Current CDC guidelines recommend a higher single dose of 500 mg ceftriaxone IM for GU (1 g for men ≥ 150 kg), and doxycycline 100 mg orally twice daily for 7 days for NGU. (medscape.com)
Because dual therapy with ceftriaxone plus azithromycin is the only recommended gonorrhea treatment, increases in azithromycin and cephalosporin MICs are cause for concern that resistance to these antimicrobial agents might be emerging. (cdc.gov)
During the outbreak, health authorities recommended doxycycline for adults and erythromycin or azithromycin for children and regnant women for the treatment of cases with moderate and severe dehydration. (who.int)
Chlamydia4
Follow-Up - Patients do not need to be retested for chlamydia after completing treatment with doxycycline or azithromycin unless symptoms persist or re-infection is suspected. (cdc.gov)
The use of doxycycline first appears to weaken the bacteria, increasing the chance for a second round of antibiotics to work, normally azithromycin, or another called moxifloxacin. (abc.net.au)
Efficacy6
For those in clinical practice who are using oral doxycycline to treat MGD with dosing as in this trial, this trial provides strong evidence that switching to azithromycin provides similar efficacy with lower risk of gastrointestinal adverse effects," she added. (medpagetoday.com)
To compare the efficacy and safety of oral Azithromycin with oral Doxycycline in patients with Meibomian Gland Dysfunction. (pafmj.org)
This study supports the clinical efficacy and safety of oral Azithromycin and Doxycycline therapy for managing refractory or severe Meibomian gland disease. (pafmj.org)
however, the safety and efficacy of azithromycin for persons less than or equal to 15 years of age have not been established. (cdc.gov)
Doxycycline has a longer history of extensive use, safety, efficacy, and the advantage of low cost. (cdc.gov)
Ofloxacin is similar in efficacy to doxycycline and azithromycin, but is more expensive than doxycycline, cannot be used during pregnancy or with persons less than or equal to 17 years of age, and offers no advantage in dosing. (cdc.gov)
Regimens3
Several different azithromycin regimens have been evaluated in MGD, most involving shorter-duration treatment, which makes it a potentially attractive alternative to doxycycline. (medpagetoday.com)
We undertook a meta-analysis of M. genitalium treatment studies using azithromycin 1 g single dose and azithromycin 500 mg on day 1 then 250 mg daily for 4 days (5-day regimen) to determine rates of treatment failure and resistance in both regimens. (bmj.com)
Recommended Regimens - Doxycycline 100 mg orally 2 times a day for 7 days, or Azithromycin 1 g orally in a single dose. (cdc.gov)
Dose2
Azithromycin has the advantage of single-dose administration. (cdc.gov)
Testing for cure is not necessary if chlamydial infection is treated with a first-line antibiotic (azithromycin or doxycycline). (aafp.org)
Meibomian gland dysfunction1
A short course of azithromycin matched a standard doxycycline regimen for relief of severe meibomian gland dysfunction (MGD) and caused fewer adverse events (AEs), a randomized trial showed. (medpagetoday.com)
Tetracycline1
Azithromycin is preferred over doxycycline for the treatment of suspected or confirmed GC, due to significant rates of tetracycline-resistant GC and concerns about multiday treatment compliance Footnote 13 Footnote 14 Footnote 15 Footnote 16 . (canada.ca)
Methods The online databases PubMed and Medline were searched using terms " Mycoplasma genitalium ", " macrolide" or " azithromycin" and " resistance" up to April 2016. (bmj.com)
Our group actually showed that you have an individual who you treat with azithromycin, which has been the first-line treatment for Mycoplasma genitalium everywhere globally, 10% of individuals seem to go from susceptible to resistant, which is an extraordinary rate of selection of resistance and explains the rapid spread of macrolide resistance in MG and really the loss of that agent. (abc.net.au)
Susceptibility1
Reduced azithromycin susceptibility (Azi-RS) (defined as minimum inhibitory concentration [MIC] ≥2.0 µ g/mL) increased from 0.6% in 2013 to 2.5% in 2014. (cdc.gov)
Organism1
The second step was implementing a resistance assay, so this would detect the organism and detect azithromycin resistance at that time. (abc.net.au)
Resistance5
Studies were eligible if they: used azithromycin 1 g or 5 days, assessed patients for macrolide resistant genetic mutations prior to treatment and patients who failed were again resistance genotyped. (bmj.com)
The random effects pooled rate of treatment failure and development of macrolide antimicrobial resistance mutations with azithromycin 1 g was 13.9% (95% CI 7.7% to 20.1%) and 12.0% (7.1% to 16.9%), respectively. (bmj.com)
Conclusion Azithromycin 1 g is associated with high rates of treatment failure and development of macrolide resistance in M. genitalium infection with no pre-existing macrolide mutations. (bmj.com)
We had no resistance to azithromycin when we started using this drug and about 15 years later we now have more than 50% of MG infections in urban Melbourne and Sydney resistant and we have seen the emergence of resistance to moxifloxacin which was really our last options for many. (abc.net.au)
Although doxycycline rarely cures MG, the bacteria hasn't developed high levels of resistance to this drug. (abc.net.au)
Genitalium1
M genitalium-positive patients were clinically and microbiologically tested after treatment with either doxycycline or azithromycin. (nih.gov)
The team partnered with Australian diagnostic company SpeeDx which has developed a way to rapidly detect whether a patient has an MG infection and whether that strain is resistant to azithromycin. (abc.net.au)
Patients6
Tangmonkongvoragul and colleagues evaluated pulsed dosing of azithromycin in a randomized trial involving patients with MGD that had not responded to initial therapies. (medpagetoday.com)
In cases where Legionella pneumonia can be ruled out prior to treatment, patients at increased risk of C. diff may benefit from the use of doxycycline as a first-line agent. (umn.edu)
Our analysis found that in patients with a prior history of C. diff , doxycycline was the only factor associated with a reduction in the incidence of new C. diff infections," said Kari A. Mergenhagen, PharmD, residency director for infectious diseases at the Veterans Affairs of Western New York Healthcare System and senior author of the study, in a press release from the journal's publisher. (umn.edu)
We have actually been diagnosing this STI longer than most services in the world, and in about 2005 I had three patients that failed azithromycin and at that point I didn't know what to do. (abc.net.au)
Oral2
The sample population comprised 172 subjects, including 86 cases in the oral Doxycycline-Group and 86 oralAzithromycin-Group. (pafmj.org)
In practice oral azithromycin is just as good as IV, but blood levels are substantially lower (which is why I didn't include it). (jwatch.org)
Clinical1
Current clinical guidelines recommend azithromycin, as it can treat all types of pneumonia, including Legionella pneumonia. (umn.edu)
Days1
LGV genotypes of CT require a longer course of treatment: Doxycycline 100 mg PO BID for 21 days. (canada.ca)
Treat1
The drug cocktail is prescribed by Care Oncology, a private clinic in London, which recommends a statin (a cholesterol-lowering drug), metformin (used to treat type-2 diabetes), doxycycline (an antibiotic) and mebendazole (an anti-worming agent). (biomedical.pl)
Severe1
For moderate or severe MGD, a 6-week course of doxycycline is common, but compliance with the extended regimen and frequent gastrointestinal AEs make the treatment problematic, Tangmonkongvoragul and team noted. (medpagetoday.com)
Daily1
Dosing azithromycin 1 g per week for 3 weeks [pulsed dosing] for MGD should provide effective drug tissue levels for more than 1 month with a treatment regimen that could result in better patient compliance than therapies requiring daily dosing," the authors wrote. (medpagetoday.com)
Effective2
Doxycycline is not effective against Legionella bacteria. (umn.edu)
Data suggest doxycycline is more effective than azithromycin for the treatment of rectal CT Footnote 11 Footnote 12 . (canada.ca)
Reduction1
The azithromycin regimen was associated with almost a fourfold reduction in gastrointestinal AEs, reported Chulaluck Tangmonkongvoragul, MD, of Chiang Mai University in Thailand, and co-authors in JAMA Ophthalmology . (medpagetoday.com)