• tumor
  • However, recent studies in mouse models of pancreatic neuroendocrine tumors, glioblastoma, and breast cancer showed an unwanted side effect of SO and related antiangiogenic substances: After initial antitumor activity, enhanced tumor progression and increased metastasis occurred ( 18 , 19 ). (aacrjournals.org)
  • The use of targeted therapy has resulted in major advances in treating several types of sarcoma, including GIST, dermatofibrosarcoma protuberans (DFSP), tenosynovial giant cell tumor, and desmoid tumors. (cancer.net)
  • Angiogenesis is necessary for tumors to grow beyond a few millimeters and is triggered by tumor hypoxia that induces the release of pro-angiogenic factors [ 3 ]. (hindawi.com)
  • Menopausal status, estrogen receptor status, progesterone receptor status [absent (0% of the cells positive) versus expressed], clinical tumor size, histologic grade, Ki-67, Her-2/ neu expression, and type and route of chemotherapy were considered. (aacrjournals.org)
  • Outside clinical trials, such treatment is indicated only for patients with locally advanced disease or those in whom a reduction of primary tumor size may allow breast conservation. (aacrjournals.org)
  • Prognosis and treatment varies on the location, stage and grade of the primary tumor as well as the presence of metastatic disease. (clinicaladvisor.com)
  • Salvage chemotherapy or palliative chemotherapy is given without curative intent, but simply to decrease tumor load and increase life expectancy. (wikipedia.org)
  • adjuvant treatment
  • Adjuvant treatment of breast cancer is designed to treat micrometastatic disease, or breast cancer cells that have escaped the breast and regional lymph nodes but have not yet had an established identifiable metastasis. (medscape.com)
  • systemic
  • Surgical complications were not more prevalent, and the positive aspect was that more patients could be offered breast-conserving surgery after primary systemic treatment. (aacrjournals.org)
  • Importantly, the use of drugs (whether chemotherapy, hormonal therapy or targeted therapy) constitutes systemic therapy for cancer in that they are introduced into the blood stream and are therefore in principle able to address cancer at any anatomic location in the body. (wikipedia.org)
  • clinical
  • On the basis of these results, we designed and conducted a phase I clinical trial of fixed dose doxorubicin followed by escalating doses of flavopiridol on two different flavopiridol schedules. (aacrjournals.org)
  • Preliminary results have shown that incorporation of docetaxel can improve the rate of breast preservation surgery and the overall clinical and pathologic complete response rates. (cancernetwork.com)
  • Treatment and Prevention of Intraepithelial Neoplasia: an Important Target for Accelerated New Agent Development Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. (jove.com)
  • There are no specific clinical features diagnostic of leiomyosarcoma of soft tissue that distinguish these tumors from other soft tissue sarcomas. (clinicaladvisor.com)
  • remission
  • The chance of obtaining pathological complete remission or node-negative status for patients with endocrine nonresponsive tumors compared with those having some estrogen receptor or progesterone receptor expression was 4.22 (95% confidence interval, 2.20-8.09, 33.3% versus 7.5%) and 3.47 (95% confidence interval, 2.09-5.76, 42.9% versus 21.7%), respectively. (aacrjournals.org)
  • Consolidation chemotherapy is given after remission in order to prolong the overall disease-free time and improve overall survival. (wikipedia.org)
  • Maintenance chemotherapy is a repeated low-dose treatment to prolong remission. (wikipedia.org)
  • Sarcoma
  • As such, we explored the potentiation of doxorubicin by flavopiridol in sarcoma, in vitro and in vivo , and conducted a phase I trial of flavopiridol with doxorubicin in patients with advanced sarcomas. (aacrjournals.org)
  • We report that flavopiridol potentiates the effects of doxorubicin in soft tissue sarcoma cell lines both in vitro and in vivo . (aacrjournals.org)
  • resistance
  • CDKs are attractive targets for drug development, given that certain malignancies are dependent on dysregulated cyclin activity ( 1 ) and CDK inhibition has been observed as a potent vehicle to overcome resistance to standard chemotherapy ( 2-4 ). (aacrjournals.org)
  • symptoms
  • Although these tumors are generally associated with small blood vessels, they usually do not present with signs or symptoms of vascular compression. (clinicaladvisor.com)
  • vascular
  • Given the important role of vascular biology in ovarian cancer, it is not surprising that these new treatment approaches have shown promising activity in this disease, even when administered as a single agent. (hindawi.com)
  • patients
  • Our results show that microtubule-associated parameters such as τ protein or tubulin III isotype are prognostic in all patients, irrespective of the type of treatment received. (aacrjournals.org)
  • lymphomas
  • This is particularly applicable in diseases where CDKs are known to be oncogenic drivers and in which doxorubicin is active, including certain types of liposarcomas, lymphomas, and leukemias. (aacrjournals.org)
  • cancer
  • Chemotherapy may be given as an injection, drip or pill, and exerts its effects on cancer by inducing oxidative stress -mainly superoxide and hydrogen peroxide - to all cells, both normal and cancerous. (thehealthbeat.com)
  • This makes the synergistic support with diet and supplementation a crucial part of a cancer treatment program. (thehealthbeat.com)
  • Chemotherapy generates high amounts of oxidative stress, and therefore it would appear that antioxidants could attenuate the effectiveness of the oxidative stress to kill cancer cells. (thehealthbeat.com)
  • In the following diagram, you can see the process by which chemotherapy generates superoxide and hydrogen peroxide to kill cancer cells. (thehealthbeat.com)
  • Chemotherapy is one of the major categories of the medical discipline specifically devoted to pharmacotherapy for cancer, which is called medical oncology. (wikipedia.org)
  • Induction chemotherapy is the first line treatment of cancer with a chemotherapeutic drug. (wikipedia.org)
  • Combined modality chemotherapy is the use of drugs with other cancer treatments, such as surgery, radiation therapy, or hyperthermia therapy. (wikipedia.org)
  • study
  • A 2005 study boldly titled "Use of Antioxidants During Chemotherapy Should Be Avoided" was not based on any conclusive findings. (thehealthbeat.com)
  • A study from 2000 found that "several studies suggest that dietary supplementation with antioxidants can influence the response to chemotherapy as well as the development of adverse side effects that results from treatment. (thehealthbeat.com)
  • The preoperative setting provides an opportunity to study the early molecular changes that may occur in response to treatment. (knowcancer.com)
  • prognosis
  • Pathologists are looking for new ways to quickly determine a tumor's subtype because this helps the health care team understand the prognosis and decide on the treatment plan. (cancer.net)