands and one locality of the northern district of the mainlands of Japan. (genetics.org)
  • These new approaches will greatly facilitate the structure-function analyses of Drosophila genes, will enhance the ease and speed with which flies can be manipulated, and should advance our understanding of biological processes during normal development and disease. (biologists.org)
  • Population genetic analysis can be used to determine whether sequence polymorphism and divergence patterns among Drosophila genes in innate immune pathways are consistent with signatures of selection acting within and between species of flies. (genetics.org)
  • When signs of selection (as inferred from sequence comparisons within Drosophila simulans populations and between D. simulans and D. melanogaster ) in immune genes and nonimmune genes were evaluated, immune genes as a group were found to have higher K A / K S ratios than nonimmune genes, providing evidence for elevated adaptive evolution ( S chlenke and B egun 2003 ). (genetics.org)
  • Genes often affect particular traits through secondary pleiotropic pathways, as the classical trait of bristle number in Drosophila has shown. (genetics.org)
  • D. melanogaster is often used for life extension studies, such as to identify genes purported to increase lifespan when mutated. (wikipedia.org)
  • From 1910 to 1927, Thomas Hunt Morgan's work with the fruit fly Drosophila melanogaster identified chromosomes as the vector of inheritance for genes. (wikipedia.org)
  • Search Strategies - Gene reports for genes from all twelve sequenced Drosophila genomes are available in FlyBase. (wikipedia.org)
  • Through the analysis of per circadian mutants and additional mutations on Drosophila clock genes, a model encompassing positive and negative autoregulatory feedback loops of transcription and translation has been proposed. (wikipedia.org)
  • Morgan's
  • This niche was initially filled community newsletters such as the Drosophila Information Service (DIS), which dates back to 1934 when the field was starting to spread from Thomas Hunt Morgan's lab. (wikipedia.org)
  • Clock
  • Translated from the three mammalian homologs of drosophila-per, one of three PER proteins (PER1, PER2, and PER3) dimerizes via its PAS domain with one of two cryptochrome proteins (CRY1 and CRY2) to form a negative element of the clock. (wikipedia.org)
  • pathways
  • While less well defined in the Drosophila model, portions of other systems also appear to affect the effectiveness of immune response, including JAK/STAT and JNK signaling pathways, hematopoesis, and iron metabolism. (genetics.org)
  • model
  • Reduced muscle power output and progressive myofibrillar defects in a Drosophila model of inclusion body myopathy 3 arise from the decreased rate of weak to strong actin-binding transition of myosin. (biologists.org)
  • researchers
  • The FlyBase project is carried out by a consortium of Drosophila researchers and computer scientists at Harvard University and Indiana University in the United States, and University of Cambridge in the United Kingdom. (wikipedia.org)
  • mainly
  • In Drosophila , transgenesis mainly relies on the P element transposon and this has been the foundation for most of the innovative developments within the fly field ( Ryder and Russell, 2003 ). (biologists.org)
  • In Drosophila , transgenesis mainly relies on the P element transposon, the introduction of which ( Rubin and Spradling, 1982 ) has been one of the most important breakthroughs in germ line transgenesis in Drosophila . (biologists.org)
  • research
  • As such, Drosophila research has been highly dependent on P element-mediated transgenesis, even though it has two major drawbacks: the size of the DNA that can be integrated is limited and the insertion sites cannot be controlled. (biologists.org)
  • As of 2017, eight Nobel prizes had been awarded for research using Drosophila. (wikipedia.org)
  • Morgan and her family moved to California in 1928, where she continued her Drosophila research at the California Institute of Technology in Pasadana while her husband Thomas Hunt Morgan became the division head. (wikipedia.org)
  • found
  • A screen of random, autosomal, homozygous-viable P -element insertions in D. melanogaster found small effects on wing shape in 11 of 50 lines. (genetics.org)
  • single
  • A resource of 192 inbred D. melanogaster lines created from a single natural population that have been both extensively sequenced and extensively phenotyped for quantitative traits. (nih.gov)
  • In 1998, the FlyBase consortium integrated the information into a single Drosophila genomics server. (wikipedia.org)
  • University
  • instead, he merely gave her working space in his laboratory at Columbia University, where she maintained her own Drosophila stocks and held no official position. (wikipedia.org)
  • function
  • Therefore, the effect of O(2) on D. melanogaster function is non-linear, may be reversible, and may include unique phenotypes that arise at some O(2) concentrations, and not others. (nih.gov)