• tumor
  • However, recent studies in mouse models of pancreatic neuroendocrine tumors, glioblastoma, and breast cancer showed an unwanted side effect of SO and related antiangiogenic substances: After initial antitumor activity, enhanced tumor progression and increased metastasis occurred ( 18 , 19 ). (aacrjournals.org)
  • Radiation therapy or chemotherapy may be used before surgery to shrink the tumor and make removal easier. (cancer.net)
  • This can also be necessary if the tumor grows back in the arm or leg after surgery, radiation therapy, and/or chemotherapy have been completed. (cancer.net)
  • Angiogenesis is necessary for tumors to grow beyond a few millimeters and is triggered by tumor hypoxia that induces the release of pro-angiogenic factors [ 3 ]. (hindawi.com)
  • Prognosis and treatment varies on the location, stage and grade of the primary tumor as well as the presence of metastatic disease. (clinicaladvisor.com)
  • Salvage chemotherapy or palliative chemotherapy is given without curative intent, but simply to decrease tumor load and increase life expectancy. (wikipedia.org)
  • A true cytostatic agent should stop the growth of tumors and could prevent the development of metastases without affecting tumor shrinkage. (aacrjournals.org)
  • systemic
  • Pancreatic cancer is an aggressive malignancy characterized by an extensive local invasion, early systemic dissemination, and pronounced resistance to chemotherapy and radiotherapy ( 1 ). (aacrjournals.org)
  • Surgical complications were not more prevalent, and the positive aspect was that more patients could be offered breast-conserving surgery after primary systemic treatment. (aacrjournals.org)
  • Importantly, the use of drugs (whether chemotherapy, hormonal therapy or targeted therapy) constitutes systemic therapy for cancer in that they are introduced into the blood stream and are therefore in principle able to address cancer at any anatomic location in the body. (wikipedia.org)
  • remission
  • The chance of obtaining pathological complete remission or node-negative status for patients with endocrine nonresponsive tumors compared with those having some estrogen receptor or progesterone receptor expression was 4.22 (95% confidence interval, 2.20-8.09, 33.3% versus 7.5%) and 3.47 (95% confidence interval, 2.09-5.76, 42.9% versus 21.7%), respectively. (aacrjournals.org)
  • Consolidation chemotherapy is given after remission in order to prolong the overall disease-free time and improve overall survival. (wikipedia.org)
  • resistance
  • CDKs are attractive targets for drug development, given that certain malignancies are dependent on dysregulated cyclin activity ( 1 ) and CDK inhibition has been observed as a potent vehicle to overcome resistance to standard chemotherapy ( 2-4 ). (aacrjournals.org)
  • In neoplasia, Hsps are associated with multidrug resistance (18) and apoptosis (19 , 20) and are functionally linked to increased tumorigenicity and treatment resistance in breast (21 , 22 , 23 , 24) and colon (25 , 26) cancers. (aacrjournals.org)
  • symptoms
  • Although these tumors are generally associated with small blood vessels, they usually do not present with signs or symptoms of vascular compression. (clinicaladvisor.com)
  • Chemotherapy may be given with a curative intent (which almost always involves combinations of drugs), or it may aim to prolong life or to reduce symptoms (palliative chemotherapy). (wikipedia.org)
  • Chemotherapy may be given with a curative intent or it may aim to prolong life or to palliate symptoms. (wikipedia.org)
  • vascular
  • While histologically similar, soft tissue leiomyosarcoma has classically been subdivided into three groups for prognostic and treatment purposes: leiomyosarcoma of soft tissue, cutaneous leiomyosarcoma and leiomyosarcoma of vascular origin. (clinicaladvisor.com)
  • lymphomas
  • This is particularly applicable in diseases where CDKs are known to be oncogenic drivers and in which doxorubicin is active, including certain types of liposarcomas, lymphomas, and leukemias. (aacrjournals.org)
  • prognostic
  • Our results show that microtubule-associated parameters such as τ protein or tubulin III isotype are prognostic in all patients, irrespective of the type of treatment received. (aacrjournals.org)
  • study
  • The preoperative setting provides an opportunity to study the early molecular changes that may occur in response to treatment. (knowcancer.com)
  • results
  • This results in the most common side-effects of chemotherapy: myelosuppression (decreased production of blood cells, hence also immunosuppression), mucositis (inflammation of the lining of the digestive tract), and alopecia (hair loss). (wikipedia.org)