• epirubicin
  • Using DOXOrubicin together with epiRUBicin can increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening, although it is a relatively rare side effect. (drugs.com)
  • cardiomyocytes
  • These results led the researchers to hypothesize that inhibition of apoptosis in Doxorubicin-treated cardiomyocytes was due to Bcl-2 acting as an antioxidant enzyme to decrease the amount of ROS, therefore inhibiting the ability of p53 to induce apoptosis. (wikipedia.org)
  • efficacy
  • The minimization of this side effect may allow for one-for-one (1:1) substitution with doxorubicin in the same treatment regimen, thereby improving safety with no loss of efficacy. (wikipedia.org)
  • reactions
  • Myelosuppression, palmar-plantar erythrodysesthesia (hand-foot syndrome), stomatitis , cardiac toxicity, and infusion-related reactions are the major dose-limiting toxicities of doxorubicin liposomal. (drugs.com)
  • type
  • The amount of doxorubicin (liposomal) you will receive depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer you have. (chemocare.com)
  • cancer cells
  • Our goal is to develop a model for the binding, internalization, and tumor-killing dynamics of liposome-enclosed doxorubicin targeted to cancer cells and develop design principles for creating more effective therapeutics. (mit.edu)
  • The proposed method of action is that upon administration zoptarelin doxorubicin binds to the LHRH receptor and is subsequently internalized, concentrating the toxic doxorubicin within cancer cells and the small subset of normal tissues, as opposed to the completely systemic distribution observed with untargeted chemotherapeutics. (wikipedia.org)